Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis.
CONCLUSIONS: The present findings suggest AQP4 involves the pathogenesis of depression by modulating astrocytic function and adult neurogenesis, highlighting a novel profile of AQP4 as a potential target for the treatment for depression. PMID: 24422972 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 15, 2014 Category: Neuroscience Authors: Kong H, Zeng XN, Fan Y, Yuan ST, Ge S, Xie WP, Wang H, Hu G Tags: CNS Neurosci Ther Source Type: research

Intracranial Artery Atherosclerosis and Lumen Dilation in Cerebral Small-Vessel Diseases: A High-resolution MRI Study.
Abstract BACKGROUND AND AIMS: Using high-resolution magnetic resonance imaging (HR-MRI), we aimed to investigate the abnormalities of intracranial artery in relation to cerebral small-vessel diseases (SVD)-related ischemic stroke and white matter lesions (WMLs). METHODS: Routine cranial MRI and HR-MRI were performed on consecutive patients with a SVD-related acute deep brain infarct (DBI) in the territory of middle cerebral artery (MCA), patients with SVD-related WMLs, and age-matched controls. The presence and distribution of MCA plaque and the area of MCA lumen and wall were comparatively analyzed among the...
Source: CNS Neuroscience and Therapeutics - January 15, 2014 Category: Neuroscience Authors: Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S Tags: CNS Neurosci Ther Source Type: research

Endothelial Nitric Oxide Synthase Protects Neurons against Ischemic Injury through Regulation of Brain-Derived Neurotrophic Factor Expression.
CONCLUSION: Collectively, our results indicate that the neuroprotection of neuron-derived eNOS against the cerebral ischemia was mediated through the regulation of BDNF secretion. In conclusion, our discovery provides a novel explanation for the neuroprotective effect of eNOS under pathological ischemic conditions such as stroke. PMID: 24397751 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 8, 2014 Category: Neuroscience Authors: Li ST, Pan J, Hua XM, Liu H, Shen S, Liu JF, Li B, Tao BB, Ge XL, Wang XH, Shi JH, Wang XQ Tags: CNS Neurosci Ther Source Type: research

Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction.
CONCLUSIONS: Sunitinib exerts its neuroprotective effects by inhibiting NO overproduction, possibly via the inhibition of nNOS activity and the decrease in nNOS expression. PMID: 24393200 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Cui W, Zhang ZJ, Hu SQ, Mak SH, Xu DP, Choi CL, Wang YQ, Tsim WK, Lee MY, Rong JH, Han YF Tags: CNS Neurosci Ther Source Type: research

Combined Treatment with Anisodamine and Neostigmine Inhibits Joint Inflammation in Collagen-Induced Arthritis Mice.
PMID: 24393231 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Zhou JX, Ke P, Huan G, Shao BZ, Liu C Tags: CNS Neurosci Ther Source Type: research

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Anthocyanins Protect against Kainic Acid-induced Excitotoxicity and Apoptosis via ROS-activated AMPK Pathway in Hippocampal Neurons.
CONCLUSIONS: In summary, our data suggest that although anthocyanins have diverse activities, at least part of their beneficial effects against KA-induced hippocampal degeneration can be attributed to their well-recognized antioxidant properties. PMID: 24393263 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Ullah I, Kim MO Tags: CNS Neurosci Ther Source Type: research

Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression.
CONCLUSIONS: Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin. PMID: 24393292 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Li ZY, Zheng SL, Wang P, Xu TY, Guan YF, Zhang YJ, Miao CY Tags: CNS Neurosci Ther Source Type: research

Long Noncoding RNA Profiles Reveal Three Molecular Subtypes in Glioma.
CONCLUSIONS: We report a novel molecular classification of glioma based on lncRNA expression profiles and believe that it would provide a potential platform for future studies on gene treatment for glioma and lead to more individualized therapies to improve survival rates. PMID: 24393335 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Li R, Qian J, Wang YY, Zhang JX, You YP Tags: CNS Neurosci Ther Source Type: research

