Trace Amounts of Copper in Drinking Water Aggravate Cerebral Ischemic Injury via Impairing Endothelial Progenitor Cells in Mice.
PMID: 26197838 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 25, 2015 Category: Neuroscience Authors: Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH Tags: CNS Neurosci Ther Source Type: research

Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy.
Abstract Zonisamide is an orally administered antiepileptic drug that was first approved for clinical use in Japan in 1989. Since then, it has been licensed in Korea for a broad spectrum of epilepsies in adults and children, and in the USA for adjunctive therapy of adults with partial seizures, and in Europe for monotherapy of adults with newly diagnosed partial seizures and adjunctive therapy of adults and adolescents and children aged ≥6 years with partial seizures with or without secondary generalization. Zonisamide is a benzisoxazole derivative with a unique chemical structure, predictable dose-depende...
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Kwan SY, Chuang YC, Huang CW, Chen TC, Jou SB, Dash A Tags: CNS Neurosci Ther Source Type: research

Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1.
CONCLUSIONS: Chloral hydrate preconditioning protects against ischemic injuries through upregulating the expression of ANXA1, and the followed antiinflammatory mechanisms. PMID: 26205642 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Liu JH, Feng D, Zhang YF, Shang Y, Wu Y, Li XF, Pei L Tags: CNS Neurosci Ther Source Type: research

The 5-HT4 Agonist Prucalopride Stimulates L-DOPA-Induced Dopamine Release in Restricted Brain Regions of the Hemiparkinsonian Rat In Vivo.
;re P PMID: 26205756 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Navailles S, Di Giovanni G, De Deurwaerdère P Tags: CNS Neurosci Ther Source Type: research

Autonomic Function Tests and MIBG in Parkinson's Disease: Correlation to Disease Duration and Motor Symptoms.
CONCLUSIONS: Our investigation suggests that ANS impairment affects the majority of patients with PD, even those PD patients showing negative MIBG, irrespective of clinical neurovegetative symptoms. The strict correlation that has been revealed with disease progression supports the routine utilization of AFTs as a reliable and inexpensive tool for monitoring peripheral sympathetic dysfunction in PD and optimizing therapy. PMID: 26205884 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Rocchi C, Pierantozzi M, Galati S, Chiaravalloti A, Pisani V, Prosperetti C, Lauretti B, Stampanoni Bassi M, Olivola E, Schillaci O, Stefani A Tags: CNS Neurosci Ther Source Type: research

The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
CONCLUSIONS: Zn(2+) is involved in neural cell apoptosis and/or death caused by hypoxia/ischemia via mediating excitotoxicity, oxidative stress, and inflammation. PMID: 26190227 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 20, 2015 Category: Neuroscience Authors: Wang WM, Liu Z, Liu AJ, Wang YX, Wang HG, An D, Heng B, Xie LH, Duan JL, Liu YQ Tags: CNS Neurosci Ther Source Type: research

Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury.
CONCLUSION: Direct i.t. administration of G-CSF provides a promising therapeutic option for SCI or related spinal diseases. PMID: 26190345 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 20, 2015 Category: Neuroscience Authors: Chen WF, Chen CH, Chen NF, Sung CS, Wen ZH Tags: CNS Neurosci Ther Source Type: research

Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response.
This study sought to evaluate the influence of the genetic polymorphisms on platelet reactivity and clinical outcomes in acute ischemic stroke patients taking clopidogrel. BACKGROUND: Little research has been published on relationships between genetic polymorphisms, platelet reactivity, and clinical outcomes in stroke patients treated with clopidogrel. METHODS: Patients hospitalized in Changhai Hospital with acute ischemic stroke were randomly enrolled into treatment with a 75-mg daily maintenance dose of clopidogrel. Genotyping was detected by the MassARRAY iPLEX genotyping system (Sequenom Inc, San Diego, CA), ...
Source: CNS Neuroscience and Therapeutics - July 15, 2015 Category: Neuroscience Authors: Han Y, Lv HH, Liu X, Dong Q, Yang XL, Li SX, Wu S, Jiang JM, Luo Z, Zhu DS, Zhang Y, Zheng Y, Guan YT, Xu JF Tags: CNS Neurosci Ther Source Type: research

Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer's Disease in a Chinese Han Population with Type 2 Diabetes.
Abstract AIMS: Alzheimer's disease (AD) is a multifactor disease that has been reported to have a close association with type 2 diabetes (T2D) where the v-akt murine thymoma viral oncogene homolog 1 (AKT1) plays an important role in the protein synthesis pathways and cell apoptosis processes. Evidence has been shown that AKT1 protein may be related to AD risk among patients with T2D. The aim of this study was to analyze the potential association between single nucleotide polymorphisms of AKT1 promoter and the risk of AD among patients with T2D. METHODS: The association between AKT1 polymorphisms and AD risk i...
Source: CNS Neuroscience and Therapeutics - July 14, 2015 Category: Neuroscience Authors: Liu SY, Zhao HD, Wang JL, Huang T, Tian HW, Yao LF, Tao H, Chen ZW, Wang CY, Sheng ST, Li H, Zhao B, Li KS Tags: CNS Neurosci Ther Source Type: research

Atypical Guillain-Barre Syndrome Caused by Primary Diffuse Large B-cell Lymphoma Originating from Dorsal Root Ganglion.
PMID: 26179114 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 14, 2015 Category: Neuroscience Authors: Wei D, Ma XL, Zhang SQ, Bi XY Tags: CNS Neurosci Ther Source Type: research

With Great Brain Hub Connectivity Comes Great Vulnerability.
PMID: 26096045 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 24, 2015 Category: Neuroscience Authors: Dai ZJ, Bi YC, He Y Tags: CNS Neurosci Ther Source Type: research

Compound MQA, a Caffeoylquinic Acid Derivative, Protects Against NMDA-Induced Neurotoxicity and Potential Mechanisms In Vitro.
CONCLUSION: The protective effects of MQA against NMDA-induced cell injury may be mediated by blocking NMDARs. The potential mechanisms are related with mitochondrial apoptosis, ERK-CREB, AKT/GSK-3β, p38, and JNK1/2 pathway. PMID: 26096046 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 24, 2015 Category: Neuroscience Authors: Tian X, An L, Gao LY, Bai JP, Wang J, Meng WH, Ren TS, Zhao QC Tags: CNS Neurosci Ther Source Type: research

Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12.
CONCLUSIONS: OPRM1-FKBP12 association played a key role in OPRM1-mediated mTOR activation, which could underlie the mechanisms of multiple physiological and pathological processes. Thus, our findings provide new avenue to modulating these processes. PMID: 26096047 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 24, 2015 Category: Neuroscience Authors: Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ, Qiu Y Tags: CNS Neurosci Ther Source Type: research

Mobile Stroke: An Experience of Intravenous Thrombolysis Guided by Teleconsultation Based on Google Glass.
PMID: 26096048 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 24, 2015 Category: Neuroscience Authors: Yuan ZW, Liu ZR, Wei D, Shi M, Wang BJ, Liu YH, Wang WZ, Zhao G Tags: CNS Neurosci Ther Source Type: research

Lymphomatoid Granulomatosis with Central Nervous System Involvement Successfully Treated with Cyclophosphamide, High-dose Cytarabine, Dexamethasone, Etoposide, and Rituximab (CHASER therapy) Followed by Brain Irradiation: A Case Study.
PMID: 26096049 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 24, 2015 Category: Neuroscience Authors: Fujimaki M, Kawajiri S, Ichikawa K, Tomizawa Y, Nakazato T, Noda K, Hattori N, Koike M, Okuma Y Tags: CNS Neurosci Ther Source Type: research

