VMAT2 availability in Parkinson ’s disease with probable REM sleep behaviour disorder
REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson ’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid... (Source: Molecular Brain)
Source: Molecular Brain - November 10, 2021 Category: Neuroscience Authors: Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu and Antonio P. Strafella Tags: Research Source Type: research
Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory
Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic c... (Source: Molecular Brain)
Source: Molecular Brain - November 8, 2021 Category: Neuroscience Authors: Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page and Sathyanarayanan V. Puthanveettil Tags: Research Source Type: research
Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocyte... (Source: Molecular Brain)
Source: Molecular Brain - November 8, 2021 Category: Neuroscience Authors: Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori and Akio Wanaka Tags: Research Source Type: research
Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson ’s disease
Parkinson ’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different ... (Source: Molecular Brain)
Source: Molecular Brain - November 6, 2021 Category: Neuroscience Authors: Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu and Min Zhuo Tags: Research Source Type: research
Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner
Songbirds are one of the few animal taxa that possess vocal learning abilities. Different species of songbirds exhibit species-specific learning programs during song acquisition. Songbirds with open-ended voca... (Source: Molecular Brain)
Source: Molecular Brain - October 29, 2021 Category: Neuroscience Authors: Shin Hayase, Chengru Shao, Masahiko Kobayashi, Chihiro Mori, Wan-chun Liu and Kazuhiro Wada Tags: Research Source Type: research
Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices
Neuroinflammation is an escalation factor shared by a vast range of central nervous system (CNS) pathologies, from neurodegenerative diseases to neuropsychiatric disorders. CNS immune status emerges by the int... (Source: Molecular Brain)
Source: Molecular Brain - October 25, 2021 Category: Neuroscience Authors: Giulia Panattoni, Roberta Amoriello, Christian Memo, Agnes Thalhammer, Clara Ballerini and Laura Ballerini Tags: Research Source Type: research
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer ’s Disease. Modified composition of γ-secretase or mutations in its subunits h... (Source: Molecular Brain)
Source: Molecular Brain - October 13, 2021 Category: Neuroscience Authors: Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia and Deepak Nair Tags: Micro report Source Type: research
Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding
Growth hormone secretagogue receptor 1a (GHS-R1a) is widely distributed in brain including the hippocampus. Studies have demonstrated the critical role of hippocampal ghrelin/GHS-R1a signaling in synaptic phys... (Source: Molecular Brain)
Source: Molecular Brain - October 12, 2021 Category: Neuroscience Authors: Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao and Yu Zhou Tags: Micro report Source Type: research
Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of t... (Source: Molecular Brain)
Source: Molecular Brain - October 11, 2021 Category: Neuroscience Authors: Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway and Chandler L. Walker Tags: Micro report Source Type: research
Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived fr... (Source: Molecular Brain)
Source: Molecular Brain - October 11, 2021 Category: Neuroscience Authors: Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orr ù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll and Cathryn L. Tags: Research Source Type: research
Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro
The generation of mature synaptic structures using neurons differentiated from human-induced pluripotent stem cells (hiPSC-neurons) is expected to be applied to physiological studies of synapses in human cells... (Source: Molecular Brain)
Source: Molecular Brain - October 11, 2021 Category: Neuroscience Authors: Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki and Yon Tags: Research Source Type: research
Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory
Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory... (Source: Molecular Brain)
Source: Molecular Brain - October 6, 2021 Category: Neuroscience Authors: Yoonjeong Jeon, Yun Lim, Jiwoo Yeom and Eun-Kyoung Kim Tags: Research Source Type: research
S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS
Studies on the development of central nervous system (CNS) primarily rely on the use of specific molecular markers for different types of neural cells. S100B is widely being used as a specific marker for astro... (Source: Molecular Brain)
Source: Molecular Brain - October 6, 2021 Category: Neuroscience Authors: Junqing Du, Min Yi, Fang Zhou, Wanjun He, Aifen Yang, Mengsheng Qiu and Hao Huang Tags: Research Source Type: research
Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents
The glutamatergic signaling pathway is involved in molecular learning and human cognitive ability. Specific single variants (SNVs, formerly single-nucleotide polymorphisms) in the genes encoding N-methyl-d-aspart... (Source: Molecular Brain)
Source: Molecular Brain - October 4, 2021 Category: Neuroscience Authors: Li-Ching Lee, Ming-Tsan Su, Hsing-Ying Huang, Ying-Chun Cho, Ting-Kuang Yeh and Chun-Yen Chang Tags: Research Source Type: research
Ackr3-Venus knock-in mouse lights up brain vasculature
The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular di... (Source: Molecular Brain)
Source: Molecular Brain - September 28, 2021 Category: Neuroscience Authors: Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier and Brigitte L. Kieffer Tags: Research Source Type: research
