Polysomnographic features associated with clonazepam and melatonin treatment in isolated REM sleep behavior disorder: Time for new therapeutic approaches?
CONCLUSION: These results suggest that the administration of MLT or CLO impacts (positively) on sleep parameters of iRBD patients. However, there is a need to better stratify patients, in order to treat them in a targeted manner, depending on the patient's individual sleep architecture and expected differential effects of these agents.PMID:38421131 | DOI:10.1111/cns.14569 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Maria P Mogavero Raffaele Ferri Sara Marelli Giuseppe Lanza Michele Terzaghi Alessandra Castelnuovo Lourdes M DelRosso Carlos H Schenck Luigi Ferini-Strambi Source Type: research
Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function
CONCLUSIONS: Our study demonstrated that pain sensitivity is associated with genetic background and Rnf20-mediated PI3K-Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.PMID:38421132 | DOI:10.1111/cns.14557 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Fuyi Xu Anran Chen Shuijing Pan Yingying Wu Hongjie He Zhe Han Lu Lu Buyan-Ochir Orgil XiaoDong Chi Cunhua Yang Shushan Jia Cuicui Yu Jia Mi Source Type: research
Serum response factor promoting axonal regeneration by activating the Ras-Raf-Cofilin signaling pathway after the spinal cord injury
CONCLUSION: Based on our research, the SRF promotes axonal regeneration by activating the "Ras-Raf-Cofilin" signaling pathway.PMID:38421133 | DOI:10.1111/cns.14585 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Limin Gao Chen Zhang Yonglin Zhu Naili Zhang Chunlei Zhang Shuai Zhou Guoying Feng Fei Huang Luping Zhang Source Type: research
Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease
CONCLUSION: Decreased stride length was the earliest characteristic of GD in CSVD. Structural and functional regulation of the left cerebellum VIIIb could play a particularly important role in early GD in CSVD.PMID:38421136 | DOI:10.1111/cns.14545 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yuting Mo Biying Ji Zhihong Ke Chenglu Mao Jialiu Jiang Yanan Huang Ruomeng Qin Lili Huang Dan Yang Zheqi Hu Yun Xu Source Type: research
Late-time window endovascular treatment is associated with neurological improvement: Evidence from the National Stroke Registry Data in China
CNS Neurosci Ther. 2024 Feb;30(2):e14572. doi: 10.1111/cns.14572.NO ABSTRACTPMID:38421137 | DOI:10.1111/cns.14572 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Jing Yuan Z Kevin Lu Minghui Li Jingwen Bai Long-De Wang Renyu Liu Jing Zhao Source Type: research
Prediction of early bladder outcomes after spinal cord injury: The HALT score
CONCLUSION: Two reliable models, the HALT score and the H-reflex, were developed to predict bladder outcomes as early as 3 months after SCI onset. Importantly, this study provides hitherto undocumented evidence regarding the predictive significance of the soleus H-reflex in relation to bladder outcomes in SCI patients.PMID:38421138 | DOI:10.1111/cns.14628 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Xiangbo Wu Xiao Xi Mulan Xu Ming Gao Ying Liang Miaoqiao Sun Xu Hu Li Mao Xingkai Liu Chenguang Zhao Xiaolong Sun Hua Yuan Source Type: research
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPAR γ/NF-κB signaling pathway
CONCLUSIONS: PA is expected to provide a valuable candidate for new drug development for AD in the future.PMID:38421141 | DOI:10.1111/cns.14581 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Tan Zhao Jianping Jia Source Type: research
Neonatal stress disrupts the glymphatic system development and increases the susceptibility to Parkinson's disease in later life
CONCLUSION: The results demonstrated that NMD could disrupt the development of the glymphatic system through PDGF-B signaling and increase the risk of PD later in life, indicating that alleviating neonatal stress could be beneficial in protecting the glymphatic system and reducing susceptibility to neurodegeneration.PMID:38421142 | DOI:10.1111/cns.14587 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Jian Song Zhen-Hua Li Xin-Yu Xue Jing-Cai Meng Wen-Xin Zhu Shufen Hu Guang-Yin Xu Lin-Hui Wang Source Type: research