Mutation Analysis of COQ2 in Chinese Patients with Cerebellar Subtype of Multiple System Atrophy.
CONCLUSION: Our results indicated that COQ2 tended to play a population-specific and subtype-depended role in conferring susceptibility to MSA. PMID: 26096180 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Wen XD, Li HF, Wang HX, Ni W, Dong Y, Wu ZY Tags: CNS Neurosci Ther Source Type: research

The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice.
CONCLUSIONS: This study provides the first direct evidence that IL-1β is key regulatory factor for the PS, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems. PMID: 26096304 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Tao AF, Xu ZH, Chen B, Wang Y, Wu XH, Zhang J, Tang YS, Xu CL, Zhao HW, Hu WW, Shi LY, Zhang SH, Chen Z Tags: CNS Neurosci Ther Source Type: research

Lovastatin Differentially Affects Neuronal Cholesterol and Amyloid-β Production in vivo and in vitro.
CONCLUSIONS: Lovastatin modifies the mevalonate pathway without affecting cholesterol levels in vivo and is able to reduce Aβ levels only in vitro. PMID: 26096465 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Mendoza-Oliva A, Ferrera P, Fragoso-Medina J, Arias C Tags: CNS Neurosci Ther Source Type: research

Unfavorable Outcome of Thrombolysis in Chinese Patients with Cardioembolic Stroke: a Prospective Cohort Study.
This study compares the outcomes at 3 months postthrombolysis in Chinese patients with AIS secondary to cardioembolism (CE) to the outcomes of those with large-artery atherosclerosis (LAA). METHODS: Using the Thrombolysis Implementation and Monitoring of Acute Ischemic Stroke in China (TIMS-China) cohort, we prospectively followed 827 patients treated within 4.5 h of onset symptoms with alteplase as an intravenous thrombolytic agent. CE and LAA were defined according to TOAST criteria. We compared symptomatic intracerebral hemorrhage (SICH), mortality, and functional outcome at 3 months using multivaria...
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Wang XG, Zhang LQ, Liao XL, Pan YS, Shi YZ, Wang CJ, Wang YL, Liu LP, Zhao XQ, Wang YJ, Li D, Wang CX, Thrombolysis Implementation and Monitoring of acute ischemic Stroke in China (TIMS-China) Investigators Tags: CNS Neurosci Ther Source Type: research

Head Transplantation in Mouse Model.
CONCLUSIONS: The results of this study support the feasibility of this method for avoiding brain ischemia during transplantation, thereby allowing for the possibility of long-term studies of head transplantation. PMID: 26096690 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Ren XP, Ye YJ, Li PW, Shen ZL, Han KC, Song Y Tags: CNS Neurosci Ther Source Type: research

Vitamin D is Not a Protective Factor in ALS.
Abstract AIMS: Vitamin D deficiency has been associated with poorer prognosis in ALS. Better understanding of the role of vitamin D in ALS is needed to determine whether trials of systematic supplementation are justified. Our aim was to report vitamin D levels during the course of ALS and to evaluate its relationship with clinical parameters at diagnosis and with disease progression. METHODS: We prospectively collected vitamin D serum concentrations from 125 consecutive ALS patients. Cox proportional hazard models analyzed the relationship between vitamin D concentrations, clinical parameters, and survival. ...
Source: CNS Neuroscience and Therapeutics - June 20, 2015 Category: Neuroscience Authors: Blasco H, Madji Hounoum B, Dufour-Rainfray D, Patin F, Maillot F, Beltran S, Gordon PH, Andres CR, Corcia P Tags: CNS Neurosci Ther Source Type: research

