Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies
CONCLUSION: While many unresolved issues remain regarding the gut microbiota and AD, the feasibility and immense potential of treating AD by modulating the gut microbiota are evident.PMID:38584341 | PMC:PMC10999574 | DOI:10.1111/cns.14704 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Junyi Liang Yueyang Wang Bin Liu Xiaohong Dong Wenhui Cai Ning Zhang Hong Zhang Source Type: research
Non-scheduled short-acting opioid to taper off opioids?
This article also proposes to develop short-acting opioids for addiction management instead of the current long-acting regimen. The authors further suggest that dezocine, a previously FDA approved medication for perioperative pain management and a non-scheduled opioid, be brought back to clinical practice in the US as a potential alternative addiction management medication, especially for those who are highly motivated to quit opioids completely using a taper off strategy.PMID:38584343 | PMC:PMC10999548 | DOI:10.1111/cns.14705 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Renyu Liu Bonnie Milas John Grothusen Source Type: research
Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease
CONCLUSION: The parahippocampal gyrus was the potential brain region for recognizing cognitive impairment in PD, specifically for identifying MCI. Thus, the fALFF of parahippocampal gyrus is expected to contribute to future study as a multimodal fingerprint for early warning.PMID:38584347 | PMC:PMC10999557 | DOI:10.1111/cns.14706 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Peng Chen Guoqiang Tang Yanglingxi Wang Weiming Xiong Yongbing Deng She Fei Jun Zhang Source Type: research
Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy
CONCLUSIONS: Our findings suggest that the downregulation of VAPB-PTPIP51 expression after IS mediates structural damage to MAMs. This may exacerbate CIRI by inhibiting the PI3K pathway and activating autophagy, thus providing new therapeutic targets for IS.PMID:38584329 | DOI:10.1111/cns.14707 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Mingyang Li Yonggang Zhang Guixiang Yu Lijuan Gu Hua Zhu Shi Feng Xiaoxing Xiong Zhihong Jian Source Type: research
Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies
CONCLUSION: While many unresolved issues remain regarding the gut microbiota and AD, the feasibility and immense potential of treating AD by modulating the gut microbiota are evident.PMID:38584341 | DOI:10.1111/cns.14704 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Junyi Liang Yueyang Wang Bin Liu Xiaohong Dong Wenhui Cai Ning Zhang Hong Zhang Source Type: research
Non-scheduled short-acting opioid to taper off opioids?
This article also proposes to develop short-acting opioids for addiction management instead of the current long-acting regimen. The authors further suggest that dezocine, a previously FDA approved medication for perioperative pain management and a non-scheduled opioid, be brought back to clinical practice in the US as a potential alternative addiction management medication, especially for those who are highly motivated to quit opioids completely using a taper off strategy.PMID:38584343 | DOI:10.1111/cns.14705 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Renyu Liu Bonnie Milas John Grothusen Source Type: research
Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease
CONCLUSION: The parahippocampal gyrus was the potential brain region for recognizing cognitive impairment in PD, specifically for identifying MCI. Thus, the fALFF of parahippocampal gyrus is expected to contribute to future study as a multimodal fingerprint for early warning.PMID:38584347 | DOI:10.1111/cns.14706 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 8, 2024 Category: Neuroscience Authors: Peng Chen Guoqiang Tang Yanglingxi Wang Weiming Xiong Yongbing Deng She Fei Jun Zhang Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | PMC:PMC10993342 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
The potential of phosphorylated α-synuclein as a biomarker for the diagnosis and monitoring of multiple system atrophy
