Resveratrol Protects Vascular Endothelial Cells from High Glucose-Induced Apoptosis through Inhibition of NADPH Oxidase Activation-Driven Oxidative Stress.
CONCLUSIONS: HG induces endothelial cell apoptosis through NF-κB/NADPH oxidase/ROS pathway, which was inhibited by resveratrol. Our findings provide new potential therapeutic targets against brain vascular complications of diabetes. PMID: 23731528 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 3, 2013 Category: Neuroscience Authors: Chen F, Qian LH, Deng B, Liu ZM, Zhao Y, Le YY Tags: CNS Neurosci Ther Source Type: research

Preclinical assessment of ketamine.
Abstract Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neurodegeneration and/or neuroprotection. The precise mechanisms are not completely understood. This review is to examine the work on ketamine and to address how developmental biology may be utilized when combined with biochemical, pathological, and pharmacokinetic assessments to produce a bridging model that may decrease the uncertainty in extrapolating preclinical data to human conditions. Advantages of using preclinical models to study critical issues related to ketamine anesthesia have been described. These in...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Wang C, Liu F, Patterson TA, Paule MG, Slikker W Tags: CNS Neurosci Ther Source Type: research

The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries.
This article reviews the current literature in regards to using ketamine in patients with traumatic brain injuries in different clinical settings associated with anesthesia, as well as reviews the potential mechanisms underlying the neuroprotective effects of ketamine. Studies examining the use of ketamine for induction, maintenance, and sedation in patients with TBI have had promising results. The use of ketamine in a controlled ventilation setting and in combination with other sedative agents has demonstrated no increase in ICP. The role of ketamine as a neuroprotective agent in humans remains inconclusive and adequately...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Chang LC, Raty SR, Ortiz J, Bailard NS, Mathew SJ Tags: CNS Neurosci Ther Source Type: research

Ketamine: use in anesthesia.
Abstract The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined. A nonsystematic review of ketamine was performed by authors from Australia, Europe, and North America. Results were discussed among authors and the final manuscript accepted. Ketamine is a useful agent for induction of anesthesia, procedural sedation, and analgesia. Its properties are appealing in many awkward clinical scenarios. Practitioners need to be cognizant of its side effects and limitations. PMID: 23521979 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Marland S, Ellerton J, Andolfatto G, Strapazzon G, Thomassen O, Brandner B, Weatherall A, Paal P Tags: CNS Neurosci Ther Source Type: research

Ketamine and peripheral inflammation.
In conclusion, ketamine appears as a unique "homeostatic regulator" of the acute inflammatory reaction and the stress-induced immune disturbances. This is of some interest at a moment when the short- and long-term deleterious consequences of inadequate inflammatory reactions are increasingly reported. Large-scale studies showing improved patient's outcome are, however, required before to definitively assert the clinical reality of this positive effect. PMID: 23574634 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: De Kock M, Loix S, Lavand'homme P Tags: CNS Neurosci Ther Source Type: research

Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings).
Abstract For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent analgesic properties. The active enantiomer is S(+)-ketamine. Ketamine is mostly metabolized in norketamine, an active metabolite. During "dissociative anesthesia", sensory inputs may reach cortical receiving areas, but fail to be perceived in some association areas. Ketamine also enhances the descending inhibiting serotoninergic pathway and exerts antidepressive effects. Analgesic effects persist for plasma concentrations ten times lower than hypnotic concentrations. Activation of the (N-Methyl-D-Aspartate...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Mion G, Villevieille T Tags: CNS Neurosci Ther Source Type: research

Ketamine as a fast acting antidepressant: current knowledge and open questions.
Abstract Several recent studies have shown that a single intravenous subanesthetic dose of ketamine, a NMDA receptor antagonist, exerts rapid antidepressant effects in patients with treatment refractory mood disorders and reduces suicidal ideation. Those insights have fueled tremendous excitement in the efforts to elucidate the mechanism underlying ketamine's antidepressant properties in animal models of depression, as well as in humans through the use of brain imaging as well as peripheral blood measurements. For example, there is emerging evidence that ketamine's antidepressant properties rely on increasing AMPA...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Salvadore G, Singh JB Tags: CNS Neurosci Ther Source Type: research