The role of diffusion tensor imaging in detecting microstructural changes in prodromal Alzheimer's disease.
Abstract The MRI technique diffusion tensor imaging (DTI) is reviewed along with microstructural changes associated with prodromal Alzheimer's disease (AD) as a potential biomarker for clinical applications. The prodromal stage of AD is characterized by mild cognitive impairment (MCI), representing a transitional state between normal aging and AD. Microstructural abnormalities on DTI are promising in vivo biomarkers of gray and white matter changes associated with the progression of AD pathology. Elevated mean diffusivity and decreased fractional anisotropy are consistently found in prodromal AD, and even in cogni...
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Zhang B, Xu Y, Zhu B, Kantarci K Tags: CNS Neurosci Ther Source Type: research

Chronic stress and Parkinson's disease.
PMID: 24341934 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Hou G, Tian R, Li J, Yuan TF Tags: CNS Neurosci Ther Source Type: research

Delayed shortening and shifting of carotid wallstent.
PMID: 24341935 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Zhao R, Feng XY, Zhang M, Shen XL, Su JJ, Liu JR Tags: CNS Neurosci Ther Source Type: research

Successful treatment of neurological malignant atrophic papulosis in child by corticosteroid combined with intravenous immunoglobulin.
PMID: 24341936 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Guo YF, Pan WH, Cheng RH, Yu H, Liao WQ, Yao ZR Tags: CNS Neurosci Ther Source Type: research

Progressive hemorrhagic transformation following dual antiplatelet therapy.
PMID: 24341937 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Zhao R, Feng XY, Zhang M, Shen XL, Su JJ, Liu JR Tags: CNS Neurosci Ther Source Type: research

Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia.
PMID: 24341938 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 21, 2013 Category: Neuroscience Authors: Liu W, Zhang XP, Yang DL, Song SW Tags: CNS Neurosci Ther Source Type: research

Convergent and Divergent Pathways Decoding Hierarchical Additive Mechanisms in Treating Cerebral Ischemia-Reperfusion Injury.
CONCLUSIONS: These results provide strong evidence that the additive mechanism is more complex than previously appreciated, and an integrative analysis of pathways may suggest an important paradigm for revealing pharmacological mechanisms underlying drug combinations. PMID: 24351012 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 19, 2013 Category: Neuroscience Authors: Zhang YY, Li HX, Chen YY, Fang H, Yu YN, Liu J, Jing ZW, Wang Z, Wang YY Tags: CNS Neurosci Ther Source Type: research

Possible Mechanism Involved in the Antinociceptive Activity of Dimer of Paederosidic Acid and Paederosidic Acid Methyl Ester in Mice.
PMID: 24351037 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 19, 2013 Category: Neuroscience Authors: Chen YF, Liu DH, Wu Q, Yang Y, Wang XW, Yang C, Zhang JY, Cai GJ Tags: CNS Neurosci Ther Source Type: research

Histone Decacetylase Inhibitors Prevent Mitochondrial Fragmentation and Elicit Early Neuroprotection against MPP+
CONCLUSIONS: Histone deacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection in PD cell model induced by MPP+. Hence, HDAC inhibitors may be a potential early treatment for PD. PMID: 24351065 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 19, 2013 Category: Neuroscience Authors: Zhu M, Li WW, Lu CZ Tags: CNS Neurosci Ther Source Type: research

Multiple Mechanisms Underlying the Long Duration of Action of Thienorphine, A Novel Partial Opioid Agonist for the Treatment of Addiction.
CONCLUSIONS: These results indicate that multiple factors, including persistent receptor occupation and enhanced receptor downregulation, may contribute to the long-lasting effects of thienorphine that would be beneficial for its application in addiction treatment. PMID: 24330593 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 16, 2013 Category: Neuroscience Authors: Yu G, Li SH, Cui MX, Yan LD, Yong Z, Zhou PL, Su RB, Gong ZH Tags: CNS Neurosci Ther Source Type: research

