Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer ’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. I... (Source: Molecular Brain)
Source: Molecular Brain - July 27, 2021 Category: Neuroscience Authors: Haiwang Zhang, Youssif Ben Zablah, An Liu, Dongju Lee, Haorui Zhang, Yanghong Meng, Changxi Zhou, Xingde Liu, Yiming Wang and Zhengping Jia Tags: Research Source Type: research
Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients
Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hen... (Source: Molecular Brain)
Source: Molecular Brain - July 23, 2021 Category: Neuroscience Authors: Arpna Srivastava, Krishan Kumar, Jyotirmoy Banerjee, Manjari Tripathi, Vivek Dubey, Devina Sharma, Nitin Yadav, M. C. Sharma, Sanjeev Lalwani, Ramesh Doddamani, P. Sarat Chandra and Aparna Banerjee Dixit Tags: Research Source Type: research
The role m6A RNA methylation is CNS development and glioma pathogenesis
Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification. m6A methylation is the most... (Source: Molecular Brain)
Source: Molecular Brain - July 19, 2021 Category: Neuroscience Authors: Ting Pan, Fan Wu, Liwen Li, Shiyan Wu, Fang Zhou, Ping Zhang, Caixing Sun and Liang Xia Tags: Review Source Type: research
Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling
Bacterial meningitis is a life-threatening infectious disease with severe neurological sequelae and a high mortality rate, in which Escherichia coli is one of the primary Gram-negative etiological bacteria. Menin... (Source: Molecular Brain)
Source: Molecular Brain - July 19, 2021 Category: Neuroscience Authors: Jiyang Fu, Liang Li, Dong Huo, Ruicheng Yang, Bo Yang, Bojie Xu, Xiaopei Yang, Menghong Dai, Chen Tan, Huanchun Chen and Xiangru Wang Tags: Research Source Type: research
Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons
We have previously reported that cellular prion protein (PrPC) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mou... (Source: Molecular Brain)
Source: Molecular Brain - July 19, 2021 Category: Neuroscience Authors: Sun Huang, Stefanie A. Black, Junting Huang, Peter K. Stys and Gerald W. Zamponi Tags: Micro report Source Type: research
RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin+ neurons
Anxiety disorders are the most common psychiatric disorders, and the change in the activity of the prefrontal cortex (PFC) is considered as the underlying pathological mechanism. Parvalbumin-expressing (PV+) i... (Source: Molecular Brain)
Source: Molecular Brain - July 19, 2021 Category: Neuroscience Authors: Ying Sun, Le Ma, Jianhua Chen, Weidi Wang, Shiyu Peng, Ying Cheng, Yu Zhang, Jinghong Chen and Peijun Ju Tags: Research Source Type: research
Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing
T-type calcium channels are important regulators of neuronal excitability. The mammalian brain expresses three T-type channel isoforms (Cav3.1, Cav3.2 and Cav3.3) with distinct biophysical properties that are ... (Source: Molecular Brain)
Source: Molecular Brain - July 17, 2021 Category: Neuroscience Authors: Fernando R. Fernandez, Mircea C. Iftinca, Gerald W. Zamponi and Ray W. Turner Tags: Micro report Source Type: research
Correction to: Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice
(Source: Molecular Brain)
Source: Molecular Brain - July 16, 2021 Category: Neuroscience Authors: Tiziana Imbriglio, Remy Verhaeghe, Nico Antenucci, Stefania Maccari, Giuseppe Battaglia, Ferdinando Nicoletti and Milena Cannella Tags: Correction Source Type: research
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy
Clock genes not only regulate the circadian rhythm of physiological activities but also participate in the pathogenesis of many diseases. Previous studies have documented the abnormal expression of clock genes... (Source: Molecular Brain)
Source: Molecular Brain - July 14, 2021 Category: Neuroscience Authors: Hao Wu, Yong Liu, Lishuo Liu, Qiang Meng, Changwang Du, Kuo Li, Shan Dong, Yong Zhang, Huanfa Li and Hua Zhang Tags: Research Source Type: research
A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Memory and long term potentiation require de novo protein synthesis. A key regulator of this process is mTORC1, a complex comprising the mTOR kinase. Growth factors activate mTORC1 via a pathway involving PI3-... (Source: Molecular Brain)
Source: Molecular Brain - July 12, 2021 Category: Neuroscience Authors: Dany Khamsing, Sol ène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen and Claire Desnos Tags: Research Source Type: research
Disruption of the astrocyte –neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte –neuron interactions on synapses are called tripartite synapses. These control the synaptic function in... (Source: Molecular Brain)
Source: Molecular Brain - July 10, 2021 Category: Neuroscience Authors: Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim and Yun Ha Jeong Tags: Micro report Source Type: research
APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer ’s disease and age-matched non-demented brains
Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factors for AD is the apolipoprotein E4 (E4) allele. The APOE4 genotype has been shown to negatively impa... (Source: Molecular Brain)
Source: Molecular Brain - July 8, 2021 Category: Neuroscience Authors: Joseph O. Ojo, Jon M. Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford and Corbin Bachmeier Tags: Research Source Type: research
Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
(Source: Molecular Brain)
Source: Molecular Brain - July 8, 2021 Category: Neuroscience Authors: Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys and Varghese John Tags: Correction Source Type: research
Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein
Rabies virus (RV) is the most widely used vector for mapping neural circuits. Previous studies have shown that the RV glycoprotein can be a target to improve the retrograde transsynaptic tracing efficiency. Ho... (Source: Molecular Brain)
Source: Molecular Brain - July 8, 2021 Category: Neuroscience Authors: Fan Jia, Li Li, Haizhou Liu, Pei Lv, Xiangwei Shi, Yang Wu, Chen Ling and Fuqiang Xu Tags: Methodology Source Type: research
Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects
Major depressive disorder (MDD) is associated with significant morbidity and mortality. Most antidepressant medications target the serotonin and norepinephrine transporters, but a significant minority of patie... (Source: Molecular Brain)
Source: Molecular Brain - July 5, 2021 Category: Neuroscience Authors: Anlong Jiang, Ping Su, Shupeng Li, Albert H. C. Wong and Fang Liu Tags: Research Source Type: research
