Activation of Muscarinic Receptors Protects against Retinal Neurons Damage and Optic Nerve Degeneration In Vitro and In Vivo Models.
CONCLUSIONS: Taken together, this highlights pilocarpine through the activation of muscarinic receptors appear to afford significant protection against retinal neurons damage and optic nerve degeneration at clinically relevant concentrations. These data also further support muscarinic receptors as potential therapeutic neuroprotective targets in glaucoma. PMID: 24279639 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Tan PP, Yuan HH, Zhu X, Cui YY, Li H, Feng XM, Qiu Y, Chen HZ, Zhou W Tags: CNS Neurosci Ther Source Type: research

Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-κB-Dependent Inflammatory/MMP-9 Pathway.
Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-κB-Dependent Inflammatory/MMP-9 Pathway. CNS Neurosci Ther. 2013 Nov 27; Authors: Shao AW, Wu HJ, Chen S, Ammar AB, Zhang JM, Hong Y PMID: 24279692 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Shao AW, Wu HJ, Chen S, Ammar AB, Zhang JM, Hong Y Tags: CNS Neurosci Ther Source Type: research

Heat Shock Protein 70 Reduces α-Synuclein-Induced Predegenerative Neuronal Dystrophy in the α-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease.
CONCLUSIONS: These data confirm that overexpression of Hsp70 holds significant potential as a disease-modulating therapeutic approach for Parkinson's disease, with protective effects against early-onset α-synuclein-induced pathology demonstrated in the AAV-α-synuclein model. PMID: 24279716 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Moloney TC, Hyland R, O'Toole D, Paucard A, Kirik D, O'Doherty A, Gorman AM, Dowd E Tags: CNS Neurosci Ther Source Type: research

Increased Activation of Synapsin 1 and Mitogen-Activated Protein Kinases/Extracellular Signal-Regulated Kinase in the Amygdala of Maternal Separation Rats.
CONCLUSION: These findings indicated that the activation of Mapk/Erk and Syn1 may be a key mechanism modulating synaptic neurotransmition in the amygdala of MS rats. PMID: 24279756 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Park HJ, Kim SK, Kang WS, Chung JH, Kim JW Tags: CNS Neurosci Ther Source Type: research

Nicorandil Inhibits Inflammasome Activation and Toll-Like Receptor-4 Signal Transduction to Protect against Oxygen-Glucose Deprivation-Induced Inflammation in BV-2 Cells.
CONCLUSIONS: Our findings reveal that KATP channel openers could protect against OGD-induced neuroinflammation via inhibiting inflammasome activation and TLR4 signal transduction. PMID: 24256503 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 20, 2013 Category: Neuroscience Authors: Zhao AP, Dong YF, Liu W, Gu J, Sun XL Tags: CNS Neurosci Ther Source Type: research

Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease.
CONCLUSION: These results taken together suggest that quercetin could be of potential use not only for correcting movement disturbances and anxiety in HD, but also for addressing inflammatory damages. PMID: 24188794 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 4, 2013 Category: Neuroscience Authors: Chakraborty J, Singh R, Dutta D, Naskar A, Rajamma U, Mohanakumar KP Tags: CNS Neurosci Ther Source Type: research

Generation and Primary Phenotypes of Imidazoline Receptor Antisera-Selected (IRAS) Knockout Mice.
PMID: 24180351 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 4, 2013 Category: Neuroscience Authors: Zhang L, Zhao TY, Hou N, Teng Y, Cheng X, Wang B, Chen Y, Jiang L, Wu N, Su RB, Yang X, Li J Tags: CNS Neurosci Ther Source Type: research

Increase in Neuroexcitability of Unmyelinated C-type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions.
CONCLUSION: These data demonstrate for the first time that the neuroexcitability of C-type VGNs increases significantly compared with A-types within initial postnatal weeks evidenced by AP discharge profiles and coordinate ion channel changes, which explain, at least in part, that initial postnatal weeks may be crucial for ontogenesis in visceral afferent reflex function. PMID: 24164691 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Qian Z, Liu DJ, Liu Y, Han LM, Yuan M, Li JN, Xu B, Lu XL, Cao PX, Wang HY, Pan XD, Wang LJ, Qiao GF, Li BY Tags: CNS Neurosci Ther Source Type: research