The Association Between CYP2C19 Genotype and of In-stent Restenosis Among Patients with Vertebral Artery Stent Treatment.
In this study, a retrospective analysis was conducted in 90 patients who had been treated with VAS between 2004 and 2011 in Nanjing Drum Tower Hospital. Patients were followed up at 3 months, 6 months,and 1 year after VAS treatment and annually thereafter. For each time point, neurological function tests, vessel ultrasound and computer tomography angiography were performed to preliminarily screen the vessel stenosis. Digital subtraction angiography was used to verify the narrow sign on CTA or ultrasound. Clinical features of each patient including clopido-grel metabolization genes (CYP2C19, CYP3A4, and P2Y12...
Source: CNS Neuroscience and Therapeutics - December 12, 2013 Category: Neuroscience Authors: Lin YJ, Li JW, Zhang MJ, Qian L, Yang WJ, Zhang CL, Shao Y, Zhang Y, Huang YJ, Xu Y Tags: CNS Neurosci Ther Source Type: research

Serological Identification of URGCP as a Potential Biomarker for Glioma.
CONCLUSION: We identified a potential new biomarker of GBM, URGCP. The findings indicate that URGCP is immunogenic in human GBM and suggest its potential use as diagnostic and immunotherapeutic for GBM patients. PMID: 24308561 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 6, 2013 Category: Neuroscience Authors: Chen LC, Zhang HY, Qin ZY, Wang Y, Mao Y, Yao Y, Zhou LF Tags: CNS Neurosci Ther Source Type: research

Specific Expression of Foreign Gene in Postnatal Mouse Glial Cells using Electroporation.
PMID: 24305011 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 4, 2013 Category: Neuroscience Authors: Ding XF, Hu ZY, Zhao YQ, Gu X, Yan R, Wu LY, Huang X, Liu SH, Wu Y, Zhao T, Zhu LL, Suo WZ, Fan M Tags: CNS Neurosci Ther Source Type: research

Valproic Acid Reduces Neuritic Plaque Formation and Improves Learning Deficits in APP(Swe) /PS1(A246E) Transgenic Mice via Preventing the Prenatal Hypoxia-Induced Down-Regulation of Neprilysin.
CONCLUSION: Valproic acid is able to attenuate the prenatal hypoxia-induced Aβ neuropathology and learning and memory deficits via inhibiting the activation of histone deacetylase 1 (HDAC1), preventing the decrease in H3-Ace in the NEP promoter regions and reducing the down-regulation of NEP. PMID: 24289518 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 2, 2013 Category: Neuroscience Authors: Wang Z, Zhang XJ, Li T, Li J, Tang Y, Le W Tags: CNS Neurosci Ther Source Type: research

Simvastatin Exerts Antiamnesic Effect in Aβ25-35 -Injected Mice.
CONCLUSION: The antiamnesia of SV in Aβ25-35 -mice depends on its neuroprotection and synaptic plasticity improvement. PMID: 24289538 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 2, 2013 Category: Neuroscience Authors: Zhi WH, Zeng YY, Lu ZH, Qu WJ, Chen WX, Chen L, Chen L Tags: CNS Neurosci Ther Source Type: research

Platelet-Derived Microparticles are Implicated in Remote Ischemia Conditioning in a Rat Model of Cerebral Infarction.
CONCLUSIONS: RIPC induces an increase in MPs, and platelet-derived MPs may confer at least part of the remote protective effect against cerebral ischemic-reperfusion injury. PMID: 24267641 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 28, 2013 Category: Neuroscience Authors: Shan LY, Li JZ, Zu LY, Niu CG, Ferro A, Zhang YD, Zheng LM, Ji Y Tags: CNS Neurosci Ther Source Type: research

Cannabinoid hyperemesis syndrome.
Oliveró MM PMID: 24267642 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 28, 2013 Category: Neuroscience Authors: Roca-Pallín JM, López-Pelayo H, Sugranyes G, Balcells-Oliveró MM Tags: CNS Neurosci Ther Source Type: research

