Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice

CONCLUSION: In sum, the early accumulation of Aβ and Tau pathology induces neuroinflammation, which subsequently leads to a decrease in neuronal activity within the OB, causing axonal transport deficits that contribute to olfactory disorders. Nr4a2 and FosB appear to be promising targets for intervention aimed at improving early olfactory impairment in AD.PMID:38366763 | PMC:PMC10873683 | DOI:10.1111/cns.14632

Source: CNS Neuroscience and Therapeutics - February 17, 2024 Category: Neuroscience Authors: Haitao Yu Fangzhou Wang Dongdong Jia Shuguang Bi Juan Gong Jia-Jun Wu Yumin Mao Jia Chen Gao-Shang Chai Source Type: research