Nitrous Oxide-Oxygen Mixture During Burn Wound Dressing: A Double-Blind Randomized Controlled Study.
PMID: 23406362 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 14, 2013 Category: Neuroscience Authors: Li YX, Han WJ, Tang HT, Wu YS, Tang L, Yu JQ, Li YC, Xia ZF, Zhao JJ Tags: CNS Neurosci Ther Source Type: research

Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation.
CONCLUSIONS: The in vivo study clearly demonstrates that artemisinin has protective effects on AD pathology due to its effects on suppressing NF-κB activity and NALP3 inflammasome activation. Our study suggests that targeting NF-κB activity and NALP3 inflammasome activation offers a valuable intervention for AD. PMID: 23406388 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 14, 2013 Category: Neuroscience Authors: Shi JQ, Zhang CC, Sun XL, Cheng XX, Wang JB, Zhang YD, Xu J, Zou HQ Tags: CNS Neurosci Ther Source Type: research

Diammonium Glycyrrhizinate Attenuates Aβ(1-42) -Induced Neuroinflammation and Regulates MAPK and NF-κB Pathways In Vitro and In Vivo.
CONCLUSIONS: DG protects Aβ(1-42) -induced AD models in vitro and in vivo through reducing activation of microglia and inflammation, which may be involved in MAPK and NF-κB pathways. PMID: 23279783 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 29, 2013 Category: Neuroscience Authors: Zhao H, Wang SL, Qian L, Jin JL, Li H, Xu Y, Zhu XL Tags: CNS Neurosci Ther Source Type: research

Reduced Frontal Activation during a Working Memory Task in Mild Cognitive Impairment: a Non-Invasive Near-Infrared Spectroscopy Study.
CONCLUSIONS: These results confirm the functional deficits in the frontal and temporal cortices and the impairment of WM and cognitive abilities in MCI patients and suggest that fNIRS may be a useful tool for evaluating brain activation in cognitive disorders. PMID: 23279823 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 29, 2013 Category: Neuroscience Authors: Niu HJ, Li X, Chen YJ, Ma C, Zhang JY, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Effects of oxysophoridine on rat hippocampal neurons sustained oxygen-glucose deprivation and reperfusion.
PMID: 23279847 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 29, 2013 Category: Neuroscience Authors: Zhao J, Li YX, Hao YJ, Chen R, Zhang JZ, Sun T, Yu JQ Tags: CNS Neurosci Ther Source Type: research

Persistence with antihypertensive agents for 12 months after ischemic stroke reduces the rates of death and dependency.
Persistence with antihypertensive agents for 12 months after ischemic stroke reduces the rates of death and dependency. CNS Neurosci Ther. 2013 Feb;19(2):142-4 Authors: Xu J, Wang CX, Wang YL, Zhao XQ, Liu LP, Wang AX, Wang YJ PMID: 23279879 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 29, 2013 Category: Neuroscience Authors: Xu J, Wang CX, Wang YL, Zhao XQ, Liu LP, Wang AX, Wang YJ Tags: CNS Neurosci Ther Source Type: research

Concerning HB-EGF Brain Levels in Schizophrenia: Cellular Distribution of Putative Sheddases May Matter.
PMID: 23339361 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 29, 2013 Category: Neuroscience Authors: Bernstein HG, Keilhoff G, Lendeckel U, Steiner J, Bogerts B Tags: CNS Neurosci Ther Source Type: research

Magnetic Resonance T2*-Weighted Study of U87 MG Glioma Tumors and its Relationship between Tumor Hypoxia and VEGF Expression.
PMID: 23347691 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 24, 2013 Category: Neuroscience Authors: An-Na T, Xiao-Yan L, Peng Y, Yan-Ming W Tags: CNS Neurosci Ther Source Type: research

The Migration of Neural Progenitor Cell Mediated by SDF-1 is NF-κB/HIF-1α Dependent upon Hypoxia.
CONCLUSIONS: Hypoxic induction of SDF-1 is reliant upon NF-κB and HIF-1α. There is a cross-talk between HIF-1α and NF-κB, both HIF-1α and SDF-1 are downstream targets of NF-κB in hypoxia condition. PMID: 23311761 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 12, 2013 Category: Neuroscience Authors: Yin W, Ma L, Zhang J, Huang K, Yang Q, Guo YY, Liu SB, Liu YH, Wu YM Tags: CNS Neurosci Ther Source Type: research

