Effect of Acupuncture on the Motor and Nonmotor Symptoms in Parkinson's Disease-A Review of Clinical Studies.
Abstract Parkinson's disease is a neurodegenerative disorder. Parkinson's clinical feature is characterized by its motor manifestations, although its many nonmotor symptoms occur earlier and have more profound impact on the quality of patient's life. Acupuncture has been increasingly popular and has been used to treat patients with Parkinson's. In this article, we have studied the clinical reports of acupuncture treatment for Parkinson's, which were listed in Medline, PubMed, EMBASE, CNKI, and CINAHL databases in the past 15 years. It was found that acupuncture either manual or electroacupuncture stimulation ...
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Zeng BY, Zhao K Tags: CNS Neurosci Ther Source Type: research

Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.
CONCLUSION: Our findings rule out the involvement of S100B/mRAGE axis in striatal reactive gliosis, DAergic axonopathy and warrant further exploration of its neurotrophic effects in a presymptomatic compensatory PD stage, which is a fundamental period for successful implementation of therapeutic strategies. PMID: 26843141 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Viana SD, Fernandes RC, Canas PM, Silva AM, Carvalho F, Ali SF, Fontes Ribeiro CA, Pereira FC Tags: CNS Neurosci Ther Source Type: research

Orosomucoid (ORM) as a Potential Biomarker for the Diagnosis of Chronic Fatigue Syndrome (CFS).
PMID: 26833758 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 2, 2016 Category: Neuroscience Authors: Sun Y, Zhang ZX, Liu X Tags: CNS Neurosci Ther Source Type: research

Novel Translational Approaches for Improving Drug Discovery Efforts in Chronic Pain.
PMID: 26778453 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 21, 2016 Category: Neuroscience Authors: Munro G Tags: CNS Neurosci Ther Source Type: research

Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury.
CONCLUSION: These results indicate a trajectory-dependent injury characterized by exacerbation of inflammation and different levels of impaired cell proliferation and neurogenesis. Such multiple brain areas showing varying levels of cell death after region-specific CCI model may closely mimic the clinical manifestations of TBI. PMID: 26775604 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Pabón MM, Acosta S, Guedes VA, Tajiri N, Kaneko Y, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen.
CONCLUSIONS: Altogether, these results suggest that disruption of astroglial AOGEN synthesis leads to cardiovascular, cognitive, behavioral, and sleep disorders that might be partly due to LC dysfunction. PMID: 26775713 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Ogier M, Bricca G, Bader M, Bezin L Tags: CNS Neurosci Ther Source Type: research

Global White Matter Hypoperfusion on CT Predicts Larger Infarcts and Hemorrhagic Transformation after Acute Ischemia.
Abstract INTRODUCTION: Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM: We sought to determine whether white matter hypoperfusion (WMHP) on perfusion CT (CTP) was related to WMH, and if WMHP predisposed to acute lacunar stroke subtype and HT after thrombolysis. METHODS: Acute ischemic stroke patients within 12 h of symptom onset at 2 centers were prospectively recruited between 2011 and 2013 for the International Stroke Perfus...
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Bivard A, Cheng X, Lin L, Levi C, Spratt N, Kleinig T, O'Brien B, Butcher K, Lou M, Zhang J, Sylaja PN, Cao W, Jannes J, Dong Q, Parsons M Tags: CNS Neurosci Ther Source Type: research

Position Emission Tomography/Single-Photon Emission Tomography Neuroimaging for Detection of Premotor Parkinson's Disease.
Abstract Premotor Parkinson's disease (PD) refers to a prodromal stage of Parkinson's disease (PD) during which nonmotor clinical features may be present. Currently, it is difficult to make an early diagnosis for premotor PD. Molecular imaging with position emission tomography (PET) or single-photon emission tomography (SPECT) offers a wide variety of tools for overcoming this difficulty. Indeed, molecular imaging techniques may play a crucial role in diagnosing, monitoring and evaluating the individuals with the risk for PD. For example, dopaminergic dysfunctions can be identified by detecting the expression of v...
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Zou J, Weng RH, Chen ZY, Wei XB, Wang R, Chen D, Xia Y, Wang Q Tags: CNS Neurosci Ther Source Type: research

