Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus

Mutations in the Presenilin genes (PSEN1 and PSEN2) are the major cause of familial Alzheimer ’s disease (AD), highlighting the importance of Presenilin (PS) in AD pathogenesis. Previous studies of PS function in ...

Source: Molecular Brain - January 30, 2023 Category: Neuroscience Authors: Sang Hun Lee, Vadim Y. Bolshakov and Jie Shen Tags: Research Source Type: research