Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping
Cortical spreading depression (CSD) is an electrophysiological event underlying migraine aura. Traditional CSD models are invasive and often cause injuries. The aim of the study was to establish a minimally in... (Source: Molecular Brain)
Source: Molecular Brain - December 5, 2022 Category: Neuroscience Authors: Chenghui Pi, Wenjing Tang, Zhishuai Li, Yang Liu, Qi Jing, Wei Dai, Tao Wang, Chunxiao Yang and Shengyuan Yu Tags: Research Source Type: research
Proteins secreted by brain arteriolar smooth muscle cells are instructive for neural development
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development. However, whether the vascular smooth mu... (Source: Molecular Brain)
Source: Molecular Brain - November 30, 2022 Category: Neuroscience Authors: Xuzhao Li, Lili Zhou, Xiaoxuan Zhang, Yuxiao Jin, Bingrui Zhao, Dongdong Zhang, Chengjie Xi, Jiayu Ruan, Zhu Zhu and Jie-Min Jia Tags: Research Source Type: research
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discove... (Source: Molecular Brain)
Source: Molecular Brain - November 30, 2022 Category: Neuroscience Authors: Maxime Pinard, Samaneh Dastpeyman, Christian Poitras, Genevi ève Bernard, Marie-Soleil Gauthier and Benoit Coulombe Tags: Research Source Type: research
Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased ... (Source: Molecular Brain)
Source: Molecular Brain - November 29, 2022 Category: Neuroscience Authors: Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean and Kazutaka Ikeda Tags: Micro report Source Type: research
Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calc... (Source: Molecular Brain)
Source: Molecular Brain - November 24, 2022 Category: Neuroscience Authors: Emanuelle Sistherenn Caminski, Flavia Tasmin Techera Antunes, Ivana Assis Souza, Eliane Dallegrave and Gerald W. Zamponi Tags: Review Source Type: research
Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intel... (Source: Molecular Brain)
Source: Molecular Brain - November 22, 2022 Category: Neuroscience Authors: Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A. Graef, Gerald R. Crabtree, Akinori Nishi and Tsuyoshi Miyakawa Tags: Research Source Type: research
Moderate effect of early-life experience on dentate gyrus function
The development, maturation, and plasticity of neural circuits are strongly influenced by experience and the interaction of an individual with their environment can have a long-lasting effect on cognitive func... (Source: Molecular Brain)
Source: Molecular Brain - November 21, 2022 Category: Neuroscience Authors: Pacifique Rukundo, Ting Feng, Vincent Pham and Simon Pieraut Tags: Research Source Type: research
Reduced oxidative stress suppresses neurotoxicity in the Drosophila model of TAF15-associated proteinopathies
TATA-binding protein associated factor 15 (TAF15) is involved in the pathology of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TAF15 accumulates as cytoplasmic aggregates in ... (Source: Molecular Brain)
Source: Molecular Brain - November 21, 2022 Category: Neuroscience Authors: Yeo Jeong Han and Kiyoung Kim Tags: Micro report Source Type: research
Dopamine-induced astrocytic Ca2+ signaling in mPFC is mediated by MAO-B in young mice, but by dopamine receptors in adult mice
Dopamine (DA) plays a vital role in brain physiology and pathology such as learning and memory, motor control, neurological diseases, and psychiatric diseases. In neurons, it has been well established that DA ... (Source: Molecular Brain)
Source: Molecular Brain - November 17, 2022 Category: Neuroscience Authors: Sunpil Kim, Jea Kwon, Mingu Gordon Park and C. Justin Lee Tags: Short report Source Type: research
Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur i... (Source: Molecular Brain)
Source: Molecular Brain - November 17, 2022 Category: Neuroscience Authors: Emilio R. Mustaf á, Eder Gambeta, Robin N. Stringer, Ivana A. Souza, Gerald W. Zamponi and Norbert Weiss Tags: Short report Source Type: research
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export
Olfactory marker protein (OMP) is a cytosolic protein expressed in mature olfactory receptor neurons (ORNs). OMP modulates cAMP signalling and regulates olfactory sensation and axonal targeting. OMP is a small... (Source: Molecular Brain)
Source: Molecular Brain - November 4, 2022 Category: Neuroscience Authors: Noriyuki Nakashima, Akiko Nakashima, Kie Nakashima and Makoto Takano Tags: Short report Source Type: research
Olfactory marker protein is unlikely to be cleaved by calpain 5
Olfactory maturation marker protein (OMP) is expressed in olfactory receptor neurons and hypothalamic neurons. OMP is a nested gene located in the intron of calpain 5 (CAPN5), a Ca2+-dep... (Source: Molecular Brain)
Source: Molecular Brain - October 29, 2022 Category: Neuroscience Authors: Noriyuki Nakashima, Kie Nakashima, Akiko Nakashima and Makoto Takano Tags: Micro report Source Type: research
Preferential subcortical collateral projections of pedunculopontine nucleus-targeting cortical pyramidal neurons revealed by brain-wide single fiber tracing
The pedunculopontine nucleus (PPN) is a heterogeneous midbrain structure involved in various brain functions, such as motor control, learning, reward, and sleep. Previous studies using conventional tracers hav... (Source: Molecular Brain)
Source: Molecular Brain - October 29, 2022 Category: Neuroscience Authors: Qiao-Qiong Liu, Yu-Xiao Cheng, Qi Jing, Ke-Ming Zhang, Lu-Feng Ding, Xiao-Wei Fan, Chun-Hui Jia, Fang Xu, Guo-Qiang Bi and Pak-Ming Lau Tags: Micro report Source Type: research
Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity
Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute... (Source: Molecular Brain)
Source: Molecular Brain - October 26, 2022 Category: Neuroscience Authors: Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B. Eyo, Christine L. Hunt, Hailong Dong and Long-Jun Wu Tags: Research Source Type: research
PV-IRES-Cre mouse line targets excitatory granule neurons in the cerebellum
Parvalbumin-expressing inhibitory neurons (PV-INs) are critical for the balance and fine-tuning of complex neuronal circuits. Studies of PV-IN biology require tools for their specific labeling, targeting and m... (Source: Molecular Brain)
Source: Molecular Brain - October 23, 2022 Category: Neuroscience Authors: Wendy Xueyi Wang, Julia Qiao and Julie L. Lefebvre Tags: Micro report Source Type: research
