Sleep and APOE- ε4 have a synergistic effect on plasma biomarkers and longitudinal cognitive decline in older adults
CONCLUSION: Our study highlights sleep disorder was associated with cognitive decline, with plasma NfL playing a partial mediating role. These findings explain how sleep disorders affect cognitive function and emphasize the importance of healthy sleep for older adults.PMID:38421124 | DOI:10.1111/cns.14558 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Xianfeng Yu Xia Zhou Zhengbo He Beiqi He Ke Wan Min Wei Tengfei Guo Ying Han Source Type: research
Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women
CONCLUSION: We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation-evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.PMID:38421125 | DOI:10.1111/cns.14584 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Hongxiu Chen Liuping Cui Songwei Chen Ran Liu Xijuan Pan Fubo Zhou Yingqi Xing Source Type: research
Associations between impulsivity and fecal microbiota in individuals abstaining from methamphetamine
CONCLUSION: Our findings potentially highlighted the importance of abstention and implicated the significant role of the microbiota-gut-brain axis in the interrelationship between microbiota and behaviors, as well as the potential of microbiota as a target for intervention of impulsivity.PMID:38421126 | DOI:10.1111/cns.14580 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Wen Liu Linzi Liu Zijing Deng Ruina Liu Tao Ma Yide Xin Yu Xie Yifang Zhou Yanqing Tang Source Type: research
Effects of noninvasive neuromodulation targeting the spinal cord on early learning of force control by the digits
CONCLUSIONS: Our findings provide insights into how the state of the corticospinal system can be leveraged to drive early motor skill learning, further emphasizing individual differences in the response to noninvasive neuromodulation. We interpret these findings in the context of biological mechanisms underlying the observed effects and implications for emerging therapeutic applications.PMID:38421127 | DOI:10.1111/cns.14561 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Michael A Urbin Charley W Lafe Manuel E Bautista George F Wittenberg Tyler W Simpson Source Type: research
Polysomnographic features associated with clonazepam and melatonin treatment in isolated REM sleep behavior disorder: Time for new therapeutic approaches?
CONCLUSION: These results suggest that the administration of MLT or CLO impacts (positively) on sleep parameters of iRBD patients. However, there is a need to better stratify patients, in order to treat them in a targeted manner, depending on the patient's individual sleep architecture and expected differential effects of these agents.PMID:38421131 | DOI:10.1111/cns.14569 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Maria P Mogavero Raffaele Ferri Sara Marelli Giuseppe Lanza Michele Terzaghi Alessandra Castelnuovo Lourdes M DelRosso Carlos H Schenck Luigi Ferini-Strambi Source Type: research
Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function
CONCLUSIONS: Our study demonstrated that pain sensitivity is associated with genetic background and Rnf20-mediated PI3K-Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.PMID:38421132 | DOI:10.1111/cns.14557 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Fuyi Xu Anran Chen Shuijing Pan Yingying Wu Hongjie He Zhe Han Lu Lu Buyan-Ochir Orgil XiaoDong Chi Cunhua Yang Shushan Jia Cuicui Yu Jia Mi Source Type: research
Serum response factor promoting axonal regeneration by activating the Ras-Raf-Cofilin signaling pathway after the spinal cord injury
CONCLUSION: Based on our research, the SRF promotes axonal regeneration by activating the "Ras-Raf-Cofilin" signaling pathway.PMID:38421133 | DOI:10.1111/cns.14585 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Limin Gao Chen Zhang Yonglin Zhu Naili Zhang Chunlei Zhang Shuai Zhou Guoying Feng Fei Huang Luping Zhang Source Type: research
Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease
