Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data
CONCLUSIONS: The increase in H3K9ac appears to enhance the recruitment of the transcription factor SP1 to its binding sites within the MGMT locus, consequently upregulating MGMT expression and driving TMZ resistance in GBM.PMID:38448295 | PMC:PMC10917648 | DOI:10.1111/cns.14649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 6, 2024 Category: Neuroscience Authors: Liguo Ye Lingui Gu Yaning Wang Hao Xing Pengtao Li Xiaopeng Guo Yu Wang Wenbin Ma Source Type: research
Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data
CONCLUSIONS: The increase in H3K9ac appears to enhance the recruitment of the transcription factor SP1 to its binding sites within the MGMT locus, consequently upregulating MGMT expression and driving TMZ resistance in GBM.PMID:38448295 | DOI:10.1111/cns.14649 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 6, 2024 Category: Neuroscience Authors: Liguo Ye Lingui Gu Yaning Wang Hao Xing Pengtao Li Xiaopeng Guo Yu Wang Wenbin Ma Source Type: research
Effect of the closed-loop hippocampal low-frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model
CONCLUSION: Applying closed-loop, low-frequency DBS at seizure onset reduced seizure severity and improved memory. In addition, the changes in power, coherence, and coupling of the LFP oscillations in the hippocampus and mPFC demonstrate low-frequency DBS efficacy as an antiepileptic treatment, returning LFPs to a seemingly non-seizure state in subjects that received DBS.PMID:38439573 | PMC:PMC10912795 | DOI:10.1111/cns.14656 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Meysam Zare Mahmoud Rezaei Milad Nazari Nastaran Kosarmadar Mona Faraz Victoria Barkley Amir Shojaei Mohammad Reza Raoufy Javad Mirnajafi-Zadeh Source Type: research
Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3 β pathway in depressed mice
CONCLUSION: This study establishes how ODEXs improve depressive-like behaviors and hippocampal neuroplasticity and might provide a promising therapeutic approach for depression.PMID:38439616 | PMC:PMC10912796 | DOI:10.1111/cns.14661 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Honghan Zhang Xin-Hui Xie Shu-Xian Xu Chao Wang Siqi Sun Xinhua Song Ruiling Li Ningyuan Li Yuqi Feng Hao Duan Di Li Zhongchun Liu Source Type: research
Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2
CONCLUSIONS: In epilepsy, Nrf2 modulates ferroptosis by involving the expression of FtMt and may be a potential therapeutic mechanism of neuronal injury after epilepsy. Targeting this relevant process for treatment may be a therapeutic strategy to prevent epilepsy.PMID:38439636 | PMC:PMC10912846 | DOI:10.1111/cns.14663 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Yu Song Mengjiao Gao Boyang Wei Xiaowei Huang Zeyu Yang Junjie Zou Yanwu Guo Source Type: research
Aberrant dynamic properties of whole-brain functional connectivity in acute mild traumatic brain injury revealed by hidden Markov models
CONCLUSIONS: Hidden Markov models provide additional information on the dynamic activity of brain networks in patients with acute mTBI and those with cognitive impairment. Our results suggest that brain network dynamics determined by the HMM could reinforce the understanding of the neuropathological mechanisms of acute mTBI patients and those with cognitive impairment.PMID:38439697 | PMC:PMC10912843 | DOI:10.1111/cns.14660 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Liyan Lu Fengfang Li Hui Li Leilei Zhou Xinying Wu Fang Yuan Source Type: research
Effect of the closed-loop hippocampal low-frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model
CONCLUSION: Applying closed-loop, low-frequency DBS at seizure onset reduced seizure severity and improved memory. In addition, the changes in power, coherence, and coupling of the LFP oscillations in the hippocampus and mPFC demonstrate low-frequency DBS efficacy as an antiepileptic treatment, returning LFPs to a seemingly non-seizure state in subjects that received DBS.PMID:38439573 | DOI:10.1111/cns.14656 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Meysam Zare Mahmoud Rezaei Milad Nazari Nastaran Kosarmadar Mona Faraz Victoria Barkley Amir Shojaei Mohammad Reza Raoufy Javad Mirnajafi-Zadeh Source Type: research
Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3 β pathway in depressed mice
CONCLUSION: This study establishes how ODEXs improve depressive-like behaviors and hippocampal neuroplasticity and might provide a promising therapeutic approach for depression.PMID:38439616 | DOI:10.1111/cns.14661 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Honghan Zhang Xin-Hui Xie Shu-Xian Xu Chao Wang Siqi Sun Xinhua Song Ruiling Li Ningyuan Li Yuqi Feng Hao Duan Di Li Zhongchun Liu Source Type: research
Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2
CONCLUSIONS: In epilepsy, Nrf2 modulates ferroptosis by involving the expression of FtMt and may be a potential therapeutic mechanism of neuronal injury after epilepsy. Targeting this relevant process for treatment may be a therapeutic strategy to prevent epilepsy.PMID:38439636 | DOI:10.1111/cns.14663 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Yu Song Mengjiao Gao Boyang Wei Xiaowei Huang Zeyu Yang Junjie Zou Yanwu Guo Source Type: research
Aberrant dynamic properties of whole-brain functional connectivity in acute mild traumatic brain injury revealed by hidden Markov models
CONCLUSIONS: Hidden Markov models provide additional information on the dynamic activity of brain networks in patients with acute mTBI and those with cognitive impairment. Our results suggest that brain network dynamics determined by the HMM could reinforce the understanding of the neuropathological mechanisms of acute mTBI patients and those with cognitive impairment.PMID:38439697 | DOI:10.1111/cns.14660 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2024 Category: Neuroscience Authors: Liyan Lu Fengfang Li Hui Li Leilei Zhou Xinying Wu Fang Yuan Source Type: research
Predictors for early-onset psychotic symptoms in patients newly diagnosed with Parkinson's disease without psychosis at baseline: A 5-year cohort study
CONCLUSION: We identified clinical and CSF predictors of early-onset psychosis in patients with PD. Our study provides evidence and implications for prognostic stratification and therapeutic approaches for PD psychosis.PMID:38432692 | DOI:10.1111/cns.14651 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Jing Chen Baoyu Chen Danhua Zhao Xiaotong Feng Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaoyu He Lin Zhang Junliang Yuan Source Type: research
Is it more effective for anhedonia and avolition? A systematic review and meta-analysis of non-invasive brain stimulation interventions for negative symptoms in schizophrenia
CONCLUSION: NIBS exerts distinct effects across multiple dimensions of negative symptom, with treatment effects related to stimulation frequency and total sessions. These results need to be confirmed in dedicated studies.PMID:38432851 | DOI:10.1111/cns.14645 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Yuying Chen Zhuofeng Li Chao Yan Laiquan Zou Source Type: research
Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke
CONCLUSION: In minor AIS, hsCRP and IL-6 levels were associated with in-hospital ND, including IL-6 levels in prognostic models improved risk classification.PMID:38432871 | DOI:10.1111/cns.14648 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Luo Yi Zi-Xiao Li Ying-Yu Jiang Yong Jiang Xia Meng Hao Li Xing-Quan Zhao Yi-Long Wang Li-Ping Liu Yong-Jun Wang Hong-Qiu Gu Source Type: research
Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single-cell RNA sequencing approach
CONCLUSION: The study offers valuable insights into WMH's complex pathophysiology following ICH, highlighting the significance and utility of scRNA-seq in understanding the cellular dynamics and contributing to future cerebrovascular research.PMID:38433011 | DOI:10.1111/cns.14652 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Lisha Ye Xiaoyan Tang Jun Zhong Wenfeng Li Ting Xu Chao Xiang Jianjun Gu Hua Feng Qianqian Luo Guohua Wang Source Type: research
SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia
CONCLUSION: BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.PMID:38433018 | DOI:10.1111/cns.14654 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Mohammad Iqbal H Bhuiyan Khadija Habib Md Tipu Sultan Fenghua Chen Israt Jahan Zhongfang Weng Md Shamim Rahman Rabia Islam Lesley M Foley T Kevin Hitchens Xianming Deng Scott W Canna Dandan Sun Guodong Cao Source Type: research
