Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons

We have previously reported that cellular prion protein (PrPC) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mou...

Source: Molecular Brain - July 19, 2021 Category: Neuroscience Authors: Sun Huang, Stefanie A. Black, Junting Huang, Peter K. Stys and Gerald W. Zamponi Tags: Micro report Source Type: research