Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
N-glycanase 1 (NGLY1) deficiency is a rare inherited disorder characterized by developmental delay, hypolacrima or alacrima, seizure, intellectual disability, motor deficits, and other neurological symptoms. The.... (Source: Molecular Brain)
Source: Molecular Brain - June 13, 2021 Category: Neuroscience Authors: Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii and Tadashi Suzuki Tags: Research Source Type: research
The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells
Homer is a postsynaptic scaffold protein, which has long and short isoforms. The long form of Homer consists of an N-terminal target-binding domain and a C-terminal multimerization domain, linking multiple pro... (Source: Molecular Brain)
Source: Molecular Brain - June 12, 2021 Category: Neuroscience Authors: Teiichi Furuichi, Yuko Muto, Tetsushi Sadakata, Yumi Sato, Kanehiro Hayashi, Yoko Shiraishi-Yamaguchi and Yo Shinoda Tags: Research Source Type: research
Cannabinoid receptors distribution in mouse cortical plasma membrane compartments
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitabi... (Source: Molecular Brain)
Source: Molecular Brain - June 7, 2021 Category: Neuroscience Authors: Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B. Laprairie and Changiz Taghibiglou Tags: Micro report Source Type: research
Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains
Immunogold labeling allows localization of proteins at the electron microscopy (EM) level of resolution, and quantification of signals. The present paper summarizes methodological issues and experiences gained... (Source: Molecular Brain)
Source: Molecular Brain - June 3, 2021 Category: Neuroscience Authors: Jung-Hwa Tao-Cheng, Virginia Crocker, Sandra Lara Moreira and Rita Azzam Tags: Methodology Source Type: research
Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Microglia, resident immunocompetent cells of the central nervous system, can display a range of reaction states and thereby exhibit distinct biological functions across development, adulthood and under disease... (Source: Molecular Brain)
Source: Molecular Brain - June 3, 2021 Category: Neuroscience Authors: Lara Friess, Mathilde Cheray, Lily Keane, Kathleen Grabert and Bertrand Joseph Tags: Research Source Type: research
