Cyclosporine A Treatment Abrogates Ischemia-Induced Neuronal Cell Death by Preserving Mitochondrial Integrity through Upregulation of the Parkinson's Disease-Associated Protein DJ-1.
CONCLUSION: These observations provided evidence that CsA maintained mitochondrial integrity likely via DJ-1 upregulation, supporting the concept that mitochondria-based treatments targeting the early phase of disease progression may prove beneficial in stroke. PMID: 27247192 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 1, 2016 Category: Neuroscience Authors: Tajiri N, Borlongan CV, Kaneko Y Tags: CNS Neurosci Ther Source Type: research

A Point-by-Point Response to Braillon.
PMID: 27177736 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2016 Category: Neuroscience Authors: Rolland B, Paille F, Gillet C, Rigaud A, Moirand R, Dano C, Dematteis M, Mann K, Aubin HJ Tags: CNS Neurosci Ther Source Type: research

Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.
CONCLUSION: Taken together, these results highlight for the first time an involvement of protein kinases in the allosteric modulation of SERT function. PMID: 27171685 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 12, 2016 Category: Neuroscience Authors: Mnie-Filali O, Lau T, Matthaeus F, Abrial E, Delcourte S, El Mansari M, Pershon A, Schloss P, Sánchez C, Haddjeri N Tags: CNS Neurosci Ther Source Type: research

Early Recanalization Postintravenous Thrombolysis in Ischemic Stroke with Large Vessel Occlusion: A Digital Subtraction Angiography Study.
CONCLUSION: Early recanalization assessed by DSA post-IV t-PA is rarely observed in acute ischemic stroke patients with LVO. PMID: 27165451 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2016 Category: Neuroscience Authors: Mao YT, Mitchell P, Churilov L, Dowling R, Dong Q, Yan B Tags: CNS Neurosci Ther Source Type: research

Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System.
CONCLUSIONS: Artesunate reduces the severity of EAE by inhibiting migration of pathogenic T cells to the CNS. PMID: 27165523 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2016 Category: Neuroscience Authors: Thomé R, de Carvalho AC, Alves da Costa T, Ishikawa LL, Fraga-Silva TF, Sartori A, de Oliveira AL, Verinaud L Tags: CNS Neurosci Ther Source Type: research

Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats.
CONCLUSION: Sodium sulfide, a H2 S donor, presents protective effect on acute cerebral ischemia, and might be a promising therapeutic drug. PMID: 27160344 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 9, 2016 Category: Neuroscience Authors: Shi HQ, Zhang Y, Cheng MH, Fan BS, Tian JS, Yu JG, Chen B Tags: CNS Neurosci Ther Source Type: research

The Combination of Scopolamine and Psychostimulants for the Prevention of Severe Motion Sickness.
CONCLUSIONS: The optimal dose ratio of scopolamine and modafinil is 1:10. This combination is beneficial for motion sickness and can abolish the side effects of scopolamine. So, it might be a good replacement of scopolamine and d-amphetamine for severe motion sickness. PMID: 27160425 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 9, 2016 Category: Neuroscience Authors: Zhang LL, Liu HQ, Yu XH, Zhang Y, Tian JS, Song XR, Han B, Liu AJ Tags: CNS Neurosci Ther Source Type: research

The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
CONCLUSION: In sum, c-Cbl inhibits expression of LPS-stimulated proinflammatory cytokines and chemokines in microglia. We demonstrate an unprecedented role for c-Cbl in microglia-mediated neuroinflammation involving PI3K/Akt/NF-κB pathway. PMID: 27156691 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 9, 2016 Category: Neuroscience Authors: Dong L, Li YZ, An HT, Wang YL, Chen SH, Qian YJ, Wang K, Zhen JL, Fan Z, Gong XL, Zheng Y, Wang XM Tags: CNS Neurosci Ther Source Type: research

Recommendations of French Alcohol Society and European Federation of Addiction Societies.
PMID: 27139924 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2016 Category: Neuroscience Authors: Braillon A Tags: CNS Neurosci Ther Source Type: research

Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice.
CONCLUSIONS: These results suggest that factors released from MSC mitigate the morphological and functional abnormalities in the PNS that are observed in SCA1-KI mice in a paracrine manner. PMID: 27140210 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2016 Category: Neuroscience Authors: Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H Tags: CNS Neurosci Ther Source Type: research

