No-reflow after stroke reperfusion therapy: An emerging phenomenon to be explored
CNS Neurosci Ther. 2024 Feb;30(2):e14631. doi: 10.1111/cns.14631.ABSTRACTIn the field of stroke thrombectomy, ineffective clinical and angiographic reperfusion after successful recanalization has drawn attention. Partial or complete microcirculatory reperfusion failure after the achievement of full patency of a former obstructed large vessel, known as the "no-reflow phenomenon" or "microvascular obstruction," was first reported in the 1960s and was later detected in both experimental models and patients with stroke. The no-reflow phenomenon (NRP) was reported to result from intraluminal occlusions formed by blood component...
Source: CNS Neuroscience and Therapeutics - February 15, 2024 Category: Neuroscience Authors: Milan Jia Feiyang Jin Sijie Li Changhong Ren Mangal Ruchi Yuchuan Ding Wenbo Zhao Xunming Ji Source Type: research
Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress
CONCLUSIONS: Taken together, the results suggest that EphB2 in BLA plays an essential role in inducing visceral hypersensitivity. In the maintenance stage, the involvement of EphB2 is crucial but not sufficient. The increase in EphB2 induced by WAS may enhance synaptic plasticity in BLA through upregulating NMDARs, which results in IBS-like symptoms. These findings may give insight into the treatment of IBS and related psychological distress.PMID:38353051 | PMC:PMC10865153 | DOI:10.1111/cns.14611 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 14, 2024 Category: Neuroscience Authors: Guang-Bing Duan Jun-Wen Wang Hui-Hui Sun Zhi-Yu Dong Yan Zhang Zhen-Xiang Wang Ye Chen Ying Chen Ying Huang Shu-Chang Xu Source Type: research
Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice
CONCLUSIONS: In summary, in this study, we show that chronic nicotine treatment ameliorates acute inflammation-induced working memory deficiency by increasing CRTC1 and HCN2 in adult male mice.PMID:38353058 | PMC:PMC10865150 | DOI:10.1111/cns.14627 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 14, 2024 Category: Neuroscience Authors: Xiaona Wang Qian Wang Min Song Yihui Wang Xianzhi Shen Yanyun Sun Chun Guo Panpan Geng Chaolin Ma Xinchun Jin Source Type: research
TREM2 gene induces differentiation of induced pluripotent stem cells into dopaminergic neurons and promotes neuronal repair via TGF- β activation in 6-OHDA-lesioned mouse model of Parkinson's disease
CONCLUSION: This work identifies a mechanistic insight for TREM2-mediated TGF-β activation in the regulation of neuronal repair in PD and suggests novel strategies for neurodegenerative disorders.PMID:38348765 | PMC:PMC10862187 | DOI:10.1111/cns.14630 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 13, 2024 Category: Neuroscience Authors: Hanbai Liang Ping Liu Zijing Wang Huan Xiong Cheng Yin Dongdong Zhao Chunhui Wu Longyi Chen Source Type: research
S-9-PAHSA's neuroprotective effect mediated by CAIII suppresses apoptosis and oxidative stress in a mouse model of type 2 diabetes
CONCLUSION: S-9-PAHSA mediated by CAIII has the potential to exert a neuroprotective effect by suppressing apoptosis and oxidative stress in neuronal cells exposed to diabetic conditions. Furthermore, S-9-PAHSA has the capability to reduce fasting blood glucose and LDL levels and enhance insulin sensitivity in mice fed with HFD.PMID:38332538 | PMC:PMC10853598 | DOI:10.1111/cns.14594 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Jian-Tao Wang Xin-Ru Wang Jiao-Qi Ren Jin-Hong Lin Zhong-Yu Yu Shan-Shan Huang Yue Hu Jia-Yu Fu Meng Wang Yan-Li Zhang Xue-Chun Wang Jing-Chun Guo Ji-Chang Xiao Hou-Guang Zhou Source Type: research
Effect of anti-CGRP-targeted therapy on migraine aura: Results of an observational case series study
CONCLUSIONS: Based on the above findings, we hypothesize that anti-CGRP Mabs did not influence neuronal and vascular events related to cortical spreading depression (CSD) which is considered the pathophysiological substrate of aura. Conversely, these antibodies are able to counteract, via their peripheral mechanisms of action, the sensitization of the trigemino-vascular pathway which is triggered by CSD. This aforementioned might explain why in our patients, migraine aura attacks remained unchanged in their frequencies, but the headache phases were either reduced or absent.PMID:38332541 | PMC:PMC10853579 | DOI:10.1111/cns....