Treatment of Status Epilepticus with Ketamine, Are we There yet?
Abstract Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies are relatively consensual, but if seizures are still not controlled, there is currently no definitive data to guide the optimal choice of therapy. The medical community seems largely reluctant to use ketamine, a noncompetitive antagonist of the N-methyl-d-aspartate glutamate receptor. However,...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Dorandeu F, Dhote F, Barbier L, Baccus B, Testylier G Tags: CNS Neurosci Ther Source Type: research

Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficits.
Abstract Subanesthetic doses of the psychomimetic, ketamine, have been used for many years to elicit behavioral effects reminiscent of schizophrenia in both healthy humans and in animal models of the disease. More recently, there has been a move toward the use of simple neurophysiological measures (event-related potentials, brain oscillations) to assay the functional integrity of neuronal circuits in schizophrenia as these measures can be assessed in patients, healthy controls, intact animals, and even in brain slices. Furthermore, alterations of these measures are correlated with basic information processing defi...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Kocsis B, Brown RE, McCarley RW, Hajos M Tags: CNS Neurosci Ther Source Type: research

Ketamine in pain management.
Abstract For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented. Its history is traced from its conception, and its heritage, as a phencyclidine offspring, delineated. The earliest roots of the conceptions concerning the mechanisms of action are sought, and then followed in preclinical as well as clinical research. The major proposed mechanisms in the literature are commented on and evaluated. The growth of the clinical evidence for perioperative pain, acute pain, and chronic pain is followed from early attempts to systematic reviews. Finally, an attempt is made to...
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Persson J Tags: CNS Neurosci Ther Source Type: research

Happy 50th anniversary ketamine.
PMID: 23694802 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 24, 2013 Category: Neuroscience Authors: Dorandeu F Tags: CNS Neurosci Ther Source Type: research

Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion-Induced Neural Injury in Mice.
CONCLUSIONS: Our findings reveal that Kir6.1 knockdown exacerbates cerebral I/R-induced brain damages via increasing ER stress and inflammatory response, indicating that Kir6.1-containing K-ATP channels may be a potential therapeutic target for stroke. PMID: 23663330 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2013 Category: Neuroscience Authors: Dong YF, Wang LX, Huang X, Cao WJ, Lu M, Ding JH, Sun XL, Hu G Tags: CNS Neurosci Ther Source Type: research

Whole-Genome mRNA Expression Profiling Identifies Functional and Prognostic Signatures in Patients with Mesenchymal Glioblastoma Multiforme.
CONCLUSIONS: The signatures were identified as risk predictors that patients who had a high-risk score tended to have unfavorable outcome, demonstrating their potential for personalizing cancer management. PMID: 23663361 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2013 Category: Neuroscience Authors: Bao ZS, Zhang CB, Wang HJ, Yan W, Liu YW, Li MY, Zhang W Tags: CNS Neurosci Ther Source Type: research

Association between EXOC3L2 rs597668 Polymorphism and Alzheimer's Disease.
CONCLUSIONS: To our knowledge, this is the first study that assesses the association between rs597668 polymorphism and AD by meta-analysis. We believe that our findings will be very useful for future genetic studies in AD. PMID: 23663385 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 11, 2013 Category: Neuroscience Authors: Shang H, Fu J, Zhang XM, Song RR, Wang WZ Tags: CNS Neurosci Ther Source Type: research

Protective Role of (RS )-glucoraphanin Bioactivated with Myrosinase in an Experimental Model of Multiple Sclerosis.
CONCLUSION: Our results clearly demonstrate that bioactive RS -GRA treatment may represent a useful therapeutic perspective in the treatment of this disease. PMID: 23638842 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Giacoppo S, Galuppo M, Iori R, De Nicola GR, Cassata G, Bramanti P, Mazzon E Tags: CNS Neurosci Ther Source Type: research

Granulocyte-Colony-Stimulating Factor Treatment Enhances Foxp3(+) T Lymphocytes and Modifies the Proinflammatory Response in Experimental Autoimmune Neuritis.
PMID: 23638874 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Pradella F, Moraes AS, Santos MP, Depaula RF, Degaki KY, Longhini AL, Silva VD, Santos LM, Farias AS Tags: CNS Neurosci Ther Source Type: research