Catastrophic Magnetic Resonance Images in the Central Nervous System of Patients Undergoing Treatment with Fingolimod.
PMID: 27140433 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2016 Category: Neuroscience Authors: Fragoso YD, Sato HK Tags: CNS Neurosci Ther Source Type: research

7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease.
CONCLUSION: Taken together, these results indicate that DHF treatment may suppress the accumulation of α-synuclein and oxidative stress via activating TrkB and subsequently block the loss of dopaminergic neurons in the SN and striatum, thereby ameliorating MPTP-induced motor deficits in the C57BL/6 mice. PMID: 27079181 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: Li XH, Dai CF, Chen L, Zhou WT, Han HL, Dong ZF Tags: CNS Neurosci Ther Source Type: research

Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration.
CONCLUSION: Our study reveals a dynamic remodeling of the ER-mitochondria interface underlying neuritic degeneration. PMID: 27080255 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: Bao FX, Shi HY, Long Q, Yang L, Wu Y, Ying ZF, Qin DJ, Zhang J, Guo YP, Li HM, Liu XG Tags: CNS Neurosci Ther Source Type: research

Baseline Differences in Minor Lymphocyte Subpopulations may Predict Response to Fingolimod in Relapsing-Remitting Multiple Sclerosis Patients.
CONCLUSION: If confirmed in a bigger cohort of patients, analysis of percentages of minor lymphocyte subpopulations in peripheral blood of patients with RRMS prior and after +1 month of treatment might predict clinical response to fingolimod. PMID: 27080413 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: Teniente-Serra A, Hervás JV, Quirant-Sánchez B, Mansilla MJ, Grau-López L, Ramo-Tello C, Martínez-Cáceres EM Tags: CNS Neurosci Ther Source Type: research

Central IGF-I Receptors in the Brain are Instrumental to Neuroprotection by Systemically Injected IGF-I in a Rat Model for Ischemic Stroke.
CONCLUSIONS: Systemically injected rhIGF-I passes the blood-brain barrier and protects neurons via IGF-I receptors in the brain in rats with an ischemic stroke. PMID: 27080541 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: De Geyter D, De Smedt A, Stoop W, De Keyser J, Kooijman R Tags: CNS Neurosci Ther Source Type: research

Successful Pain Management with Epidural Oxytocin.
acute;mez J, González-Hernández A PMID: 27080720 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: Condés-Lara M, Zayas-González H, Manzano-García A, Córdova-Quiroz E, Granados-Mortera J, García-Cuevas M, Morales-Gómez J, González-Hernández A Tags: CNS Neurosci Ther Source Type: research

Dync1h1 Mutation Causes Proprioceptive Sensory Neuron Loss and Impaired Retrograde Axonal Transport of Dorsal Root Ganglion Neurons.
CONCLUSION: The Swl/Swl mutation of Dync1h1 gene led to embryonic mal-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid- to late-developmental stages. The underlying mechanism of the mutation may not be due to impaired homodimerization of DYNC1H1. PMID: 27080913 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 15, 2016 Category: Neuroscience Authors: Zhao J, Wang Y, Xu H, Fu Y, Qian T, Bo D, Lu YX, Xiong Y, Wan J, Zhang X, Dong Q, Chen XJ Tags: CNS Neurosci Ther Source Type: research

Head Transplants and Personal Identity: A Philosophical and Literary Survey.
Abstract The criterion of personal identity is clearly called into question by the project to perform a human head transplant. Is identity provided by psychological continuity alone, or does it depend on bodily continuity as well? And how do these different perspectives interface with our notion of mind and mind-body relationship? The reader will be provided with a discussion concerning these problems, together with a philosophical and literary survey about the conception of body-mind relationship from the Greek thought to contemporary philosophy. The analysis will conclude with a discussion concerning the possibi...
Source: CNS Neuroscience and Therapeutics - March 25, 2016 Category: Neuroscience Authors: Mori G Tags: CNS Neurosci Ther Source Type: research

