Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR < sub > 2 < /sub > /SRC pathway in vascular cognitive impairment mice
CONCLUSION: Hyperforin effectively modulated microglial M1 polarization and neuroinflammation by inhibiting the VEGFR2 /SRC signaling pathways, thereby ameliorating WMLs and cognitive impairment in VCI mice.PMID:38468126 | DOI:10.1111/cns.14666 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xin Gao Jingjing Chen Ge Yin Yanqun Liu Zhengsheng Gu Rui Sun Xu Sun Xuehao Jiao Ling Wang Nuo Wang Yanbo Zhang Yuting Kan Xiaoying Bi Bingying Du Source Type: research
Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure
CONCLUSIONS: Our study identifies LA microglial activation as a critical mediator of noise-induced anxiety-like behaviors, leading to neuronal and behavioral changes through selective synapse phagocytosis. Our results highlight the pivotal but previously unrecognized roles of LA microglia in chronic moderate noise-induced behavioral changes.PMID:38468130 | DOI:10.1111/cns.14674 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xiaoqi Peng Yunfeng Mao Yehao Liu Qian Dai Yingju Tai Bin Luo Yue Liang Ruirui Guan Wenjie Zhou Lin Chen Zhi Zhang Guoming Shen Haitao Wang Source Type: research
CD4 < sup > + < /sup > CD11b < sup > + < /sup > T cells infiltrate and aggravate the traumatic brain injury depending on brain-to-cervical lymph node signaling
CONCLUSION: The infiltration of CD4+ CD11b+ T cells exacerbates secondary brain damage in TBI, and this process is modulated by brain-to-CLN signaling.PMID:38468459 | DOI:10.1111/cns.14673 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Weiwei Jiang Xuanhui Liu Yupeng Chen Mingqi Liu Jiangyuan Yuan Meng Nie Yibing Fan Di Wu Yu Qian Zhuang Sha Shiying Dong Chenrui Wu Tao Liu Jinhao Huang Jianning Zhang Chuang Gao Rongcai Jiang Source Type: research
Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma
CONCLUSIONS: This investigation underscores that EVsPDPN derived from glioblastoma cells contributes to M2 macrophage-mediated immunosuppression and is a potential prognostic marker and therapeutic target in glioblastoma.PMID:38470096 | DOI:10.1111/cns.14643 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Mengwan Wu Ying Shi Yuyang Liu Hongxiang Huang Jiajia Che Jing Shi Chuan Xu Source Type: research
Retraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010)
CNS Neurosci Ther. 2024 Mar;30(3):e14667. doi: 10.1111/cns.14667.ABSTRACTRetraction: Abdallah MS, Ramadan AN, Omara-Reda H, et al. Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder. CNS Neurosci. Ther. 2021;27:1540-1548 (https://doi.org/10.1111/cns.13731) The above article, published online on September 21, 2021 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the journal's Editor-in-Chief, Xiaoming Hu, and John Wiley and Sons Ltd. Following publicatio...
Source: CNS Neuroscience and Therapeutics - March 11, 2024 Category: Neuroscience Source Type: research
Retraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010)
CNS Neurosci Ther. 2024 Mar;30(3):e14668. doi: 10.1111/cns.14668.ABSTRACTRetraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010) The above article, published online on November 07, 2022 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the journal's Editor-in-Chief, Xiaoming Hu, and John Wiley and Sons Ltd. Following publication, the Editor-in-Chief raised concerns about t...
Source: CNS Neuroscience and Therapeutics - March 11, 2024 Category: Neuroscience Source Type: research
Retraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010)
CNS Neurosci Ther. 2024 Mar;30(3):e14667. doi: 10.1111/cns.14667.ABSTRACTRetraction: Abdallah MS, Ramadan AN, Omara-Reda H, et al. Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder. CNS Neurosci. Ther. 2021;27:1540-1548 (https://doi.org/10.1111/cns.13731) The above article, published online on September 21, 2021 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the journal's Editor-in-Chief, Xiaoming Hu, and John Wiley and Sons Ltd. Following publicatio...
