Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus
Post-traumatic stress disorder (PTSD) is a trauma-related disorder that is associated with pro-inflammatory activation and neurobiological impairments in the brain and leads to a series of affective-like behav... (Source: Molecular Brain)
Source: Molecular Brain - September 26, 2021 Category: Neuroscience Authors: Yi-Hung Chen, Sheng-Yun Xie, Chao-Wei Chen and Dah-Yuu Lu Tags: Research Source Type: research
Hypoxia with inflammation and reperfusion alters membrane resistance by dynamically regulating voltage-gated potassium channels in hippocampal CA1 neurons
Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the effect of hypoxia in combination with inflammation (Hypo-Inf) on... (Source: Molecular Brain)
Source: Molecular Brain - September 23, 2021 Category: Neuroscience Authors: Yoon-Sil Yang, Joon Ho Choi and Jong-Cheol Rah Tags: Research Source Type: research
Rapid generation of conditional knockout mice using the CRISPR-Cas9 system and electroporation for neuroscience research
The Cre/LoxP-based conditional knockout technology is a powerful tool for gene function analysis that allows region- and time-specific gene manipulation. However, inserting a pair of LoxP cassettes to generate... (Source: Molecular Brain)
Source: Molecular Brain - September 23, 2021 Category: Neuroscience Authors: Hirofumi Nishizono, Yuki Hayano, Yoshihisa Nakahata, Yasuhito Ishigaki and Ryohei Yasuda Tags: Micro report Source Type: research
Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1
Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient variations in intracellular Ca2+. I... (Source: Molecular Brain)
Source: Molecular Brain - September 20, 2021 Category: Neuroscience Authors: Yana Van Den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto and Ilse Smolders Tags: Short report Source Type: research
Splice-variant specific effects of a CACNA1H mutation associated with writer ’s cramp
The CACNA1H gene encodes the α1 subunit of the low voltage-activated Cav3.2 T-type calcium channel, an important regulator of neuronal excitability. Alternative mRNA splicing can generate multiple channel variant... (Source: Molecular Brain)
Source: Molecular Brain - September 20, 2021 Category: Neuroscience Authors: Ivana A. Souza, Maria A. Gandini and Gerald W. Zamponi Tags: Micro report Source Type: research
Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery
Chronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this mouse model, while both incision and electrocaute... (Source: Molecular Brain)
Source: Molecular Brain - September 20, 2021 Category: Neuroscience Authors: Yosuke Katsuda, Kenichi Tanaka, Tomohisa Mori, Michiko Narita, Hideyuki Takeshima, Takashige Kondo, Yoshiyuki Yamabe, Misa Matsufuji, Daisuke Sato, Yusuke Hamada, Keisuke Yamaguchi, Toshikazu Ushijima, Eiichi Inada, Naoko Kuzumaki, Masako Iseki and Minoru Tags: Research Source Type: research
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition
Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson ’s disease. Here, we stud... (Source: Molecular Brain)
Source: Molecular Brain - September 16, 2021 Category: Neuroscience Authors: Chelsie A. Kadgien, Anusha Kamesh and Austen J. Milnerwood Tags: Research Source Type: research
Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice
Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) is one of the diffusible messengers for enhancing synaptic transmission in the hippocampus. Less information is available about ... (Source: Molecular Brain)
Source: Molecular Brain - September 15, 2021 Category: Neuroscience Authors: Hui-Hui Miao, Zhuang Miao, Ji-Gang Pan, Xu-Hui Li and Min Zhuo Tags: Research Source Type: research
Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons
Arginine vasopressin (AVP) is expressed in both hypothalamic and extra-hypothalamic neurons. The expression and role of AVP exhibit remarkable divergence between these two neuronal populations. Polysynaptic pa... (Source: Molecular Brain)
Source: Molecular Brain - September 15, 2021 Category: Neuroscience Authors: Wen Han Tong, Samira Abdulai-Saiku and Ajai Vyas Tags: Micro report Source Type: research
The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain
Assessment of neural activity in the specific brain area is critical for understanding the circuit mechanisms underlying altered brain function and behaviors. A number of immediate early genes (IEGs) that are ... (Source: Molecular Brain)
Source: Molecular Brain - September 15, 2021 Category: Neuroscience Authors: Sang Ho Yoon, Woo Seok Song, Sung Pyo Oh, Young Sook Kim and Myoung-Hwan Kim Tags: Micro report Source Type: research
Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain
Chronic pain easily leads to concomitant mood disorders, and the excitability of anterior cingulate cortex (ACC) pyramidal neurons (PNs) is involved in chronic pain-related anxiety. However, the mechanism by w... (Source: Molecular Brain)
Source: Molecular Brain - September 10, 2021 Category: Neuroscience Authors: Fang-bing Shao, Jun-fan Fang, Si-si Wang, Meng-ting Qiu, Dan-ning Xi, Xiao-ming Jin, Jing-gen Liu, Xiao-mei Shao, Zui Shen, Yi Liang, Jian-qiao Fang and Jun-ying Du Tags: Research Source Type: research
Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events
To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although ... (Source: Molecular Brain)
Source: Molecular Brain - September 8, 2021 Category: Neuroscience Authors: Yong Gyu Kim, Jae Jin Shin and Sang Jeong Kim Tags: Methodology Source Type: research
Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation
Innately aversive experiences produce rapid defensive responses and powerful emotional memories. The midbrain periaqueductal gray (PAG) drives defensive behaviors through projections to brainstem motor control... (Source: Molecular Brain)
Source: Molecular Brain - September 8, 2021 Category: Neuroscience Authors: Li-Feng Yeh, Takaaki Ozawa and Joshua P. Johansen Tags: Research Source Type: research
Multivalent electrostatic pi –cation interaction between synaptophysin and synapsin is responsible for the coacervation
We recently showed that synaptophysin (Syph) and synapsin (Syn) can induce liquid –liquid phase separation (LLPS) to cluster small synaptic-like microvesicles in living cells which are highly reminiscent of SV ... (Source: Molecular Brain)
Source: Molecular Brain - September 8, 2021 Category: Neuroscience Authors: Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park and Sunghoe Chang Tags: Short report Source Type: research
Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila
Experimental animals, such as non-human primates (NHPs), mice, Zebrafish, and Drosophila, are frequently employed as models to gain insights into human physiology and pathology. In developmental neuroscience a... (Source: Molecular Brain)
Source: Molecular Brain - September 7, 2021 Category: Neuroscience Authors: Ryuichi Nakajima, Hideo Hagihara and Tsuyoshi Miyakawa Tags: Micro report Source Type: research
