Multivalent electrostatic pi –cation interaction between synaptophysin and synapsin is responsible for the coacervation
We recently showed that synaptophysin (Syph) and synapsin (Syn) can induce liquid –liquid phase separation (LLPS) to cluster small synaptic-like microvesicles in living cells which are highly reminiscent of SV ... (Source: Molecular Brain)
Source: Molecular Brain - September 8, 2021 Category: Neuroscience Authors: Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park and Sunghoe Chang Tags: Short report Source Type: research
Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila
Experimental animals, such as non-human primates (NHPs), mice, Zebrafish, and Drosophila, are frequently employed as models to gain insights into human physiology and pathology. In developmental neuroscience a... (Source: Molecular Brain)
Source: Molecular Brain - September 7, 2021 Category: Neuroscience Authors: Ryuichi Nakajima, Hideo Hagihara and Tsuyoshi Miyakawa Tags: Micro report Source Type: research
GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis
Growth differentiation factor 11 (GDF11) is a transforming factor- β superfamily member that functions as a negative regulator of neurogenesis during embryonic development. However, when recombinant GDF11 (rGDF... (Source: Molecular Brain)
Source: Molecular Brain - September 6, 2021 Category: Neuroscience Authors: Brittany A. Mayweather, Sean M. Buchanan and Lee L. Rubin Tags: Research Source Type: research
Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression
Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, the role of interaction between gut dysbiosis and C-reactive protein (CRP) in th... (Source: Molecular Brain)
Source: Molecular Brain - September 4, 2021 Category: Neuroscience Authors: Yujing Chen, Peilin Meng, Shiqiang Cheng, Yumeng Jia, Yan Wen, Xuena Yang, Yao Yao, Chuyu Pan, Chun ’e Li, Huijie Zhang, Jingxi Zhang, Zhen Zhang and Feng Zhang Tags: Research Source Type: research
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining attention as beneficial brain fuels in several neurological disorders. The protective effects of C8 and C10 have been propose... (Source: Molecular Brain)
Source: Molecular Brain - September 3, 2021 Category: Neuroscience Authors: Jens V. Andersen, Emil W. Westi, Emil Jakobsen, Nerea Urruticoechea, Karin Borges and Blanca I. Aldana Tags: Research Source Type: research
Modeling PTEN overexpression-induced microcephaly in human brain organoids
The phosphatase and tensin homolog (PTEN) protein, encoded by the PTEN gene on chromosome 10, is a negative regulator of the phosphoinositide 3-kinase (PI3K) signaling pathway. Loss of PTEN has been linked to an ... (Source: Molecular Brain)
Source: Molecular Brain - August 30, 2021 Category: Neuroscience Authors: Navroop Dhaliwal, Wendy W.Y. Choi, Julien Muffat and Yun Li Tags: Micro report Source Type: research
Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto... (Source: Molecular Brain)
Source: Molecular Brain - August 24, 2021 Category: Neuroscience Authors: Anne-Sophie Racine, Fran çois-Xavier Michon, Isabel Laplante and Jean-Claude Lacaille Tags: Research Source Type: research
Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits
Hypobaric hypoxia (HH) is a typical characteristic of high altitude environment and causes a spectrum of pathophysiological effects, including headaches, gliovascular dysfunction and cognitive retardation. Her... (Source: Molecular Brain)
Source: Molecular Brain - August 21, 2021 Category: Neuroscience Authors: Yang Zhou, Huanyu Lu, Ying Liu, Zaihua Zhao, Qian Zhang, Chong Xue, Yuankang Zou, Zipeng Cao and Wenjing Luo Tags: Research Source Type: research
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement. Here we tested whether treatment with the histo... (Source: Molecular Brain)
Source: Molecular Brain - August 20, 2021 Category: Neuroscience Authors: Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee and Angela S. Laird Tags: Research Source Type: research
De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy
Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies that are characterized by seizures and developmental delay. DEEs are primarily attributed to genetic causes and an increasin... (Source: Molecular Brain)
Source: Molecular Brain - August 16, 2021 Category: Neuroscience Authors: Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Ivana A. Souza, Judy Ibrahim, Tomas Vacik, Waseem Mahmoud Fathalla, Jozef Hertecant, Gerald W. Zamponi, Lubica Lacinova and Norbert Weiss Tags: Micro report Source Type: research
Correction to: Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
(Source: Molecular Brain)
Source: Molecular Brain - August 16, 2021 Category: Neuroscience Authors: Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii and Tadashi Suzuki Tags: Correction Source Type: research
Altered hippocampal transcriptome dynamics following sleep deprivation
Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cogni... (Source: Molecular Brain)
Source: Molecular Brain - August 12, 2021 Category: Neuroscience Authors: Marie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Jacob J. Michaelson, Ted Abel and Lisa C. Lyons Tags: Research Source Type: research
TPEN attenuates amyloid- β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels
To understand the role of intracellular zinc ion (Zn2+) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity resulting from the generation of excessive neurotoxic amyloid- β... (Source: Molecular Brain)
Source: Molecular Brain - August 12, 2021 Category: Neuroscience Authors: Wen-bo Chen, Yu-xiang Wang, Hong-gang Wang, Di An, Dan Sun, Pan Li, Tao Zhang, Wan-ge Lu and Yan-qiang Liu Tags: Research Source Type: research
Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKK β/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury
Cerebral ischemia, a common cerebrovascular disease, is characterized by functional deficits and apoptotic cell death. Autophagy, a type of programmed cell death, plays critical roles in controlling neuronal d... (Source: Molecular Brain)
Source: Molecular Brain - August 6, 2021 Category: Neuroscience Authors: Yuan Yao, Yingshi Ji, Jinghong Ren, Huanyu Liu, Rajesh Khanna and Li Sun Tags: Research Source Type: research
Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging ... (Source: Molecular Brain)
Source: Molecular Brain - July 28, 2021 Category: Neuroscience Authors: Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim and Sang Myun Park Tags: Research Source Type: research
