BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome
CONCLUSION: BRCC3 shows promise as a novel target to enhance neurological recovery and attenuate the inflammatory responses and pyroptosis caused by NLRP6 activation in cerebral I/R injury.PMID:38544474 | DOI:10.1111/cns.14697 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Xiaohuan Huang Junyi Tan Yanyan Ji Jing Luo Yong Zhao Jing Zhao Source Type: research
Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup
CONCLUSION: In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.PMID:38532275 | PMC:PMC10965754 | DOI:10.1111/cns.14619 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Wanqing Xie Szuyao Hsu Yuxuan Lin Lv Xie Xia Jin Ziyu Zhu Yunlu Guo Caiyang Chen Dan Huang Johannes Boltze Peiying Li Source Type: research
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats
CONCLUSION: Our findings indicate that RACK1 protected against TBI-induced neuronal damage partly through autophagy induction by regulating the PERK signaling pathway.PMID:38532543 | PMC:PMC10966134 | DOI:10.1111/cns.14691 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Haibo Ni Xugang Kan Qin Rui Yang Zhang Weiwei Zhai Baole Zhang Zhengquan Yu Source Type: research
Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | PMC:PMC10966135 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup
CONCLUSION: In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.PMID:38532275 | DOI:10.1111/cns.14619 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Wanqing Xie Szuyao Hsu Yuxuan Lin Lv Xie Xia Jin Ziyu Zhu Yunlu Guo Caiyang Chen Dan Huang Johannes Boltze Peiying Li Source Type: research
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats
CONCLUSION: Our findings indicate that RACK1 protected against TBI-induced neuronal damage partly through autophagy induction by regulating the PERK signaling pathway.PMID:38532543 | DOI:10.1111/cns.14691 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Haibo Ni Xugang Kan Qin Rui Yang Zhang Weiwei Zhai Baole Zhang Zhengquan Yu Source Type: research
Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
Role of dendritic cells in spinal cord injury
CONCLUSIONS: This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.PMID:38528832 | PMC:PMC10964036 | DOI:10.1111/cns.14593 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Xiaonan Han Mingkang Zhang Liyan Yan Yikun Fu Hongwei Kou Chunfeng Shang Junmin Wang Hongjian Liu Chao Jiang Jian Wang Tian Cheng Source Type: research
ERBB1 alleviates secondary brain injury induced by experimental intracerebral hemorrhage in rats by modulating neuronal death via PLC- γ/PKC pathway
CONCLUSIONS: ERBB1 can improve SBI and has a neuroprotective effect in experimental ICH rats via PLC-γ/PKC pathway.PMID:38528842 | PMC:PMC10964039 | DOI:10.1111/cns.14679 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Bing Li Jiang Wu Demao Cao Cheng Cao Juyi Zhang Xiang Li Haiying Li Haitao Shen Zhengquan Yu Source Type: research
The use of optical coherence tomography (OCT) and OCT angiography in borderline personality disorder compared to health control subjects
CONCLUSION: The OCT and OCTA can non-invasively detect microvascular and morphology changes of the retina in BPD patients compared to healthy control subjects.PMID:38529526 | PMC:PMC10964035 | DOI:10.1111/cns.14699 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Bei Xu Fangling Li Zhejia Zhang Qian Xiao Source Type: research
Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy
CONCLUSION: These findings suggest that loops in the cerebellum and TP are crucial for ECT regulation of mood and cognition, which provides new evidence for the antidepressant effects of ECT and the potential molecular mechanism leading to cognitive impairment.PMID:38529527 | PMC:PMC10964037 | DOI:10.1111/cns.14690 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Xiaohui Yu Kexuan Chen Yingzi Ma Tongjian Bai Shunli Zhu Defang Cai Xing Zhang Kai Wang Yanghua Tian Jiaojian Wang Source Type: research
Morphometric similarity differences in drug-naive Parkinson's disease correlate with transcriptomic signatures
CONCLUSIONS: These findings advance our understanding of the microscale genetic and cellular mechanisms driving macroscale morphological abnormalities in early drug-naive PD patients and provide potential targets for future therapeutic trials.PMID:38529533 | PMC:PMC10964038 | DOI:10.1111/cns.14680 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 26, 2024 Category: Neuroscience Authors: Yajie Wang Yiwen Xiao Yi Xing Miao Yu Xiao Wang Jingru Ren Weiguo Liu Yuan Zhong Source Type: research
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway
CONCLUSION: Inhibition of HDAC1/2 reduces neuro-ferroptosis by modifying the heterogeneity of microglia via the Nrf2/HO1 pathway, with a particular focus on acetyl-Nrf2. Additionally, this inhibition aids in the faster removal of hematomas and lessens prolonged neurological impairments, indicating novel approach for treating ICH.PMID:38523117 | PMC:PMC10961428 | DOI:10.1111/cns.14646 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 25, 2024 Category: Neuroscience Authors: Zhiwen Jiang Heng Yang Wei Ni Xinjie Gao Xu Pei Hanqiang Jiang Jiabin Su Ruiyuan Weng Yuchao Fei Yanqin Gao Yuxiang Gu Source Type: research
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway
CONCLUSION: Inhibition of HDAC1/2 reduces neuro-ferroptosis by modifying the heterogeneity of microglia via the Nrf2/HO1 pathway, with a particular focus on acetyl-Nrf2. Additionally, this inhibition aids in the faster removal of hematomas and lessens prolonged neurological impairments, indicating novel approach for treating ICH.PMID:38523117 | DOI:10.1111/cns.14646 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 25, 2024 Category: Neuroscience Authors: Zhiwen Jiang Heng Yang Wei Ni Xinjie Gao Xu Pei Hanqiang Jiang Jiabin Su Ruiyuan Weng Yuchao Fei Yanqin Gao Yuxiang Gu Source Type: research
Efficacy and safety of venlafaxine hydrochloride combined with tandospirone citrate for patients with vascular depression accompanied by somatic symptoms: An open-labeled randomized control trial
CONCLUSION: The combined therapy rapidly acts on VaDep comorbid with anxiety and somatic symptoms and significantly alleviates the anxiety and somatic symptoms. The plasma levels of 5-HT may serve as potential objective candidates in evaluating VaDep severity and the efficacy of the undertaken treatment regimen.PMID:38514905 | PMC:PMC10957720 | DOI:10.1111/cns.14650 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 22, 2024 Category: Neuroscience Authors: Hongbin Chen Yongsen Lin Zijun Zhao Ting Lin Qianwen Lin Xinyan Chen Weiwei Wu Guiying Zeng Shufang Wu Nan Liu Hui Chen Ronghua Chen Yingchun Xiao Source Type: research