β-Phenethylamine-A Phenylalanine Derivative in Brain-Contributes to Oxidative Stress by Inhibiting Mitochondrial Complexes and DT-Diaphorase: An In Silico Study.
CONCLUSION: As lowering of cellular antioxidant molecules is evident in many neurodegenerative disorders, β-PEA-induced lowering of DT-diaphorase activity may have the capability to cause neurodegeneration, which may be potentiated by its ability to inhibit mitochondrial complexes. Thus, β-PEA-due to its cumulative actions-may be more potent in causing neurodegeneration as compared to other endogenous neurotoxins. PMID: 23638910 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Mazumder MK, Paul R, Borah A Tags: CNS Neurosci Ther Source Type: research

The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.
CONCLUSIONS: PDCD5-induced apoptosis and over-expression of PDCD5 are harmful to the ischemic neurons in vivo. Meanwhile, the inhibition of PDCD5 may be protective via reducing the apoptotic-related protein such as p53, Bax, and caspase-3. This observation may have potential for the treatment of ischemic cerebral stroke. PMID: 23638963 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen YY, Han JY, Zhang JH, Zhou CM Tags: CNS Neurosci Ther Source Type: research

Rho Kinase Inhibitor Fasudil Protects against β-Amyloid-Induced Hippocampal Neurodegeneration in Rats.
CONCLUSIONS: Fasudil can protect against Aβ-induced hippocampal neurodegeneration by suppressing inflammatory response, suggesting that fasudil might be a promising agent for the prevention and treatment of inflammation-related diseases, such as AD. PMID: 23638992 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Song Y, Chen X, Wang LY, Gao W, Zhu MJ Tags: CNS Neurosci Ther Source Type: research

Hemoglobin is Associated with Periventricular but Not Deep White Matter Hyperintensities in Lacunar Ischemic Stroke.
PMID: 23634946 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 2, 2013 Category: Neuroscience Authors: Pan J, Yin B, Xu ZQ, Lou HY, Liang H Tags: CNS Neurosci Ther Source Type: research

High-Dose Donepezil (23 mg/day) for the Treatment of Moderate and Severe Alzheimer's Disease: Drug Profile and Clinical Guidelines.
Discussions were based on a large, 6-month, phase 3 clinical trial in patients with moderate to severe AD that compared continuing donepezil 10 mg/day versus switching to 23 mg/day. In this trial, donepezil 23 mg/day demonstrated significantly greater cognitive benefits (mean change in Severe Impairment Battery score, 2.11 points; P 
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Cummings JL, Geldmacher D, Farlow M, Sabbagh M, Christensen D, Betz P Tags: CNS Neurosci Ther Source Type: research

Vestibular schwannoma surgical treatment.
In this report, we focused on facial nerve and vestibulocochlear nerve preservation and analyzed the major techniques used for identifying the nerve-tumor relationship. PMID: 23462373 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: You YP, Zhang JX, Lu AL, Liu N Tags: CNS Neurosci Ther Source Type: research

M9, a novel region of amino-nogo-a, attenuates cerebral ischemic injury by inhibiting NADPH oxidase-derived superoxide production in mice.
CONCLUSIONS: Our results demonstrate that TAT-M9 administration attenuates cerebral ischemia by inhibiting NADPH oxidase-mediated oxidative damage and neuronal apoptosis in mice. TAT-M9 may be a potential treatment for cerebrovascular disease. PMID: 23490284 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Guo F, Jin WL, Li LY, Song WY, Wang HW, Gou XC, Mi YJ, Wang Q, Xiong L Tags: CNS Neurosci Ther Source Type: research

The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus.
CONCLUSIONS: The disturbance of CaMKII/PKA/PKC phosphorylation in the hippocampus is an early change that may be associated with the development and progression of diabetes-related cognitive dysfunction. PMID: 23490331 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Liao MH, Xiang YC, Huang JY, Tao RR, Tian Y, Ye WF, Zhang GS, Lu YM, Ahmed MM, Liu ZR, Fukunaga K, Han F Tags: CNS Neurosci Ther Source Type: research

Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy.
CONCLUSIONS: Our findings confirm that reduced availability of mature NGF and NGF signaling impairment favors vascular and neuronal alterations in diabetic septo-hippocampal areas and corroborate the ability of oNGF to act as a neuroprotective agent in brain. PMID: 23528019 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Tirassa P, Maccarone M, Florenzano F, Cartolano S, De Nicolò S Tags: CNS Neurosci Ther Source Type: research