Cortical Microvascularization in Moyamoya Disease: Characteristics and the Relations with Surgical Outcomes of Encephaloduroarteriosynangiosis.
PMID: 27000480 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 25, 2016 Category: Neuroscience Authors: Wang H, Wu H, Han C, Zhang ZS, Xian P, Zhao F, Zong R, Li DS, Bao XY, Liu B, Duan L Tags: CNS Neurosci Ther Source Type: research

MiR-150 Regulates Poststroke Cerebral Angiogenesis via Vascular Endothelial Growth Factor in Rats.
CONCLUSIONS: Our data suggested that miR-150 could regulate cerebral poststroke angiogenesis in rats through VEGF. PMID: 26922365 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 28, 2016 Category: Neuroscience Authors: He QW, Li Q, Jin HJ, Zhi F, Suraj B, Zhu YY, Xia YP, Mao L, Chen XL, Hu B Tags: CNS Neurosci Ther Source Type: research

Atomoxetine Increased Effect over Time in Adults with Attention-Deficit/Hyperactivity Disorder Treated for up to 6 Months: Pooled Analysis of Two Double-Blind, Placebo-Controlled, Randomized Trials.
Abstract INTRODUCTION: Changes in the magnitude of efficacy throughout 26 weeks of atomoxetine treatment, along with impact of dosing, were evaluated in adults with ADHD from two randomized, double-blind, placebo-controlled studies. AIMS: Pooled placebo (n = 485) and atomoxetine (n = 518) patients, dosed 25, 40, 60, 80 (target dose), or 100 mg daily, were assessed. Change from baseline in Conners' Adult ADHD Rating Scale-Investigator Rated Scale: Screening Version (CAARS) total ADHD symptoms score and Adult ADHD Investigator Symptom Rating Scale (AISRS) total score were analyzed using mixed-model repeated mea...
Source: CNS Neuroscience and Therapeutics - February 28, 2016 Category: Neuroscience Authors: Wietecha LA, Clemow DB, Buchanan AS, Young JL, Sarkis EH, Findling RL Tags: CNS Neurosci Ther Source Type: research

Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.
CONCLUSION: The MTLE mouse model displays a differential sensitivity to AEDs with a greater efficacy of drug that facilitates GABAergic transmission. This model provides an efficient tool to identify new treatment for drug-resistant forms of focal epilepsies. PMID: 26899987 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 22, 2016 Category: Neuroscience Authors: Duveau V, Pouyatos B, Bressand K, Bouyssières C, Chabrol T, Roche Y, Depaulis A, Roucard C Tags: CNS Neurosci Ther Source Type: research

Amiloride Analogs as ASIC1a Inhibitors.
CONCLUSION: Addition of a benzyl group to the terminal guanidinyl group resulted in enhanced inhibitory activity on ASIC1a. On the other hand, the bulky groups added to the 5-amino residues slightly decreased the activity. Among the tested amiloride analogs, benzamil is the most potent ASIC1a inhibitor. PMID: 26890278 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 18, 2016 Category: Neuroscience Authors: Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG Tags: CNS Neurosci Ther Source Type: research

Spinal Cord Stimulation and Augmentative Control Strategies for Leg Movement after Spinal Paralysis in Humans.
Abstract Severe spinal cord injury is a devastating condition, tearing apart long white matter tracts and causing paralysis and disability of body functions below the lesion. But caudal to most injuries, the majority of neurons forming the distributed propriospinal system, the localized gray matter spinal interneuronal circuitry, and spinal motoneuron populations are spared. Epidural spinal cord stimulation can gain access to this neural circuitry. This review focuses on the capability of the human lumbar spinal cord to generate stereotyped motor output underlying standing and stepping, as well as full weight-bear...
Source: CNS Neuroscience and Therapeutics - February 18, 2016 Category: Neuroscience Authors: Minassian K, Hofstoetter US Tags: CNS Neurosci Ther Source Type: research

The Spark of Life: Engaging the Cortico-Truncoreticulo-Propriospinal Pathway by Electrical Stimulation.
PMID: 26888177 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2016 Category: Neuroscience Authors: Canavero S, Ren XP Tags: CNS Neurosci Ther Source Type: research

The Age of Head Transplants.
PMID: 26888325 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2016 Category: Neuroscience Authors: Ren XP Tags: CNS Neurosci Ther Source Type: research