CONCLUSION: Decreased stride length was the earliest characteristic of GD in CSVD. Structural and functional regulation of the left cerebellum VIIIb could play a particularly important role in early GD in CSVD.PMID:38421136 | DOI:10.1111/cns.14545 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yuting Mo Biying Ji Zhihong Ke Chenglu Mao Jialiu Jiang Yanan Huang Ruomeng Qin Lili Huang Dan Yang Zheqi Hu Yun Xu Source Type: research
Late-time window endovascular treatment is associated with neurological improvement: Evidence from the National Stroke Registry Data in China
CNS Neurosci Ther. 2024 Feb;30(2):e14572. doi: 10.1111/cns.14572.NO ABSTRACTPMID:38421137 | DOI:10.1111/cns.14572 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Jing Yuan Z Kevin Lu Minghui Li Jingwen Bai Long-De Wang Renyu Liu Jing Zhao Source Type: research
Prediction of early bladder outcomes after spinal cord injury: The HALT score
CONCLUSION: Two reliable models, the HALT score and the H-reflex, were developed to predict bladder outcomes as early as 3 months after SCI onset. Importantly, this study provides hitherto undocumented evidence regarding the predictive significance of the soleus H-reflex in relation to bladder outcomes in SCI patients.PMID:38421138 | DOI:10.1111/cns.14628 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Xiangbo Wu Xiao Xi Mulan Xu Ming Gao Ying Liang Miaoqiao Sun Xu Hu Li Mao Xingkai Liu Chenguang Zhao Xiaolong Sun Hua Yuan Source Type: research
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPAR γ/NF-κB signaling pathway
CONCLUSIONS: PA is expected to provide a valuable candidate for new drug development for AD in the future.PMID:38421141 | DOI:10.1111/cns.14581 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Tan Zhao Jianping Jia Source Type: research
Neonatal stress disrupts the glymphatic system development and increases the susceptibility to Parkinson's disease in later life
CONCLUSION: The results demonstrated that NMD could disrupt the development of the glymphatic system through PDGF-B signaling and increase the risk of PD later in life, indicating that alleviating neonatal stress could be beneficial in protecting the glymphatic system and reducing susceptibility to neurodegeneration.PMID:38421142 | DOI:10.1111/cns.14587 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Jian Song Zhen-Hua Li Xin-Yu Xue Jing-Cai Meng Wen-Xin Zhu Shufen Hu Guang-Yin Xu Lin-Hui Wang Source Type: research
Thymoma-associated autoimmune encephalitis with myasthenia gravis: Case series and literature review
CONCLUSIONS: There was no significant difference in the clinical manifestations between these patients and others with only TAMG or TAAE. TAAE was commonly associated with AMPAR2-Ab. Significantly, AE more commonly heralded thymoma recurrences than MG onset. And the intervals of thymectomy and MG or AE onset had different meanings for thymoma recurrence and prognoses of patients.PMID:38421083 | DOI:10.1111/cns.14568 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Miao Su Qiuyan Luo Zichao Wu Huiyu Feng Hongyan Zhou Source Type: research
Activation of testosterone-androgen receptor mediates cerebrovascular protection by photobiomodulation treatment in photothrombosis-induced stroke rats
CONCLUSIONS: Our study provides evidence that PBMT attenuates cerebrovascular injury and behavioral deficits associated with testosterone/AR following ischemic stroke. Our findings suggest that PBMT may be a promising alternative approach for managing cerebrovascular diseases.PMID:38421088 | DOI:10.1111/cns.14574 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yu Feng Zhihai Huang Xiaohui Ma Xuemei Zong Celeste Yin-Chieh Wu Reggie Hui-Chao Lee Hung Wen Lin Michael R Hamblin Quanguang Zhang Source Type: research
Absence in CX3CR1 receptor signaling promotes post-ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
CONCLUSION: Our study demonstrated that CX3CR1 gene deletion was beneficial to PSCI recovery. The mechanism might lie in inhibited pyroptosis and enhanced neurogenesis. CX3CR1 receptor may serve as a therapeutic target for improving the PSCI.PMID:38421089 | DOI:10.1111/cns.14551 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yangyang Ge Juexi Yang Jiayi Chen Maosha Dai Xiaoke Dou Shanglong Yao Chenye Yao Yun Lin Source Type: research
