The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence

Spinal cord injury (SCI) is a devastating neurological impairment affecting between 250,000 and 500,000 people worldwide each year [1]. Around 90% of SCI patients are left with permanent disabilities that include the loss of motor and sensory function below the level of injury. SCI patients often develop other secondary complications including autonomic/bladder/bowel dysfunctions, neuropathic pain, pressure ulcers and urinary tract infections [2,3]. While there is currently no effective treatment available for SCI, there are promising preclinical studies that have examined the efficacies of the long chain polyunsaturated ω-3 fatty acids (hereafter referred to as PUFAs) using animal models of SCI.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Tags: Original research article Source Type: research