Propagation of Pathology through Brain Networks in Neurodegenerative Diseases: From Molecules to Clinical Phenotypes.
Abstract The cellular mechanisms underlying the stereotypical progression of pathology in neurodegenerative diseases are incompletely understood, but increasing evidence indicates that misfolded protein aggregates can spread by a self-perpetuating neuron-to-neuron transmission. Novel neuroimaging techniques can help elucidating how these disorders spread across brain networks. Recent knowledge from structural and functional connectivity studies suggests that the relation between neurodegenerative diseases and distinct brain networks is likely to be a strict consequence of diffuse network dynamics. Diffusion tensor...
Source: CNS Neuroscience and Therapeutics - June 1, 2015 Category: Neuroscience Authors: Agosta F, Weiler M, Filippi M Tags: CNS Neurosci Ther Source Type: research

Hypoxemia, Sleep Disturbances, and Depression Correlated with Fatigue in Neuromyelitis Optica Spectrum Disorder.
This study aimed to investigate the incidence of fatigue and explore impacting factors attributed to fatigue in NMOSD. METHODS: Thirty-three patients with NMOSD and twenty matched healthy controls were enrolled. A battery of self-reported questionnaires was conducted to assess quality of sleep, daytime sleepiness, fatigue, depression, and level of activity of daily life. The structure of sleep was assessed by polysomnography with blood oxygen saturation monitored by noninvasive pulse oximeter. Brain and spinal cord lesions were evaluated by MRIs. RESULTS: Fatigue was more severe and more prevalent among the patie...
Source: CNS Neuroscience and Therapeutics - June 1, 2015 Category: Neuroscience Authors: Pan J, Zhao P, Cai H, Su L, Wood K, Shi FD, Fu Y Tags: CNS Neurosci Ther Source Type: research

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells.
CONCLUSIONS: Taken together, our findings suggest linagliptin can restore the impaired insulin signaling caused by Aβ in neuronal cells, suggesting DPP-4 inhibitors may have therapeutic potential for reducing Aβ-induced impairment of insulin signaling and neurotoxicity in AD pathogenesis. PMID: 26010513 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 26, 2015 Category: Neuroscience Authors: Kornelius E, Lin CL, Chang HH, Li HH, Huang WN, Yang YS, Lu YL, Peng CH, Huang CN Tags: CNS Neurosci Ther Source Type: research

Peroxynitrite Decomposition Catalyst Reduces Delayed Thrombolysis-induced Hemorrhagic Transformation in Ischemia-reperfused Rat Brains.
CONCLUSION: Peroxynitrite decomposition catalyst could prevent hemorrhagic transformation and improve neurological outcome ischemic rat brains with delayed t-PA treatment via inhibiting peroxynitrite-mediated MMP activation. PMID: 25996167 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 21, 2015 Category: Neuroscience Authors: Chen HS, Chen XM, Feng JH, Liu KJ, Qi SH, Shen JG Tags: CNS Neurosci Ther Source Type: research

Increasing the Permeability of the Blood-brain Barrier in Three Different Models in vivo.
CONCLUSION: The MCAO model was the most suitable for studying the permeability of BBB among the three models in vivo. PMID: 25982054 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2015 Category: Neuroscience Authors: Liu WY, Wang ZB, Wang Y, Tong LC, Li Y, Wei X, Luan P, Li L Tags: CNS Neurosci Ther Source Type: research

Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.
CONCLUSION: Our studies reveal a crucial role for the ion channel Kv1.3 in the regulation of NPC differentiation and maturation, making Psora-4 a promising candidate molecule for MS treatment. PMID: 25976092 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 15, 2015 Category: Neuroscience Authors: Zhou YY, Hou GQ, He SW, Xiao Z, Xu HJ, Qiu YT, Jiang S, Zheng H, Li ZY Tags: CNS Neurosci Ther Source Type: research

Low-dose Methylphenidate Monotherapy for Features of Attention-Deficit/Hyperactivity Disorder Secondary to Hereditary Cerebellar Ataxia.
PMID: 25976218 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 15, 2015 Category: Neuroscience Authors: Hu LY, Lin YL, Chang HS, Lu T, Lin WS Tags: CNS Neurosci Ther Source Type: research

Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy.
Abstract Clobazam is an oral 1,5-benzodiazepine used worldwide for the treatment of many types of epilepsies, although it is currently only approved for Lennox-Gastaut syndrome in the USA. This anticonvulsant and anxiolytic therapeutic has repeatedly demonstrated great efficacy and a high safety profile in refractory epilepsy as well as in a few monotherapy trials in both children and adults. Clobazam allosterically activates the GABAA receptor, and it binds less to subunits that mediate sedative effects than other benzodiazepines. It acts quickly, maintaining a therapeutic effect for a long duration due to its ac...
Source: CNS Neuroscience and Therapeutics - April 28, 2015 Category: Neuroscience Authors: Gauthier AC, Mattson RH Tags: CNS Neurosci Ther Source Type: research

High Blood Pressure Increases the Risk of Poor Outcome at Discharge and 12-month Follow-up in Patients with Symptomatic Intracranial Large Artery Stenosis and Occlusions: Subgroup analysis of the CICAS Study.
Abstract AIMS: The purpose of this study was to discuss the relationship between blood pressure and prognosis of patients with symptomatic intracranial arterial stenosis. METHODS: Data on 2426 patients with symptomatic intracranial large artery stenosis and occlusion who participated in the Chinese Intracranial Atherosclerosis (CICAS) study were analyzed. According to the JNC 7 criteria, blood pressure of all patients was classified into one of the four subgroups: normal, prehypertension, hypertension stage I, and hypertension stage II. Poor outcomes were defined as death and functional dependency (mRS 3-5) a...
Source: CNS Neuroscience and Therapeutics - April 28, 2015 Category: Neuroscience Authors: Yu DD, Pu YH, Pan YS, Zou XY, Soo Y, Leung T, Liu LP, Wang DZ, Wong KS, Wang YL, Wang YJ, Chinese Intracranial Atherosclerosis (CICAS) Study Group Tags: CNS Neurosci Ther Source Type: research

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.
CONCLUSION: B7C promoted neurite outgrowth through the activation of α7-nAChR/ERK pathway, which offers novel insight into the potential application of B7C in the treatment of neurodegenerative disorders. PMID: 25917415 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 28, 2015 Category: Neuroscience Authors: Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Tsim KW, Pang YP, Han YF Tags: CNS Neurosci Ther Source Type: research

Epicentral Disruption of Structural Connectivity in Alzheimer's Disease.
Abstract AIMS: Neurodegenerative changes observed in Alzheimer's disease (AD) have been suggested to begin at the entorhinal cortex and hippocampus and then to propagate in a stereotypical fashion. Using diffusion-weighted imaging, we test whether disruption of structural connectivity in AD is centered on these "epicenters of disease". METHODS: Fifteen healthy controls, 14 amnestic mild cognitive impairment (aMCI), 13 mild, and 15 moderate patients with AD were enrolled. The percentages of affected connections directly linking to the epicenter (named first ring) and to nodes with topological distanc...
Source: CNS Neuroscience and Therapeutics - April 21, 2015 Category: Neuroscience Authors: Mallio CA, Schmidt R, de Reus MA, Vernieri F, Quintiliani L, Curcio G, Beomonte Zobel B, Quattrocchi CC, van den Heuvel MP Tags: CNS Neurosci Ther Source Type: research

Levetiracetam-associated Hypokalemia and Hypomagnesaemia among Two Patients Treated for Seizures.
PMID: 25899700 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2015 Category: Neuroscience Authors: Vallianou NG, Geladari E, Chroni P, Kokkinakis E Tags: CNS Neurosci Ther Source Type: research

An Improved Elevated Platform for Simultaneously Assessing Rodent Locomotor Activity and Anxiety.
PMID: 25879537 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 16, 2015 Category: Neuroscience Authors: Ding XF, Zhao YQ, Liu SH, Zhao T, Zhu LL, Suo WZ, Fan M Tags: CNS Neurosci Ther Source Type: research

