Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum
The 18 kDa translocator protein (TSPO) is a classical marker of neuroinflammation targeted for in vivo molecular imaging. Microglial cells were originally thought to be the only source of TSPO overexpression b... (Source: Molecular Brain)
Source: Molecular Brain - July 5, 2023 Category: Neuroscience Authors: Kelly Ceyz ériat, Alekos Nicolaides, Quentin Amossé, Christine Fossey, Thomas Cailly, Frédéric Fabis, Valentina Garibotto, Carole Escartin, Benjamin B. Tournier and Philippe Millet Tags: Research Source Type: research
Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as survival and differentiation, in neurons. In the current study, we... (Source: Molecular Brain)
Source: Molecular Brain - July 4, 2023 Category: Neuroscience Authors: Bobae Hyeon, Heeyoung Lee, Nury Kim and Won Do Heo Tags: Research Source Type: research
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory. Bidirectional modulation of somatostatin cell mTORC1 activity, a crucial translational control mechanism in synaptic plas... (Source: Molecular Brain)
Source: Molecular Brain - July 3, 2023 Category: Neuroscience Authors: Fran çois-Xavier Michon, Isabel Laplante, Anthony Bosson, Richard Robitaille and Jean-Claude Lacaille Tags: Research Source Type: research
The lateral habenula nucleus regulates pruritic sensation and emotion
Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and systemic diseases, it lacks efficient treatments. The lateral habenula nucleus (LHb) encodes ... (Source: Molecular Brain)
Source: Molecular Brain - June 27, 2023 Category: Neuroscience Authors: Rui Chen, Xiang Xu, Xin-Yue Wang, Wen-Bin Jia, De-Shan Zhao, Na Liu, Zhen Pang, Xiao-Qing Liu and Yan Zhang Tags: Research Source Type: research
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely controlled process, with the production of different neuronal subtypes governed by strict time... (Source: Molecular Brain)
Source: Molecular Brain - June 21, 2023 Category: Neuroscience Authors: Shukui Zhang, Jinyue Zhao, Cheng Zhao, Libo Su and Jianwei Jiao Tags: Research Source Type: research
Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch
Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise functio... (Source: Molecular Brain)
Source: Molecular Brain - June 13, 2023 Category: Neuroscience Authors: Chiwoo Lee, Jihae Oh, Jae-Hyung Lee, Bong-Kiun Kaang and Hyoung-Gon Ko Tags: Micro report Source Type: research
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice
Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1 –7), which in turn acts on MAS receptors (ACE2/Ang (1–7)/MAS receptors pathway). This pathway has neuroprotective properties, making it a ... (Source: Molecular Brain)
Source: Molecular Brain - June 13, 2023 Category: Neuroscience Authors: Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto and Koichi Tan-No Tags: Research Source Type: research
A new AAV tool for highly preferentially targeting hippocampal CA2
Mice hippocampus contains three prominent subregions, CA1, CA3 and DG and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three ... (Source: Molecular Brain)
Source: Molecular Brain - June 11, 2023 Category: Neuroscience Authors: Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie and Moyi Li Tags: Methodology Source Type: research
Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin
The relationship between autism spectrum disorder (ASD) and dendritic spine abnormalities is well known, but it is unclear whether the deficits relate to specific neuron types and brain regions most relevant t... (Source: Molecular Brain)
Source: Molecular Brain - June 9, 2023 Category: Neuroscience Authors: Lucia Celora, Fanny Jaudon, Carmela Vitale and Lorenzo A. Cingolani Tags: Micro report Source Type: research
Partial inactivation of songbird auditory cortex impairs both tempo and pitch discrimination
Neuronal tuning for spectral and temporal features has been studied extensively in the auditory system. In the auditory cortex, diverse combinations of spectral and temporal tuning have been found, but how spe... (Source: Molecular Brain)
Source: Molecular Brain - June 3, 2023 Category: Neuroscience Authors: Gunsoo Kim, Miguel S ánchez-Valpuesta and Mimi H. Kao Tags: Micro report Source Type: research
Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels
Delta-9-tetrahydrocannabinol ( Δ9-THC) is known to produce systemic analgesia that involves CB1 and CB2 cannabinoid receptors. However, there is compelling evidence that Δ9-THC can potently inhibit Cav3.2T-type ca... (Source: Molecular Brain)
Source: Molecular Brain - May 25, 2023 Category: Neuroscience Authors: Vinicius de Maria Gadotti, Flavia Tasmin Techera Antunes and Gerald W. Zamponi Tags: Micro report Source Type: research
Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
Social behavior emerges early in development, a time marked by the onset of neurodevelopmental disorders featuring social deficits, including autism spectrum disorder (ASD). Although social deficits are at the... (Source: Molecular Brain)
Source: Molecular Brain - May 24, 2023 Category: Neuroscience Authors: Melina Matthiesen, Abdessattar Khlaifia, Carl Frank David Steininger Jr, Maryam Dadabhoy, Unza Mumtaz and Maithe Arruda-Carvalho Tags: Research Source Type: research
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha ( α1–4) and β subunits. The GlyR subunits play major roles in the mammalian central nervous system, ranging from regulating simple s... (Source: Molecular Brain)
Source: Molecular Brain - May 22, 2023 Category: Neuroscience Authors: Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie and Keizo Takao Tags: Research Source Type: research
Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses
High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst... (Source: Molecular Brain)
Source: Molecular Brain - May 22, 2023 Category: Neuroscience Authors: Yoonsub Kim, Sooyun Kim, Won-Kyung Ho and Suk-Ho Lee Tags: Research Source Type: research
Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via ionotropic and G-protein coupled mechanisms. GABAergic interne... (Source: Molecular Brain)
Source: Molecular Brain - May 20, 2023 Category: Neuroscience Authors: Simo Ojanen, Tatiana Kuznetsova, Zoia Kharybina, Vootele Voikar, Sari E. Lauri and Tomi Taira Tags: Research Source Type: research