Overexpression of Adiponectin Improves Neurobehavioral Outcomes After Focal Cerebral Ischemia in Aged Mice.
Abstract AIMS: To study whether adiponectin (APN) could improve neurological outcomes in aged mice after ischemic stroke. METHODS: Adeno-associated virus carrying APN gene was injected into aged and young adult mice 7 days before transient middle cerebral artery occlusion (tMCAO). Atrophic volumes and neurobehavioral deficiencies were determined up to 28 days after tMCAO. Focal angiogenesis was determined based on blood vessel number in the ischemic regions. RESULTS: Increased atrophic volume and more sever neurobehavioral deficits were found in the aged mice compared with young adult mice (P 
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Miao J, Shen LH, Tang YH, Wang YT, Tao MX, Jin KL, Zhao YJ, Yang GY Tags: CNS Neurosci Ther Source Type: research

Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo.
CONCLUSION: This study shows that curcumin holds a great promise for SHH/GLI1 targeted therapy against gliomas. PMID: 24165291 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, Lei XH, Sun X, Liu X, Wang HB, Li XF, Yang DB, Sun Y, Zhao ZF, Jiang T, Li YL, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Multiple Meningiomas Characterized by Benign and Malignant Tumor Entities.
PMID: 24165389 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Yang G, Chen X, Li CG, Zhang DM, Zhang WG, Shi CB, Zhao SG Tags: CNS Neurosci Ther Source Type: research

Nonfluent Aphasia and Cognitive Impairment Caused by Anterior Cerebral Artery Infarction.
PMID: 24165417 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Zhou XY, Chen L, Zhang SQ Tags: CNS Neurosci Ther Source Type: research

Phosphatidylethanolamine-Binding Protein 1 (PEBP1) as a Potential Target for the Treatment for Depression.
PMID: 24165496 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Sun Y, Luo ZM, Zheng MJ, Liu X Tags: CNS Neurosci Ther Source Type: research

Postischemic Administration of a Potent PTEN Inhibitor Reduces Spontaneous Lung Infection Following Experimental Stroke.
PMID: 24165543 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Guan YT, Mao LL, Jia J, Dong CS, Zhou XM, Zheng SL, Liu H, Kong HM, Zhen XC, Cheng J Tags: CNS Neurosci Ther Source Type: research

Glia Protein Aquaporin-4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze.
CONCLUSIONS: Our findings, along with a previous report that AQP4 regulates memory consolidation, implicate a novel role for this glial protein in modulating the aversive motivation in spatial learning paradigm. PMID: 24165567 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 25, 2013 Category: Neuroscience Authors: Zhang J, Li Y, Chen ZG, Dang H, Ding JH, Fan Y, Hu G Tags: CNS Neurosci Ther Source Type: research

Atypical Sneezing Attack Induced by Lateral Medullary Infarction.
PMID: 24127694 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 15, 2013 Category: Neuroscience Authors: Hu HT, Yan SQ, Campbell B, Lou M Tags: CNS Neurosci Ther Source Type: research

CT Perfusion Mismatch in Subacute Stroke: Oligemia or Luxury Perfusion? Response to Persistent Benign Oligemia Causes CT Perfusion Mismatch in Patients with Intracranial Large Artery Occlusive Disease during Subacute Stroke.
PMID: 24127742 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 15, 2013 Category: Neuroscience Authors: Morelli N, Morelli J, Rota E, Michieletti E, Guidetti D Tags: CNS Neurosci Ther Source Type: research

Effects of Intravenous and Intrathecal Dexmedetomidine in Spinal Anesthesia: A Meta-Analysis.
Abstract PURPOSE: To assess the effects of dexmedetomidine on the duration of sensory and motor block, postoperative analgesia, hypotension, bradycardia, and side effects in patients undergoing spinal anesthesia. METHODS: Two researchers searched MEDLINE, EMBASE, and the Cochrane controlled trial register independently for randomized controlled trials comparing dexmedetomidine with a placebo without any language restrictions. RESULTS: A total of 412 patients from eight trials were included in this study. The results revealed that dexmedetomidine was statistically significant in prolonging the duration of...
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Niu XY, Ding XB, Guo T, Chen MH, Fu SK, Li Q Tags: CNS Neurosci Ther Source Type: research

Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action.
Abstract Silymarin, a C25 containing flavonoid from the plant Silybum marianum, has been the gold standard drug to treat liver disorders associated with alcohol consumption, acute and chronic viral hepatitis, and toxin-induced hepatic failures since its discovery in 1960. Apart from the hepatoprotective nature, which is mainly due to its antioxidant and tissue regenerative properties, Silymarin has recently been reported to be a putative neuroprotective agent against many neurologic diseases including Alzheimer's and Parkinson's diseases, and cerebral ischemia. Although the underlying neuroprotective mechanism of ...
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP Tags: CNS Neurosci Ther Source Type: research

Establishment of Depression Behavioral Criteria in Cynomolgus Monkeys.
PMID: 24118874 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Fan BS, Sun Y, Liu X, Yu JG Tags: CNS Neurosci Ther Source Type: research

Combining Statins with Tissue Plasminogen Activator Treatment After Experimental and Human Stroke: A Safety Study on Hemorrhagic Transformation.
CONCLUSION: This study consistently confirms that the use of statins does not increase HT rates and severity when is combined with tPA administration. PMID: 24118905 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Campos M, García-Bonilla L, Hernández-Guillamon M, Barceló V, Morancho A, Quintana M, Rubiera M, Rosell A, Montaner J Tags: CNS Neurosci Ther Source Type: research

Zinc Monotherapy and a Low-copper Diet are Beneficial in Patients with Wilson Disease After Liver Transplantation.
PMID: 24119323 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 14, 2013 Category: Neuroscience Authors: Ni W, Dong QY, Zhang Y, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Neuroprotection by Sildenafil: Neuronal Networks Potentiation in Acute Experimental Stroke.
CONCLUSIONS: Sildenafil produces significant neuroprotective effects on injured neurons in acute stroke, and these are mediated by the cGMP-dependent Nogo-R pathway, NGF/TrkA, and BDNF/TrkB. PMID: 24034153 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 30, 2013 Category: Neuroscience Authors: Chen XM, Wang NN, Zhang TY, Wang F, Wu CF, Yang JY Tags: CNS Neurosci Ther Source Type: research

Lack of Association between Family History of Stroke and 1-year Outcomes after Acute Ischemic Stroke in Chinese.
PMID: 24034211 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 30, 2013 Category: Neuroscience Authors: Wang XG, Wang CX, Yang HJ, Wang AX, Li D, Zheng HG, Wang YL, Liu GF, Zhao XQ, Wang YJ Tags: CNS Neurosci Ther Source Type: research

Therapeutic Time Window and Dose Dependence of Xenon Delivered via Echogenic Liposomes for Neuroprotection in Stroke.
CONCLUSION: This study demonstrates the therapeutic efficacy of Xe-ELIP administered within 5 h after stroke onset with an optimal dosage range of 7-14 mg/kg for maximal neuroprotection. PMID: 23981565 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 24, 2013 Category: Neuroscience Authors: Peng T, Britton GL, Kim H, Cattano D, Aronowski J, Grotta J, McPherson DD, Huang SL Tags: CNS Neurosci Ther Source Type: research

Moderate Hypothermia Inhibits Brain Inflammation and Attenuates Stroke-Induced Immunodepression in Rats.
CONCLUSIONS: Brief intra-ischemic hypothermia attenuated SIID and protected against acute brain inflammation. PMID: 23981596 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 24, 2013 Category: Neuroscience Authors: Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H Tags: CNS Neurosci Ther Source Type: research

A New Motif in the N-Terminal of Acetylcholinesterase Triggers Amyloid-β Aggregation and Deposition.
CONCLUSIONS: AChE 7-20, a β-hairpin region in AChE, might be a new motif in AChE capable of triggering Aβ aggregation and deposition. This finding will be helpful to design new and more effective Aβ aggregation inhibitors for AD treatment. PMID: 23981668 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 24, 2013 Category: Neuroscience Authors: Hou LN, Xu JR, Zhao QN, Gao XL, Cui YY, Xu J, Wang H, Chen HZ Tags: CNS Neurosci Ther Source Type: research