CONCLUSION: The p-syn stands out as a promising biomarker for MSA. It is found in oligodendrocytes and shows a correlation with disease severity and progression. However, further research and validation studies are necessary to establish p-syn as a reliable biomarker for MSA. If proven, p-syn could significantly contribute to early diagnosis, disease monitoring, and assessing treatment response.PMID:38572788 | PMC:PMC10993367 | DOI:10.1111/cns.14678 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Toufik Abdul-Rahman Ranferi Eduardo Herrera-Calder ón Arjun Ahluwalia Andrew Awuah Wireko Tomas Ferreira Joecelyn Kirani Tan Maximillian Wolfson Shankhaneel Ghosh Viktoriia Horbas Vandana Garg Asma Perveen Marios Papadakis Ghulam Md Ashraf Athanasios Ale Source Type: research
Molecular mechanism analyses of post-traumatic epilepsy and hereditary epilepsy based on 10 × single-cell transcriptome sequencing technology
CONCLUSION: Our study explored differences in cells found in a patient with PE compared to a patient with HE, and the transcriptome in the different cells was analyzed for the first time. Studying inflammatory and immune functions might be the best approach for investigating traumatic temporal lobe epilepsy in neurons.PMID:38572804 | PMC:PMC10993349 | DOI:10.1111/cns.14702 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Fang Wen Zhigang Tan Dezhi Huang Jun Xiang Source Type: research
SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy
CONCLUSION: These results showed that SIRT3 overexpression ameliorates PDN via activation of FoxO3a-PINK1-Parkin-mediated mitophagy, suggesting that SIRT3 may become an encouraging therapeutic strategy for PDN.PMID:38572816 | PMC:PMC10993345 | DOI:10.1111/cns.14703 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Jing Yang Zhuoying Yu Ye Jiang Zixian Zhang Yue Tian Jie Cai Min Wei Yanhan Lyu Dongsheng Yang Shixiong Shen Guo-Gang Xing Min Li Source Type: research
Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R
CONCLUSION: Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R axis.PMID:38572785 | PMC:PMC10993342 | DOI:10.1111/cns.14657 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Waimei Si Zhenni Chen Jing Bei Shiquan Chang Yachun Zheng Li Gao Guoping Zhao Xin Li Di Zhang Source Type: research
The potential of phosphorylated α-synuclein as a biomarker for the diagnosis and monitoring of multiple system atrophy
CONCLUSION: The p-syn stands out as a promising biomarker for MSA. It is found in oligodendrocytes and shows a correlation with disease severity and progression. However, further research and validation studies are necessary to establish p-syn as a reliable biomarker for MSA. If proven, p-syn could significantly contribute to early diagnosis, disease monitoring, and assessing treatment response.PMID:38572788 | PMC:PMC10993367 | DOI:10.1111/cns.14678 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Toufik Abdul-Rahman Ranferi Eduardo Herrera-Calder ón Arjun Ahluwalia Andrew Awuah Wireko Tomas Ferreira Joecelyn Kirani Tan Maximillian Wolfson Shankhaneel Ghosh Viktoriia Horbas Vandana Garg Asma Perveen Marios Papadakis Ghulam Md Ashraf Athanasios Ale Source Type: research
Molecular mechanism analyses of post-traumatic epilepsy and hereditary epilepsy based on 10 × single-cell transcriptome sequencing technology
CONCLUSION: Our study explored differences in cells found in a patient with PE compared to a patient with HE, and the transcriptome in the different cells was analyzed for the first time. Studying inflammatory and immune functions might be the best approach for investigating traumatic temporal lobe epilepsy in neurons.PMID:38572804 | PMC:PMC10993349 | DOI:10.1111/cns.14702 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Fang Wen Zhigang Tan Dezhi Huang Jun Xiang Source Type: research
SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy
CONCLUSION: These results showed that SIRT3 overexpression ameliorates PDN via activation of FoxO3a-PINK1-Parkin-mediated mitophagy, suggesting that SIRT3 may become an encouraging therapeutic strategy for PDN.PMID:38572816 | PMC:PMC10993345 | DOI:10.1111/cns.14703 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Jing Yang Zhuoying Yu Ye Jiang Zixian Zhang Yue Tian Jie Cai Min Wei Yanhan Lyu Dongsheng Yang Shixiong Shen Guo-Gang Xing Min Li Source Type: research