Biochemical and Neuroimaging Studies in Subjective Cognitive Decline: Progress and Perspectives.
In conclusion, there is promising evidence indicating that clinicians should be able to differentiate pre-AD SCD based on the presence of pathophysiological biomarkers in cerebrospinal fluid (CSF) and neuroimaging. However, this neuroimaging approach is still at an immature stage without an established rubric of standards. A substantial amount of work remains in terms of replicating recent findings and validating the clinical utility of identifying SCD. PMID: 25864576 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 13, 2015 Category: Neuroscience Authors: Sun Y, Yang FC, Lin CP, Han Y Tags: CNS Neurosci Ther Source Type: research

Age-Related Changes in Resting-State Networks of A Large Sample Size of Healthy Elderly.
CONCLUSION: The results of this study suggest that only the ventral default mode subnetwork had age-related decline in functional connectivity and several reverse patterns of resting-state networks for network development. Understanding age-related network changes may provide solutions for the impact of population aging and diagnosis of neurodegenerative diseases. PMID: 25864728 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 13, 2015 Category: Neuroscience Authors: Huang CC, Hsieh WJ, Lee PL, Peng LN, Liu LK, Lee WJ, Huang JK, Chen LK, Lin CP Tags: CNS Neurosci Ther Source Type: research

Perspective for stroke and brain injury research: mechanisms and potential therapeutic targets.
PMID: 25809674 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2015 Category: Neuroscience Authors: Chen J, Leak RK, Yang GY Tags: CNS Neurosci Ther Source Type: research

Neuropsychological and Neuroimaging Characteristics of Amnestic Mild Cognitive Impairment Subtypes: A Selective Overview.
Abstract Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. Amnestic mild cognitive impairment (aMCI) is considered to represent early AD. Various aMCI clinical subtypes have been identified as either single domain (SD) or multidomain (MD). The various subtypes represent heterogeneous syndrome, indicating the different probability of progression to AD. Understanding the heterogeneous concept of aMCI can help to construct potential biomarkers to monitor the progression of aMCI to AD. This review provides an overview of various neuroimaging measures for subtypes of aMCI. Focusing on neu...
Source: CNS Neuroscience and Therapeutics - March 26, 2015 Category: Neuroscience Authors: Li X, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Nicotinamide Phosphoribosyltransferase Facilitates Post-Stroke Angiogenesis.
PMID: 25753018 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2015 Category: Neuroscience Authors: Wang P, Guan YF, Li WL, Lu GC, Liu JM, Miao CY Tags: CNS Neurosci Ther Source Type: research

Glial Pathology in Bipolar Disorder: Potential Therapeutic Implications.
Abstract Bipolar disorder (BD) is a chronic and severe mental disorder with recurrent episodes of mania and depression. In addition to neuronal alterations, accumulating evidences have revealed the importance of glial system in pathophysiology and phenotype of the illness. Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated microglia and inflammatory cytokines are proposed to be the potential biomarkers that may help to predict disease exacerbation in BD. On the other hand, anti-BD drugs have been shown to produce profound effects on g...
Source: CNS Neuroscience and Therapeutics - March 9, 2015 Category: Neuroscience Authors: Dong XH, Zhen XC Tags: CNS Neurosci Ther Source Type: research

Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease.
Abstract Nogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer's disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer's disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid β-protein (Aβ), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and...
Source: CNS Neuroscience and Therapeutics - March 2, 2015 Category: Neuroscience Authors: Xu YQ, Sun ZQ, Wang YT, Xiao F, Chen MW Tags: CNS Neurosci Ther Source Type: research

Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant.
CONCLUSION: Taken together, we identified Diol as a potent neuroprotectant. It may represent a novel and promising neuroprotectant for stroke intervention. PMID: 25678034 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 13, 2015 Category: Neuroscience Authors: Yan M, Liu AL, Zhou SJ, Tang LP, Ou YQ, Yin W, Chen XY, Su XW, Qiu PX, Huang YJ, Zhang JX, Yan GM, Leng TD Tags: CNS Neurosci Ther Source Type: research

