Dihydroartemisinin attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting oxidative stress
Neonatal hypoxic-ischemic encephalopathy (HIE) induced by perinatal asphyxia is a major cause of neurological disability among infants. Dihydroartemisinin (DHA), derived from artemisinin, well known as an anti... (Source: Molecular Brain)
Source: Molecular Brain - April 28, 2022 Category: Neuroscience Authors: Qian Xiong, Xiaohuan Li, Lei Xia, Zhengyu Yao, Xiuyu Shi and Zhifang Dong Tags: Research Source Type: research
Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory. Several lines of condit... (Source: Molecular Brain)
Source: Molecular Brain - April 28, 2022 Category: Neuroscience Authors: Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue and Toshio Ohshima Tags: Research Source Type: research
Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
RUN and FYVE domain-containing 3 (Rufy3) is a well-known adapter protein of a small GTPase protein family and is bound to the activated Ras family protein to maintain neuronal polarity. However, in experimenta... (Source: Molecular Brain)
Source: Molecular Brain - April 23, 2022 Category: Neuroscience Authors: Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li and Gang Chen Tags: Research Source Type: research
Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum
Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of... (Source: Molecular Brain)
Source: Molecular Brain - April 11, 2022 Category: Neuroscience Authors: Yongqiang Wu, Yanzi Zhong, Xufeng Liao, Xiangguang Miao, Jianbo Yu, Xinsheng Lai, Yu Zhang, Chaolin Ma, Haili Pan and Shunqi Wang Tags: Research Source Type: research
Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome
(Source: Molecular Brain)
Source: Molecular Brain - April 11, 2022 Category: Neuroscience Authors: Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto and Takanobu Nakazawa Tags: Correction Source Type: research
Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppNL-G-F/NL-G-F mice
As the proportion of elderly in society increases, so do the number of older patients undergoing surgical procedures. This is concerning as exposure to anesthesia has been identified as a risk factor for Alzhe... (Source: Molecular Brain)
Source: Molecular Brain - April 7, 2022 Category: Neuroscience Authors: Ryo Niikura, Tomoyuki Miyazaki, Kenkichi Takase, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido and Takahisa Goto Tags: Research Source Type: research
Failure of observing NeuroD1-induced microglia-to-neuron conversion in vitro is not attributed to the low NeuroD1 expression level
NeuroD1-induced microglia-to-neuron conversion is hotly debated. Recently, we published a paper in Neuron demonstrating that NeuroD1 cannot induce microglia-to-neuron cross-lineage conversion. In the same issue o... (Source: Molecular Brain)
Source: Molecular Brain - April 5, 2022 Category: Neuroscience Authors: Yanxia Rao and Bo Peng Tags: Letter to the Editor Source Type: research
Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice
Olfactory receptors have been detected in extraolfactory organs. Olfactory receptor 78 (Olfr78), proposed to respond to small organic acids, is widely expressed in the kidney, arterioles, colon, and prostate. ... (Source: Molecular Brain)
Source: Molecular Brain - April 4, 2022 Category: Neuroscience Authors: Akiko Nakashima, Noriyuki Nakashima, Kie Nakashima and Makoto Takano Tags: Micro report Source Type: research
CTCF in parvalbumin-expressing neurons regulates motor, anxiety and social behavior and neuronal identity
CCCTC-binding factor (CTCF) is a regulator of chromatin organization and has direct effects on gene transcription. Mutations in CTCF have been identified in individuals with neurodevelopmental conditions. Ther... (Source: Molecular Brain)
Source: Molecular Brain - April 4, 2022 Category: Neuroscience Authors: Liron Davis, Prudhvi Raj Rayi, Dmitriy Getselter, Hanoch Kaphzan and Evan Elliott Tags: Research Source Type: research
Hif1 α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model
Hypoxia-inducible factor 1 α (Hif1α) plays a crucial role in brain development. To study the function of Hif1α in early brain development, we generated neuroepithelial cell-specific Hif1α-knockout mice. Hif1α-kno... (Source: Molecular Brain)
Source: Molecular Brain - March 31, 2022 Category: Neuroscience Authors: Daisuke Sakai, Takeru Sugawara, Tomonori Kurokawa, Yuki Murakami, Mitsuhiro Tomosugi, Hiroko Masuta, Hiromi Sakata-Haga, Toshihisa Hatta and Hiroki Shoji Tags: Research Source Type: research
Locus specific reduction of L1 expression in the cortices of individuals with amyotrophic lateral sclerosis
The activation and dysregulation of retrotransposons has been identified in the CNS of individuals with the fatal neurodegenerative disorder Amyotrophic lateral sclerosis (ALS). This includes elements from mul... (Source: Molecular Brain)
Source: Molecular Brain - March 28, 2022 Category: Neuroscience Authors: Abigail L. Pfaff, Vivien J. Bubb, John P. Quinn and Sulev Koks Tags: Research Source Type: research
Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 mi... (Source: Molecular Brain)
Source: Molecular Brain - March 28, 2022 Category: Neuroscience Authors: Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto and Takanobu Nakazawa Tags: Micro report Source Type: research
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
Abnormal deposition of α-synuclein aggregates in Lewy bodies and Lewy neurites is the hallmark lesion in Parkinson’s disease (PD). These aggregates, thought to be the culprit of disease pathogenesis, spread th... (Source: Molecular Brain)
Source: Molecular Brain - March 28, 2022 Category: Neuroscience Authors: Joo-Ok Min, Timo Stroh äker, Byung-Chul Jeong, Markus Zweckstetter and Seung-Jae Lee Tags: Research Source Type: research
Brain region networks for the assimilation of new associative memory into a schema
Alterations in long-range functional connectivity between distinct brain regions are thought to contribute to the encoding of memory. However, little is known about how the activation of an existing network of... (Source: Molecular Brain)
Source: Molecular Brain - March 24, 2022 Category: Neuroscience Authors: Tomonori Takeuchi, Makoto Tamura, Dorothy Tse, Yasushi Kajii, Guill én Fernández and Richard G. M. Morris Tags: Research Source Type: research
Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior
Calsyntenins (CLSTNs) are important synaptic molecules whose molecular functions are not fully understood. Although mutations in calsyntenin (CLSTN) genes have been associated with psychiatric disorders in humans... (Source: Molecular Brain)
Source: Molecular Brain - March 12, 2022 Category: Neuroscience Authors: Keita Mori, Michinori Koebis, Kazuki Nakao, Shizuka Kobayashi, Yuji Kiyama, Masahiko Watanabe, Toshiya Manabe, Yuichi Iino and Atsu Aiba Tags: Research Source Type: research
