APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer ’s disease and age-matched non-demented brains

Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factors for AD is the apolipoprotein E4 (E4) allele. The APOE4 genotype has been shown to negatively impa...

Source: Molecular Brain - July 8, 2021 Category: Neuroscience Authors: Joseph O. Ojo, Jon M. Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford and Corbin Bachmeier Tags: Research Source Type: research