The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.
CONCLUSION: TREK-1 plays an important role in the therapeutic effects of the SSRI escitalopram in PSD model, making TREK-1 an attractive candidate molecule for further understanding the pathophysiology and treatment of PSD. PMID: 25675906 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Lin DH, Zhang XR, Ye DQ, Xi GJ, Hui JJ, Liu SS, Li LJ, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Evaluating Response to High-Dose 13.3 mg/24 h Rivastigmine Patch in Patients with Severe Alzheimer's Disease.
CONCLUSIONS: A significant therapeutic effect of high-dose rivastigmine patch on ADCS-CGIC response was observed. The 13.3 mg/24 h patch was identified as a predictor of "improvement" or "improvement or no change". Patients with minimal worsening/improvement/no change after treatment initiation may be more likely to respond following long-term therapy. PMID: 25675992 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Farlow MR, Sadowsky CH, Velting DM, Meng X, Islam MZ Tags: CNS Neurosci Ther Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Reduction of Orexin-A is Responsible for Prolonged Emergence of the Rat Subjected to Sleep Deprivation from Isoflurane Anesthesia.
PMID: 25678147 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Ran M, Wu W, Li J, Yang C, Ouyang P, Deng J, Dong H Tags: CNS Neurosci Ther Source Type: research

MicroRNA-29c Correlates with Neuroprotection Induced by FNS by Targeting Both Birc2 and Bak1 in Rat Brain after Stroke.
CONCLUSIONS: MiR-29c correlates with the neuroprotection induced by FNS by negatively regulating Birc2 and Bak1. PMID: 25678279 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Huang LG, Li JP, Pang XM, Chen CY, Xiang HY, Feng LB, Su SY, Li SH, Zhang L, Liu JL Tags: CNS Neurosci Ther Source Type: research

Inflammation and epilepsy in the developing brain: clinical and experimental evidence.
Abstract There is an increasing evidence to support a role of inflammatory processes in epilepsy. However, most clinical and experimental studies have been conducted in adult patients or using adult rodents. The pediatric epilepsies constitute a varied group of diseases that are most frequently age specific. In this review, we will focus on the possible role of inflammation in pediatric epilepsy syndromes. We will first describe the clinical data available and provide an overview of our current understanding of the role of inflammation in these clinical situations. We will then review experimental data regarding t...
Source: CNS Neuroscience and Therapeutics - January 26, 2015 Category: Neuroscience Authors: Dupuis N, Auvin S Tags: CNS Neurosci Ther Source Type: research

Surgical Stress Induces Brain-Derived Neurotrophic Factor Reduction and Postoperative Cognitive Dysfunction Via Glucocorticoid Receptor Phosphorylation in Aged Mice.
CONCLUSION: These results presented a mechanism that surgical stress-induced GR phosphorylation contributes to POCD in aged individuals. Inhibition of GR activation and phosphorylation might be a potential treatment target of POCD. PMID: 25611431 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 22, 2015 Category: Neuroscience Authors: Tian XS, Tong YW, Li ZQ, Li LX, Zhang T, Ren TY, Zhou T, Wang HC, Zhan R, Sun Y, Yan Z, Wang QD, Fan DS, Kong FJ, Guo XY, Xiao WZ, Chui H Tags: CNS Neurosci Ther Source Type: research

Plasma Amino Acid Profiling in Major Depressive Disorder Treated With Selective Serotonin Reuptake Inhibitors.
CONCLUSION: Metabolism of amino acids, including ABA and glutamic acid, has the potential to contribute to understandings of pathogenesis and predictions of therapeutic response in MDD. PMID: 25611566 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 22, 2015 Category: Neuroscience Authors: Woo HI, Chun MR, Yang JS, Lim SW, Kim MJ, Kim SW, Myung W, Kim DK, Lee SY Tags: CNS Neurosci Ther Source Type: research