Morphological Changes of Amygdala in Turner Syndrome Patients.
CONCLUSIONS: Our findings provide novel insight into the pathological changes in the amygdala of patients with TS. PMID: 26778543 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Li SY, Xie YQ, Li H, Li XW, Zhang ZX, Zhao QL, Xie S, Gong GL Tags: CNS Neurosci Ther Source Type: research

Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies.
This article summarizes the effects of donepezil, a cholinesterase inhibitor, on the NPS of dementia with emphasis on AD and dementia with Lewy bodies. PMID: 26778658 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Cummings J, Lai TJ, Hemrungrojn S, Mohandas E, Yun Kim S, Nair G, Dash A Tags: CNS Neurosci Ther Source Type: research

Treatment for Ischemic Stroke: A New Approach from the Ancient Art of War.
PMID: 26768684 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 1, 2016 Category: Neuroscience Authors: Xu ZQ, Liu C, Su DF Tags: CNS Neurosci Ther Source Type: research

Pharmacotherapy for Alcohol Dependence: The 2015 Recommendations of the French Alcohol Society, Issued in Partnership with the European Federation of Addiction Societies.
This article aims to synthesize the GPRs focused on the pharmacotherapy of alcohol dependence. METHODS: A four-member European steering committee defined the questions that were addressed to an 18-member multiprofessional working group (WG). The WG developed the GPRs based on a systematic, hierarchical, and structured literature search and submitted the document to two review processes involving 37 French members from multiple disciplines and 5 non-French EUFAS members. The final GPRs were graded A, B, or C, or expert consensus (EC) using a reference recommendation grading system. RESULTS: The treatment of alcoho...
Source: CNS Neuroscience and Therapeutics - January 1, 2016 Category: Neuroscience Authors: Rolland B, Paille F, Gillet C, Rigaud A, Moirand R, Dano C, Dematteis M, Mann K, Aubin HJ Tags: CNS Neurosci Ther Source Type: research

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.
Abstract Visceral pain is a global term used to describe pain originating from the internal organs of the body, which affects a significant proportion of the population and is a common feature of functional gastrointestinal disorders (FGIDs) such as irritable bowel syndrome (IBS). While IBS is multifactorial, with no single etiology to completely explain the disorder, many patients also experience comorbid behavioral disorders, such as anxiety or depression; thus, IBS is described as a disorder of the gut-brain axis. Stress is implicated in the development and exacerbation of visceral pain disorders. Chronic stres...
Source: CNS Neuroscience and Therapeutics - December 10, 2015 Category: Neuroscience Authors: Moloney RD, Johnson AC, O'Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF Tags: CNS Neurosci Ther Source Type: research

Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain.
CONCLUSION: The present studies report for the first time the characterization of the affective component of acute postoperative pain using the mPEAP in a rodent model, which may facilitate development of improved understanding and treatment of postoperative pain. PMID: 26663888 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 10, 2015 Category: Neuroscience Authors: Bree D, Moriarty O, Broom DC, Kelly JP, Roche M, Finn DP Tags: CNS Neurosci Ther Source Type: research

Preclinical Assessment of Inflammatory Pain.
Abstract While acute inflammation is a natural physiological response to tissue injury or infection, chronic inflammation is maladaptive and engenders a considerable amount of adverse pain. The chemical mediators responsible for tissue inflammation act on nociceptive nerve endings to lower neuronal excitation threshold and sensitize afferent firing rate leading to the development of allodynia and hyperalgesia, respectively. Animal models have aided in our understanding of the pathophysiological mechanisms responsible for the generation of chronic inflammatory pain and allowed us to identify and validate numerous a...
Source: CNS Neuroscience and Therapeutics - December 10, 2015 Category: Neuroscience Authors: Muley MM, Krustev E, McDougall JJ Tags: CNS Neurosci Ther Source Type: research

NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.
CONCLUSIONS: NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. It is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits. PMID: 26663905 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 10, 2015 Category: Neuroscience Authors: Munro G, Christensen JK, Erichsen HK, Dyhring T, Demnitz J, Dam E, Ahring PK Tags: CNS Neurosci Ther Source Type: research

Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice.
CONCLUSIONS: Icariin shows neuroprotective effects in 3 × Tg-AD mice and may be a promising multitarget drug in the prevention/protection against AD. PMID: 26584824 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 20, 2015 Category: Neuroscience Authors: Chen YJ, Zheng HY, Huang XX, Han SX, Zhang DS, Ni JZ, He XY Tags: CNS Neurosci Ther Source Type: research

