The emergence of molecular systems neuroscience
Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior. Many of the studies in this field have trad... (Source: Molecular Brain)
Source: Molecular Brain - January 4, 2022 Category: Neuroscience Authors: Yang Shen, Alessandro Luchetti, Giselle Fernandes, Won Do Heo and Alcino J. Silva Tags: Review Source Type: research
Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases
Brain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only after symptoms develop, at which point very few treatment options are available. Therefor... (Source: Molecular Brain)
Source: Molecular Brain - December 24, 2021 Category: Neuroscience Authors: Yanjun Xu, Zhiyu Huang, Xiaoqing Yu, Kaiyan Chen and Yun Fan Tags: Research Source Type: research
Enhanced synchronization between prelimbic and infralimbic cortices during fear extinction learning
The ability to extinguish aversive memories when they are no longer associated with danger is critical for balancing survival with competing adaptive demands. Previous studies demonstrated that the infralimbic... (Source: Molecular Brain)
Source: Molecular Brain - December 11, 2021 Category: Neuroscience Authors: Mayumi Watanabe, Akira Uematsu and Joshua P. Johansen Tags: Micro report Source Type: research
Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its m... (Source: Molecular Brain)
Source: Molecular Brain - December 7, 2021 Category: Neuroscience Authors: Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda and Bong-Kiun Kaang Tags: Micro report Source Type: research
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro
Dopamine (DA) and norepinephrine (NE) are pivotal neuromodulators that regulate a broad range of brain functions, often in concert. Despite their physiological importance, untangling the relationship between D... (Source: Molecular Brain)
Source: Molecular Brain - December 6, 2021 Category: Neuroscience Authors: Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harps øe, David E. Gloriam, Kazuhiro Aoki and Tomonori Takeuchi Tags: Methodology Source Type: research
Retrosplenial cortex in spatial memory: focus on immediate early genes mapping
The ability to form, retrieve and update autobiographical memories is one of the most fascinating features of human behavior. Spatial memory, the ability to remember the layout of the external environment and ... (Source: Molecular Brain)
Source: Molecular Brain - December 4, 2021 Category: Neuroscience Authors: Edyta Balcerek, Urszula W łodkowska and Rafał Czajkowski Tags: Review Source Type: research
Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus
Light is a powerful external cue modulating the biological rhythm of internal clock neurons in the suprachiasmatic nucleus (SCN). GABA signaling in SCN is critically involved in this process. Both phasic and t... (Source: Molecular Brain)
Source: Molecular Brain - November 27, 2021 Category: Neuroscience Authors: Jea Kwon, Minwoo Wendy Jang and C. Justin Lee Tags: Short report Source Type: research
Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons
Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables inve... (Source: Molecular Brain)
Source: Molecular Brain - November 18, 2021 Category: Neuroscience Authors: Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker and Jeremy H. Herskowitz Tags: Research Source Type: research
Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture ... (Source: Molecular Brain)
Source: Molecular Brain - November 18, 2021 Category: Neuroscience Authors: Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda and Yu Hayashi Tags: Micro report Source Type: research
Brain substrates for automatic retrieval of value memory in the primate basal ganglia
Our behavior is often carried out automatically. Automatic behavior can be guided by past experiences, such as learned values associated with objects. Passive-viewing and free-viewing tasks with no immediate o... (Source: Molecular Brain)
Source: Molecular Brain - November 16, 2021 Category: Neuroscience Authors: Hyoung F. Kim Tags: Review Source Type: research
The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels
T-type calcium channels are known molecular targets of certain phytocannabinoids and endocannabinoids. Here we explored the modulation of Cav3.2 T-type calcium channels by terpenes derived from cannabis plants... (Source: Molecular Brain)
Source: Molecular Brain - November 14, 2021 Category: Neuroscience Authors: Vinicius M. Gadotti, Sun Huang and Gerald W. Zamponi Tags: Research Source Type: research
Avoidance memory requires CaMKII activity to persist after recall
Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/... (Source: Molecular Brain)
Source: Molecular Brain - November 14, 2021 Category: Neuroscience Authors: Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, G ênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua and Martín Cammarota Tags: Micro report Source Type: research
Correction to: Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes
(Source: Molecular Brain)
Source: Molecular Brain - November 10, 2021 Category: Neuroscience Authors: Adan Hernandez, Chunfeng Tan, Florian Plattner, Aric F. Logsdon, Karine Pozo, Mohammad A. Yousuf, Tanvir Singh, Ryan C. Turner, Brandon P. Lucke-Wold, Jason D. Huber, Charles L. Rosen and James A. Bibb Tags: Correction Source Type: research
VMAT2 availability in Parkinson ’s disease with probable REM sleep behaviour disorder
REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson ’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid... (Source: Molecular Brain)
Source: Molecular Brain - November 10, 2021 Category: Neuroscience Authors: Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu and Antonio P. Strafella Tags: Research Source Type: research
Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic c... (Source: Molecular Brain)
Source: Molecular Brain - November 8, 2021 Category: Neuroscience Authors: Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page and Sathyanarayanan V. Puthanveettil Tags: Research Source Type: research