Central Pain Following Cord Severance for Cephalosomatic Anastomosis.
Abstract One of the key obstacles to a successful head transplant is the possible onset of central pain, a chronic pain condition that would impair the quality of life of the transplantee. In this review, we provide the reader with a knowledge of this neglected aspect of the head transplant initiative and outline the management should this eventuality occur. PMID: 26880305 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 16, 2016 Category: Neuroscience Authors: Canavero S, Bonicalzi V Tags: CNS Neurosci Ther Source Type: research

Detecting Change over Time: A Comparison of the SLUMS Examination and the MMSE in Older Adults at Risk for Cognitive Decline.
Abstract AIMS: To directly compare the 1-year stability of Mini-Mental State Examination (MMSE) score and Saint Louis University Mental Status (SLUMS) examination score and correlate score changes with demographic variables, clinical factors, and functional domains. METHODS: A sample of 304 study participants was recruited from residential and clinical settings in Ohio. Follow-up assessments were administered after 1 year with a retention rate of 92% (n = 281). Functional domains included the Instrumental Activities of Daily Living (IADL) scale. RESULTS: MMSE and SLUMS scores correlated with each other (r = 0.65, P
Source: CNS Neuroscience and Therapeutics - February 10, 2016 Category: Neuroscience Authors: Howland M, Tatsuoka C, Smyth KA, Sajatovic M Tags: CNS Neurosci Ther Source Type: research

Morphological Changes of Cortical and Hippocampal Neurons after Treatment with VEGF and Bevacizumab.
CONCLUSION: Therefore, bevacizumab obviously has a cytotoxic effect in cortical cultures and decreases the dendritic length in hippocampal neurons after long-term treatment. PMID: 26861512 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2016 Category: Neuroscience Authors: Latzer P, Schlegel U, Theiss C Tags: CNS Neurosci Ther Source Type: research

DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons.
CONCLUSIONS: The slow conversion of DopAmide to l-DOPA provides a sustained level of DA in the dopaminergic cells, shown by the long 6-OHDA steady rotations. The water solubility and improved bioavailability may help reduce medication frequency associated with l-DOPA treatment of PD. Sustained levels of DA might lower the super-sensitization of DA signaling and potentially attenuate l-DOPA adverse effects. PMID: 26861609 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2016 Category: Neuroscience Authors: Atlas D Tags: CNS Neurosci Ther Source Type: research

DT(270-326) , a Truncated Diphtheria Toxin, Increases Blood-Tumor Barrier Permeability by Upregulating the Expression of Caveolin-1.
CONCLUSIONS: DT(270-326) might provide a novel strategy to increase the delivery of macromolecular therapeutic agents across the BTB. PMID: 26861687 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 10, 2016 Category: Neuroscience Authors: Lin Y, Wang P, Liu YH, Shang XL, Chen LY, Xue YX Tags: CNS Neurosci Ther Source Type: research

Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity.
CONCLUSION: SOMCL-668, a novel allosteric modulator of sigma-1 receptors, elicits a potent and rapid acting antidepressant effect. The present data provide the first evidence that allosteric modulation of sigma-1 receptors may represent a new approach for antidepressant drug discovery. PMID: 26854125 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 8, 2016 Category: Neuroscience Authors: Wang Y, Guo L, Jiang H, Zheng L, Zhang A, Zhen X Tags: CNS Neurosci Ther Source Type: research

Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation.
CONCLUSIONS: Our results have revealed a novel role of ATP13A2 in modulating astrocyte-mediated neuroinflammation via NLRP3 inflammasome activation, thus bringing to light of a direct link between astrocyte lysosome and neuroinflammation in the pathological model of PD. PMID: 26848562 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 5, 2016 Category: Neuroscience Authors: Qiao C, Yin N, Gu HY, Zhu JL, Ding JH, Lu M, Hu G Tags: CNS Neurosci Ther Source Type: research

Increased Plasma S100β Level in Patients with Major Depressive Disorder.
Increased Plasma S100β Level in Patients with Major Depressive Disorder. CNS Neurosci Ther. 2016 Feb 5; Authors: Fang Y, Xiao SF, Zhang SY, Qiu Q, Wang T, Li X PMID: 26848720 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 5, 2016 Category: Neuroscience Authors: Fang Y, Xiao SF, Zhang SY, Qiu Q, Wang T, Li X Tags: CNS Neurosci Ther Source Type: research

