(R)-alpha-methylhistamine Suppresses Inhibitory Neurotransmission in Hippocampal CA1 Pyramidal Neurons Counteracting Propofol-Induced Amnesia in Rats.
CONCLUSIONS: Our results suggest that RAMH, by inhibiting presynaptic GABAergic neurotransmission, suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons, which in turn reverses inhibition of CA1 LTP and the spatial memory deficits induced by propofol in rats. PMID: 24948006 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2014 Category: Neuroscience Authors: Li WW, Cheng LZ, Zou Z, Tian ML, Zhang H, Raya AD, Wang Y, Shi XY Tags: CNS Neurosci Ther Source Type: research

Amiloride and SN-6 Suppress Audiogenic Seizure Susceptibility in Genetically Epilepsy-Prone Rats.
CONCLUSIONS: These findings suggest acid-sensing ion channels and the Na(+) /Ca(2+) exchanger may play an important role in the pathophysiology of inherited AGS susceptibility in the GEPR-3s. PMID: 24948133 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2014 Category: Neuroscience Authors: Quansah H, N'Gouemo P Tags: CNS Neurosci Ther Source Type: research

Electrical Stimulation of Cerebellar Fastigial Nucleus: Mechanism of Neuroprotection and Prospects for Clinical Application against Cerebral Ischemia.
Abstract For around two decades, electrical fastigial nucleus stimulation (FNS) has been demonstrated to induce neuroprotection involving multiple mechanisms. In this review, we summarize the protective effects of FNS against cerebral ischemia through the inhibition of electrical activity around the lesion, excitotoxic damage on neurons, and brain inflammatory response, as well as apoptosis. Moreover, FNS has been reported to promote nerve tissue repair, reconstruction, and neurological rehabilitation and improve stroke-related complications including poststroke cognitive dysfunction, depression, and abnormal hear...
Source: CNS Neuroscience and Therapeutics - June 16, 2014 Category: Neuroscience Authors: Wang J, Dong WW, Zhang WH, Zheng J, Wang X Tags: CNS Neurosci Ther Source Type: research

In vivo Administration of TLR9 Agonist Reduces the Severity of Experimental Autoimmune Encephalomyelitis. The Role of Plasmacytoid Dendritic Cells and B Lymphocytes.
PMID: 24931054 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 16, 2014 Category: Neuroscience Authors: Longhini AL, Santos MP, Pradella F, Moraes AS, Dionete AC, Andrade MD, Russini PG, Oliveira EC, de Paula RO, Morais GA, Fonseca ES, Farias AS, Santos LM Tags: CNS Neurosci Ther Source Type: research

Negative Symptoms in Schizophrenia: Where We have been and Where We are Heading.
Abstract This review traces the history of negative symptom profiles in neuropsychiatry from their earliest emergence in the 19th century to the current psychiatric concepts and therapeutic approaches. Recent investigations performing exploratory and confirmatory factor analysis have suggested that negative symptoms are multidimensional, including evidence for at least two distinct negative symptom subdomains: diminished expression and amotivation. Preliminary studies have demonstrated the clinical validity of this distinction. Several potential pathophysiological validating factors based on brain imaging analysis...
Source: CNS Neuroscience and Therapeutics - June 16, 2014 Category: Neuroscience Authors: Azorin JM, Belzeaux R, Adida M Tags: CNS Neurosci Ther Source Type: research

Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer's Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway.
CONCLUSIONS: Taken together, these results clearly demonstrate that T3CA protects neurons against OS-induced cell death partially through Nrf2/ARE/HO-1 signaling pathway, which further supports that T3CA might be a promising novel therapeutic agent for OS-associated diseases. PMID: 24922524 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 12, 2014 Category: Neuroscience Authors: Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB Tags: CNS Neurosci Ther Source Type: research

Quality of Life in Children with Narcolepsy.
nco P Abstract AIMS: To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. METHODS: We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. RESULTS: The cohort included 69 control subjects (29 boys) and 117 patients (65 boys; 59 de novo patients). Cataplexy was present in 81% and DQB1*0602 was positive in 91%. The control children were older (13.5 ± 3.2 vs. 11.6 ± 3.1 years, P 
Source: CNS Neuroscience and Therapeutics - June 12, 2014 Category: Neuroscience Authors: Inocente CO, Gustin MP, Lavault S, Guignard-Perret A, Raoux A, Christol N, Gerard D, Dauvilliers Y, Reimão R, Bat-Pitault F, Lin JS, Arnulf I, Lecendreux M, Franco P Tags: CNS Neurosci Ther Source Type: research