Gene-Wide Tagging Study of the Association Between KCNT1 Polymorphisms and the Susceptibility and Efficacy of Genetic Generalized Epilepsy in Chinese Population.
CONCLUSION: This gene-wide tagging study revealed no association between KCNT1 17 common variations and susceptibility of GGEs or AEDs (anti-epileptic drugs) efficacy of genetic generalized epilepsies in Chinese population. PMID: 24279416 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Qu J, Zhang Y, Yang ZQ, Mao XY, Zhou BT, Yin JY, He H, Li XP, Long HY, Lv N, Xu XJ, Xiao B, Zhang Y, Tang Q, Hu DL, Zhou HH, Liu ZQ Tags: CNS Neurosci Ther Source Type: research

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors.
CONCLUSION: These data suggest for the first time that the NLRP3 inflammasome is involved in lipopolysaccharide-induced mice depressive-like behaviors. The NLRP3 inflammasome may be a central mediator between immune activation and depression, which raises the possibility that it may be a more specific target for the depression treatments in the near future. PMID: 24279434 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Zhang Y, Liu L, Peng YL, Liu YZ, Wu TY, Shen XL, Zhou JR, Sun DY, Huang AJ, Wang X, Wang YX, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Prognostic Value of a Nine-Gene Signature in Glioma Patients Based on mRNA Expression Profiling.
CONCLUSION: This 9-gene-signature prediction model provided a more accurate predictor of prognosis that denoted patients with high risk score have poor outcome. Moreover, these risk models based on defined molecular profiles showed the considerable prospect in personalized cancer management. PMID: 24279471 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Bao ZS, Li MY, Wang JY, Zhang CB, Wang HJ, Yan W, Liu YW, Zhang W, Chen L, Tao J Tags: CNS Neurosci Ther Source Type: research

Surgery for Primary Filum Terminale Ependymomas: Outcome and Prognostic Factors.
This study aimed to evaluate the clinical features, outcomes, and prognostic factors of PFTE in the largest series of cases. RESULT: Thirty-eight patients were included in this study. Gross total removal (GTR) of the tumors was achieved in 33(87%) patients. Five (13%) patients had subtotal resection (STR). For the residual tumors, postoperative radiotherapy increased the interval between the first surgery and tumor regrowth (P = 0.063). Six patients had local recurrence/progression. Univariate analysis identified STR(P = 0.001), unencapsulated tumor (P = 0.018), tumor involving more than ...
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Xie TH, Chen XZ, Qian J, Lu YC, Jiang YK, Zhang L, Hu GH, Ding XH, Luo C Tags: CNS Neurosci Ther Source Type: research

Characterization of Polyethylene Glycol-Polyethyleneimine as a Vector for Alpha-Synuclein siRNA Delivery to PC12 Cells for Parkinson's Disease.
CONCLUSIONS: Our results demonstrate that PEG-PEI performs well as a vector for alpha-synuclein siRNA delivery into PC12 cells. Additionally, PEG-PEI/siSNCA complexes were suggested to be able to protect cells from death via apoptosis induced by MPP(+) . These findings suggest that PEG-PEI/siSNCA nanoparticles exhibit remarkable potential as a gene delivery system for Parkinson's disease. PMID: 24279586 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Liu YY, Yang XY, Li Z, Liu ZL, Cheng D, Wang Y, Wen XJ, Hu JY, Liu J, Wang LM, Wang HJ Tags: CNS Neurosci Ther Source Type: research

Meserine, a Novel Carbamate AChE Inhibitor, Ameliorates Scopolamine-Induced Dementia and Alleviates Amyloidogenesis of APP/PS1 Transgenic Mice.
CONCLUSION: Meserine executes dual actions against cholinergic deficiency and amyloidogenesis and provides a promising lead compound for symptomatic and modifying therapy of AD. PMID: 24279603 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Shao BY, Xia Z, Xie Q, Ge XX, Zhang WW, Sun J, Jiang P, Wang H, Le WD, Qiu ZB, Lu Y, Chen HZ Tags: CNS Neurosci Ther Source Type: research