Change in Plasma Levels of Amino Acid Neurotransmitters and its Correlation with Clinical Heterogeneity in Early Parkinson's Disease Patients.
CONCLUSION: The decrease in plasma Asp, Glu, Tau, L-ser levels, and the value of Glu/GABA ratio may be helpful for early PD diagnosis. The elevated GABA level may be the biochemical basis for the specific symptoms of PIGD PD. PMID: 23981689 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 24, 2013 Category: Neuroscience Authors: Yuan YS, Zhou XJ, Tong Q, Zhang L, Zhang L, Qi ZQ, Ge S, Zhang KZ Tags: CNS Neurosci Ther Source Type: research

Demyelination Initiated by Oligodendrocyte Apoptosis through Enhancing Endoplasmic Reticulum-Mitochondria Interactions and Id2 Expression after Compressed Spinal Cord Injury in Rats.
CONCLUSION: Demyelination occurred after CSCI and might be partly caused by oligodendrocyte apoptosis, which was positively correlated with ER-mitochondria interactions and enhanced Id2 expression after CSCI in rats. PMID: 23937638 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 13, 2013 Category: Neuroscience Authors: Huang SQ, Tang CL, Sun SQ, Yang C, Xu J, Wang KJ, Lu WT, Huang J, Zhuo F, Qiu GP, Wu XY, Qi W Tags: CNS Neurosci Ther Source Type: research

Concept of Pharmacogenomics and Future Considerations.
PMID: 23919514 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 7, 2013 Category: Neuroscience Authors: Kaur H, Grover S, Kukreti R Tags: CNS Neurosci Ther Source Type: research

A 24-Week, Randomized, Controlled Trial of Rivastigmine Patch 13.3 mg/24 h Versus 4.6 mg/24 h in Severe Alzheimer's Dementia.
A 24-Week, Randomized, Controlled Trial of Rivastigmine Patch 13.3 mg/24 h Versus 4.6 mg/24 h in Severe Alzheimer's Dementia. CNS Neurosci Ther. 2013 Aug 7; Authors: Farlow MR, Grossberg GT, Sadowsky CH, Meng X, Somogyi M Abstract AIMS: The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS: Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome measures were as follows...
Source: CNS Neuroscience and Therapeutics - August 7, 2013 Category: Neuroscience Authors: Farlow MR, Grossberg GT, Sadowsky CH, Meng X, Somogyi M Tags: CNS Neurosci Ther Source Type: research

A Binarization Preprocessing Method for the Three-Dimensional Reconstruction of Carotids.
PMID: 23911081 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 2, 2013 Category: Neuroscience Authors: Qin HQ, Zhou P, Gong YY, Sui BB, Liu L, Wang YJ Tags: CNS Neurosci Ther Source Type: research

Persistent Benign Oligemia Causes CT Perfusion Mismatch in Patients with Intracranial Large Artery Occlusive Disease during Subacute Stroke.
PMID: 23876019 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 28, 2013 Category: Neuroscience Authors: Li JJ, Chen XY, Soo Y, Abrigo JM, Leung TW, Wong E, Mok V, Cheung JS, Ahuja AT, Zeng JS, Wong KS Tags: CNS Neurosci Ther Source Type: research

MicroRNA-26a Promotes Tumor Growth and Angiogenesis in Glioma by Directly Targeting Prohibitin.
CONCLUSION: These results reveal that miR-26a regulates PHB and promotes glioma progression both in vitro and in vivo and that miR-26a and its target PHB are associated with glioma development, which can be helpful in developing microRNA-based treatment for glioma in the future. PMID: 23870455 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 22, 2013 Category: Neuroscience Authors: Qian X, Zhao P, Li W, Shi ZM, Wang L, Xu Q, Wang M, Liu N, Liu LZ, Jiang BH Tags: CNS Neurosci Ther Source Type: research