Current status of endovascular procedures in management of ischemic stroke in china.
PMID: 24836738 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 23, 2014 Category: Neuroscience Authors: Liu LP, Wong LK, Wang DZ, Miao ZR Tags: CNS Neurosci Ther Source Type: research

Systematic review of clinical trials assessing pharmacological properties of salvia species on memory, cognitive impairment and Alzheimer's disease.
Abstract Salvia officinalis L. and Salvia lavandulaefolia L. have a longstanding use as traditional herbal remedies that can enhance memory and improve cognitive functions. Pharmacological actions of S. officinalis and S. lavandulaefolia on healthy subjects and on patients suffering of cognitive decline have been investigated. Aim of this review was to summarize published clinical trials assessing effectiveness and safety of S. officinalis and S. lavandulaefolia in the enhancement of cognitive performance in healthy subjects and neurodegenerative illnesses. Furthermore, to purchase a more compl...
Source: CNS Neuroscience and Therapeutics - May 23, 2014 Category: Neuroscience Authors: Miroddi M, Navarra M, Quattropani MC, Calapai F, Gangemi S, Calapai G Tags: CNS Neurosci Ther Source Type: research

Vagomimetic effects of fingolimod: physiology and clinical implications.
Abstract Fingolimod is a sphingosine 1-phosphate (S1P) receptor modulator approved to treat relapsing-remitting multiple sclerosis (MS). Initiation of treatment with fingolimod has been found to produce transient bradycardia and/or slowing of atrioventricular impulse conduction in a small proportion of patients. This effect is thought to be due to the interaction of fingolimod with S1P receptors on the surface membrane of atrial myocytes causing a vagomimetic effect, similar to the action of acetylcholine on muscarinic receptors. As a precaution, patients are under electrocardiogram (ECG) monitoring for 6 h a...
Source: CNS Neuroscience and Therapeutics - May 23, 2014 Category: Neuroscience Authors: Vanoli E, Pentimalli F, Botto G Tags: CNS Neurosci Ther Source Type: research

Abdominal acupuncture changes cortical responses to nociceptive stimuli in fibromyalgia patients.
PMID: 24836741 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 23, 2014 Category: Neuroscience Authors: de Tommaso M, Delussi M, Ricci K, D'Angelo G Tags: CNS Neurosci Ther Source Type: research

Procognitive Properties of Drugs with Single and Multitargeting H3 Receptor Antagonist Activities.
Abstract The histamine H3 receptor (H3 R) is an important modulator of numerous central control mechanisms. Novel lead optimizations for H3 R antagonists/inverse agonists involved studies of structure-activity relationships, cross-affinities, and pharmacokinetic properties of promising ligands. Blockade of inhibitory histamine H3 autoreceptors reinforces histaminergic transmission, while antagonism of H3  heteroreceptors accelerates the corticolimbic liberation of acetylcholine, norepinephrine, glutamate, dopamine, serotonin and gamma-aminobutyric acid (GABA). The H3 R positioned at numerous neurotransmission...
Source: CNS Neuroscience and Therapeutics - May 19, 2014 Category: Neuroscience Authors: Nikolic K, Filipic S, Agbaba D, Stark H Tags: CNS Neurosci Ther Source Type: research

Treatment Options to Reduce Disease Activity After Natalizumab: Paradoxical Effects of Corticosteroids.
Abstract AIM: Natalizumab (NTZ) discontinuation leads to multiple sclerosis (MS) recurrence, but represents the only known strategy to limit the risk of progressive multifocal leukoencephalopathy (PML) in JCV seropositive patients. Here, we compared the clinical and imaging features of three groups of patients who discontinued NTZ treatment. METHODS: We treated 25 patients with subcutaneous INFβ-1b (INF group), 40 patients with glatiramer acetate (GA group), and 40 patients with GA plus pulse steroid (GA+CS group). RESULTS: Six of 25 patients (24%) of the INF group were relapse-free 6 months af...
Source: CNS Neuroscience and Therapeutics - May 19, 2014 Category: Neuroscience Authors: Rossi S, Motta C, Studer V, Boffa L, De Chiara V, Castelli M, Barbieri F, Buttari F, Monteleone F, Germani G, Macchiarulo G, Weiss S, Centonze D Tags: CNS Neurosci Ther Source Type: research

