AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
Calcium ions (Ca2+) play pivotal roles in regulating diverse brain functions, including cognition, emotion, locomotion, and learning and memory. These functions are intricately regulated by a variety of Ca2+-depe... (Source: Molecular Brain)
Source: Molecular Brain - October 17, 2023 Category: Neuroscience Authors: Yeon Hee Kook, Hyoin Lee, Jinsu Lee, Yeonji Jeong, Jaerang Rho, Won Do Heo and Sangkyu Lee Tags: Methodology Source Type: research
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the aversive value of a painful or oftentimes even a similar, non-painful stimulus. Mechani... (Source: Molecular Brain)
Source: Molecular Brain - October 13, 2023 Category: Neuroscience Authors: Hyun Jung Jee, Elaine Zhu, Mengqi Sun, Weizhuo Liu, Qiaosheng Zhang and Jing Wang Tags: Research Source Type: research
Rab11a in the spinal cord: an essential contributor to complete Freund ’s adjuvant-induced inflammatory pain in mice
Inflammatory pain is a commonly observed clinical symptom in a range of acute and chronic diseases. However, the mechanism of inflammatory pain is far from clear yet. Rab11a, a small molecule guanosine triphos... (Source: Molecular Brain)
Source: Molecular Brain - September 28, 2023 Category: Neuroscience Authors: Jun-Xiang Gu, Jian Wang, Fu-Juan Ma, Miao-Miao Liu, Si-Hai Chen, Yi Wei, Yi-Fan Xiao, Pei-Yuan Lv, Xin Liu, Jian-Qiang Qu, Xian-Xia Yan and Tao Chen Tags: Research Source Type: research
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes t... (Source: Molecular Brain)
Source: Molecular Brain - September 25, 2023 Category: Neuroscience Authors: Kristoffer H øjgaard, Bianka Szöllősi, Kim Henningsen, Natsumi Minami, Nobuhiro Nakanishi, Erik Kaadt, Makoto Tamura, Richard G.M. Morris, Tomonori Takeuchi and Betina Elfving Tags: Research Source Type: research
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels. Recently, a new heterozygous missense muta... (Source: Molecular Brain)
Source: Molecular Brain - September 21, 2023 Category: Neuroscience Authors: Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard and Norbert Weiss Tags: Micro report Source Type: research
Comparison of Huntington ’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Huntington ’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment due to the expansion of a polyglutamine (CAG) repeat in the N-te... (Source: Molecular Brain)
Source: Molecular Brain - September 19, 2023 Category: Neuroscience Authors: Si Han Li, Tash-Lynn L. Colson, Jingwei Chen, Khaled S. Abd-Elrahman and Stephen S. G. Ferguson Tags: Research Source Type: research
Recombinase-independent AAV for anterograde transsynaptic tracing
Viral transsynaptic labeling has become indispensable for investigating the functional connectivity of neural circuits in the mammalian brain. Adeno-associated virus serotype 1 (AAV1) allows for anterograde tr... (Source: Molecular Brain)
Source: Molecular Brain - September 15, 2023 Category: Neuroscience Authors: Islam Faress, Valentina Khalil, Haruka Yamamoto, Szilard Sajgo, Keisuke Yonehara and Sadegh Nabavi Tags: Micro report Source Type: research
Changes in oligodendroglial subpopulations in Parkinson ’s disease
Parkinson ’s disease (PD) is characterized by a selective loss of dopaminergic neurons. While most research on PD conducted to date has focused on neurons and, to a certain extent, glia, few studies have invest... (Source: Molecular Brain)
Source: Molecular Brain - September 14, 2023 Category: Neuroscience Authors: Eun-Jin Bae, Dayana P érez-Acuña, Ka Hyun Rhee and Seung-Jae Lee Tags: Micro report Source Type: research
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) ... (Source: Molecular Brain)
Source: Molecular Brain - August 21, 2023 Category: Neuroscience Authors: Helo ísa Alonso-Matielo, Zizhen Zhang, Eder Gambeta, Junting Huang, Lina Chen, Gabriel Oliveira de Melo, Camila Squarzoni Dale and Gerald W. Zamponi Tags: Micro report Source Type: research
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Alzheimer ’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflammation, and impaired cognition. The recent identification of associations between protein kinases a... (Source: Molecular Brain)
Source: Molecular Brain - August 14, 2023 Category: Neuroscience Authors: Hyun-ju Lee, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang and Hyang-Sook Hoe Tags: Micro report Source Type: research
Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress
Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DNA-binding protein 43 kDa (TDP-43), which is a common component of neuronal inclusions i... (Source: Molecular Brain)
Source: Molecular Brain - July 26, 2023 Category: Neuroscience Authors: Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi and Hirotaka James Okano Tags: Research Source Type: research
C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
Changes in neural activity induced by learning and novel environments have been reported to lead to the formation of new synapses in the adult brain. However, the underlying molecular mechanism is not well und... (Source: Molecular Brain)
Source: Molecular Brain - July 24, 2023 Category: Neuroscience Authors: Takahiro Aimi, Keiko Matsuda and Michisuke Yuzaki Tags: Research Source Type: research
Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels
The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction ... (Source: Molecular Brain)
Source: Molecular Brain - July 18, 2023 Category: Neuroscience Authors: Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vin ícius M. Gadotti and Gerald W. Zamponi Tags: Micro report Source Type: research
Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
Schizophrenia is a psychiatric disorder that affects around 1% of the population in widespread populations, with severe cases leading to long-term hospitalization and necessitation of lifelong treatment. Recen... (Source: Molecular Brain)
Source: Molecular Brain - July 12, 2023 Category: Neuroscience Authors: Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A. Kato and Takatoshi Hikida Tags: Research Source Type: research
Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation
Intrinsic plasticity of the cerebellar Purkinje cell (PC) plays a critical role in motor memory consolidation. However, detailed changes in their intrinsic properties during memory consolidation are not well u... (Source: Molecular Brain)
Source: Molecular Brain - July 10, 2023 Category: Neuroscience Authors: Dong Cheol Jang, Geehoon Chung, Sun Kwang Kim and Sang Jeong Kim Tags: Research Source Type: research