Upregulation of Glutamate-Aspartate Transporter by Glial Cell Line-Derived Neurotrophic Factor Ameliorates Cell Apoptosis in Neural Retina in Streptozotocin-Induced Diabetic Rats.
CONCLUSIONS: GDNF, administrated at the early stage of diabetes, could rescue retinal cells from neurodegeneration by upregulating the expression of GLAST. PMID: 23870489 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 22, 2013 Category: Neuroscience Authors: Wang L, Deng QQ, Wu XH, Yu J, Yang XL, Zhong YM Tags: CNS Neurosci Ther Source Type: research

Heme Oxygenase-1 Mediated Memorial and Revivable Protective Effect of Ischemic Preconditioning on Brain Injury.
CONCLUSIONS: We found for the first time that the protective effect of IPC can be remembered to protect brain injury occurred after acute response disappear. The results indicate that interventional treatment can achieve protective effect for future cerebral injury not only through interventional treatment itself but also through the memorial and revivable IPC, eliminating the concern that temporary ischemia caused by interventional treatment may leave harmful effect in the brain. PMID: 23870531 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 22, 2013 Category: Neuroscience Authors: Le LL, Li XY, Meng D, Liang QJ, Wang XH, Li N, Quan J, Xiang M, Jiang M, Sun J, Chen SF Tags: CNS Neurosci Ther Source Type: research

Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair.
Abstract Multiple sclerosis (MS) is a central nervous system disorder that is associated with progressive oligodendrocyte and neuronal loss, axonal degeneration, and demyelination. Several medications that mitigate immune abnormalities reduce both the frequency of relapses and inflammation on magnetic resonance imaging, leading to improved outcomes for people with the relapsing-remitting form of MS. However, there are no treatments for the progressive forms of MS where neurons and axons continue to degenerate; here, neuroprotective therapies, or medications that rebuild myelin to confer axonal well-being, may be u...
Source: CNS Neuroscience and Therapeutics - July 22, 2013 Category: Neuroscience Authors: Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM Tags: CNS Neurosci Ther Source Type: research

Brain MAPKs Levels are Differentially Associated with Seizures Threshold and Severity Progression in Pentylenetetrazole-Kindled Mice.
r R, Walz R PMID: 23841844 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 10, 2013 Category: Neuroscience Authors: Ben J, Marques Gonçalves F, Alexandre Oliveira P, Vieira Peres T, Hohl A, Bainy Leal R, Abrão Cavalheiro E, Daniel Schroder Prediger R, Walz R Tags: CNS Neurosci Ther Source Type: research

BCL2A1 is a Potential Biomarker for Postoperative Seizure Control in Patients with Low-grade Gliomas.
CONCLUSION: Increased anti-apoptotic activity of tumor cells appears to contribute to seizure recurrence after surgery in patients with LGGs. These findings provide insights that may lead to the development of effective treatment strategies for prolonging the survival of patients with LGG in the future. PMID: 23841872 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 10, 2013 Category: Neuroscience Authors: You G, Feng L, Yan W, Zhang W, Wang YZ, Li SW, Li SW, Li GL, Song YJ, Kang CS, You YP, Jiang T Tags: CNS Neurosci Ther Source Type: research

Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway.
CONCLUSIONS: Our results demonstrate that B3C blocks K(+) deprivation-induced apoptosis in CGNs through regulating VEGFR-2/Akt/GSK3β and VEGFR-2/ERK signaling pathways, providing a molecular insight into the therapeutic potential of B3C for the treatment of neurodegenerative diseases. PMID: 23826635 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF Tags: CNS Neurosci Ther Source Type: research

MicroRNA-124 Protects Neurons Against Apoptosis in Cerebral Ischemic Stroke.
CONCLUSIONS: miR-124 plays a neurons-protective role via apoptosis-inhibiting pathway in ischemic stroke. PMID: 23826665 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Sun Y, Gui H, Li Q, Luo ZM, Zheng MJ, Duan JL, Liu X Tags: CNS Neurosci Ther Source Type: research

