Targeting blood brain barrier-Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats
CONCLUSION: Chronic RIC intervention exerts vascular and neuroprotective roles, suggesting that RIC could be a promising therapeutic strategy targeting the BBB and NVU during AD development.PMID:38379185 | PMC:PMC10879645 | DOI:10.1111/cns.14613 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Yuxuan Ma Wuxiang Sun Jing Bai Fujia Gao Haoran Ma Huiyu Liu Jiewei Hu Chao Xu Xin Zhang Zixuan Liu Tao Yuan Chenxu Sun Yuanyuan Huang Ruimin Wang Source Type: research
Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery
CONCLUSION: Stroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post-stroke sleep disturbances, indicating its potential to promote stroke recovery.PMID:38380702 | PMC:PMC10880125 | DOI:10.1111/cns.14637 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Zhi-Gang Zhong Gui-Jin Tao Shu-Mei Hao Hui Ben Wei-Min Qu Feng-Yan Sun Zhi-Li Huang Mei-Hong Qiu Source Type: research
Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity
CONCLUSIONS: This study is the first to suggest that ANXA6 enhances synaptic plasticity and protects against transient cerebral ischemia.PMID:38380783 | PMC:PMC10880127 | DOI:10.1111/cns.14639 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Yilin Wang Zhenhong Yang Rongliang Wang Yangmin Zheng Ziping Han Junfen Fan Feng Yan Ping Liu Yumin Luo Source Type: research
Advancing stroke therapy: A deep dive into early phase of ischemic stroke and recanalization
CNS Neurosci Ther. 2024 Feb;30(2):e14634. doi: 10.1111/cns.14634.ABSTRACTIschemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis and mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application and patient-specific factors. This review focuses on the early phase pathophysiological mechanisms of ischemic stroke and the nuances of recanalization. It highlights the dual role of neutrophils in tissue damage and repair, and the critical involvem...
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Qianyan He Yueqing Wang Cheng Fang Ziying Feng Meifang Yin Juyang Huang Yinzhong Ma Zhizhun Mo Source Type: research
Targeting blood brain barrier-Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats
CONCLUSION: Chronic RIC intervention exerts vascular and neuroprotective roles, suggesting that RIC could be a promising therapeutic strategy targeting the BBB and NVU during AD development.PMID:38379185 | DOI:10.1111/cns.14613 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Yuxuan Ma Wuxiang Sun Jing Bai Fujia Gao Haoran Ma Huiyu Liu Jiewei Hu Chao Xu Xin Zhang Zixuan Liu Tao Yuan Chenxu Sun Yuanyuan Huang Ruimin Wang Source Type: research
Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery
CONCLUSION: Stroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post-stroke sleep disturbances, indicating its potential to promote stroke recovery.PMID:38380702 | DOI:10.1111/cns.14637 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Zhi-Gang Zhong Gui-Jin Tao Shu-Mei Hao Hui Ben Wei-Min Qu Feng-Yan Sun Zhi-Li Huang Mei-Hong Qiu Source Type: research
Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity
CONCLUSIONS: This study is the first to suggest that ANXA6 enhances synaptic plasticity and protects against transient cerebral ischemia.PMID:38380783 | DOI:10.1111/cns.14639 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Yilin Wang Zhenhong Yang Rongliang Wang Yangmin Zheng Ziping Han Junfen Fan Feng Yan Ping Liu Yumin Luo Source Type: research
The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression
CONCLUSION: We will provide insights into the prospects of leveraging eATP as a novel avenue for the treatment of depression.PMID:38375982 | PMC:PMC10877668 | DOI:10.1111/cns.14536 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 20, 2024 Category: Neuroscience Authors: Kaixin Wang Shiqian Huang Daan Fu Xinxin Yang Lulin Ma Tianhao Zhang Wenjing Zhao Daling Deng Yuanyuan Ding Yanyan Zhang Li Huang Xiangdong Chen Source Type: research
The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression
