Neonatal stress disrupts the glymphatic system development and increases the susceptibility to Parkinson's disease in later life
CONCLUSION: The results demonstrated that NMD could disrupt the development of the glymphatic system through PDGF-B signaling and increase the risk of PD later in life, indicating that alleviating neonatal stress could be beneficial in protecting the glymphatic system and reducing susceptibility to neurodegeneration.PMID:38421142 | DOI:10.1111/cns.14587 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Jian Song Zhen-Hua Li Xin-Yu Xue Jing-Cai Meng Wen-Xin Zhu Shufen Hu Guang-Yin Xu Lin-Hui Wang Source Type: research
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
CONCLUSION: Our findings demonstrated that PCSK9 induced morphology-related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque.PMID:38402551 | PMC:PMC10894644 | DOI:10.1111/cns.14640 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 25, 2024 Category: Neuroscience Authors: Ran Xu Tianhua Li Jichang Luo Xiao Zhang Tao Wang Yabing Wang Yan Ma Bin Yang Jinzhu Jia Adam A Dmytriw Wenjing Li Liqun Jiao Source Type: research
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
CONCLUSION: Our findings demonstrated that PCSK9 induced morphology-related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque.PMID:38402551 | PMC:PMC10894644 | DOI:10.1111/cns.14640 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 25, 2024 Category: Neuroscience Authors: Ran Xu Tianhua Li Jichang Luo Xiao Zhang Tao Wang Yabing Wang Yan Ma Bin Yang Jinzhu Jia Adam A Dmytriw Wenjing Li Liqun Jiao Source Type: research
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
CONCLUSION: Our findings demonstrated that PCSK9 induced morphology-related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque.PMID:38402551 | PMC:PMC10894644 | DOI:10.1111/cns.14640 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 25, 2024 Category: Neuroscience Authors: Ran Xu Tianhua Li Jichang Luo Xiao Zhang Tao Wang Yabing Wang Yan Ma Bin Yang Jinzhu Jia Adam A Dmytriw Wenjing Li Liqun Jiao Source Type: research
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
CONCLUSION: Our findings demonstrated that PCSK9 induced morphology-related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque.PMID:38402551 | PMC:PMC10894644 | DOI:10.1111/cns.14640 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 25, 2024 Category: Neuroscience Authors: Ran Xu Tianhua Li Jichang Luo Xiao Zhang Tao Wang Yabing Wang Yan Ma Bin Yang Jinzhu Jia Adam A Dmytriw Wenjing Li Liqun Jiao Source Type: research
Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice
CONCLUSION: These findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age-related disruptions in the circadian rhythm.PMID:38385622 | PMC:PMC10883092 | DOI:10.1111/cns.14592 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Qiong Wu Qiuyang Ren Xin Wang Huiyuan Bai Dandan Tian Guofen Gao Fudi Wang Peng Yu Yan-Zhong Chang Source Type: research
The promise of N-acetylcysteine in the treatment of obsessive-compulsive disorder
CNS Neurosci Ther. 2024 Feb;30(2):e14653. doi: 10.1111/cns.14653.NO ABSTRACTPMID:38385640 | PMC:PMC10883097 | DOI:10.1111/cns.14653 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Massimo Carollo Nicola Carollo Giulia Montan Source Type: research
Myofascial edema of gastrocnemius: A prominent MRI characteristic in dermatomyositis patients with anti-transcriptional intermediate factor 1- γ antibody
CONCLUSIONS: Myofascial edema of gastrocnemius was a prominent characteristic of anti-TIF1-γ-positive DM. Early detection of muscle edema, as well as CK levels, may be helpful for monitoring disease activity.PMID:38385674 | PMC:PMC10883095 | DOI:10.1111/cns.14647 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Chao Zhen Bing Zhao Jingzhen He Li Wei Chuanzhu Yan Tingjun Dai Ying Hou Source Type: research
Temporal and spatial variability of dynamic microstate brain network in disorders of consciousness
CONCLUSION: Constructing features based on microstates to distinguish between two categories of DOC patients had effectiveness.PMID:38385681 | PMC:PMC10883110 | DOI:10.1111/cns.14641 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Yaqian Li Junfeng Gao Ying Yang Yvtong Zhuang Qianruo Kang Xiang Li Min Tian Haoan Lv Jianghong He Source Type: research
Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice
CONCLUSION: These findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age-related disruptions in the circadian rhythm.PMID:38385622 | PMC:PMC10883092 | DOI:10.1111/cns.14592 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Qiong Wu Qiuyang Ren Xin Wang Huiyuan Bai Dandan Tian Guofen Gao Fudi Wang Peng Yu Yan-Zhong Chang Source Type: research
The promise of N-acetylcysteine in the treatment of obsessive-compulsive disorder
CNS Neurosci Ther. 2024 Feb;30(2):e14653. doi: 10.1111/cns.14653.NO ABSTRACTPMID:38385640 | PMC:PMC10883097 | DOI:10.1111/cns.14653 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Massimo Carollo Nicola Carollo Giulia Montan Source Type: research
Myofascial edema of gastrocnemius: A prominent MRI characteristic in dermatomyositis patients with anti-transcriptional intermediate factor 1- γ antibody
CONCLUSIONS: Myofascial edema of gastrocnemius was a prominent characteristic of anti-TIF1-γ-positive DM. Early detection of muscle edema, as well as CK levels, may be helpful for monitoring disease activity.PMID:38385674 | PMC:PMC10883095 | DOI:10.1111/cns.14647 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Chao Zhen Bing Zhao Jingzhen He Li Wei Chuanzhu Yan Tingjun Dai Ying Hou Source Type: research
Temporal and spatial variability of dynamic microstate brain network in disorders of consciousness
CONCLUSION: Constructing features based on microstates to distinguish between two categories of DOC patients had effectiveness.PMID:38385681 | PMC:PMC10883110 | DOI:10.1111/cns.14641 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Yaqian Li Junfeng Gao Ying Yang Yvtong Zhuang Qianruo Kang Xiang Li Min Tian Haoan Lv Jianghong He Source Type: research
Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice
CONCLUSION: These findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age-related disruptions in the circadian rhythm.PMID:38385622 | PMC:PMC10883092 | DOI:10.1111/cns.14592 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Qiong Wu Qiuyang Ren Xin Wang Huiyuan Bai Dandan Tian Guofen Gao Fudi Wang Peng Yu Yan-Zhong Chang Source Type: research
The promise of N-acetylcysteine in the treatment of obsessive-compulsive disorder
CNS Neurosci Ther. 2024 Feb;30(2):e14653. doi: 10.1111/cns.14653.NO ABSTRACTPMID:38385640 | PMC:PMC10883097 | DOI:10.1111/cns.14653 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Massimo Carollo Nicola Carollo Giulia Montan Source Type: research
