Transcriptomic profiling of sporadic Alzheimer ’s disease patients
Alzheimer ’s disease (AD) manifested before age 65 is commonly referred to as early-onset AD (EOAD) (Reitz et al. Neurol Genet. 2020;6:e512). While the majority (> 90%) of EOAD cases are not caused by autosomal... (Source: Molecular Brain)
Source: Molecular Brain - October 12, 2022 Category: Neuroscience Authors: Andrew B. Caldwell, Balaji G. Anantharaman, Srinivasan Ramachandran, Phuong Nguyen, Qing Liu, Ivy Trinh, Douglas R. Galasko, Paula A. Desplats, Steven L. Wagner and Shankar Subramaniam Tags: Micro report Source Type: research
Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs... (Source: Molecular Brain)
Source: Molecular Brain - September 19, 2022 Category: Neuroscience Authors: Ève Honoré, Inês Belo do Nascimento, Isabel Laplante and Jean-Claude Lacaille Tags: Micro report Source Type: research
Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia
Tubby mice exhibit hearing impairment due to the loss of stereocilin from the tip regions that connect the tallest stereocilia of the outer hair cells (OHCs) to the tectorial membrane. Stereocilin is an essentia... (Source: Molecular Brain)
Source: Molecular Brain - September 14, 2022 Category: Neuroscience Authors: Song Yi Youn, Hyehyun Min, Se Rok Jeong, Jiahn Lee, Seok Jun Moon, Jinwoong Bok and Chul Hoon Kim Tags: Micro report Source Type: research
Beta amyloid deposition and cognitive decline in Parkinson ’s disease: a study of the PPMI cohort
The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson ’s disease pathology and much controversy remains regarding its role, specifically in cog... (Source: Molecular Brain)
Source: Molecular Brain - September 13, 2022 Category: Neuroscience Authors: Alexander S. Mihaescu, Mikaeel Valli, Carme Uribe, Maria Diez-Cirarda, Mario Masellis, Ariel Graff-Guerrero and Antonio P. Strafella Tags: Research Source Type: research
Spatiotemporal Pavlovian head-fixed reversal learning task for mice
Our world is full of uncertainty. Animals, including humans, need to behave flexibly to adjust to ever-changing environments. Reversal learning tasks have been used to assess behavioral flexibility in many spe... (Source: Molecular Brain)
Source: Molecular Brain - September 7, 2022 Category: Neuroscience Authors: Kohei Yamamoto, Kota Yamada, Saya Yatagai, Yusuke Ujihara and Koji Toda Tags: Research Source Type: research
Systemic injection of nicotinic acetylcholine receptor antagonist mecamylamine affects licking, eyelid size, and locomotor and autonomic activities but not temporal prediction in male mice
Nicotinic acetylcholine receptors are thought to be associated with a wide range of phenomena, such as movement, learning, memory, attention, and addiction. However, the causal relationship between nicotinic r... (Source: Molecular Brain)
Source: Molecular Brain - September 6, 2022 Category: Neuroscience Authors: Shohei Kaneko, Yasuyuki Niki, Kota Yamada, Daiki Nasukawa, Yusuke Ujihara and Koji Toda Tags: Research Source Type: research
Silencing of hypothalamic FGF11 prevents diet-induced obesity
Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor family. Here, we report the central role of FGF11 in the regulation of metabolism. Lentiviral injection of Fgf11 shRNA... (Source: Molecular Brain)
Source: Molecular Brain - September 5, 2022 Category: Neuroscience Authors: Jae Hyun Cho, Kyungchan Kim, Han Chae Cho, Jaemeun Lee and Eun-Kyoung Kim Tags: Research Source Type: research
MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning
Loss of function mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MECP2) cause Rett syndrome (RTT), a postnatal neurological disorder. The loss of motor function is an important clinical f... (Source: Molecular Brain)
Source: Molecular Brain - September 5, 2022 Category: Neuroscience Authors: Yuanlei Yue, Ryan T. Ash, Natalie Boyle, Anna Kinter, Yipeng Li, Chen Zeng and Hui Lu Tags: Research Source Type: research
Prior episode of colitis impairs contextual fear memory
Accumulating evidence has shown that intestinal inflammations in inflammatory bowel disease (IBD) also drive pathological responses in organs outside the intestine, including the brain. Previous studies using ... (Source: Molecular Brain)
Source: Molecular Brain - August 29, 2022 Category: Neuroscience Authors: Chia-Shan Wu and Valerie Endres Tags: Micro report Source Type: research
Toll-like receptors and their role in neuropathic pain and migraine
Migraine is a complex neurological disease of unknown etiology involving both genetic and environmental factors. It has previously been reported that persistent pain may be mediated by the immune and inflammat... (Source: Molecular Brain)
Source: Molecular Brain - August 20, 2022 Category: Neuroscience Authors: Xuejiao Liu, Wenping Yang, Chenlu Zhu, Songtang Sun, Shouyi Wu, Longde Wang, Yonggang Wang and Zhaoming Ge Tags: Review Source Type: research
Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development
Ubiquitination involves three types of enzymes (E1, E2, and E3) that sequentially attach ubiquitin (Ub) to target proteins. This posttranslational modification controls key cellular processes, such as the degr... (Source: Molecular Brain)
Source: Molecular Brain - August 16, 2022 Category: Neuroscience Authors: Alexandre Bouron and Marie-Odile Fauvarque Tags: Research Source Type: research
Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifica... (Source: Molecular Brain)
Source: Molecular Brain - August 9, 2022 Category: Neuroscience Authors: Ping Su, Dongxu Zhai, Albert H. C. Wong and Fang Liu Tags: Research Source Type: research
Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection
HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes indu... (Source: Molecular Brain)
Source: Molecular Brain - August 8, 2022 Category: Neuroscience Authors: Vaishnavi Sundar, Jay P. McLaughlin and Thangavel Samikkannu Tags: Nano review Source Type: research
The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency
Adeno-associated virus (AAV) vector is a critical tool for gene delivery through its durable transgene expression and safety profile. Among many serotypes, AAV2-retro is typically utilized for dissecting neura... (Source: Molecular Brain)
Source: Molecular Brain - August 8, 2022 Category: Neuroscience Authors: Ryota Nakahama, Aika Saito, Sensho Nobe, Kazuya Togashi, Ikuo K. Suzuki, Akira Uematsu and Kazuo Emoto Tags: Research Source Type: research
Copper ions, prion protein and A β modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic... (Source: Molecular Brain)
Source: Molecular Brain - July 26, 2022 Category: Neuroscience Authors: Shigeki Tsutsui, Megan Morgan, Hugo Tedford, Haitao You, Gerald W. Zamponi and Peter K. Stys Tags: Micro report Source Type: research
