Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β-common receptor in mice with cerebral ischemic stroke
CONCLUSION: ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role of ARA290 in ischemic stroke intervention.PMID:38488446 | PMC:PMC10941562 | DOI:10.1111/cns.14676 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Rong-Liang Wang Zhen-Hong Yang Yu-You Huang Yue Hu Yi-Lin Wang Feng Yan Yang-Min Zheng Zi-Ping Han Jun-Fen Fan Zhen Tao Hai-Ping Zhao Si-Jie Li Yu-Min Luo Source Type: research
Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia
CONCLUSION: This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.PMID:38488453 | PMC:PMC10941502 | DOI:10.1111/cns.14675 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Fuyang Cao Yongxin Guo Shuting Guo Xinyu Hao Lujia Yang Jiangbei Cao Zhikang Zhou Weidong Mi Li Tong Source Type: research
Real-time field-programmable gate array-based closed-loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia
CONCLUSION: Our real-time FPGA-based DCN-DBS system could be a potential clinical strategy for alleviating cerebellar ataxia and other movement disorders.PMID:38488445 | DOI:10.1111/cns.14638 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Gajendra Kumar Zhanhong Zhou Zhihua Wang Kin Ming Kwan Chung Tin Chi Him Eddie Ma Source Type: research
Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β-common receptor in mice with cerebral ischemic stroke
CONCLUSION: ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role of ARA290 in ischemic stroke intervention.PMID:38488446 | DOI:10.1111/cns.14676 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Rong-Liang Wang Zhen-Hong Yang Yu-You Huang Yue Hu Yi-Lin Wang Feng Yan Yang-Min Zheng Zi-Ping Han Jun-Fen Fan Zhen Tao Hai-Ping Zhao Si-Jie Li Yu-Min Luo Source Type: research
Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia
CONCLUSION: This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.PMID:38488453 | DOI:10.1111/cns.14675 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Fuyang Cao Yongxin Guo Shuting Guo Xinyu Hao Lujia Yang Jiangbei Cao Zhikang Zhou Weidong Mi Li Tong Source Type: research
Theory and application of TTFields in newly diagnosed glioblastoma
CONCLUSION: This review summarizes mechanisms of TTFields in the treatment of ndGBM, and describes the current clinical application of TTFields in ndGBM. Through the understanding of its principle and application status, we believe that TTFields still has the potential to further prolong the survival of ndGBM patients. Thus,research is still needed to explore new ways to combine TTFields with other therapies and optimize the use of TTFields to realize its full potential in ndGBM patients.PMID:38481068 | PMC:PMC10938032 | DOI:10.1111/cns.14563 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2024 Category: Neuroscience Authors: Ao Yu Juan Zeng Jinhui Yu Shuo Cao Ailin Li Source Type: research
Theory and application of TTFields in newly diagnosed glioblastoma
CONCLUSION: This review summarizes mechanisms of TTFields in the treatment of ndGBM, and describes the current clinical application of TTFields in ndGBM. Through the understanding of its principle and application status, we believe that TTFields still has the potential to further prolong the survival of ndGBM patients. Thus,research is still needed to explore new ways to combine TTFields with other therapies and optimize the use of TTFields to realize its full potential in ndGBM patients.PMID:38481068 | DOI:10.1111/cns.14563 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2024 Category: Neuroscience Authors: Ao Yu Juan Zeng Jinhui Yu Shuo Cao Ailin Li Source Type: research
Long term for patients with futile endovascular reperfusion after stroke
CONCLUSIONS: Futile recanalization accounts for a large proportion of stroke patients after thrombectomy. This study on the long-term prognosis of such patients is beneficial to the formulation of treatment plans and the prediction of therapeutic effects.PMID:38475869 | DOI:10.1111/cns.14588 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 13, 2024 Category: Neuroscience Authors: Mengke Zhang Ruiwen Che Jiali Xu Wenting Guo Xi Chen Wenbo Zhao Changhong Ren Milan Jia Xunming Ji Source Type: research