G-Protein-Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System.
L, Franco R Abstract The overall architecture of the nervous system, especially the CNS, is remarkable. The anatomy of the nervous system is constituted not only by macroscopic and microscopy identifiable regions and neuronal cell types, but also by protein complexes whose identification and localization require sophisticated techniques. G-protein-coupled receptors (GPCRs) constitute an example of proteins that are the key factors in the framework needed to sustain brain and nerve structure and function. The versatility underlying nervous system anatomy takes advantage of a recently discovered feature of GPCRs, th...
Source: CNS Neuroscience and Therapeutics - May 9, 2014 Category: Neuroscience Authors: Brugarolas M, Navarro G, Martínez-Pinilla E, Angelats E, Casadó V, Lanciego JL, Franco R Tags: CNS Neurosci Ther Source Type: research

BASI, A Potent Small Molecular Inhibitor, Inhibits Glioblastoma Progression by Targeting microRNA-mediated β-Catenin Signaling.
CONCLUSIONS: Taken together, our findings offer preclinical validation of BASI as a promising new type of β-catenin inhibitor with a mechanism of inhibition that has broad potential for the improved treatment of glioblastoma. PMID: 24810017 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 9, 2014 Category: Neuroscience Authors: Shi ZD, Qian XM, Zhang JX, Han L, Zhang KL, Chen LY, Zhou X, Zhang JN, Kang CS Tags: CNS Neurosci Ther Source Type: research

Dopamine D3 Receptor-Regulated NR2B Subunits of N-Methyl-d-Aspartate Receptors in the Nucleus Accumbens Involves in Morphine-Induced Locomotor Activity.
CONCLUSIONS: These findings suggest that D3Rs are involved in morphine-induced behavioral locomotor sensitization in mice by regulating the NR2B subunits of NMDA receptors in the NAc. PMID: 24797707 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 2, 2014 Category: Neuroscience Authors: Liu XS, Hou Y, Yan TL, Guo YY, Han W, Guan FL, Chen T, Li T Tags: CNS Neurosci Ther Source Type: research

Neuroprotective Effects of the MAO-B Inhibitor, PF9601N, in an In Vivo Model of Excitotoxicity.
CONCLUSIONS: The results suggest PF9601N to be a good candidate for the treatment of neurodegenerative diseases mediated by excitotoxicity. PMID: 24767579 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 28, 2014 Category: Neuroscience Authors: Bolea I, Colivicchi MA, Ballini C, Marco-Contelles J, Tipton KF, Unzeta M, Della Corte L Tags: CNS Neurosci Ther Source Type: research

Noradrenergic Terminals Regulate l-DOPA-derived Dopamine Extracellular Levels in a Region-dependent Manner in Parkinsonian Rats.
CONCLUSION: Noradrenalin neurons are indirectly involved in the mechanism of action of l-DOPA in part through the heterologous reuptake of DA in extrastriatal regions. PMID: 24775184 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 28, 2014 Category: Neuroscience Authors: Navailles S, Milan L, Khalki H, Di Giovanni G, Lagière M, De Deurwaerdère P Tags: CNS Neurosci Ther Source Type: research

P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage.
CONCLUSIONS: These results suggest P2X7 receptor antagonists may be suitable as frontline or adjunctive treatments of pediatric status epilepticus or other early-life seizures, particularly when associated with brain damage. PMID: 24750893 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2014 Category: Neuroscience Authors: Mesuret G, Engel T, Hessel EV, Sanz-Rodriguez A, Jimenez-Pacheco A, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC Tags: CNS Neurosci Ther Source Type: research