Thymoma-associated autoimmune encephalitis with myasthenia gravis: Case series and literature review
CONCLUSIONS: There was no significant difference in the clinical manifestations between these patients and others with only TAMG or TAAE. TAAE was commonly associated with AMPAR2-Ab. Significantly, AE more commonly heralded thymoma recurrences than MG onset. And the intervals of thymectomy and MG or AE onset had different meanings for thymoma recurrence and prognoses of patients.PMID:38421083 | DOI:10.1111/cns.14568 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Miao Su Qiuyan Luo Zichao Wu Huiyu Feng Hongyan Zhou Source Type: research
Activation of testosterone-androgen receptor mediates cerebrovascular protection by photobiomodulation treatment in photothrombosis-induced stroke rats
CONCLUSIONS: Our study provides evidence that PBMT attenuates cerebrovascular injury and behavioral deficits associated with testosterone/AR following ischemic stroke. Our findings suggest that PBMT may be a promising alternative approach for managing cerebrovascular diseases.PMID:38421088 | DOI:10.1111/cns.14574 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yu Feng Zhihai Huang Xiaohui Ma Xuemei Zong Celeste Yin-Chieh Wu Reggie Hui-Chao Lee Hung Wen Lin Michael R Hamblin Quanguang Zhang Source Type: research
Absence in CX3CR1 receptor signaling promotes post-ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
CONCLUSION: Our study demonstrated that CX3CR1 gene deletion was beneficial to PSCI recovery. The mechanism might lie in inhibited pyroptosis and enhanced neurogenesis. CX3CR1 receptor may serve as a therapeutic target for improving the PSCI.PMID:38421089 | DOI:10.1111/cns.14551 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yangyang Ge Juexi Yang Jiayi Chen Maosha Dai Xiaoke Dou Shanglong Yao Chenye Yao Yun Lin Source Type: research
Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study
CONCLUSION: The findings evidence that abnormal WM microstructures may present themselves as early as in the MOH phase and that these structural abnormalities are associated with cognitive functions and cognition-related plasma biomarkers.PMID:38421091 | DOI:10.1111/cns.14586 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Yingzhe Cheng Lin Lin Shaofan Jiang Peilin Huang Jiejun Zhang Jiawei Xin Haibin Xu Yanping Wang Xiaodong Pan Source Type: research
Synchronous monitoring of brain-heart electrophysiology using heart rate variability coupled with rapid quantitative electroencephalography in orthostatic hypotension patients with α-synucleinopathies: Rapid prediction of orthostatic hypotension and preliminary exploration of brain stimulation therapy
CONCLUSION: Rapid resting-state HRV with certain time-domain parameters below normal levels may serve as a predictive indicator for the occurrence of orthostatic hypotension (OH) in patients with α-synucleinopathies. Additionally, the deterioration of HRV parameters correlates with synchronous abnormal qEEG patterns, which can provide insights into the brain stimulation target areas for OH in α-synucleinopathy patients.PMID:38421092 | DOI:10.1111/cns.14571 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Lin Lin Yingzhe Cheng Peilin Huang Jiejun Zhang Jiahao Zheng Xiaodong Pan Source Type: research
Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
CONCLUSION: Our results demonstrate metabolic vulnerability in female prenatally MAM-exposed rats, indicating that findings from healthy animals likely provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology.PMID:38421095 | DOI:10.1111/cns.14565 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Katerina Horska Silje Skrede Jan Kucera Gabriela Kuzminova Pavel Suchy Vincenzo Micale Jana Ruda-Kucerova Source Type: research
HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease
CONCLUSIONS: HDAC9-mediated CaM deacetylation induces memory impairment in AD, HDAC9, or CaM acetylation may become potential therapeutic targets for AD.PMID:38421101 | DOI:10.1111/cns.14573 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Hai-Long Zhang Shufen Hu Pin Yang Han-Chun Long Quan-Hong Ma Dong-Min Yin Guang-Yin Xu Source Type: research