Baicalin Regulates Neuronal Fate Decision in Neural Stem/Progenitor Cells and Stimulates Hippocampal Neurogenesis in Adult Rats.
CONCLUSIONS: These results identify the existence of a single molecule, baicalin, which can specify the neuronal fate of multipotent NSPCs and stimulate neurogenesis, making it a promising candidate for developing clinically relevant strategies to manipulate neuronal fate of NSPCs for brain repair. PMID: 23302221 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 9, 2013 Category: Neuroscience Authors: Zhuang PW, Cui GZ, Zhang YJ, Zhang MX, Guo H, Zhang JB, Lu ZQ, Isaiah AO, Lin YX Tags: CNS Neurosci Ther Source Type: research

Gene Transfer into the Both Sides of Postnatal Cerebral Cortex Using Tweezer Electrode.
PMID: 23302253 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 9, 2013 Category: Neuroscience Authors: Ding XF, Zhao YQ, Fan WH, Wu LY, Huang X, Wang F, He YL, Liu SH, Wu Y, Zhao T, Wu Y, Zhu LL, Fan M Tags: CNS Neurosci Ther Source Type: research

Generalized Periodic Epileptiform Discharges in a Case of Viral Encephalitis with a good prognosis.
PMID: 23294491 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 7, 2013 Category: Neuroscience Authors: Chen WZ, Liu XY, Liu K, Chen YJ Tags: CNS Neurosci Ther Source Type: research

Phenylephrine Versus Ephedrine for the Management of Hypotension in the Obstetric Patient; Do We Have an Updated Answer?
PMID: 23279908 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 2, 2013 Category: Neuroscience Authors: Habib AS Tags: CNS Neurosci Ther Source Type: research

PRRT2 c.649dupC Mutation Derived from De Novo in Paroxysmal Kinesigenic Dyskinesia.
CONCLUSION: These findings demonstrate the heterogeneity of PKD, and the de novo mutagenesis of PRRT2 gene might indicate the genetic instability of this region. PMID: 23176561 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 1, 2013 Category: Neuroscience Authors: Li HF, Ni W, Xiong ZQ, Xu J, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Implementation and Outcome of Thrombolysis with Alteplase 3 to 4.5 h After Acute Stroke in Chinese Patients.
CONCLUSION: This study suggests that intravenous rtPA treatment at 3 to 4.5 h of symptom onset remains safe and effective in Chinese patients with AIS. PMID: 23206165 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 1, 2013 Category: Neuroscience Authors: Liao XL, Wang CX, Wang YL, Wang CJ, Zhao XQ, Zhang LQ, Liu LP, Pan YS, Wang YJ Tags: CNS Neurosci Ther Source Type: research

Cell therapy: the final frontier for treatment of neurological diseases.
Abstract Neurodegenerative diseases are devastating because they cause increasing loss of cognitive and physical functions and affect an estimated 1 billion individuals worldwide. Unfortunately, no drugs are currently available to halt their progression, except a few that are largely inadequate. This mandates the search of new treatments for these progressively degenerative diseases. Neural stem cells (NSCs) have been successfully isolated, propagated, and characterized from the adult brains of mammals, including humans. The confirmation that neurogenesis occurs in the adult brain via NSCs opens up fresh avenues f...
Source: CNS Neuroscience and Therapeutics - January 1, 2013 Category: Neuroscience Authors: Dutta S, Singh G, Sreejith S, Mamidi MK, Husin JM, Datta I, Pal R, Das AK Tags: CNS Neurosci Ther Source Type: research

Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System.
Abstract Tripterygium wilfordii Hook.f. (TWHF) has a long history as a Traditional Chinese Medicine (TCM) herb that aids in treating inflammatory and autoimmune diseases. The major bioactive component of TWHF is triptolide, which has been recognized to possess a broad spectrum of biological profiles including antiinflammatory, immunosuppressive, antifertility, and antitumor activities, as well as neurotrophic and neuroprotective effects. Limitation of triptolide, such as poor water solubility and severe systemic toxicity, has postponed clinical development and trials; however, the wide range of medicinal value of ...
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Zheng Y, Zhang WJ, Wang XM Tags: CNS Neurosci Ther Source Type: research

Edaravone Protects HT22 Neurons from H(2) O(2) -induced Apoptosis by Inhibiting the MAPK Signaling Pathway.
CONCLUSIONS: Our results provide the first evidence that edaravone can protect H(2) O(2) -induced cell injury in HT22 neurons via its antioxidant action. These findings suggest that edaravone may be useful in the treatment of neurodegenerative disorders in which oxidative stress has been principally implicated. PMID: 23253171 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Zhao ZY, Luan P, Huang SX, Xiao SH, Zhao J, Zhang B, Gu BB, Pi RB, Liu J Tags: CNS Neurosci Ther Source Type: research

