The cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation
Protein kinases are responsible for protein phosphorylation and are involved in important signal transduction pathways; however, a considerable number of poorly characterized kinases may be involved in neurona... (Source: Molecular Brain)
Source: Molecular Brain - July 26, 2022 Category: Neuroscience Authors: Jun Egawa, Reza K. Arta, Vance P. Lemmon, Melissa Mu ños-Barrero, Yan Shi, Michihiro Igarashi and Toshiyuki Someya Tags: Micro report Source Type: research
Knockdown of myorg leads to brain calcification in zebrafish
Primary familial brain calcification (PFBC) is a neurogenetic disorder characterized by bilateral calcified deposits in the brain. We previously identified that MYORG as the first pathogenic gene for autosomal re... (Source: Molecular Brain)
Source: Molecular Brain - July 23, 2022 Category: Neuroscience Authors: Miao Zhao, Xiao-Hong Lin, Yi-Heng Zeng, Hui-Zhen Su, Chong Wang, Kang Yang, Yi-Kun Chen, Bi-Wei Lin, Xiang-Ping Yao and Wan-Jin Chen Tags: Short report Source Type: research
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
This study aims to systematically analyze the associatio... (Source: Molecular Brain)
Source: Molecular Brain - July 23, 2022 Category: Neuroscience Authors: Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun ’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen and Feng Zhang Tags: Research Source Type: research
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Previous immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated nerves. However, functions of these channels at NRs remain elusive. In the present study... (Source: Molecular Brain)
Source: Molecular Brain - July 20, 2022 Category: Neuroscience Authors: Sotatsu Tonomura, Jennifer Ling and Jianguo G. Gu Tags: Research Source Type: research
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
Cell senescence is a basic aging mechanism. Previous studies have found that the cellular senescence in adipose tissue and other tissues, such as the pancreas, muscle and liver, is associated with the pathogen... (Source: Molecular Brain)
Source: Molecular Brain - July 18, 2022 Category: Neuroscience Authors: Wen-Jiao Xue, Cheng-Feng He, Ren-Yuan Zhou, Xiao-Die Xu, Lv-Xuan Xiang, Jian-Tao Wang, Xin-Ru Wang, Hou-Guang Zhou and Jing-Chun Guo Tags: Research Source Type: research
Subacute and chronic proteomic and phosphoproteomic analyses of a mouse model of traumatic brain injury at two timepoints and comparison with chronic traumatic encephalopathy in human samples
Repetitive mild traumatic brain injury (r-mTBI) is the most widespread type of brain trauma worldwide. The cumulative injury effect triggers long-lasting pathological and molecular changes that may increase ri... (Source: Molecular Brain)
Source: Molecular Brain - July 18, 2022 Category: Neuroscience Authors: Alexander Morin, Roderick Davis, Teresa Darcey, Michael Mullan, Benoit Mouzon and Fiona Crawford Tags: Research Source Type: research
Donepezil ameliorates A β pathology but not tau pathology in 5xFAD mice
The cholinesterase inhibitor donepezil is used to improve A β pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear. Thus, we e... (Source: Molecular Brain)
Source: Molecular Brain - July 18, 2022 Category: Neuroscience Authors: Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon and Hyang-Sook Hoe Tags: Micro report Source Type: research
Correction to: Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
(Source: Molecular Brain)
Source: Molecular Brain - July 13, 2022 Category: Neuroscience Authors: Siqi Wang, Yiyu Sun, Shaobo Hu, Cen Lou and Yuan ‑Bo Pan Tags: Correction Source Type: research
Increased spine PIP3 is sequestered from dendritic shafts
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study unco... (Source: Molecular Brain)
Source: Molecular Brain - July 4, 2022 Category: Neuroscience Authors: Yoshibumi Ueda, Naotoshi Sugimoto and Takeaki Ozawa Tags: Research Source Type: research
Distribution of five clinically important neuroglial proteins in the human brain
Glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), neurofilament light chain (NFL), tau and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) are five neuroglial proteins that are used as CSF or... (Source: Molecular Brain)
Source: Molecular Brain - June 29, 2022 Category: Neuroscience Authors: Karl Sj ölin, Kim Kultima, Anders Larsson, Eva Freyhult, Christina Zjukovskaja, Kanar Alkass and Joachim Burman Tags: Research Source Type: research
Correction to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson ’s disease
(Source: Molecular Brain)
Source: Molecular Brain - June 22, 2022 Category: Neuroscience Authors: Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu and Min Zhuo Tags: Correction Source Type: research
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells
Cerebral malaria is the most serious complication of malaria infection, with 26% of surviving children having neurological sequelae, which may be caused by neuron damage, but the mechanism is not clear. Ferrop... (Source: Molecular Brain)
Source: Molecular Brain - June 20, 2022 Category: Neuroscience Authors: Jiao Liang, Yan Shen, Yi Wang, Yuxiao Huang, Jun Wang, Qinghao Zhu, Guodong Tong, Kangjie Yu, Wei Cao, Qi Wang, Yinghui Li and Ya Zhao Tags: Research Source Type: research
mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination
Hippocampal CA1 parvalbumin-expressing interneurons (PV INs) play a central role in controlling principal cell activity and orchestrating network oscillations. PV INs receive excitatory inputs from CA3 Schaffe... (Source: Molecular Brain)
Source: Molecular Brain - June 17, 2022 Category: Neuroscience Authors: Abdessattar Khlaifia, Eve Honor é, Julien Artinian, Isabel Laplante and Jean-Claude Lacaille Tags: Research Source Type: research
Genome-wide translation control analysis of developing human neurons
During neuronal differentiation, neuroprogenitor cells become polarized, change shape, extend axons, and form complex dendritic trees. While growing, axons are guided by molecular cues to their final destinati... (Source: Molecular Brain)
Source: Molecular Brain - June 15, 2022 Category: Neuroscience Authors: Érico Moreto Lins, Natássia Cristina Martins Oliveira, Osvaldo Reis, Adriano Ferrasa, Roberto Herai, Alysson R. Muotri, Katlin Brauer Massirer and Mário Henrique Bengtson Tags: Research Source Type: research
Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice
Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment and Parkinson ’s disease (PD)-related circadian perturbations that may represent an early prodromal marker of PD. Cyclin-dep... (Source: Molecular Brain)
Source: Molecular Brain - June 14, 2022 Category: Neuroscience Authors: Hu Zhou, Jingxin Zhang, Huaxiang Shi, Pengfei Li, Xin Sui, Yongan Wang and Liyun Wang Tags: Research Source Type: research
