PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain
Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely unclear. PDZD8 is a lipid transfer protein and mice... (Source: Molecular Brain)
Source: Molecular Brain - January 19, 2023 Category: Neuroscience Authors: Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa and Michiko Shirane Tags: Research Source Type: research
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in ... (Source: Molecular Brain)
Source: Molecular Brain - January 18, 2023 Category: Neuroscience Authors: Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles and Nahum Sonenberg Tags: Research Source Type: research
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier. Recently, we demonstrated that K2P channels, TWIK-related K+ chann... (Source: Molecular Brain)
Source: Molecular Brain - January 17, 2023 Category: Neuroscience Authors: Hirosato Kanda, Koichi Noguchi and Yi Dai Tags: Micro report Source Type: research
Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson ’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy
Studies of mouse models of Alzheimer's disease (AD) have demonstrated that nitric oxide synthase 2 (NOS2) is involved in AD pathology. However, the effects of NOS2 on the pathology of Parkinson ’s disease (PD) ... (Source: Molecular Brain)
Source: Molecular Brain - January 16, 2023 Category: Neuroscience Authors: Jieun Kim, Jung-Youn Han, Yujeong Lee, Kipom Kim, Young Pyo Choi, Sehyun Chae and Hyang-Sook Hoe Tags: Micro report Source Type: research
Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology
Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer ’s disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary ta... (Source: Molecular Brain)
Source: Molecular Brain - January 13, 2023 Category: Neuroscience Authors: Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen and J ürgen Götz Tags: Micro report Source Type: research
Circadian rhythms in the blood –brain barrier: impact on neurological disorders and stress responses
Circadian disruption has become more prevalent in society due to the increase in shift work, sleep disruption, blue light exposure, and travel via different time zones. The circadian rhythm is a timed transcri... (Source: Molecular Brain)
Source: Molecular Brain - January 12, 2023 Category: Neuroscience Authors: Nicolette Schurhoff and Michal Toborek Tags: Review Source Type: research
Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice
Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focuse... (Source: Molecular Brain)
Source: Molecular Brain - January 6, 2023 Category: Neuroscience Authors: Si-Bo Zhou, Man Xue, Weiqi Liu, Yu-Xin Chen, Qi-Yu Chen, Jing-Shan Lu, Jinjun Wang, Keqiang Ye, Xu-Hui Li and Min Zhuo Tags: Research Source Type: research
14-3-3 γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice
The 14-3-3 protein family with seven isoforms found in mammals is widely expressed in the brain and plays various roles in cellular processes. Several studies have reported that 14-3-3 γ, one of the 14-3-3 prot... (Source: Molecular Brain)
Source: Molecular Brain - January 5, 2023 Category: Neuroscience Authors: Eunsil Cho, Jinsil Park, Eun Mi Hwang, Hyung Wook Kim and Jae-Yong Park Tags: Research Source Type: research
Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex
Pain is known to have sensory and affective components. The sensory pain component is encoded by neurons in the primary somatosensory cortex (S1), whereas the emotional or affective pain experience is in large... (Source: Molecular Brain)
Source: Molecular Brain - January 5, 2023 Category: Neuroscience Authors: Guanghao Sun, Michael McCartin, Weizhuo Liu, Qiaosheng Zhang, George Kenefati, Zhe Sage Chen and Jing Wang Tags: Short Report Source Type: research
Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer ’s disease
Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain, stiffness, and gait disturbance. The relationship between knee OA and neurodegenerati... (Source: Molecular Brain)
Source: Molecular Brain - January 2, 2023 Category: Neuroscience Authors: Deepak Prasad Gupta, Young-Sun Lee, Youngshik Choe, Kun-Tae Kim, Gyun Jee Song and Sun-Chul Hwang Tags: Research Source Type: research
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Hippocampus-dependent learning and memory originate from long-term synaptic changes in hippocampal networks. The activity of CA1 somatostatin interneurons (SOM-INs) during aversive stimulation is necessary for... (Source: Molecular Brain)
Source: Molecular Brain - December 21, 2022 Category: Neuroscience Authors: Eve Honor é and Jean-Claude Lacaille Tags: Short report Source Type: research
Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memory, addictive behavior, and hippocampal neurogenesis. These changes are closely associat... (Source: Molecular Brain)
Source: Molecular Brain - December 21, 2022 Category: Neuroscience Authors: Kyeong-No Yoon, Yujin Kim, Yidan Cui, Jungeun Ji, Gunhyuk Park, Jin Ho Chung, Yong-Seok Lee, Joon-Yong An and Dong Hun Lee Tags: Micro report Source Type: research
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala
We recently reported that a neuronal population in the claustrum (CLA) identified under exposure to psychological stressors plays a key role in stress response processing. Upon stress exposure, the main inputs... (Source: Molecular Brain)
Source: Molecular Brain - December 20, 2022 Category: Neuroscience Authors: Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto and Atsushi Kasai Tags: Short report Source Type: research
Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping
Cortical spreading depression (CSD) is an electrophysiological event underlying migraine aura. Traditional CSD models are invasive and often cause injuries. The aim of the study was to establish a minimally in... (Source: Molecular Brain)
Source: Molecular Brain - December 5, 2022 Category: Neuroscience Authors: Chenghui Pi, Wenjing Tang, Zhishuai Li, Yang Liu, Qi Jing, Wei Dai, Tao Wang, Chunxiao Yang and Shengyuan Yu Tags: Research Source Type: research
Proteins secreted by brain arteriolar smooth muscle cells are instructive for neural development
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development. However, whether the vascular smooth mu... (Source: Molecular Brain)
Source: Molecular Brain - November 30, 2022 Category: Neuroscience Authors: Xuzhao Li, Lili Zhou, Xiaoxuan Zhang, Yuxiao Jin, Bingrui Zhao, Dongdong Zhang, Chengjie Xi, Jiayu Ruan, Zhu Zhu and Jie-Min Jia Tags: Research Source Type: research
