Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
(Source: Molecular Brain)
Source: Molecular Brain - March 13, 2023 Category: Neuroscience Authors: Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi and Naoya Oishi Tags: Correction Source Type: research
Experience-dependent changes in affective valence of taste in male mice
Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to b... (Source: Molecular Brain)
Source: Molecular Brain - March 11, 2023 Category: Neuroscience Authors: Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka and Ayako M. Watabe Tags: Research Source Type: research
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice
In this study, we g... (Source: Molecular Brain)
Source: Molecular Brain - March 7, 2023 Category: Neuroscience Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo and Jianguo G. Gu Tags: Research Source Type: research
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury
In this study, we explored the changes occurring in the gut microbiota and their metabo... (Source: Molecular Brain)
Source: Molecular Brain - February 20, 2023 Category: Neuroscience Authors: Ganggang Kong, Wenwu Zhang, Siyun Zhang, Jiewen Chen, kejun He, Changming Zhang, Xi Yuan and Baoshu Xie Tags: Research Source Type: research
Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for t... (Source: Molecular Brain)
Source: Molecular Brain - February 15, 2023 Category: Neuroscience Authors: Cristina Nu ñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, Charlotte Welinder, Karl Swärd and Malin Wennström Tags: Research Source Type: research
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation
The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we... (Source: Molecular Brain)
Source: Molecular Brain - February 13, 2023 Category: Neuroscience Authors: Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen and Bin Xue Tags: Research Source Type: research
The deficiency of Maged1 attenuates Parkinson's disease progression in mice
Melanoma-associated antigen D1 (Maged1) has critical functions in the central nervous system in both developmental and adult stages. Loss of Maged1 in mice has been linked to depression, cognitive disorder, an... (Source: Molecular Brain)
Source: Molecular Brain - February 11, 2023 Category: Neuroscience Authors: Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You and Jun Gao Tags: Research Source Type: research
A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case ... (Source: Molecular Brain)
Source: Molecular Brain - February 11, 2023 Category: Neuroscience Authors: Guilherme M. Gomes, Julia B är, Anna Karpova and Michael R. Kreutz Tags: Micro report Source Type: research
Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis
Electromagnetic pulse (EMP), a unique type of electromagnetic radiation, may induce diverse neuropsychiatric disorders, such as irritability, hyperkinesis, retardation of learning and memory. However, the unde... (Source: Molecular Brain)
Source: Molecular Brain - February 7, 2023 Category: Neuroscience Authors: Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing and Tao Chen Tags: Research Source Type: research
The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain
NLGN4X was identified as a single causative gene of rare familial nonsyndromic autism for the first time. It encodes the postsynaptic membrane protein Neuroligin4 (NLGN4), the functions and roles of which, howeve... (Source: Molecular Brain)
Source: Molecular Brain - February 6, 2023 Category: Neuroscience Authors: Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki and Atsuo Nakayama Tags: Research Source Type: research
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we evaluated whether chronic pain stimuli could directly affect... (Source: Molecular Brain)
Source: Molecular Brain - February 3, 2023 Category: Neuroscience Authors: Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Takatsune Shimizu, Naoko Kuzumaki and Minoru Narita Tags: Research Source Type: research
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus
A growing body of evidence suggests that excess stress could aggravate tumor progression. The paraventricular nucleus (PVN) of the hypothalamus plays an important role in the adaptation to stress because the h... (Source: Molecular Brain)
Source: Molecular Brain - February 2, 2023 Category: Neuroscience Authors: Sara Yoshida, Yusuke Hamada, Michiko Narita, Daisuke Sato, Kenichi Tanaka, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Hideki Tamura, Kazunori Aoki, Naoko Kuzumaki and Minoru Narita Tags: Research Source Type: research
Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Mutations in the Presenilin genes (PSEN1 and PSEN2) are the major cause of familial Alzheimer ’s disease (AD), highlighting the importance of Presenilin (PS) in AD pathogenesis. Previous studies of PS function in ... (Source: Molecular Brain)
Source: Molecular Brain - January 30, 2023 Category: Neuroscience Authors: Sang Hun Lee, Vadim Y. Bolshakov and Jie Shen Tags: Research Source Type: research
G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses
It is well documented that 17 β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ). H... (Source: Molecular Brain)
Source: Molecular Brain - January 28, 2023 Category: Neuroscience Authors: Leigh Clements, Amy Alexander, Kirsty Hamilton, Andrew Irving and Jenni Harvey Tags: Research Source Type: research
A β42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model
Our previous study showed that the flotillin level is decreased in the blood of patients with Alzheimer ’s disease (AD) when compared to that of patients with non-AD and vascular dementia; however, the molecula... (Source: Molecular Brain)
Source: Molecular Brain - January 26, 2023 Category: Neuroscience Authors: Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga and Makoto Michikawa Tags: Research Source Type: research