Intermittent hypoxia preconditioning can attenuate acute hypoxic injury after a sustained normobaric hypoxic exposure: A randomized clinical trial
CONCLUSION: The short-term moderate IH improved the tolerance to hypoxia and exerted protection against acute hypoxic injury induced by exposure to sustained normobaric hypoxia, which provided a novel method and randomized controlled trial evidence to develop treatments for hypoxia-related disease.PMID:38477221 | PMC:PMC10934266 | DOI:10.1111/cns.14662 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 13, 2024 Category: Neuroscience Authors: Yuan Wang Qihan Zhang Qingfeng Ma Qing Wang Dan Huang Xunming Ji Source Type: research
Machine-learning model for the prediction of acute orthostatic hypotension after levodopa administration
CONCLUSIONS: The validated classifier could serve as a valuable tool for clinicians, offering the probability of a patient developing AOHPL at an early stage. This supports clinical decision-making, potentially enhancing the quality of life for PD patients.PMID:38467597 | DOI:10.1111/cns.14575 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Zhu Liu Shinuan Lin Junhong Zhou Xuemei Wang Zhan Wang Yaqin Yang Huizi Ma Zhonglue Chen Kang Ren Lingyu Wu Haimei Zhuang Yun Ling Tao Feng Source Type: research
Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR < sub > 2 < /sub > /SRC pathway in vascular cognitive impairment mice
CONCLUSION: Hyperforin effectively modulated microglial M1 polarization and neuroinflammation by inhibiting the VEGFR2 /SRC signaling pathways, thereby ameliorating WMLs and cognitive impairment in VCI mice.PMID:38468126 | DOI:10.1111/cns.14666 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xin Gao Jingjing Chen Ge Yin Yanqun Liu Zhengsheng Gu Rui Sun Xu Sun Xuehao Jiao Ling Wang Nuo Wang Yanbo Zhang Yuting Kan Xiaoying Bi Bingying Du Source Type: research
Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure
CONCLUSIONS: Our study identifies LA microglial activation as a critical mediator of noise-induced anxiety-like behaviors, leading to neuronal and behavioral changes through selective synapse phagocytosis. Our results highlight the pivotal but previously unrecognized roles of LA microglia in chronic moderate noise-induced behavioral changes.PMID:38468130 | DOI:10.1111/cns.14674 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xiaoqi Peng Yunfeng Mao Yehao Liu Qian Dai Yingju Tai Bin Luo Yue Liang Ruirui Guan Wenjie Zhou Lin Chen Zhi Zhang Guoming Shen Haitao Wang Source Type: research
CD4 < sup > + < /sup > CD11b < sup > + < /sup > T cells infiltrate and aggravate the traumatic brain injury depending on brain-to-cervical lymph node signaling
CONCLUSION: The infiltration of CD4+ CD11b+ T cells exacerbates secondary brain damage in TBI, and this process is modulated by brain-to-CLN signaling.PMID:38468459 | DOI:10.1111/cns.14673 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Weiwei Jiang Xuanhui Liu Yupeng Chen Mingqi Liu Jiangyuan Yuan Meng Nie Yibing Fan Di Wu Yu Qian Zhuang Sha Shiying Dong Chenrui Wu Tao Liu Jinhao Huang Jianning Zhang Chuang Gao Rongcai Jiang Source Type: research
Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma
CONCLUSIONS: This investigation underscores that EVsPDPN derived from glioblastoma cells contributes to M2 macrophage-mediated immunosuppression and is a potential prognostic marker and therapeutic target in glioblastoma.PMID:38470096 | DOI:10.1111/cns.14643 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Mengwan Wu Ying Shi Yuyang Liu Hongxiang Huang Jiajia Che Jing Shi Chuan Xu Source Type: research
Machine-learning model for the prediction of acute orthostatic hypotension after levodopa administration
CONCLUSIONS: The validated classifier could serve as a valuable tool for clinicians, offering the probability of a patient developing AOHPL at an early stage. This supports clinical decision-making, potentially enhancing the quality of life for PD patients.PMID:38467597 | DOI:10.1111/cns.14575 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Zhu Liu Shinuan Lin Junhong Zhou Xuemei Wang Zhan Wang Yaqin Yang Huizi Ma Zhonglue Chen Kang Ren Lingyu Wu Haimei Zhuang Yun Ling Tao Feng Source Type: research
