Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice
Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone m... (Source: Molecular Brain)
Source: Molecular Brain - July 3, 2021 Category: Neuroscience Authors: Yong Gyu Kim, Myeong Seong Bak, Ahbin Kim, Yujin Kim, Yun-Cheol Chae, Ye Lee Kim, Yang-Sook Chun, Joon-Yong An, Sang-Beom Seo, Sang Jeong Kim and Yong-Seok Lee Tags: Research Source Type: research
Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice
Recently, a pathological condition called cochlear synaptopathy has been clarified, and as a disorder of the auditory nerve synapses that occurs prior to failure of hair cells, it has been recognized as a majo... (Source: Molecular Brain)
Source: Molecular Brain - July 3, 2021 Category: Neuroscience Authors: Yutaka Koizumi, Kunio Mizutari, Satoko Kawauchi, Shunichi Sato, Akihiro Shiotani and Seiji Kakehata Tags: Research Source Type: research
Aversive emotion rapidly activates orexin neurons and increases heart rate in freely moving mice
The perifornical area of the hypothalamus has been known as the center for the defense response, or fight-or-flight response, which is characterized by a concomitant rise in arterial blood pressure, heart rate... (Source: Molecular Brain)
Source: Molecular Brain - June 30, 2021 Category: Neuroscience Authors: Akira Yamashita, Shunpei Moriya, Ryusei Nishi, Jun Kaminosono, Akihiro Yamanaka and Tomoyuki Kuwaki Tags: Research Source Type: research
Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Mitochondrial function is required for brain energy homeostasis and neuroadaptation. Recent studies demonstrate that cocaine affects mitochondrial dynamics and morphological characteristics within the nucleus ... (Source: Molecular Brain)
Source: Molecular Brain - June 29, 2021 Category: Neuroscience Authors: Shannon L. Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J. Russo, Gustavo Turecki, Amy M. Gancarz-Kausch, David M. Dietz and Mary Kay Lobo Tags: Research Source Type: research
In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events
Identification of neurons undergoing plasticity in response to external stimuli is one of the pertinent problems in neuroscience. Immediate early genes (IEGs) are widely used as a marker for neuronal plasticit... (Source: Molecular Brain)
Source: Molecular Brain - June 29, 2021 Category: Neuroscience Authors: P. Meenakshi, S. Kumar and J. Balaji Tags: Research Source Type: research
Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
(Source: Molecular Brain)
Source: Molecular Brain - June 29, 2021 Category: Neuroscience Authors: Hyungju Park, Kyung-Seok Han, Jinsoo Seo, Jaekwang Lee, Shashank M. Dravid, Junsung Woo, Heejung Chun, Sukhee Cho, Jin Young Bae, Heeyoung An, Woohyun Koh, Bo-Eun Yoon, Rolando Berlinguer-Palmini, Guido Mannaioni, Stephen F. Traynelis, Yong Chul Bae & hel Tags: Correction Source Type: research
The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury
Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are ... (Source: Molecular Brain)
Source: Molecular Brain - June 28, 2021 Category: Neuroscience Authors: Jiyun Peng, Min-Hee Yi, Heejin Jeong, Przemyslaw Peter McEwan, Jiaying Zheng, Gongxiong Wu, Shashank Ganatra, Yi Ren, Jason R. Richardson, Seog Bae Oh and Long-Jun Wu Tags: Research Source Type: research
Autophagy activity contributes to the impairment of social recognition in Epac2 −/− mice
Autophagy is a lysosomal degradation pathway that regulates cellular homeostasis. It is constitutively active in neurons and controls the essential steps of neuronal development, leading to its dysfunction in ... (Source: Molecular Brain)
Source: Molecular Brain - June 28, 2021 Category: Neuroscience Authors: Ji-Hye Kwak, You-kyung Lee, Mi-Hee Jun, Mootaek Roh, Hyunhyo Seo, Juhyun Lee, Kyungmin Lee and Jin-A Lee Tags: Micro report Source Type: research
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotr... (Source: Molecular Brain)
Source: Molecular Brain - June 26, 2021 Category: Neuroscience Authors: Tertia D. Purves-Tyson, Amelia M. Brown, Christin Weissleder, Debora A. Rothmond and Cynthia Shannon Weickert Tags: Research Source Type: research
Adult neurogenesis mediates forgetting of multiple types of memory in the rat
The formation and retention of hippocampus-dependent memories is impacted by neurogenesis, a process that involves the production of new neurons in the dentate gyrus of the hippocampus. Recent studies demonstr... (Source: Molecular Brain)
Source: Molecular Brain - June 26, 2021 Category: Neuroscience Authors: Gavin A. Scott, Dylan J. Terstege, Andrew J. Roebuck, Kelsea A. Gorzo, Alex P. Vu, John G. Howland and Jonathan R. Epp Tags: Research Source Type: research
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they captu... (Source: Molecular Brain)
Source: Molecular Brain - June 26, 2021 Category: Neuroscience Authors: Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak Tags: Research Source Type: research
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice
The neuronal circuitry for pain signals has been intensively studied for decades. The external lateral parabrachial nucleus (PB) was shown to play a crucial role in nociceptive information processing. Previous... (Source: Molecular Brain)
Source: Molecular Brain - June 24, 2021 Category: Neuroscience Authors: Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato and Ayako M. Watabe Tags: Short report Source Type: research
In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons
Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterised by deficits in social interactions and repetitive behaviours. ASDs have a strong genetic basis with mutations involved in the dev... (Source: Molecular Brain)
Source: Molecular Brain - June 24, 2021 Category: Neuroscience Authors: Yukti Vyas, Yewon Jung, Kevin Lee, Craig C. Garner and Johanna M. Montgomery Tags: Micro report Source Type: research
Correction to: Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Brain)
Source: Molecular Brain - June 17, 2021 Category: Neuroscience Authors: Gi Seok Jeong, Joon Young Chang, Ji Soo Park, Seung-A Lee, DoYeun Park, Junsung Woo, Heeyoung An, C. Justin Lee and Sang-Hoon Lee Tags: Correction Source Type: research
Molecular laterality encodes stress susceptibility in the medial prefrontal cortex
Functional lateralization of the prefrontal cortex has been implicated in stress and emotional disorders, yet underlying gene expression changes remains unknown. Here, we report molecular signatures lateralize... (Source: Molecular Brain)
Source: Molecular Brain - June 14, 2021 Category: Neuroscience Authors: Sujin Chae, Jiso Hong, Keunsoo Kang, Anna Shin, Dae-Gun Kim, Sinjeong Lee, Moo-young Kim, Inkyung Jung and Daesoo Kim Tags: Research Source Type: research