Endothelial progenitor cells contribute to neointima formation in rabbit elastase-induced aneurysm after flow diverter treatment.
CONCLUSIONS: BM-derived EPCs participate in neointima formation and reendothelialization in elastase-induced aneurysm after flow diverter treatment. The EPCs may differentiate into different cell types according to the stages of neointima formation in vivo. PMID: 23528070 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Li ZF, Fang XG, Yang PF, Huang QH, Zhao WY, Liang C, Zhao R, Liu JM Tags: CNS Neurosci Ther Source Type: research

Increased expression of toll-like receptor 4 on neurons after surgery in aged rats.
PMID: 23534838 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Wang Y, He HJ, Ouyang W Tags: CNS Neurosci Ther Source Type: research

Administration of MS-275 Improves Cognitive Performance and Reduces Cell Death Following Traumatic Brain Injury in Rats.
In this study, we examined the behavioral-cognitive performance as well as histology outcome in adult rats to evaluate whether postinjury administration of MS-275 (15 and 45 mg/kg) would provide neuroprotection benefits and ameliorate cognitive deficits following fluid percussion injury. METHODS: Traumatic brain injury (˜2.15 ATMs) was produced using a fluid percussion device with the lateral orientation. MS-275 was administered (15 and 45 mg/kg) systemically once daily for 7 days starting at 30 min after lateral fluid percussion TBI. Acquisition of spatial learning and memory retention was a...
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Cao P, Liang Y, Gao X, Zhao MG, Liang GB Tags: CNS Neurosci Ther Source Type: research

Recommendations for the Use of Prolonged-Release Fampridine in Patients with Multiple Sclerosis (MS).
Stourac P, Talab R, Turcani P, Vachova M, Vecsei L, Vodusek D, Zapletalova O, Berger T Abstract Prolonged-release fampridine (fampridine PR) is a potassium channel blocker that improves conductivity of signal on demyelinated axons in central nervous system. Fampridine PR has been approved to improve speed of walking in patients with multiple sclerosis. This statement provides a brief summary of data on fampridine PR and recommendations on practical use of the medication in clinical practice, prediction, and evaluation of response to treatment and patient management. PMID: 23607697 [PubMed - in process] (Sour...
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Preiningerova JL, Baumhackl U, Csepany T, Czaplinski A, Deisenhammer F, Derfuss T, Fabjan TH, Fazekas F, Fuchs S, Havrdova E, Ledinek AH, Illes Z, Jazbec SS, Klimova E, Komoly S, Kurca E, Linnebank M, Lisy L, Mares J, Prochazkova L, Csilla R, Szilasiova J Tags: CNS Neurosci Ther Source Type: research

EGFP Tags Affect Cellular Localization of ATP7B Mutants.
CONCLUSION: EGFP tags may not be suitable for the detection of cellular localization of ATP7B mutants. PMID: 23607698 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Zhu M, Ni W, Dong Y, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning.
PMID: 23607699 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Shen MH, Cai JM, Sun Q, Zhang DW, Huo ZL, He J, Sun XJ Tags: CNS Neurosci Ther Source Type: research

Involvement of protein kinase b/akt in analgesic effect of dexmedetomidine on neuropathic pain.
PMID: 23607700 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Li SS, Zhang WS, Yang JL, Xiong YC, Zhang YQ, Xu H Tags: CNS Neurosci Ther Source Type: research

Involvement of fibroblast growth factor in the restoration of arterial baroreflex by dietary restriction.
PMID: 23607701 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 1, 2013 Category: Neuroscience Authors: Zang P, Dong J, Song XR, Zhang LL, Liu AJ Tags: CNS Neurosci Ther Source Type: research

Oxidative Stress is not Involved in Motion Sickness in Mice.
CONCLUSION: Oxidative stress is not involved in the development of motion sickness in mice. PMID: 23611339 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 24, 2013 Category: Neuroscience Authors: Wang ZB, Han P, Tu Y, Liu WY, Tao BL, Zhang LC, Li L Tags: CNS Neurosci Ther Source Type: research