Source: CNS Neuroscience and Therapeutics - March 11, 2024 Category: Neuroscience Source Type: research
Retraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010)
CNS Neurosci Ther. 2024 Mar;30(3):e14668. doi: 10.1111/cns.14668.ABSTRACTRetraction: Abdallah MS, Mosalam EM, Hassan A, et al. Pentoxifylline as an adjunctive in treatment of negative symptoms in chronic schizophrenia: A double-blind, randomized, placebo-controlled trial. CNS Neurosci. Ther. 2023;29:354-364 (https://doi.org/10.1111/cns.14010) The above article, published online on November 07, 2022 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the journal's Editor-in-Chief, Xiaoming Hu, and John Wiley and Sons Ltd. Following publication, the Editor-in-Chief raised concerns about t...
Source: CNS Neuroscience and Therapeutics - March 11, 2024 Category: Neuroscience Source Type: research
The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases
CONCLUSION: The cGAS-STING signaling plays an important role in the pathogenesis of NDs. Inhibiting the cGAS-STING signaling may provide new measures in the treatment of NDs.PMID:38459658 | PMC:PMC10924111 | DOI:10.1111/cns.14671 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Xiaofeng Guo Lin Yang Jiawei Wang You Wu Yi Li Lixia Du Ling Li Zongping Fang Xijing Zhang Source Type: research
The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography
CONCLUSION: The study results show multiple factors are linked with PD assessment. Moreover, the inflammatory marker Cys C and transcranial sonography measurement could objectively predict PD symptom severity, helping doctors monitor PD evolution in patients while targeting interventions.PMID:38459662 | PMC:PMC10924109 | DOI:10.1111/cns.14670 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Yue Lu Wenwen Dong Xingya Xue Jian Sun Jiuqi Yan Xiang Wei Lei Chang Liang Zhao Bei Luo Chang Qiu Wenbin Zhang Source Type: research
Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system
CONCLUSIONS: In brief, these findings suggest that fingolimod alleviates whole-brain inflammation and GS system damage after DBI and that inhibiting the GS could weaken the positive effect of fingolimod on nerve function in rats with DBI. Thus, inhibiting inflammation and regulating the GS may be critical for the therapeutic effect of fingolimod on DBI.PMID:38459666 | PMC:PMC10924110 | DOI:10.1111/cns.14669 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Dongyi Feng Tao Liu Xinjie Zhang Tangtang Xiang Wanqiang Su Wei Quan Rongcai Jiang Source Type: research
The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases
CONCLUSION: The cGAS-STING signaling plays an important role in the pathogenesis of NDs. Inhibiting the cGAS-STING signaling may provide new measures in the treatment of NDs.PMID:38459658 | DOI:10.1111/cns.14671 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Xiaofeng Guo Lin Yang Jiawei Wang You Wu Yi Li Lixia Du Ling Li Zongping Fang Xijing Zhang Source Type: research
The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography
CONCLUSION: The study results show multiple factors are linked with PD assessment. Moreover, the inflammatory marker Cys C and transcranial sonography measurement could objectively predict PD symptom severity, helping doctors monitor PD evolution in patients while targeting interventions.PMID:38459662 | DOI:10.1111/cns.14670 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Yue Lu Wenwen Dong Xingya Xue Jian Sun Jiuqi Yan Xiang Wei Lei Chang Liang Zhao Bei Luo Chang Qiu Wenbin Zhang Source Type: research
Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system
CONCLUSIONS: In brief, these findings suggest that fingolimod alleviates whole-brain inflammation and GS system damage after DBI and that inhibiting the GS could weaken the positive effect of fingolimod on nerve function in rats with DBI. Thus, inhibiting inflammation and regulating the GS may be critical for the therapeutic effect of fingolimod on DBI.PMID:38459666 | DOI:10.1111/cns.14669 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Dongyi Feng Tao Liu Xinjie Zhang Tangtang Xiang Wanqiang Su Wei Quan Rongcai Jiang Source Type: research
Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data
CONCLUSIONS: The increase in H3K9ac appears to enhance the recruitment of the transcription factor SP1 to its binding sites within the MGMT locus, consequently upregulating MGMT expression and driving TMZ resistance in GBM.PMID:38448295 | PMC:PMC10917648 | DOI:10.1111/cns.14649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 6, 2024 Category: Neuroscience Authors: Liguo Ye Lingui Gu Yaning Wang Hao Xing Pengtao Li Xiaopeng Guo Yu Wang Wenbin Ma Source Type: research