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation.
CONCLUSION: Our results indicate that PFT-α enhances the survival of grafted NSCs through the inhibition of p53 translocation into the nucleus. PMID: 23253187 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Lei XH, Zhao D, Li YL, Li XF, Sun X, Du WZ, Sun Y, Hao ZF, Xin SY, Liu C, Zhang ZR, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Effect of Different Depths of Anesthesia on Perioperative Stress Response in Children Undergoing Adenoidectomy and Tonsillectomy.
PMID: 23241353 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 14, 2012 Category: Neuroscience Authors: Yang LQ, Li JJ, Chen SQ, Wang YW Tags: CNS Neurosci Ther Source Type: research

Electroacupuncture Suppresses Mechanical Allodynia and Nuclear Factor Kappa B Signaling in Streptozotocin-Induced Diabetic Rats.
CONCLUSIONS: These data indicate that EA produced an analgesic effect, which might be mediated at least in a part by inhibition of NF-κB signaling pathway in primary sensory neurons in rats with diabetes. PMID: 23230847 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Shi L, Zhang HH, Xiao Y, Hu J, Xu GY Tags: CNS Neurosci Ther Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

Aspirin-/TMZ-coloaded Microspheres Exert Synergistic Antiglioma Efficacy vial Inhibition of β-catenin Transactivation.
CONCLUSIONS: Aspirin sensitized TMZ chemotherapy efficacy through inhibition of β-catenin transactivation; furthermore, the coloaded microspheres achieved a sustained release action to reduce the TMZ dosage, offering the potential for improved treatment of glioblastomas. PMID: 23230963 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Shi ZD, Qian XM, Liu CY, Han L, Zhang KL, Chen LY, Zhang JX, Pu PY, Yuan XB, Kang CS, Chinese Glioma Cooperative Group (CGCG) Tags: CNS Neurosci Ther Source Type: research

Clinical Effectiveness of Rivastigmine Monotherapy and Combination Therapy in Alzheimer's Patients.
CONCLUSION: Poor metabolizer subjects of UGT2B7 polymorphism in patients under rivastigmine combination therapy have higher drug levels with a poor response to the drug treatments. PMID: 23206182 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 4, 2012 Category: Neuroscience Authors: Sonali N, Tripathi M, Sagar R, Velpandian T, Subbiah V Tags: CNS Neurosci Ther Source Type: research

Motion Sickness Induces Intestinal Transit Increase in Mice.
PMID: 23206222 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 4, 2012 Category: Neuroscience Authors: Wang ZB, Tu Y, Liu WY, Ke P, Tao BL, Li L, Zhang LC Tags: CNS Neurosci Ther Source Type: research

Circulating MicroRNAs as Potential Risk Biomarkers for Hematoma Enlargement after Intracerebral Hemorrhage.
CONCLUSIONS: We demonstrated that multiple miRNAs are differentially expressed in the plasma of ICH patients with or without HE and may serve as circulating biomarkers for predicting HE after ICH. PMID: 23190933 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 1, 2012 Category: Neuroscience Authors: Zheng HW, Wang YL, Lin JX, Li N, Zhao XQ, Liu GF, Liu LP, Jiao Y, Gu WK, Wang DZ, Wang YJ Tags: CNS Neurosci Ther Source Type: research

Transplantation of human retinal pigment epithelium cells in the treatment for Parkinson disease.
CONCLUSION: Human retinal pigment epithelial cells have the characteristics of neural progenitor cells and can be induced to differentiate into DA neurons. The results of this clinical trial suggest that the treatment of transplanted hRPE cells could improve symptoms of PD. These cells might serve as a useful source of DA neurons for neural graft in the treatment for PD. PMID: 23190934 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 1, 2012 Category: Neuroscience Authors: Yin F, Tian ZM, Liu S, Zhao QJ, Wang RM, Shen L, Wieman J, Yan Y Tags: CNS Neurosci Ther Source Type: research

AKT/GSK3β-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model.
CONCLUSIONS: These results aid optimization of the time window for RIPostC use and offer novel insight into, and a better understanding of, the protective mechanism of autophagy in limb RIPostC. PMID: 23191937 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 28, 2012 Category: Neuroscience Authors: Qi ZF, Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM Tags: CNS Neurosci Ther Source Type: research

Autophagy in the Disorders of Central Nervous System: Vital and/or Fatal?
PMID: 23191986 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 28, 2012 Category: Neuroscience Authors: Wang P, Miao CY Tags: CNS Neurosci Ther Source Type: research