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?
Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track? CNS Neurosci Ther. 2013 Apr 18; Authors: Esposito Z, Belli L, Toniolo S, Sancesario G, Bianconi C, Martorana A Abstract Alzheimer's disease (AD) has a devastating impact on aged people worldwide. Although sophisticated and advanced molecular methods have been developed for its diagnosis since early phases, pharmacological treatment still represents an unresolved topic. The more the disease progresses, the more the uneffectiveness of antidementia drugs emerges. New and encouraging results from experimental works ind...
Source: CNS Neuroscience and Therapeutics - April 18, 2013 Category: Neuroscience Authors: Esposito Z, Belli L, Toniolo S, Sancesario G, Bianconi C, Martorana A Tags: CNS Neurosci Ther Source Type: research

Zinc Promotes the Death of Hypoxic Astrocytes by Upregulating Hypoxia-Induced Hypoxia-Inducible Factor-1alpha Expression via Poly(ADP-ribose) Polymerase-1.
CONCLUSIONS: Our studies show that zinc promotes hypoxic cell death through overexpression of the hypoxia response factor HIF-1α via the cell fate determine factor PARP-1 modification, which provides a novel mechanism for zinc-mediated ischemic brain injury. PMID: 23582235 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 13, 2013 Category: Neuroscience Authors: Pan R, Chen C, Liu WL, Liu KJ Tags: CNS Neurosci Ther Source Type: research

Lymphomatoid Granulomatosis with CNS Involvement can Lead to Spontaneous Remission: Case Study.
PMID: 23582284 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 13, 2013 Category: Neuroscience Authors: Zhang YX, Ding MP, Zhang T, Tang YL, Guo Y, Fan J, Chen LR, Chen Q Tags: CNS Neurosci Ther Source Type: research

Neural Pathway Interference by Retained Acupuncture: A Functional MRI Study of a Dog Model of Parkinson's Disease.
DISCUSSION: Standard veterinary neurological examination was performed on dogs with MPTP-induced PD. A homogeneous grade similar to human PD patients was evident in all dogs. The fMRI study showed that insertion of the acupuncture needle at acupoint ST 36 significantly affected the proprioceptive brain activation by decreasing blood oxygenation level-dependent signal intensity in basal ganglia, limbic system, and cerebellum. Compared with normal and PD brain, we suggest that acupuncture at ST 36 has different modulation effects depending on the pathologic condition of the brain. The study provides evidence of the potential...
Source: CNS Neuroscience and Therapeutics - April 12, 2013 Category: Neuroscience Authors: Lee SH, Jahng GH, Choe IH, Choi CB, Kim DH, Kim HY Tags: CNS Neurosci Ther Source Type: research

Establishment of Tube Formation Assay of Bone Marrow-Derived Endothelial Progenitor Cells.
PMID: 23574617 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2013 Category: Neuroscience Authors: Chen JK, Deng YP, Jiang GJ, Liu YZ, Zhao T, Shen FM Tags: CNS Neurosci Ther Source Type: research

Impact of Obesity in Children with Narcolepsy.
CONCLUSION: Obesity affects more than 50% of narcoleptic children, mostly younger at disease onset, and has a deleterious impact on sleep quality as well as on school attendance. PMID: 23574649 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2013 Category: Neuroscience Authors: Inocente CO, Lavault S, Lecendreux M, Dauvilliers Y, Reimao R, Gustin MP, Castets S, Spiegel K, Lin JS, Arnulf I, Franco P Tags: CNS Neurosci Ther Source Type: research

Hemifacial Spasm Developing After the Adhesion of the Facial Nerve and Vertebral Artery.
PMID: 23574687 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2013 Category: Neuroscience Authors: Zhang QB, Wang WH, Chen XZ, Yin J Tags: CNS Neurosci Ther Source Type: research

A Minority Subpopulation of CD133(+) /EGFRvIII(+) /EGFR(-) Cells Acquires Stemness and Contributes to Gefitinib Resistance.
CONCLUSIONS: EGFRvIII contributes to the stemness of cancer stem cells through coexpression with CD133 in GBMs. Furthermore, CD133(+) /EGFRvIII(+) /EGFR(-) cells have the ability to initiate tumor formation and may contribute to gefitinib resistance. PMID: 23575351 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 10, 2013 Category: Neuroscience Authors: Liu XJ, Wu WT, Wu WH, Yin F, Ma SH, Qin JZ, Liu XX, Liu YN, Zhang XY, Li P, Han S, Liu KY, Zhang JM, He QH, Shen L Tags: CNS Neurosci Ther Source Type: research