Extracellular Visfatin has Nicotinamide Phosphoribosyltransferase Enzymatic Activity and is Neuroprotective Against Ischemic Injury.
CONCLUSIONS: Extracellular visfatin has NAMPT enzymatic activity and maybe be neuroprotective just as intracellular visfatin in cerebral ischemic injury. PMID: 24750959 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2014 Category: Neuroscience Authors: Zhao Y, Liu XZ, Tian WW, Guan YF, Wang P, Miao CY Tags: CNS Neurosci Ther Source Type: research

Use of Statin During Hospitalization Improves the Outcome After Intracerebral Hemorrhage.
CONCLUSIONS: In-hospital statin use in ICH patients is associated with better functional outcome and lower mortality at 3 months and 1 year. PMID: 24750990 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2014 Category: Neuroscience Authors: Pan YS, Jing J, Wang YL, Zhao XQ, Song B, Wang WJ, Wang D, Liu GF, Liu LP, Wang CX, Wang YJ, on behalf of the CNSR investigators Tags: CNS Neurosci Ther Source Type: research

Hepatocyte Transplants Improve Liver Function and Encephalopathy in Portacaval Shunted Rats.
CONCLUSIONS: The results support the therapeutic values of hepatocyte transplants in chronic liver diseases and the temporary character of PCS-exerted CNS dysfunctions. PMID: 24716845 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2014 Category: Neuroscience Authors: Fogel WA, Stasiak A, Maksymowicz M, Kobos J, Unzeta M, Mussur M Tags: CNS Neurosci Ther Source Type: research

Early Failure of the Default-Mode Network and the Pathogenesis of Alzheimer's Disease.
Abstract The default-mode network (DMN) is a major resting-state network that supports most of the baseline brain activity. Recent studies revealed that DMN cortical hub regions, including the medial prefrontal cortex, parietal cortex, posterior cingulum, and precuneus, are all affected early during Alzheimer's disease (AD) and exhibit high amounts of Aβ deposits. The cells generating Aβ are chiefly cortical and some brainstem projection neurons. Because processing of the amyloid precursor protein is activity-dependent, it can be speculated that due to their constant activity, DMN neurons produce and rel...
Source: CNS Neuroscience and Therapeutics - April 8, 2014 Category: Neuroscience Authors: Simic G, Babic M, Borovecki F, Hof PR Tags: CNS Neurosci Ther Source Type: research

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1.
CONCLUSIONS: Down-regulation or inhibition of Drp1 may reduce cerebral ischemic damage through maintaining normal mitochondrial morphology and function, and decreasing Bax insertion and oligomerization in mitochondria. PMID: 24712408 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2014 Category: Neuroscience Authors: Zhao YX, Cui M, Chen SF, Dong Q, Liu XY Tags: CNS Neurosci Ther Source Type: research

Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders.
Abstract Aquaporin 4 (AQP4) is the main water channel in the central nervous system (CNS) and specifically localized to astrocyte processes. Recent studies indicate that AQP4 regulates various biological functions of astrocytes, including maintaining CNS water balance, spatial buffering of extracellular potassium, calcium signal transduction, regulation of neurotransmission, synaptic plasticity, and adult neurogenesis, while under neuropathological conditions, AQP4 has a role in astrogliosis and proinflammatory cytokine secretion. In addition, accumulating evidence suggests that, besides cerebral edema, neuromyeli...
Source: CNS Neuroscience and Therapeutics - April 8, 2014 Category: Neuroscience Authors: Xiao M, Hu G Tags: CNS Neurosci Ther Source Type: research

In Vivo Two-photon Fluorescence Microscopy Reveals Disturbed Cerebral Capillary Blood Flow and Increased Susceptibility to Ischemic Insults in Diabetic Mice.
CONCLUSION: Diabetic mice are more susceptible to disturbances of cerebral capillary blood flow which may predispose them to neurovascular defects following ischemia. PMID: 24712523 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2014 Category: Neuroscience Authors: Huang JY, Li LT, Wang H, Liu SS, Lu YM, Liao MH, Tao RR, Hong LJ, Fukunaga K, Chen Z, Wilcox CS, Lai EY, Han F Tags: CNS Neurosci Ther Source Type: research

Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234.
PMID: 24712554 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2014 Category: Neuroscience Authors: Del Pino J, Ramos E, Aguilera OM, Marco-Contelles J, Romero A Tags: CNS Neurosci Ther Source Type: research

