Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2
CONCLUSIONS: In epilepsy, Nrf2 modulates ferroptosis by involving the expression of FtMt and may be a potential therapeutic mechanism of neuronal injury after epilepsy. Targeting this relevant process for treatment may be a therapeutic strategy to prevent epilepsy.PMID:38439636 | DOI:10.1111/cns.14663 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Yu Song Mengjiao Gao Boyang Wei Xiaowei Huang Zeyu Yang Junjie Zou Yanwu Guo Source Type: research
Aberrant dynamic properties of whole-brain functional connectivity in acute mild traumatic brain injury revealed by hidden Markov models
CONCLUSIONS: Hidden Markov models provide additional information on the dynamic activity of brain networks in patients with acute mTBI and those with cognitive impairment. Our results suggest that brain network dynamics determined by the HMM could reinforce the understanding of the neuropathological mechanisms of acute mTBI patients and those with cognitive impairment.PMID:38439697 | DOI:10.1111/cns.14660 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Liyan Lu Fengfang Li Hui Li Leilei Zhou Xinying Wu Fang Yuan Source Type: research
Predictors for early-onset psychotic symptoms in patients newly diagnosed with Parkinson's disease without psychosis at baseline: A 5-year cohort study
CONCLUSION: We identified clinical and CSF predictors of early-onset psychosis in patients with PD. Our study provides evidence and implications for prognostic stratification and therapeutic approaches for PD psychosis.PMID:38432692 | DOI:10.1111/cns.14651 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Jing Chen Baoyu Chen Danhua Zhao Xiaotong Feng Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaoyu He Lin Zhang Junliang Yuan Source Type: research
Is it more effective for anhedonia and avolition? A systematic review and meta-analysis of non-invasive brain stimulation interventions for negative symptoms in schizophrenia
CONCLUSION: NIBS exerts distinct effects across multiple dimensions of negative symptom, with treatment effects related to stimulation frequency and total sessions. These results need to be confirmed in dedicated studies.PMID:38432851 | DOI:10.1111/cns.14645 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Yuying Chen Zhuofeng Li Chao Yan Laiquan Zou Source Type: research
Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke
CONCLUSION: In minor AIS, hsCRP and IL-6 levels were associated with in-hospital ND, including IL-6 levels in prognostic models improved risk classification.PMID:38432871 | DOI:10.1111/cns.14648 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Luo Yi Zi-Xiao Li Ying-Yu Jiang Yong Jiang Xia Meng Hao Li Xing-Quan Zhao Yi-Long Wang Li-Ping Liu Yong-Jun Wang Hong-Qiu Gu Source Type: research
Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single-cell RNA sequencing approach
CONCLUSION: The study offers valuable insights into WMH's complex pathophysiology following ICH, highlighting the significance and utility of scRNA-seq in understanding the cellular dynamics and contributing to future cerebrovascular research.PMID:38433011 | DOI:10.1111/cns.14652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Lisha Ye Xiaoyan Tang Jun Zhong Wenfeng Li Ting Xu Chao Xiang Jianjun Gu Hua Feng Qianqian Luo Guohua Wang Source Type: research
SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia
CONCLUSION: BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.PMID:38433018 | DOI:10.1111/cns.14654 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Mohammad Iqbal H Bhuiyan Khadija Habib Md Tipu Sultan Fenghua Chen Israt Jahan Zhongfang Weng Md Shamim Rahman Rabia Islam Lesley M Foley T Kevin Hitchens Xianming Deng Scott W Canna Dandan Sun Guodong Cao Source Type: research
Serotonergic neurotransmission mediated cognitive dysfunction in two mouse models of sepsis-associated encephalopathy
CONCLUSIONS: Our study demonstrated that serotonergic neurotransmission plays a significant role in mechanisms underlying cognitive impairment in SAE. These findings contribute to identification of novel targets to prevent and arrest cognitive impairment in SAE.PMID:38433019 | DOI:10.1111/cns.14655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Chen Zhang Fafa Tian Jing Peng Xia Wang Jingchen Li Lina Zhang Zheren Tan Source Type: research
Human umbilical cord mesenchymal stem cells reverse depression in rats induced by chronic unpredictable mild stress combined with lipopolysaccharide
CONCLUSIONS: Rat depression can be reversed or recovered by treatment with hUC-MSCs.PMID:38433020 | PMC:PMC10909725 | DOI:10.1111/cns.14644 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Pengxiang Wang Yunxia Li Yongli Song Yuan Gao Chunxia Hao Yang Zhou Siqin Bao Jitong Guo Xihe Li Source Type: research
Predictors for early-onset psychotic symptoms in patients newly diagnosed with Parkinson's disease without psychosis at baseline: A 5-year cohort study
CONCLUSION: We identified clinical and CSF predictors of early-onset psychosis in patients with PD. Our study provides evidence and implications for prognostic stratification and therapeutic approaches for PD psychosis.PMID:38432692 | DOI:10.1111/cns.14651 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Jing Chen Baoyu Chen Danhua Zhao Xiaotong Feng Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaoyu He Lin Zhang Junliang Yuan Source Type: research
Is it more effective for anhedonia and avolition? A systematic review and meta-analysis of non-invasive brain stimulation interventions for negative symptoms in schizophrenia
CONCLUSION: NIBS exerts distinct effects across multiple dimensions of negative symptom, with treatment effects related to stimulation frequency and total sessions. These results need to be confirmed in dedicated studies.PMID:38432851 | DOI:10.1111/cns.14645 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Yuying Chen Zhuofeng Li Chao Yan Laiquan Zou Source Type: research
Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke
CONCLUSION: In minor AIS, hsCRP and IL-6 levels were associated with in-hospital ND, including IL-6 levels in prognostic models improved risk classification.PMID:38432871 | DOI:10.1111/cns.14648 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Luo Yi Zi-Xiao Li Ying-Yu Jiang Yong Jiang Xia Meng Hao Li Xing-Quan Zhao Yi-Long Wang Li-Ping Liu Yong-Jun Wang Hong-Qiu Gu Source Type: research
Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single-cell RNA sequencing approach
CONCLUSION: The study offers valuable insights into WMH's complex pathophysiology following ICH, highlighting the significance and utility of scRNA-seq in understanding the cellular dynamics and contributing to future cerebrovascular research.PMID:38433011 | DOI:10.1111/cns.14652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Lisha Ye Xiaoyan Tang Jun Zhong Wenfeng Li Ting Xu Chao Xiang Jianjun Gu Hua Feng Qianqian Luo Guohua Wang Source Type: research
SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia
CONCLUSION: BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.PMID:38433018 | DOI:10.1111/cns.14654 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Mohammad Iqbal H Bhuiyan Khadija Habib Md Tipu Sultan Fenghua Chen Israt Jahan Zhongfang Weng Md Shamim Rahman Rabia Islam Lesley M Foley T Kevin Hitchens Xianming Deng Scott W Canna Dandan Sun Guodong Cao Source Type: research
Serotonergic neurotransmission mediated cognitive dysfunction in two mouse models of sepsis-associated encephalopathy
CONCLUSIONS: Our study demonstrated that serotonergic neurotransmission plays a significant role in mechanisms underlying cognitive impairment in SAE. These findings contribute to identification of novel targets to prevent and arrest cognitive impairment in SAE.PMID:38433019 | DOI:10.1111/cns.14655 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Chen Zhang Fafa Tian Jing Peng Xia Wang Jingchen Li Lina Zhang Zheren Tan Source Type: research