Vascular Endothelial Growth Factor Gene Promoter Polymorphisms and Alzheimer's Disease Risk: A Meta-Analysis.
Conclusions on the association between polymorphisms in the vascular endothelial growth factor (VEGF) gene promoter and risk of Alzheimer's disease (AD) are ambiguous, and sufficient evaluation of the association is lacking. Therefore, we performed a meta-analysis of observational studies to explore the association between polymorphisms in the VEGF gene promoter and AD risk. METHODS: Bibliographical searches were performed in the MEDLINE, EMBASE, and China National Knowledge Infrastructure (CNKI) databases without any language limitations. Three investigators independently assessed abstracts for relevant studies and indepe...
Source: CNS Neuroscience and Therapeutics - April 10, 2013 Category: Neuroscience Authors: Liu SY, Zeng FF, Chen ZW, Wang CY, Zhao B, Li KS Tags: CNS Neurosci Ther Source Type: research

MiR-139 Inhibits Mcl-1 Expression and Potentiates TMZ-Induced Apoptosis in Glioma.
CONCLUSION: Our results suggested that miR-139 negatively regulated Mcl-1 and induced apoptosis in cooperation with an anticancer drug TMZ in glioma. PMID: 23551751 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 2, 2013 Category: Neuroscience Authors: Li RY, Chen LC, Zhang HY, Du WZ, Feng Y, Wang HB, Wen JQ, Liu X, Li XF, Sun Y, Yang DB, Jiang T, Li YL, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices.
PMID: 23441748 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Romero A, Gomez-Rangel V, Egea J, Samadi A, Marco-Contelles J, Lopez MG Tags: CNS Neurosci Ther Source Type: research

The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.
CONCLUSIONS: This study provides electrophysiological evidence that the proconvulsant activity of leptin is mediated, at least in part, by inhibition of cannabinoids in the experimental model of epilepsy. PMID: 23521910 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Arslan G, Alici SK, Ayyildiz M, Agar E Tags: CNS Neurosci Ther Source Type: research

Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses.
CONCLUSION: This is the first study to demonstrate that RvD1 effects on the reduction of pro-inflammatory responses in LPS-induced microglial cells. The mechanisms underlying these effects may include its potent intracellular NF-κB down-regulation and subsequent pro-inflammatory cytokines release in LPS-activated microglia. PMID: 23521911 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Xu MX, Tan BC, Zhou W, Wei T, Lai WH, Tan JW, Dong JH Tags: CNS Neurosci Ther Source Type: research

Exercise training lowers the enhanced tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.
CONCLUSION: Our findings suggest that ExT attenuates the enhancement in the tonically acting glutamatergic input to the RVLM of hypertensive rats, thereby reducing the sympathetic hyperactivity and blood pressure. PMID: 23521912 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Zha YP, Wang YK, Deng Y, Zhang RW, Tan X, Yuan WJ, Deng XM, Wang WZ Tags: CNS Neurosci Ther Source Type: research

Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway.
CONCLUSION: GSH may prevent FFAs-induced HBVECs damage, oxidative stress, and apoptosis through activating the Akt pathway. PMID: 23521913 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Zhou HG, Liu L, Zhang Y, Huang YY, Tao YH, Zhang S, Su JJ, Tang YP, Guo ZL, Hu RM, Dong Q Tags: CNS Neurosci Ther Source Type: research

Vitamin D3 induces IDO(+) tolerogenic DCs and enhances Treg, reducing the severity of EAE.
CONCLUSION: These mechanisms contribute actively to the generation of a microenvironment in the lymph nodes that suppresses the activation of encephalitogenic T cells, resulting in the downregulation of the inflammatory response in the central nervous system. PMID: 23521914 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Farias AS, Spagnol GS, Bordeaux-Rego P, Oliveira CO, Fontana AG, de Paula RF, Santos MP, Pradella F, Moraes AS, Oliveira EC, Longhini AL, Rezende AC, Vaisberg MW, Santos LM Tags: CNS Neurosci Ther Source Type: research