Positive Allosteric Modulation of GABAB Receptors Ameliorates Sensorimotor Gating in Rodent Models.
CONCLUSIONS: The present data further support the implication of GABAB Rs in the modulation of sensorimotor gating and point to their PAMs as a novel promising tool for antipsychotic treatment, with fewer side effects than GABAB R agonists. PMID: 24703381 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2014 Category: Neuroscience Authors: Frau R, Bini V, Pillolla G, Malherbe P, Pardu A, Thomas AW, Devoto P, Bortolato M Tags: CNS Neurosci Ther Source Type: research

Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1(G93A) Transgenic Mice and Evaluation of a Sativex(®) -like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis.
CONCLUSIONS: Our results demonstrated changes in endocannabinoid signaling, in particular a marked up-regulation of CB2 receptors, in SOD1(G93A) transgenic mice, and provide support that Sativex(®) may serve as a novel disease-modifying therapy in ALS. PMID: 24703394 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 7, 2014 Category: Neuroscience Authors: Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E Tags: CNS Neurosci Ther Source Type: research

Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia.
Abstract Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, form a functional unit with axons and play a crucial role in axonal integrity. An episode of hypoxia-ischemia causes rapid and severe damage to these particularly vulnerable cells via multiple pathways such as overactivation of glutamate and ATP receptors, oxidative stress, and disruption of mitochondrial function. The cardinal effect of OL pathology is demyelination and dysmyelination, and this has profound effects on axonal function, transport, structure, metabolism, and survival. The OL is a primary target of ischemia in ad...
Source: CNS Neuroscience and Therapeutics - April 7, 2014 Category: Neuroscience Authors: Mifsud G, Zammit C, Muscat R, Di Giovanni G, Valentino M Tags: CNS Neurosci Ther Source Type: research

The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease.
Abstract Parkinson's disease (PD) is an incurable neurodegenerative disorder leading to progressive motor impairment and for which there is no cure. From the first postmortem account describing a lack of mitochondrial complex I in the substantia nigra of PD sufferers, the direct association between mitochondrial dysfunction and death of dopaminergic neurons has ever since been consistently corroborated. In this review, we outline common pathways shared by both sporadic and familial PD that remarkably and consistently converge at the level of mitochondrial integrity. Furthermore, such knowledge has incontrovertibly...
Source: CNS Neuroscience and Therapeutics - April 7, 2014 Category: Neuroscience Authors: Camilleri A, Vassallo N Tags: CNS Neurosci Ther Source Type: research

The epigenetics changes in Parkinson's disease: a novel therapeutic target.
PMID: 24629108 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2014 Category: Neuroscience Authors: Yuan TF, Li J, Shan CL Tags: CNS Neurosci Ther Source Type: research

Astrocytic JWA Expression is Essential to Dopaminergic Neuron Survival in the Pathogenesis of Parkinson's Disease.
Abstract AIMS: To investigate the role of astrocytic JWA expression in dopaminergic (DA) neuron degeneration and in the pathogenesis of Parkinson's disease (PD). METHODS: Conditional astrocytic JWA null (JWA(∆2/∆2) /GFAP-Cre) mice and U251 glioma cells were used to evaluate the effects of JWA gene on DA neuron degeneration. The oxidative stress-driven molecular events were determined in both in vivo and in vitro models. RESULTS: Conditional astrocytic JWA knockout resulted in significant activation of astrocytes measured by increase in glial fibrillary acidic protein-positive cells (1.34&nb...
Source: CNS Neuroscience and Therapeutics - March 17, 2014 Category: Neuroscience Authors: Miao SH, Sun HB, Ye Y, Yang JJ, Shi YW, Lu M, Hu G, Zhou JW Tags: CNS Neurosci Ther Source Type: research