Functional Connectivity of Vim Nucleus in Tremor- and Akinetic-/Rigid-Dominant Parkinson's Disease.
CONCLUSIONS: This study demonstrates that the Vim nucleus has an important role in the tremor-related network, but not in the akinetic-/rigid-related network. Our finding is helpful to explain the selective effect of Vim deep brain stimulation in PD. PMID: 26849713 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 5, 2016 Category: Neuroscience Authors: Zhang JR, Feng T, Hou YN, Chan P, Wu T Tags: CNS Neurosci Ther Source Type: research

Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects.
Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects. CNS Neurosci Ther. 2016 Feb 5; Authors: Sramek JJ, Hardy LW, Bieck P, Zamora C, Versavel M, Kharidia J, Grinnell T, Chen YL, Sullivan M, Ding H, Cutler NR Abstract INTRODUCTION: SEP-432 is a triple monoamine reuptake inhibitor of norepinephrine (NE), serotonin (5-HT), and dopamine (DA), based on in vitro binding studies. We sought evidence that SEP-432 engages these monoamine systems by measuring concentrations of monoamines and/or their main met...
Source: CNS Neuroscience and Therapeutics - February 5, 2016 Category: Neuroscience Authors: Sramek JJ, Hardy LW, Bieck P, Zamora C, Versavel M, Kharidia J, Grinnell T, Chen YL, Sullivan M, Ding H, Cutler NR Tags: CNS Neurosci Ther Source Type: research

Comparison of Antiepileptic Approaches in Treatment of Benzodiazepine Nonresponsive Status Epilepticus.
CONCLUSION: Our data support the use of the modern antiepileptic treatment strategies, such as levetiracetam, valproic acid, and lacosamide in the treatment of status epilepticus and seizure clusters. PMID: 26841716 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Bachhuber A, Lasrich M, Halmer R, Fassbender K, Walter S Tags: CNS Neurosci Ther Source Type: research

Increased Expression of Transient Receptor Potential Vanilloid 4 in Cortical Lesions of Patients with Focal Cortical Dysplasia.
CONCLUSION: The overexpression and altered cellular distribution of TRPV4 in FCD suggest that TRPV4 may potentially contribute to the epileptogenesis of FCD. PMID: 26842013 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Chen X, Sun FJ, Wei YJ, Wang LK, Zang ZL, Chen B, Li S, Liu SY, Yang H Tags: CNS Neurosci Ther Source Type: research

Expression Profile of Long Noncoding RNAs in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients.
CONCLUSIONS: We identified a subset of dysregulated lncRNAs and mRNAs. The differentially expressed lncRNAs may be important in the process of MS. However, the specific molecular mechanisms and biological functions of these lncRNAs in the pathogenesis of MS need further study. PMID: 26842313 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Zhang F, Gao C, Ma X, Peng X, Zhang R, Kong D, Simard AR, Hao J Tags: CNS Neurosci Ther Source Type: research

Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats.
Abstract OBJECTIVES: Dynamically observe cerebral vascular changes in hyperglycemic rats in vivo and explore the effect of diabetes on endothelial function after ischemic stroke. BACKGROUND: Diabetes affects both large and small vessels in the brain, but the dynamic process and mechanism are unclear. METHODS: We investigated the structural and functional changes of brain vasculature in living hyperglycemic rats and their impact on stroke outcomes via a novel technique: synchrotron radiation angiography. We also examined the effect of prolonged fasudil treatment on arterial reactivity and hemorrhagic...
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Mu ZH, Jiang Z, Lin XJ, Wang LP, Xi Y, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus.
an CV Abstract BACKGROUND: Exportin 1 (XPO1/CRM1) plays prominent roles in the regulation of nuclear protein export. Selective inhibitors of nuclear export (SINE) are small orally bioavailable molecules that serve as drug-like inhibitors of XPO1, with potent anti-cancer properties. Traumatic brain injury (TBI) presents with a secondary cell death characterized by neuroinflammation that is putatively regulated by nuclear receptors. AIMS AND RESULTS: Here, we report that the SINE compounds (KPT-350 or KPT-335) sequestered TBI-induced neuroinflammation-related proteins (NF-k B, AKT, FOXP1) within the nucleus of ...
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, Carlson R, Shacham S, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction.
CONCLUSION: Hyperglycemia enhances APP expression with increased Aβ production, which downregulates junctional proteins causing increased intercellular permeability in ECs. PMID: 26842741 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Chao AC, Lee TC, Juo SH, Yang DI Tags: CNS Neurosci Ther Source Type: research