Long-Term Effects of Repeated Cycles of Intrathecal Triamcinolone Acetonide on Spasticity in MS Patients.
Abstract MAIN PROBLEM: Spasticity is a common feature in patients with multiple sclerosis (MS). Although options have broadened over the last years, there are still patients with no response to common therapeutic agents. Intrathecal administered triamcinolone acetonide (TCA) has been tested for spasticity in patients with MS. However, the long run effects are not known so far. The aim of this study was to evaluate the effects of repeated cycles of intrathecal TCA instillations on clinical parameters. METHODS: A total of 54 patients with clinically definite MS and no response to commonly utilized antispastic d...
Source: CNS Neuroscience and Therapeutics - November 20, 2015 Category: Neuroscience Authors: Rommer PS, Kamin F, Abu-Mugheisib M, Koehler W, Hoffmann F, Winkelmann A, Benecke R, Zettl UK Tags: CNS Neurosci Ther Source Type: research

Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological State.
Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological State. CNS Neurosci Ther. 2015 Nov 11; Authors: Martorana A, Di Lorenzo F, Belli L, Sancesario G, Toniolo S, Sallustio F, Sancesario GM, Koch G Abstract Impaired amyloid beta (Aβ) metabolism is currently considered central to understand the pathophysiology of Alzheimer's disease (AD). Measurements of cerebrospinal fluid Aβ levels remain the most useful marker for diagnostic purposes and to individuate people at risk for AD. Despite recent advances criticized the direct role in neurodegeneration of cortical neurons, ...
Source: CNS Neuroscience and Therapeutics - November 11, 2015 Category: Neuroscience Authors: Martorana A, Di Lorenzo F, Belli L, Sancesario G, Toniolo S, Sallustio F, Sancesario GM, Koch G Tags: CNS Neurosci Ther Source Type: research

Efficacy of Donepezil for Cognitive Impairments in Familial Hypercholesterolemia: Preclinical Proof of Concept.
PMID: 26555675 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 11, 2015 Category: Neuroscience Authors: Lopes JB, de Oliveira J, Engel DF, de Paula GC, Moreira EL, de Bem AF Tags: CNS Neurosci Ther Source Type: research

Differential Control by 5-HT and 5-HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus.
PMID: 26555767 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 11, 2015 Category: Neuroscience Authors: Crunelli V, Di Giovanni G Tags: CNS Neurosci Ther Source Type: research

Linagliptin-Role in the Reversal of Aβ-Mediated Impairment of Insulin Signaling and Reduced Neurotoxicity in AD Pathogenesis: Some Considerations.
Linagliptin-Role in the Reversal of Aβ-Mediated Impairment of Insulin Signaling and Reduced Neurotoxicity in AD Pathogenesis: Some Considerations. CNS Neurosci Ther. 2015 Nov 7; Authors: Srinivas NR PMID: 26547267 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 7, 2015 Category: Neuroscience Authors: Srinivas NR Tags: CNS Neurosci Ther Source Type: research

Morphological Bases of Neuronal Hyperexcitability in Neurodegeneration.
PMID: 26494127 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2015 Category: Neuroscience Authors: Yuan TF, Peng B, Machado S, Arias-Carrion O Tags: CNS Neurosci Ther Source Type: research

TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia.
CONCLUSIONS: By ameliorating astrogliosis-related damage, Poly IC is a potential therapeutic agent for attenuating neuronal damage and promoting recovery after brain ischemia. PMID: 26494128 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2015 Category: Neuroscience Authors: Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q, Wang J Tags: CNS Neurosci Ther Source Type: research

Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
CONCLUSION: The present study indicates that pramipexole reduces the harmaline-induced tremor, which may suggest its beneficial effects in ET patients. However, mechanisms underlying its action are still unclear and need further examination. PMID: 26459182 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 13, 2015 Category: Neuroscience Authors: Kosmowska B, Wardas J, Głowacka U, Ananthan S, Ossowska K Tags: CNS Neurosci Ther Source Type: research

Motion Sickness: Current Knowledge and Recent Advance.
Abstract Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphism...
Source: CNS Neuroscience and Therapeutics - October 9, 2015 Category: Neuroscience Authors: Zhang LL, Wang JQ, Qi RR, Pan LL, Li M, Cai YL Tags: CNS Neurosci Ther Source Type: research