Abnormally Altered Patterns of Whole Brain Functional Connectivity Network of Posterior Cingulate Cortex in Remitted Geriatric Depression: A Longitudinal Study.
CONCLUSIONS: RGD patients performed worse cognitive function, and altered PCC functional connectivity network might have a role in these cognitive declines. PMID: 24628776 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 17, 2014 Category: Neuroscience Authors: Jiang WH, Yuan YG, Zhou H, Bai F, You JY, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Inordinate Glucose Variation Poststroke is Associated with Poor Neurological Improvement in Patients Without History of Diabetes.
Abstract INTRODUCTION: Glucose variation is an important risk factor for the complications of diabetes mellitus. The plasma glucose level poststroke is in continuous fluctuation. However, whether the variation influences neurological improvement remains unknown. AIMS: This observational study aimed to investigate the association of glucose variation with neurological improvement poststroke. METHODS: We consecutively enrolled 216 ischemic stroke patients with no history of diabetes mellitus within 72 h of onset, with instant blood glucose
Source: CNS Neuroscience and Therapeutics - March 17, 2014 Category: Neuroscience Authors: Yu J, Zhang CG, Zhang SP, Xiao WM, Pan XP, Liu ZH, Chu XF, Gao QC, Xu AD, Xu ZQ, Zeng JS Tags: CNS Neurosci Ther Source Type: research

Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
CONCLUSION: The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2014 Category: Neuroscience Authors: Cai JJ, Qi ZX, Hua W, Zhu JJ, Zhang X, Yao Y, Mao Y Tags: CNS Neurosci Ther Source Type: research

Predicting Dopaminergic Effects of L-DOPA in the Treatment for Parkinson's Disease.
;re P PMID: 24628826 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2014 Category: Neuroscience Authors: Navailles S, Di Giovanni G, De Deurwaerdère P Tags: CNS Neurosci Ther Source Type: research

Overexpression of BAT3 Alleviates Prion Protein Fragment PrP106-126-Induced Neuronal Apoptosis.
CONCLUSIONS: Our present data showed a novel molecular mechanism of PrP106-126-induced apoptotic process regulation through the overexpression of BAT3, which may be important for the basic regulatory mechanism of neuron survival in prion diseases and associated neurodegenerative diseases in vivo. PMID: 24629137 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2014 Category: Neuroscience Authors: Song ZQ, Yang LF, Wang YS, Zhu T, Zhou XM, Yin XM, Yao HQ, Zhao DM Tags: CNS Neurosci Ther Source Type: research

A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats.
CONCLUSIONS: The spinal astrocytic Cx43 contributes to the development of morphine antinociceptive tolerance by activating astrocytes and NMDA receptors, and inhibiting GLT-1 expression. We also demonstrate that the role of interaction between the spinal astrocytic Cx43 and neuronal NMDA receptors is important in morphine tolerant rats. PMID: 24629168 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2014 Category: Neuroscience Authors: Shen N, Mo LQ, Hu F, Chen PX, Guo RX, Feng JQ Tags: CNS Neurosci Ther Source Type: research

CNS Neurotoxicity of Bacterial Cellulose-Poly(acrylamide-sodium acrylate) Hydrogel: A Future Therapeutic Carrier.
PMID: 24588895 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2014 Category: Neuroscience Authors: Pandey M, Mohd Amin MC Tags: CNS Neurosci Ther Source Type: research

Long-Acting Versus Standard Non-Ergot Dopamine Agonists in Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSIONS: Our meta-analysis showed long-acting NEDAs were noninferior to standard NEDAs in efficacy, tolerability, and safety in the treatment of PD. PMID: 24588909 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2014 Category: Neuroscience Authors: Zhou CQ, Lou JH, Zhang YP, Zhong L, Chen YL, Lu FJ, Peng GG Tags: CNS Neurosci Ther Source Type: research

Inhibitory Effect of Bcl-xL Gene on Toxicity Induced by Sodium Nitroprusside in SH-SY5Y cells.
PMID: 24588944 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2014 Category: Neuroscience Authors: Yang LH, Cai XD, Jiang LY, Liang YR, Xiao SH, Liu SQ, Tao EX, Luan P, Liu J Tags: CNS Neurosci Ther Source Type: research

Relations of Serum Soluble E-Selectin and Adiponectin with Enlarged Perivascular Spaces in Patients with Recent Lacunar Infarction.
PMID: 24588964 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2014 Category: Neuroscience Authors: Sun W, Huang ZX, Duan ZW, Xiao LL, Liu XF Tags: CNS Neurosci Ther Source Type: research