Transient Receptor Potential Vanilloid 4 Mediates Hypotonicity-Induced Enhancement of Synaptic Transmission in Hippocampal Slices.
CONCLUSION: TRPV4 is involved in hypotonicity-induced enhancement of hippocampal synaptic transmission, which may be mediated through promoting presynaptic glutamate release and increasing postsynaptic AMPA receptor function. PMID: 23826708 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Li L, Yin J, Jie PH, Lu ZH, Zhou LB, Chen L, Chen L Tags: CNS Neurosci Ther Source Type: research

Vascular Niche for Astrocyte Proliferation: Limited and In situ.
PMID: 23826723 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Cui Y, Li J, Yuan TF Tags: CNS Neurosci Ther Source Type: research

Cerebral Infarction and Cranial Venous Sinus Thrombosis Caused by Paragonimiasis.
PMID: 23826750 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Wu JY, Zhang BR, Zhao GH Tags: CNS Neurosci Ther Source Type: research

Aerobic Exercise Combined with Antioxidative Treatment does not Counteract Moderate- or Mid-Stage Alzheimer-Like Pathophysiology of APP/PS1 Mice.
CONCLUSION: This study reveals that a combined treatment of aerobic exercise plus antioxidative stress does not counteract pathophysiology in the moderate- or mid-stages of AD. PMID: 23827013 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Xu ZQ, Zhang LQ, Wang Q, Marshall C, Xiao N, Gao JY, Wu T, Ding J, Hu G, Xiao M Tags: CNS Neurosci Ther Source Type: research

The Regulation of SKF38393 on the Dopamine and D1 Receptor Expression in Hippocampus during Chronic REM Sleep Restriction.
PMID: 23827052 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 4, 2013 Category: Neuroscience Authors: Wen XS, Chen XM, Rong F, Jing T, Chen S, Ma WL Tags: CNS Neurosci Ther Source Type: research

Comparison of Clinical Features in Patients with Persistent and Nonpersistent Cryptococcal Meningitis: Twelve Years of Clinical Experience in Four Centers in China.
Abstract BACKGROUND AND AIMS: Cryptococcal meningitis (CM) has gradually increased in the recent 20 years in the whole world. Although the mortality decreased significantly in recent years, it was still high, especially in patients with persistent infection. Therefore, we compare differences of clinical features between persistent and nonpersistent CM patients. METHODS: We conducted a retrospective review of medical records of patients diagnosed with CM from January 2000 to December 2011 in four centers in China, including demographic features, underlying diseases, clinical presentations, laboratory data...
Source: CNS Neuroscience and Therapeutics - June 25, 2013 Category: Neuroscience Authors: Xu XG, Pan WH, Bi XL, Fang W, Chen M, Zhu Y, Zhou J, Zhou N, Pan B, Li M, Liao WQ, Qi ZT Tags: CNS Neurosci Ther Source Type: research

Impaired Hippocampal Theta Oscillations in the Mice Null Alpha7 Nicotinic Acetylcholine Receptors.
PMID: 23795917 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 25, 2013 Category: Neuroscience Authors: Jin Y, Su QX, Shen JX, Marks MJ, Wu J Tags: CNS Neurosci Ther Source Type: research

Effect of Rosiglitazone, a PPAR-γ Ligand on Haloperidol-Induced Catalepsy.
Effect of Rosiglitazone, a PPAR-γ Ligand on Haloperidol-Induced Catalepsy. CNS Neurosci Ther. 2013 Jun 21; Authors: Gupta G, Singh R, David SR, Verma RK PMID: 23786164 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 21, 2013 Category: Neuroscience Authors: Gupta G, Singh R, David SR, Verma RK Tags: CNS Neurosci Ther Source Type: research

Histamine Modulation of Acute Nociception Involves Regulation of Nav 1.8 in Primary Afferent Neurons in Mice.
CONCLUSION: Our results indicate that histamine participates in acute pain modulation in a dose-related manner. The regulation of Nav 1.8 expression and the excitability of nociceptive primary afferent neurons may be involved in the underlying mechanisms. PMID: 23773488 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2013 Category: Neuroscience Authors: Yu J, Fang Q, Lou GD, Shou WT, Yue JX, Tang YY, Hou WW, Xu TL, Ohtsu H, Zhang SH, Chen Z Tags: CNS Neurosci Ther Source Type: research