A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in di... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2023 Category: Neuroscience Authors: Ke-Ming Zhang, Yan Shen, Chun-Hui Jia, Hao Wang, Guo-Qiang Bi and Pak-Ming Lau Tags: Micro report Source Type: research
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate ... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2023 Category: Neuroscience Authors: Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee & hellip; Tags: Research Source Type: research
A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice
Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease. The recently developed flexible micro ( μ)-elect... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2023 Category: Neuroscience Authors: Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi and Noriaki Ohkawa Tags: Methodology Source Type: research
Towards multiplexed immunofluorescence of 3D tissues
Profiling molecular expression in situ allows the integration of biomolecular and cellular features, enabling an in-depth understanding of biological systems. Multiplexed immunofluorescence methods can visuali... (Source: Molecular Brain)
Source: Molecular Brain - May 2, 2023 Category: Neuroscience Authors: Wonjin Cho, Sehun Kim and Young-Gyun Park Tags: Nano review Source Type: research
Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus
Increasing evidence indicates the major role of mitochondrial function in neurodegenerative disease. However, it is unclear whether mitochondrial dynamics directly affect postoperative neurocognitive disorder ... (Source: Molecular Brain)
Source: Molecular Brain - April 25, 2023 Category: Neuroscience Authors: Zhibin Xiao, Xiajing Zhang, Guangyao Li, Li Sun, Jiangjing Li, Ziwei Jing, Qingya Qiu, Guangxiang He, Changjun Gao and Xude Sun Tags: Research Source Type: research
Increased social interaction in Shank2-deficient mice following acute social isolation
Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well characterized phenotypes, loneliness issue resides in patients with... (Source: Molecular Brain)
Source: Molecular Brain - April 15, 2023 Category: Neuroscience Authors: Ja Eun Choi and Bong-Kiun Kaang Tags: Micro report Source Type: research
Ablation of microglia does not alter circadian rhythm of locomotor activity
Microglia, as macrophages in the brain, are responsible for immune responses and synaptic remodeling. Although the function of microglia is regulated by circadian rhythms, it is still unclear whether microglia... (Source: Molecular Brain)
Source: Molecular Brain - April 7, 2023 Category: Neuroscience Authors: Futaba Matsui, Sho T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou and Hiroaki Norimoto Tags: Micro report Source Type: research
FMRP binds Per1 mRNA and downregulates its protein expression in mice
FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian... (Source: Molecular Brain)
Source: Molecular Brain - April 5, 2023 Category: Neuroscience Authors: Xiangrong Tang, Jing Zhang, Xin Li, Ying Hu, Dengfeng Liu, Jia-Da Li and Renbin Lu Tags: Research Source Type: research
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice
The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5... (Source: Molecular Brain)
Source: Molecular Brain - March 29, 2023 Category: Neuroscience Authors: Hirotaka Shoji, Kazutaka Ikeda and Tsuyoshi Miyakawa Tags: Research Source Type: research
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates
Cognitive functions depend on the time of day in various organisms. Previously, we found that 24-h recognition memory performance of nocturnal mice changes diurnally through SCOP protein-dependent regulation. ... (Source: Molecular Brain)
Source: Molecular Brain - March 25, 2023 Category: Neuroscience Authors: Kimiko Shimizu, Ken-ichi Inoue, Takao Oishi, Masahiko Takada, Yoshitaka Fukada and Hiroo Imai Tags: Research Source Type: research
Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases
Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development and maintaining their stability until adulthood. The intrace... (Source: Molecular Brain)
Source: Molecular Brain - March 18, 2023 Category: Neuroscience Authors: Yanruo Huang, Qihang Wang, Yunsong Peng, Wenjie Du, Qi Wang, Jiangtao Qi, Zijian Hao and Yingwei Wang Tags: Research Source Type: research
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
(Source: Molecular Brain)
Source: Molecular Brain - March 13, 2023 Category: Neuroscience Authors: Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi and Naoya Oishi Tags: Correction Source Type: research
Experience-dependent changes in affective valence of taste in male mice
Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to b... (Source: Molecular Brain)
Source: Molecular Brain - March 11, 2023 Category: Neuroscience Authors: Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka and Ayako M. Watabe Tags: Research Source Type: research
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice
In this study, we g... (Source: Molecular Brain)
Source: Molecular Brain - March 7, 2023 Category: Neuroscience Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo and Jianguo G. Gu Tags: Research Source Type: research
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury
In this study, we explored the changes occurring in the gut microbiota and their metabo... (Source: Molecular Brain)
Source: Molecular Brain - February 20, 2023 Category: Neuroscience Authors: Ganggang Kong, Wenwu Zhang, Siyun Zhang, Jiewen Chen, kejun He, Changming Zhang, Xi Yuan and Baoshu Xie Tags: Research Source Type: research