Imaging Brain Networks in Neurodegenerative Diseases.
PMID: 26387575 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 23, 2015 Category: Neuroscience Authors: He Y Tags: CNS Neurosci Ther Source Type: research

Different Patterns of Spontaneous Brain Activity between Tremor-Dominant and Postural Instability/Gait Difficulty Subtypes of Parkinson's Disease: A Resting-State fMRI Study.
CONCLUSION: Different patterns of spontaneous neural activity in the cerebellum and putamen may underlie the neural substrate of PD motor subtypes. PMID: 26387576 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 23, 2015 Category: Neuroscience Authors: Chen HM, Wang ZJ, Fang JP, Gao LY, Ma LY, Wu T, Hou YN, Zhang JR, Feng T Tags: CNS Neurosci Ther Source Type: research

Na(+) -Ca(2+) Exchanger, Leak K(+) Channel and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Comediate the Histamine-Induced Excitation on Rat Inferior Vestibular Nucleus Neurons.
CONCLUSION: These results demonstrate the multiple ionic mechanisms underlying the excitatory modulation of histamine/central histaminergic system on IVN neurons and the related vestibular reflexes and functions. The findings also suggest potential targets for the treatment of vestibular disorders in the clinic, at the level of ionic channels in central vestibular nuclei. PMID: 26387685 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 21, 2015 Category: Neuroscience Authors: Yu L, Zhang XY, Cao SL, Peng SY, Ji DY, Zhu JN, Wang JJ Tags: CNS Neurosci Ther Source Type: research

Spinal Reflexes and Windup In Vitro: Effects of Analgesics and Anesthetics.
Abstract The spinal cord is the first relay center for nociceptive information. Following peripheral injury, the spinal cord sensitizes. A sign of spinal sensitization is the hyper-reflexia which develops shortly after injury and can be detected in the isolated spinal cord as a "memory of pain." In this context, it is easy to understand that many analgesic compounds target spinally located sites of action to attain analgesia. In vitro isolated spinal cord preparations have been used for a number of years, and experience on the effects of compounds of diverse pharmacological families on spinal function ha...
Source: CNS Neuroscience and Therapeutics - September 19, 2015 Category: Neuroscience Authors: Rivera-Arconada I, Roza C, Lopez-Garcia JA Tags: CNS Neurosci Ther Source Type: research

Bone Marrow Endothelial Progenitor Cell Transplantation After Ischemic Stroke: An Investigation Into Its Possible Mechanism.
CONCLUSION: The eNOS/BDNF pathway may be involved in the EPC-mediated functional recovery of stroke mice. DTI is feasible for dynamically tracking the orientation of axonal projections after EPC treatment. PMID: 26384586 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 19, 2015 Category: Neuroscience Authors: Bai YY, Peng XG, Wang LS, Li ZH, Wang YC, Lu CQ, Ding J, Li PC, Zhao Z, Ju SH Tags: CNS Neurosci Ther Source Type: research

Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses.
CONCLUSION: Our results reveal dramatic immune changes during RIPC-afforded neuroprotection against cerebral ischemia. PMID: 26384716 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 19, 2015 Category: Neuroscience Authors: Liu ZJ, Chen C, Li XR, Ran YY, Xu T, Zhang Y, Geng XK, Zhang Y, Du HS, Leak RK, Ji XM, Hu XM Tags: CNS Neurosci Ther Source Type: research

Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.
This study was designed to assess whether 185 variants in 32 genes central to synaptic plasticity and signal transduction contribute to vulnerability to develop heroin and/or cocaine addiction. METHODS: Analyses were conducted in a sample of 1860 subjects divided according to ancestry (African and European) and drug of abuse (heroin or cocaine). RESULTS: Eighteen SNPs in 11 genes (CDK5R1, EPHA4, EPHA6, FOSL2, MAPK3, MBP, MPDZ, NFKB1, NTRK2, NTSR1, and PRKCE) showed significant associations (P
Source: CNS Neuroscience and Therapeutics - September 19, 2015 Category: Neuroscience Authors: Levran O, Peles E, Randesi M, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ Tags: CNS Neurosci Ther Source Type: research