CONCLUSION: We will provide insights into the prospects of leveraging eATP as a novel avenue for the treatment of depression.PMID:38375982 | DOI:10.1111/cns.14536 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 20, 2024 Category: Neuroscience Authors: Kaixin Wang Shiqian Huang Daan Fu Xinxin Yang Lulin Ma Tianhao Zhang Wenjing Zhao Daling Deng Yuanyuan Ding Yanyan Zhang Li Huang Xiangdong Chen Source Type: research
Autonomic dysfunction and treatment strategies in intracerebral hemorrhage
CONCLUSION: The review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.PMID:38372446 | DOI:10.1111/cns.14544 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 19, 2024 Category: Neuroscience Authors: Kaijiang Kang Kaibin Shi Jiexin Liu Na Li Jianwei Wu Xingquan Zhao Source Type: research
Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice
CONCLUSION: In sum, the early accumulation of Aβ and Tau pathology induces neuroinflammation, which subsequently leads to a decrease in neuronal activity within the OB, causing axonal transport deficits that contribute to olfactory disorders. Nr4a2 and FosB appear to be promising targets for intervention aimed at improving early olfactory impairment in AD.PMID:38366763 | PMC:PMC10873683 | DOI:10.1111/cns.14632 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2024 Category: Neuroscience Authors: Haitao Yu Fangzhou Wang Dongdong Jia Shuguang Bi Juan Gong Jia-Jun Wu Yumin Mao Jia Chen Gao-Shang Chai Source Type: research
Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice
CONCLUSION: In sum, the early accumulation of Aβ and Tau pathology induces neuroinflammation, which subsequently leads to a decrease in neuronal activity within the OB, causing axonal transport deficits that contribute to olfactory disorders. Nr4a2 and FosB appear to be promising targets for intervention aimed at improving early olfactory impairment in AD.PMID:38366763 | PMC:PMC10873683 | DOI:10.1111/cns.14632 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2024 Category: Neuroscience Authors: Haitao Yu Fangzhou Wang Dongdong Jia Shuguang Bi Juan Gong Jia-Jun Wu Yumin Mao Jia Chen Gao-Shang Chai Source Type: research
Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice
CONCLUSION: In sum, the early accumulation of Aβ and Tau pathology induces neuroinflammation, which subsequently leads to a decrease in neuronal activity within the OB, causing axonal transport deficits that contribute to olfactory disorders. Nr4a2 and FosB appear to be promising targets for intervention aimed at improving early olfactory impairment in AD.PMID:38366763 | DOI:10.1111/cns.14632 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2024 Category: Neuroscience Authors: Haitao Yu Fangzhou Wang Dongdong Jia Shuguang Bi Juan Gong Jia-Jun Wu Yumin Mao Jia Chen Gao-Shang Chai Source Type: research
Phosphorylation of PBK at Thr9 by CDK5 correlates with invasion of prolactinomas
CONCLUSIONS: Phosphorylation of PBK at Thr9 by CDK5 promotes cell proliferation and EMT progression in prolactinomas.PMID:38363020 | PMC:PMC10870245 | DOI:10.1111/cns.14629 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 16, 2024 Category: Neuroscience Authors: Qiuyue Fang Changxiaofeng Liu Ding Nie Jing Guo Weiyan Xie Yazhuo Zhang Source Type: research
Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations
CONCLUSION: We successfully established transgenic zebrafish epileptic models expressing human mutant GABRG2(P282S), in which CBZ and VPA showed antiepileptic effects. Differential inflammatory responses, especially the SOCS/JAK/STAT signaling pathway, might be related to the phenotypes of genetic epilepsy induced by GABRG2 mutations. Further study will expand the pathological mechanisms of genetic epilepsies and provide a theoretical basis for searching for effective drug treatment.PMID:38357846 | PMC:PMC10867793 | DOI:10.1111/cns.14583 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 15, 2024 Category: Neuroscience Authors: Jiahui Sui Longwu Zhan Shengtao Ji Wenwen Wu Yuhan Chen Feng Yun Wenpeng Liang Jie Wang Maohong Cao Dingding Shen Qi Zhang Source Type: research
