Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice
Parkinson ’s disease, the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. FBXO7 (F-box protein only 7) (PARK15) mutations cause early-onset Parkinson’... (Source: Molecular Brain)
Source: Molecular Brain - June 14, 2022 Category: Neuroscience Authors: Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Shinichi Ueno, Norihiro Tada and Nobutaka Hattori Tags: Micro report Source Type: research
Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer ’s disease
Alzheimer's disease is associated with various brain dysfunctions, including memory impairment, neuronal loss, astrocyte activation, amyloid- β plaques, and neurofibrillary tangles. Transgenic animal models of ... (Source: Molecular Brain)
Source: Molecular Brain - June 8, 2022 Category: Neuroscience Authors: Sung Hyun Tag, Baeksun Kim, Jinhee Bae, Keun-A Chang and Heh-In Im Tags: Research Source Type: research
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training... (Source: Molecular Brain)
Source: Molecular Brain - June 7, 2022 Category: Neuroscience Authors: Maria Carolina Gonzalez, Andressa Radiske, Janine I. Rossato, Sergio Conde-Ocazionez, Lia R. M. Bevilaqua and Mart ín Cammarota Tags: Micro report Source Type: research
Blood –brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders
The integrity of the blood –brain barrier (BBB) is essential for normal central nervous system (CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the neural environment, we ai... (Source: Molecular Brain)
Source: Molecular Brain - June 1, 2022 Category: Neuroscience Authors: Hema Kumari Alajangi, Mandeep Kaur, Akanksha Sharma, Sumedh Rana, Shipali Thakur, Mary Chatterjee, Neha Singla, Pradeep Kumar Jaiswal, Gurpal Singh and Ravi Pratap Barnwal Tags: Review Source Type: research
Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system
The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic systems. As an anti-reward center, it has been implicated in the etiology of various neuro... (Source: Molecular Brain)
Source: Molecular Brain - May 25, 2022 Category: Neuroscience Authors: Hyun Jung Kim, Hyeijung Yoo, Ji Yeon Kim, Soo Hyun Yang, Hyun Woo Lee, Heon-Jeong Lee, Gi Hoon Son and Hyun Kim Tags: Micro report Source Type: research
Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice
Self-grooming plays an essential role in hygiene maintenance, thermoregulation, and stress response. However, the neural populations involved in self-grooming remain largely unknown. The paraventricular hypoth... (Source: Molecular Brain)
Source: Molecular Brain - May 23, 2022 Category: Neuroscience Authors: Md Tarikul Islam, Takashi Maejima, Ayako Matsui and Michihiro Mieda Tags: Research Source Type: research
Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was shown to be an epileptic drug target... (Source: Molecular Brain)
Source: Molecular Brain - May 16, 2022 Category: Neuroscience Authors: Burcu A. Pazarlar, Sanjay S. Aripaka, Viktor Petukhov, Lars Pinborg, Konstantin Khodosevich and Jens D. Mikkelsen Tags: Research Source Type: research
Cell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer ’s disease patient-derived induced pluripotent stem cells
The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, the CO model may only be representative of certain clinical f... (Source: Molecular Brain)
Source: Molecular Brain - May 16, 2022 Category: Neuroscience Authors: Ju-Hyun Lee, Geon Yoo, Juhyun Choi, Si-Hyung Park, Hyogeun Shin, Renuka Prasad, Yeunehee Lee, Mee Ryung Ahn, Il-Joo Cho and Woong Sun Tags: Micro report Source Type: research
Exogenous expression of an allatotropin-related peptide receptor increased the membrane excitability in Aplysia neurons
Neuropeptides act mostly on a class of G-protein coupled receptors, and play a fundamental role in the functions of neural circuits underlying behaviors. However, physiological functions of some neuropeptide r... (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2022 Category: Neuroscience Authors: Guo Zhang, Shi-Qi Guo, Si-Yuan Yin, Wang-Ding Yuan, Ping Chen, Ji-il Kim, Hui-Ying Wang, Hai-Bo Zhou, Abraham J. Susswein, Bong-Kiun Kaang and Jian Jing Tags: Micro report Source Type: research
CaV β-subunit dependence of forward and reverse trafficking of CaV1.2 calcium channels
Auxiliary CaV β subunits interact with the pore forming CaVα1 subunit to promote the plasma membrane expression of high voltage-activated calcium channels and to modulate the biophysical properties of Ca2+ current... (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2022 Category: Neuroscience Authors: Laurent Ferron, Sydney D. Guderyan, Ethan J. Smith and Gerald W. Zamponi Tags: Short report Source Type: research
Profile of dorsal root ganglion neurons: study of oxytocin expression
Although dorsal root ganglion (DRG) neurons have been so far classified according to the difference in their fibers (A β, Aδ, and C), this classification should be further subdivided according to gene expressio... (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2022 Category: Neuroscience Authors: Taisei Noguri, Dai Hatakeyama, Takashi Kitahashi, Kotaro Oka and Etsuro Ito Tags: Short report Source Type: research
Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model
Monoamine oxidase (MAO) inhibitors have been investigated for the treatment of neuropathic pain. Here, we assessed the antiallodynic effects of a novel MAO-B inhibitor, KDS2010, on paclitaxel (PTX)-induced mec... (Source: Molecular Brain)
Source: Molecular Brain - May 7, 2022 Category: Neuroscience Authors: Su Eun Park, Chiranjivi Neupane, Chan Noh, Ramesh Sharma, Hyun Jin Shin, Thuy Linh Pham, Gyu-Seung Lee, Ki Duk Park, C. Justin Lee, Dong-Wook Kang, So Yeong Lee, Hyun-Woo Kim and Jin Bong Park Tags: Research Source Type: research
New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue
Adult neurogenesis, the proliferation and integration of newly generated neurons, has been observed in the adult mammalian hippocampus of many species. Numerous studies have also found adult neurogenesis in th... (Source: Molecular Brain)
Source: Molecular Brain - May 2, 2022 Category: Neuroscience Authors: Dylan J. Terstege, Kwaku Addo-Osafo, G. Campbell Teskey and Jonathan R. Epp Tags: Micro report Source Type: research
Central and peripheral contributions of T-type calcium channels in pain
Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among the key players in this pathway are T-type calcium channels,... (Source: Molecular Brain)
Source: Molecular Brain - May 2, 2022 Category: Neuroscience Authors: Erika K. Harding and Gerald W. Zamponi Tags: Review Source Type: research
Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
Traumatic brain injury (TBI) is a major public health problem worldwide which causes high mortality and disability. Functioning as microRNA (miRNA) sponges, long non-coding RNA (lncRNA) regulates the expressio... (Source: Molecular Brain)
Source: Molecular Brain - May 2, 2022 Category: Neuroscience Authors: Siqi Wang, Yiyu Sun, Shaobo Hu, Cen Lou and Yuan-Bo Pan Tags: Research Source Type: research
