Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations

CONCLUSION: We successfully established transgenic zebrafish epileptic models expressing human mutant GABRG2(P282S), in which CBZ and VPA showed antiepileptic effects. Differential inflammatory responses, especially the SOCS/JAK/STAT signaling pathway, might be related to the phenotypes of genetic epilepsy induced by GABRG2 mutations. Further study will expand the pathological mechanisms of genetic epilepsies and provide a theoretical basis for searching for effective drug treatment.PMID:38357846 | PMC:PMC10867793 | DOI:10.1111/cns.14583

Source: CNS Neuroscience and Therapeutics - February 15, 2024 Category: Neuroscience Authors: Jiahui Sui Longwu Zhan Shengtao Ji Wenwen Wu Yuhan Chen Feng Yun Wenpeng Liang Jie Wang Maohong Cao Dingding Shen Qi Zhang Source Type: research