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model.
CONCLUSION: VPA improves behavioral deficits in AD, modifies synaptic structure, and accelerates neurite outgrowth, by inhibiting the activity of GSK-3β, decreasing hyperphosphorylated tau, enhancing CREB and BDNF expression. PMID: 26385876 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 19, 2015 Category: Neuroscience Authors: Long ZM, Zhao L, Jiang R, Wang KJ, Luo SF, Zheng M, Li XF, He GQ Tags: CNS Neurosci Ther Source Type: research

Mitochondrial NADH Dehydrogenase Subunit 3 Polymorphism Associated with an Earlier Age at Onset in Male Machado-Joseph disease Patients.
CONCLUSION: Six candidate SNPs have been screened in Chinese patients with MJD. A remarkable earlier AAO was noted in male Chinese MJD patients with MT-ND3 gene 10398A polymorphism. PMID: 26336829 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 4, 2015 Category: Neuroscience Authors: Chen S, Gan SR, Cai PP, Ni W, Zhou Q, Dong Y, Wang N, Wu ZY Tags: CNS Neurosci Ther Source Type: research

The Brain Connectivity Basis of Semantic Dementia: A Selective Review.
Abstract Semantic dementia (SD) is a neurodegenerative disorder characterized by the progressive loss of semantic memory and conceptual knowledge, coupled with asymmetric local brain atrophy concentrated in the anterior temporal lobe. Recent developments in neuroimaging techniques, especially the emergence of the "human connectomics," have made possible the study of the brain's functional and structural connections and the topological properties of the brain networks. Recent studies applying these techniques have shown that SD manifests extensive structural and functional connectivity alterations, provid...
Source: CNS Neuroscience and Therapeutics - September 4, 2015 Category: Neuroscience Authors: Yang Q, Guo QH, Bi YC Tags: CNS Neurosci Ther Source Type: research

Commentary: A Quest for a Novel Peripheral Biomarker for Narcolepsy.
PMID: 26281778 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 22, 2015 Category: Neuroscience Authors: Peyron C, Seugnet L, Lin JS Tags: CNS Neurosci Ther Source Type: research

NF-κB Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy.
CONCLUSION: Intranasal delivery of hNSCs could prevent HI-induced brain injury and improve neurobehavioral outcomes in neonatal HI rats, which is possibly related to the modulation of NF-κB signaling. PMID: 26255634 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 8, 2015 Category: Neuroscience Authors: Ji G, Liu M, Zhao XF, Liu XY, Guo QL, Guan ZF, Zhou HG, Guo JC Tags: CNS Neurosci Ther Source Type: research

Disrupted Topological Organization of Resting-State Functional Brain Network in Subcortical Vascular Mild Cognitive Impairment.
CONCLUSION: Together, our results indicate that svMCI patients exhibit dysregulation of the topological organization of functional brain networks, which has important implications for understanding the pathophysiological mechanism of svMCI. PMID: 26257386 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 8, 2015 Category: Neuroscience Authors: Yi LY, Liang X, Liu DM, Sun B, Ying S, Yang DB, Li QB, Jiang CL, Han Y Tags: CNS Neurosci Ther Source Type: research

Exposure to Methylmercury Does Not Change the Sexual Preference of C57BL Male Mice.
PMID: 26257387 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 8, 2015 Category: Neuroscience Authors: Song XR, Tan BY, Su K, Cao JY, Liu AJ, Qian J Tags: CNS Neurosci Ther Source Type: research

Head Transplantation: Editorial Commentary.
PMID: 26197837 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 25, 2015 Category: Neuroscience Authors: Barker JH, Frank JM, Leppik L Tags: CNS Neurosci Ther Source Type: research

Trace Amounts of Copper in Drinking Water Aggravate Cerebral Ischemic Injury via Impairing Endothelial Progenitor Cells in Mice.
PMID: 26197838 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 25, 2015 Category: Neuroscience Authors: Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH Tags: CNS Neurosci Ther Source Type: research

Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy.
Abstract Zonisamide is an orally administered antiepileptic drug that was first approved for clinical use in Japan in 1989. Since then, it has been licensed in Korea for a broad spectrum of epilepsies in adults and children, and in the USA for adjunctive therapy of adults with partial seizures, and in Europe for monotherapy of adults with newly diagnosed partial seizures and adjunctive therapy of adults and adolescents and children aged ≥6 years with partial seizures with or without secondary generalization. Zonisamide is a benzisoxazole derivative with a unique chemical structure, predictable dose-depende...
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Kwan SY, Chuang YC, Huang CW, Chen TC, Jou SB, Dash A Tags: CNS Neurosci Ther Source Type: research

Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1.
CONCLUSIONS: Chloral hydrate preconditioning protects against ischemic injuries through upregulating the expression of ANXA1, and the followed antiinflammatory mechanisms. PMID: 26205642 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Liu JH, Feng D, Zhang YF, Shang Y, Wu Y, Li XF, Pei L Tags: CNS Neurosci Ther Source Type: research

The 5-HT4 Agonist Prucalopride Stimulates L-DOPA-Induced Dopamine Release in Restricted Brain Regions of the Hemiparkinsonian Rat In Vivo.
;re P PMID: 26205756 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Navailles S, Di Giovanni G, De Deurwaerdère P Tags: CNS Neurosci Ther Source Type: research

Autonomic Function Tests and MIBG in Parkinson's Disease: Correlation to Disease Duration and Motor Symptoms.
CONCLUSIONS: Our investigation suggests that ANS impairment affects the majority of patients with PD, even those PD patients showing negative MIBG, irrespective of clinical neurovegetative symptoms. The strict correlation that has been revealed with disease progression supports the routine utilization of AFTs as a reliable and inexpensive tool for monitoring peripheral sympathetic dysfunction in PD and optimizing therapy. PMID: 26205884 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 24, 2015 Category: Neuroscience Authors: Rocchi C, Pierantozzi M, Galati S, Chiaravalloti A, Pisani V, Prosperetti C, Lauretti B, Stampanoni Bassi M, Olivola E, Schillaci O, Stefani A Tags: CNS Neurosci Ther Source Type: research

The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
CONCLUSIONS: Zn(2+) is involved in neural cell apoptosis and/or death caused by hypoxia/ischemia via mediating excitotoxicity, oxidative stress, and inflammation. PMID: 26190227 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 20, 2015 Category: Neuroscience Authors: Wang WM, Liu Z, Liu AJ, Wang YX, Wang HG, An D, Heng B, Xie LH, Duan JL, Liu YQ Tags: CNS Neurosci Ther Source Type: research

Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury.
CONCLUSION: Direct i.t. administration of G-CSF provides a promising therapeutic option for SCI or related spinal diseases. PMID: 26190345 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 20, 2015 Category: Neuroscience Authors: Chen WF, Chen CH, Chen NF, Sung CS, Wen ZH Tags: CNS Neurosci Ther Source Type: research

Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response.
This study sought to evaluate the influence of the genetic polymorphisms on platelet reactivity and clinical outcomes in acute ischemic stroke patients taking clopidogrel. BACKGROUND: Little research has been published on relationships between genetic polymorphisms, platelet reactivity, and clinical outcomes in stroke patients treated with clopidogrel. METHODS: Patients hospitalized in Changhai Hospital with acute ischemic stroke were randomly enrolled into treatment with a 75-mg daily maintenance dose of clopidogrel. Genotyping was detected by the MassARRAY iPLEX genotyping system (Sequenom Inc, San Diego, CA), ...
Source: CNS Neuroscience and Therapeutics - July 15, 2015 Category: Neuroscience Authors: Han Y, Lv HH, Liu X, Dong Q, Yang XL, Li SX, Wu S, Jiang JM, Luo Z, Zhu DS, Zhang Y, Zheng Y, Guan YT, Xu JF Tags: CNS Neurosci Ther Source Type: research

Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer's Disease in a Chinese Han Population with Type 2 Diabetes.
Abstract AIMS: Alzheimer's disease (AD) is a multifactor disease that has been reported to have a close association with type 2 diabetes (T2D) where the v-akt murine thymoma viral oncogene homolog 1 (AKT1) plays an important role in the protein synthesis pathways and cell apoptosis processes. Evidence has been shown that AKT1 protein may be related to AD risk among patients with T2D. The aim of this study was to analyze the potential association between single nucleotide polymorphisms of AKT1 promoter and the risk of AD among patients with T2D. METHODS: The association between AKT1 polymorphisms and AD risk i...
Source: CNS Neuroscience and Therapeutics - July 14, 2015 Category: Neuroscience Authors: Liu SY, Zhao HD, Wang JL, Huang T, Tian HW, Yao LF, Tao H, Chen ZW, Wang CY, Sheng ST, Li H, Zhao B, Li KS Tags: CNS Neurosci Ther Source Type: research