Activation of Muscarinic Receptors Protects against Retinal Neurons Damage and Optic Nerve Degeneration In Vitro and In Vivo Models.
CONCLUSIONS: Taken together, this highlights pilocarpine through the activation of muscarinic receptors appear to afford significant protection against retinal neurons damage and optic nerve degeneration at clinically relevant concentrations. These data also further support muscarinic receptors as potential therapeutic neuroprotective targets in glaucoma. PMID: 24279639 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Tan PP, Yuan HH, Zhu X, Cui YY, Li H, Feng XM, Qiu Y, Chen HZ, Zhou W Tags: CNS Neurosci Ther Source Type: research

Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-κB-Dependent Inflammatory/MMP-9 Pathway.
Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-κB-Dependent Inflammatory/MMP-9 Pathway. CNS Neurosci Ther. 2013 Nov 27; Authors: Shao AW, Wu HJ, Chen S, Ammar AB, Zhang JM, Hong Y PMID: 24279692 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Shao AW, Wu HJ, Chen S, Ammar AB, Zhang JM, Hong Y Tags: CNS Neurosci Ther Source Type: research

Heat Shock Protein 70 Reduces α-Synuclein-Induced Predegenerative Neuronal Dystrophy in the α-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease.
CONCLUSIONS: These data confirm that overexpression of Hsp70 holds significant potential as a disease-modulating therapeutic approach for Parkinson's disease, with protective effects against early-onset α-synuclein-induced pathology demonstrated in the AAV-α-synuclein model. PMID: 24279716 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Moloney TC, Hyland R, O'Toole D, Paucard A, Kirik D, O'Doherty A, Gorman AM, Dowd E Tags: CNS Neurosci Ther Source Type: research

Increased Activation of Synapsin 1 and Mitogen-Activated Protein Kinases/Extracellular Signal-Regulated Kinase in the Amygdala of Maternal Separation Rats.
CONCLUSION: These findings indicated that the activation of Mapk/Erk and Syn1 may be a key mechanism modulating synaptic neurotransmition in the amygdala of MS rats. PMID: 24279756 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Park HJ, Kim SK, Kang WS, Chung JH, Kim JW Tags: CNS Neurosci Ther Source Type: research

Nicorandil Inhibits Inflammasome Activation and Toll-Like Receptor-4 Signal Transduction to Protect against Oxygen-Glucose Deprivation-Induced Inflammation in BV-2 Cells.
CONCLUSIONS: Our findings reveal that KATP channel openers could protect against OGD-induced neuroinflammation via inhibiting inflammasome activation and TLR4 signal transduction. PMID: 24256503 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 20, 2013 Category: Neuroscience Authors: Zhao AP, Dong YF, Liu W, Gu J, Sun XL Tags: CNS Neurosci Ther Source Type: research

Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease.
CONCLUSION: These results taken together suggest that quercetin could be of potential use not only for correcting movement disturbances and anxiety in HD, but also for addressing inflammatory damages. PMID: 24188794 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 4, 2013 Category: Neuroscience Authors: Chakraborty J, Singh R, Dutta D, Naskar A, Rajamma U, Mohanakumar KP Tags: CNS Neurosci Ther Source Type: research

Generation and Primary Phenotypes of Imidazoline Receptor Antisera-Selected (IRAS) Knockout Mice.
PMID: 24180351 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 4, 2013 Category: Neuroscience Authors: Zhang L, Zhao TY, Hou N, Teng Y, Cheng X, Wang B, Chen Y, Jiang L, Wu N, Su RB, Yang X, Li J Tags: CNS Neurosci Ther Source Type: research

Increase in Neuroexcitability of Unmyelinated C-type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions.
CONCLUSION: These data demonstrate for the first time that the neuroexcitability of C-type VGNs increases significantly compared with A-types within initial postnatal weeks evidenced by AP discharge profiles and coordinate ion channel changes, which explain, at least in part, that initial postnatal weeks may be crucial for ontogenesis in visceral afferent reflex function. PMID: 24164691 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Qian Z, Liu DJ, Liu Y, Han LM, Yuan M, Li JN, Xu B, Lu XL, Cao PX, Wang HY, Pan XD, Wang LJ, Qiao GF, Li BY Tags: CNS Neurosci Ther Source Type: research