Angiotensin Converting Enzyme 2/Ang-(1-7)/Mas Axis Protects Brain from Ischemic Injury with a Tendency of Age-dependence.
CONCLUSIONS: Angiotensin converting enzyme 2/Ang-(1-7)/Mas axis protects brain from ischemic injury via the Nox/ROS signaling pathway, with a greater effect in older animals. PMID: 24581232 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 2, 2014 Category: Neuroscience Authors: Zheng JL, Li GZ, Chen SZ, Wang JJ, Olson JE, Xia HJ, Lazartigues E, Zhu YL, Chen YF Tags: CNS Neurosci Ther Source Type: research

Endogenous Endothelial Progenitor Cells Participate in Neovascularization via CXCR4/SDF-1 axis and Improve Outcome After Stroke.
CONCLUSIONS: Our findings suggested that endogenous EPCs participated in the neovascularization via CXCR4/SDF-1 axis after pMCAO and mobilizing endogenous EPCs could be a treatment alternative for stroke. PMID: 24581269 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 2, 2014 Category: Neuroscience Authors: Mao L, Huang M, Chen SC, Li YN, Xia YP, He QW, Wang MD, Huang Y, Zheng L, Hu B Tags: CNS Neurosci Ther Source Type: research

Chinese Consensus Statement on the Evaluation and Intervention of Collateral Circulation for Ischemic Stroke.
CONCLUSION: Assessment of collateral circulation is crucial for selecting therapeutic options, predicting infarction volume and making prognosis after ischemic stroke. Data is still needed to provide therapeutic evidence for many new developed technologies. Until more evidence is available, the clinical significance of applying the new technologies is unclear and perhaps limited. PMID: 24495505 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 5, 2014 Category: Neuroscience Authors: Liu LP, Xu AD, Wong LK, Wang DZ, Wang YJ, Expert consensus group of the evaluation & intervention of collateral circulation for ischemic stroke Tags: CNS Neurosci Ther Source Type: research

Vitamin d as a potential therapy in amyotrophic lateral sclerosis.
Abstract Vitamin D has been demonstrated to influence multiple aspects of amyotrophic lateral sclerosis (ALS) pathology. Both human and rodent central nervous systems express the vitamin D receptor (VDR) and/or its enzymatic machinery needed to fully activate the hormone. Clinical research suggests that vitamin D treatment can improve compromised human muscular ability and increase muscle size, supported by loss of motor function and muscle mass in animals following VDR knockout, as well as increased muscle protein synthesis and ATP production following vitamin D supplementation. Vitamin D has also been shown to r...
Source: CNS Neuroscience and Therapeutics - January 19, 2014 Category: Neuroscience Authors: Gianforcaro A, Hamadeh MJ Tags: CNS Neurosci Ther Source Type: research

Acid-sensing Ion Channels Activation and Hypoxia Upregulate Homer1a Expression.
CONCLUSION: Homer1a might act as an activity-dependent regulator responding to extracellular stimuli during cerebral ischemia. PMID: 24433527 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 17, 2014 Category: Neuroscience Authors: Su JJ, Pan H, Zhou HG, Tang YP, Dong Q, Liu JR Tags: CNS Neurosci Ther Source Type: research

Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response.
CONCLUSIONS: Our results support a definite role for CRHR1 in the pharmacogenetics of antidepressant drugs. This may contribute to interpatient differences in their responses to antidepressant drugs. PMID: 24422887 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2014 Category: Neuroscience Authors: Geng LY, Ye DQ, Shi YY, Xu Z, Pu MJ, Li ZY, Li XL, Li Y, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Differential Effect of Conditioning Sequences in Coupling Inhibitory/Facilitatory Repetitive Transcranial Magnetic Stimulation for PostStroke Motor Recovery.
CONCLUSIONS: Conditioning the contralesional M1 prior to ipsilesional iTBS was found to be optimal for enhancing hand function, and this effect persisted for at least 3 months. Early modulation within 6 months poststroke rebalances interhemispheric competition and appears to be a feasible time window for rTMS intervention. PMID: 24422912 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2014 Category: Neuroscience Authors: Wang CP, Tsai PY, Yang TF, Yang KY, Wang CC Tags: CNS Neurosci Ther Source Type: research