The Neural Basis of Postural Instability Gait Disorder Subtype of Parkinson's Disease: A PET and fMRI Study.
CONCLUSION: The involvement of the caudate, FG, and prefrontal-parietal network may be associated with the prominent gait impairments of PIGD subtype. Our findings expand the pathophysiological knowledge of PIGD subtype and provide valuable information for potential neuromodulation therapies alleviating gait disorders. PMID: 26842842 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Zhang L, Li TN, Yuan YS, Jiang SM, Tong Q, Wang M, Wang JW, Chen HJ, Ding J, Xu QR, Zhang KZ Tags: CNS Neurosci Ther Source Type: research

The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination.
CONCLUSION: The cannabinoid agonist WIN55212.2 promotes oligodendrocyte differentiation in vitro. Moreover, 0.5 mg/kg of the drug confers neuroprotection during cuprizone-induced demyelination, while 1 mg/kg aggravates the demyelination process. PMID: 26842941 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Tomas-Roig J, Wirths O, Salinas-Riester G, Havemann-Reinecke U Tags: CNS Neurosci Ther Source Type: research

Effect of Acupuncture on the Motor and Nonmotor Symptoms in Parkinson's Disease-A Review of Clinical Studies.
Abstract Parkinson's disease is a neurodegenerative disorder. Parkinson's clinical feature is characterized by its motor manifestations, although its many nonmotor symptoms occur earlier and have more profound impact on the quality of patient's life. Acupuncture has been increasingly popular and has been used to treat patients with Parkinson's. In this article, we have studied the clinical reports of acupuncture treatment for Parkinson's, which were listed in Medline, PubMed, EMBASE, CNKI, and CINAHL databases in the past 15 years. It was found that acupuncture either manual or electroacupuncture stimulation ...
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Zeng BY, Zhao K Tags: CNS Neurosci Ther Source Type: research

Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.
CONCLUSION: Our findings rule out the involvement of S100B/mRAGE axis in striatal reactive gliosis, DAergic axonopathy and warrant further exploration of its neurotrophic effects in a presymptomatic compensatory PD stage, which is a fundamental period for successful implementation of therapeutic strategies. PMID: 26843141 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Viana SD, Fernandes RC, Canas PM, Silva AM, Carvalho F, Ali SF, Fontes Ribeiro CA, Pereira FC Tags: CNS Neurosci Ther Source Type: research

Orosomucoid (ORM) as a Potential Biomarker for the Diagnosis of Chronic Fatigue Syndrome (CFS).
PMID: 26833758 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 2, 2016 Category: Neuroscience Authors: Sun Y, Zhang ZX, Liu X Tags: CNS Neurosci Ther Source Type: research

Novel Translational Approaches for Improving Drug Discovery Efforts in Chronic Pain.
PMID: 26778453 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 21, 2016 Category: Neuroscience Authors: Munro G Tags: CNS Neurosci Ther Source Type: research

Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury.
CONCLUSION: These results indicate a trajectory-dependent injury characterized by exacerbation of inflammation and different levels of impaired cell proliferation and neurogenesis. Such multiple brain areas showing varying levels of cell death after region-specific CCI model may closely mimic the clinical manifestations of TBI. PMID: 26775604 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Pabón MM, Acosta S, Guedes VA, Tajiri N, Kaneko Y, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen.
CONCLUSIONS: Altogether, these results suggest that disruption of astroglial AOGEN synthesis leads to cardiovascular, cognitive, behavioral, and sleep disorders that might be partly due to LC dysfunction. PMID: 26775713 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2016 Category: Neuroscience Authors: Ogier M, Bricca G, Bader M, Bezin L Tags: CNS Neurosci Ther Source Type: research