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Elena Cresta Alessia Bellotti Giovanni Rinaldi Ilenia Corbelli Paola Sarchielli Source Type: research
A novel NMDA receptor modulator: the antidepressant effect and mechanism of GW043
CONCLUSION: Our findings disclose that GW043, as a partial agonist of NMDAR, can reverse depression-like behaviors in rats by modulating synaptic plasticity, indicating its potential as an antidepressant agent.PMID:38332552 | PMC:PMC10853642 | DOI:10.1111/cns.14598 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Murezati Tiliwaerde Nana Gao Yaqi Yang Zengliang Jin Source Type: research
Research hotpots and frontier trends of neuroprotective effects of magnesium from 1999 to 2023: A bibliometric analysis
CONCLUSION: The neuroprotective effects of magnesium in preterm infants have been extensively studied and adequately confirmed. The therapeutic effects of magnesium on cerebral ischemia and subarachnoid hemorrhage have been demonstrated in animal models. However, the results of clinical studies were not satisfactory, and exploring new therapeutic strategies may be the solution. Recently, the combination of magnesium and hypothermia had great potential in neuroprotective therapy and may become a development trend and hotspot in the future.PMID:38332558 | PMC:PMC10853652 | DOI:10.1111/cns.14597 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Baoying Song Miaowen Jiang Yang Zhang Yi Xu Chuanjie Wu Di Wu Chen Zhou Ming Li Xunming Ji Source Type: research
Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes
CONCLUSION: The present study illustrated a new mechanism of glioblastoma resistance to TMZ, which based on GSCs-exo educated TAAs delivering ALKBH7 to enhance APNG expression of GBM cells, which implied that targeting on ALKBH7/APNG regulation network may provide a new strategy of enhancing TMZ therapeutic effects against glioblastoma.PMID:38332576 | PMC:PMC10853646 | DOI:10.1111/cns.14599 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Xinglei Liu Liang Liu Anyi Wu Shilu Huang Zhipeng Xu Xiaopei Zhang Zengyang Li Haoran Li Jun Dong Source Type: research
Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine
CONCLUSION: BDNF downregulation mediates synaptic plasticity and excitability damage, leading to cognitive impairments in adulthood following repeated ketamine exposure during the neonatal period.PMID:38332635 | PMC:PMC10853651 | DOI:10.1111/cns.14604 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Jie Wan Linhui Ma Xinhao Jiao Wei Dong Jiatao Lin Yongkang Qiu Weifeng Wu Qiang Liu Chen Chen He Huang Shuai Li Hui Zheng Yuqing Wu Source Type: research
Identification and validation of a glycolysis-related taxonomy for improving outcomes in glioma
CONCLUSION: This study elucidates that evaluating GS is essential for comprehending the heterogeneity of glioma, which is pivotal for predicting immune cell infiltration (ICI) characterization, prognosis, and personalized immunotherapy regimens. We also explored the glycolysis-related genes ADM and IM to develop a theoretical framework for anti-tumor strategies targeting glycolysis.PMID:38332637 | PMC:PMC10853657 | DOI:10.1111/cns.14601 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Tianshu Ying Yaming Lai Shiyang Lu Shaolong E Source Type: research
Transcription factor CEBPB mediates intracranial aneurysm rupture by inflammatory and immune response
CONCLUSION: The inflammatory and immune response may be closely associated with aneurysm rupture. CEBPB may be the hub gene for aneurysm rupture and may have diagnostic value. Therefore, CEBPB may serve as the diagnostic signature for RIAs and a potential target for intervention.PMID:38332649 | PMC:PMC10853640 | DOI:10.1111/cns.14603 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Zhongbin Tian Xuefang Wu Baorui Zhang Wei Li Chao Wang Source Type: research
The role of magnetoencephalography in preoperative localization and postoperative outcome prediction in patients with posterior cortical epilepsy
CNS Neurosci Ther. 2024 Feb;30(2):e14602. doi: 10.1111/cns.14602.ABSTRACTOBJECTIVE: We aimed to explore the value of magnetoencephalography in the presurgical evaluation of patients with posterior cortex epilepsy.METHODS: A total of 39 patients with posterior cortex epilepsy (PCE) and intact magnetoencephalography (MEG) images were reviewed from August 2019 to July 2022. MEG dipole clusters were classified into single clusters, multiple clusters, and scatter dipoles based on tightness criteria. The association of the surgical outcome with MEG dipole classifications was evaluated using Fisher's exact tests.RESULTS: Among th...
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Guiliang Hao Hao Yan Xueyuan Wang Runshi Gao Yansong Xue Xiating Zhang Duanyu Ni Wei Shu Liang Qiao Liu He Tao Yu Source Type: research
HTRA1 promotes EMT through the HDAC6/Ac- α-tubulin pathway in human GBM cells
CONCLUSION: Our results indicate that HTRA1 promotes the proliferation and migration of GBM cells in vitro and in vivo, and thus may be a potential target for treatment in gliomas.PMID:38334007 | PMC:PMC10853898 | DOI:10.1111/cns.14605 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Wenbo Zhao Yibo Wu Shuai Wang Feihu Zhao Wenyu Liu Zhiyi Xue Lin Zhang Jian Wang Mingzhi Han Xingang Li Bin Huang Source Type: research
Association between plasma CTRPs with cognitive impairment and neurodegeneration of Alzheimer's disease
CONCLUSIONS: All the findings preliminarily uncovered associations between plasma CTRPs and AD and suggested the potential of CTRPs as a blood-derived biomarker for AD.PMID:38334009 | PMC:PMC10853890 | DOI:10.1111/cns.14606 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Xiao Huang Jialing Zhao Qinghua Wang Tingqi Yan Shu Gou Xiaofeng Zhu Liu Yang Fang Ye Jie Zhang Yanjiang Wang Shaojie Yang Weidong Le Yang Xiang Source Type: research