Overexpression of Adiponectin Improves Neurobehavioral Outcomes After Focal Cerebral Ischemia in Aged Mice.
Abstract AIMS: To study whether adiponectin (APN) could improve neurological outcomes in aged mice after ischemic stroke. METHODS: Adeno-associated virus carrying APN gene was injected into aged and young adult mice 7 days before transient middle cerebral artery occlusion (tMCAO). Atrophic volumes and neurobehavioral deficiencies were determined up to 28 days after tMCAO. Focal angiogenesis was determined based on blood vessel number in the ischemic regions. RESULTS: Increased atrophic volume and more sever neurobehavioral deficits were found in the aged mice compared with young adult mice (P 
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Miao J, Shen LH, Tang YH, Wang YT, Tao MX, Jin KL, Zhao YJ, Yang GY Tags: CNS Neurosci Ther Source Type: research

Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo.
CONCLUSION: This study shows that curcumin holds a great promise for SHH/GLI1 targeted therapy against gliomas. PMID: 24165291 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, Lei XH, Sun X, Liu X, Wang HB, Li XF, Yang DB, Sun Y, Zhao ZF, Jiang T, Li YL, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Multiple Meningiomas Characterized by Benign and Malignant Tumor Entities.
PMID: 24165389 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Yang G, Chen X, Li CG, Zhang DM, Zhang WG, Shi CB, Zhao SG Tags: CNS Neurosci Ther Source Type: research

Nonfluent Aphasia and Cognitive Impairment Caused by Anterior Cerebral Artery Infarction.
PMID: 24165417 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Zhou XY, Chen L, Zhang SQ Tags: CNS Neurosci Ther Source Type: research

Phosphatidylethanolamine-Binding Protein 1 (PEBP1) as a Potential Target for the Treatment for Depression.
PMID: 24165496 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Sun Y, Luo ZM, Zheng MJ, Liu X Tags: CNS Neurosci Ther Source Type: research

Postischemic Administration of a Potent PTEN Inhibitor Reduces Spontaneous Lung Infection Following Experimental Stroke.
PMID: 24165543 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Guan YT, Mao LL, Jia J, Dong CS, Zhou XM, Zheng SL, Liu H, Kong HM, Zhen XC, Cheng J Tags: CNS Neurosci Ther Source Type: research

Glia Protein Aquaporin-4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze.
CONCLUSIONS: Our findings, along with a previous report that AQP4 regulates memory consolidation, implicate a novel role for this glial protein in modulating the aversive motivation in spatial learning paradigm. PMID: 24165567 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Zhang J, Li Y, Chen ZG, Dang H, Ding JH, Fan Y, Hu G Tags: CNS Neurosci Ther Source Type: research

Atypical Sneezing Attack Induced by Lateral Medullary Infarction.
PMID: 24127694 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 15, 2013 Category: Neuroscience Authors: Hu HT, Yan SQ, Campbell B, Lou M Tags: CNS Neurosci Ther Source Type: research

CT Perfusion Mismatch in Subacute Stroke: Oligemia or Luxury Perfusion? Response to Persistent Benign Oligemia Causes CT Perfusion Mismatch in Patients with Intracranial Large Artery Occlusive Disease during Subacute Stroke.
PMID: 24127742 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 15, 2013 Category: Neuroscience Authors: Morelli N, Morelli J, Rota E, Michieletti E, Guidetti D Tags: CNS Neurosci Ther Source Type: research

Effects of Intravenous and Intrathecal Dexmedetomidine in Spinal Anesthesia: A Meta-Analysis.
Abstract PURPOSE: To assess the effects of dexmedetomidine on the duration of sensory and motor block, postoperative analgesia, hypotension, bradycardia, and side effects in patients undergoing spinal anesthesia. METHODS: Two researchers searched MEDLINE, EMBASE, and the Cochrane controlled trial register independently for randomized controlled trials comparing dexmedetomidine with a placebo without any language restrictions. RESULTS: A total of 412 patients from eight trials were included in this study. The results revealed that dexmedetomidine was statistically significant in prolonging the duration of...
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Niu XY, Ding XB, Guo T, Chen MH, Fu SK, Li Q Tags: CNS Neurosci Ther Source Type: research