Behavioral and Electrophysiological Alterations for Reinforcement Learning in Manic and Euthymic Patients with Bipolar Disorder.
CONCLUSIONS: These findings suggest that patients with bipolar disorder during euthymic or manic states have behavioral and electrophysiological alterations in reward learning compared to healthy subjects. This dysfunctional reward processing may be related to the abnormal decision-making or altered goal-directed activities frequently seen in patients with bipolar disorder. PMID: 28098430 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2017 Category: Neuroscience Authors: Ryu V, Ha RY, Lee SJ, Ha K, Cho HS Tags: CNS Neurosci Ther Source Type: research

Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor.
CONCLUSION: Cognitive stress reduces the levodopa effect on Parkinson's tremor. This effect may be explained by a stress-related depletion of dopamine in the basal ganglia motor circuit, by stress-related involvement of nondopaminergic mechanisms in tremor (e.g., noradrenaline), or both. Targeting these mechanisms may open new windows for treatment. Clinical tremor assessments under evoked cognitive stress (e.g., counting tasks) may avoid overestimation of treatment effects in real life. PMID: 28071873 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2017 Category: Neuroscience Authors: Zach H, Dirkx MF, Pasman JW, Bloem BR, Helmich RC Tags: CNS Neurosci Ther Source Type: research

The Change of Nociceptive Neurons in the Rat Trigeminal Ganglia at Different Postnatal Ages.
PMID: 28052528 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2017 Category: Neuroscience Authors: Zeng MQ, Niu JF, Luan P, Ying Y, Pang RP, Su QN, Zhu HZ, Huang JQ, Chi HJ, Zhang LH, Fan XM, Sha O Tags: CNS Neurosci Ther Source Type: research

Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients.
zar JA, Bullón P PMID: 28052569 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2017 Category: Neuroscience Authors: Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P Tags: CNS Neurosci Ther Source Type: research

Ocular Nerve Growth Factor Administration Modulates Brain-derived Neurotrophic Factor Signaling in Prefrontal Cortex of Healthy and Diabetic Rats.
CONCLUSION: The present data confirm the capacity of ed-NGF treatment to affect brain neurons and lead to brain damage recovery by activating protective and remodeling pathways triggered by BDNF. We suggest that the ed-NGF-induced changes in BDNF signaling might influence the manifestation of depressive phenotype in diabetic rats. PMID: 28044424 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2017 Category: Neuroscience Authors: Rosso P, De Nicolò S, Carito V, Fiore M, Iannitelli A, Moreno S, Tirassa P Tags: CNS Neurosci Ther Source Type: research

Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease.
CONCLUSION: Our findings do reveal that abnormal regional brain activity within attention and salience network and altered FC of above abnormal regions are involved in neural mechanism of fatigue in patients with PD. PMID: 28044431 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2017 Category: Neuroscience Authors: Zhang JJ, Ding J, Li JY, Wang M, Yuan YS, Zhang L, Jiang SM, Wang XX, Zhu L, Zhang KZ Tags: CNS Neurosci Ther Source Type: research

GSK-3 β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.
CONCLUSIONS: The present work identified GSK-3β as a new interacting protein for D1R functional regulation and revealed a novel mechanism for GSK-3β-regulated D1R function which may underlie D1R dysfunction in schizophrenia. PMID: 27996211 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 20, 2016 Category: Neuroscience Authors: Wang JR, Sun PH, Ren ZX, Meltzer HY, Zhen XC Tags: CNS Neurosci Ther Source Type: research

Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats.
CONCLUSION: This study confirms the protective efficacy of inhibiting microglia migration at the hyperacute phase as a therapeutic strategy for ischemic stroke in tMCAO model of rats, and its therapeutic time window could last for 24 h after cerebral ischemia reperfusion. PMID: 27991729 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 19, 2016 Category: Neuroscience Authors: Huang M, Wan Y, Mao L, He QW, Xia YP, Li M, Li YN, Jin HJ, Hu B Tags: CNS Neurosci Ther Source Type: research

Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.
CONCLUSION: Data suggested that the enhanced activities of P2X7Rs in IC, likely through a presynaptic mechanism, contributed to visceral hypersensitivity of adult rats with NMD. PMID: 27976523 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 15, 2016 Category: Neuroscience Authors: Zhang PA, Xu Q, Xue L, Zheng H, Yan J, Xiao Y, Xu GY Tags: CNS Neurosci Ther Source Type: research

Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission.
CONCLUSION: GNE-7915 can be validated for further therapeutic development for PD. PMID: 27943591 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 9, 2016 Category: Neuroscience Authors: Qin Q, Zhi LT, Li XT, Yue ZY, Li GZ, Zhang H Tags: CNS Neurosci Ther Source Type: research

Effect of Redox-Modifying Agents on the Activity of Channelrhodopsin-2.
CONCLUSION: Taken together, these data suggest that redox modification of ChR2 plays an important role in its sensitivity to the light stimulation. Our findings not only help for a better understanding of how ChR2 may behave in physiological/pathological conditions where changes in redox state are common, but also provide a new direction for further optimization of this important opsin. PMID: 27917616 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 4, 2016 Category: Neuroscience Authors: Wu BM, Leng TD, Inoue K, Li J, Xiong ZG Tags: CNS Neurosci Ther Source Type: research

MicroRNA Profile in Cerebrospinal Fluid and Plasma of Patients with Spontaneous Intracerebral Hemorrhage.
PMID: 27870468 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 23, 2016 Category: Neuroscience Authors: Iwuchukwu I, Nguyen D, Sulaiman W Tags: CNS Neurosci Ther Source Type: research

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
Abstract Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Several lines of pathological ...
Source: CNS Neuroscience and Therapeutics - November 22, 2016 Category: Neuroscience Authors: Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A Tags: CNS Neurosci Ther Source Type: research

Anthoxanthin Polyphenols Attenuate A β Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease.
CONCLUSIONS: Together, these findings identify the dominant mechanism by which these anthoxanthins attenuate Aβ oligomer-induced neuronal responses, elucidate their prospective synergy, and demonstrate the potential of anthoxanthin polyphenols as natural AD therapeutics. PMID: 27864869 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 18, 2016 Category: Neuroscience Authors: Pate KM, Rogers M, Reed JW, van der Munnik N, Vance SZ, Moss MA Tags: CNS Neurosci Ther Source Type: research

Differential Impairment of Thalamocortical Structural Connectivity in Amyotrophic Lateral Sclerosis.
CONCLUSION: Our findings provide direct evidence for selective impairment of the thalamocortical structural connectivity in ALS. PMID: 27860375 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 12, 2016 Category: Neuroscience Authors: Zhang JQ, Ji B, Zhou CY, Li LC, Li ZH, Hu XP, Hu J Tags: CNS Neurosci Ther Source Type: research

Sleep-Related Disorders in Children with Attention-Deficit Hyperactivity Disorder: Preliminary Results of a Full Sleep Assessment Study.
CONCLUSIONS: Our study further highlights the need to design an efficient sleep diagnostic algorithm for children with ADHD, thereby more accurately identifying cases in which a full sleep assessment is indicated. PMID: 27255788 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Miano S, Esposito M, Foderaro G, Ramelli GP, Pezzoli V, Manconi M Tags: CNS Neurosci Ther Source Type: research

Multifactorial Influences, Including Comorbidities, Contributing to Sleep Disturbance in Children with a Neurodevelopmental Disorder.
Abstract The term neurodevelopmental disorder (NDD) implies an impairment of the growth and development of the CNS caused by genetic, metabolic, toxic, or traumatic factors. Childhood neuropsychiatric disorder is a subset of NDD. Sleep disturbance is reported in many children with NDD although the details of this association, including extent and types of sleep disturbance, etiology, and assessment and treatment issues, need to be clarified by further research. This review considers the nature of sleep disturbance in NDD. Emphasis is placed on sleep disorders (i.e., the specific conditions that cause sleep problem...
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Stores G Tags: CNS Neurosci Ther Source Type: research

"Emplotted Narratives" and Structured "Behavioral Observations" Supporting the Diagnosis of Willis-Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions.
CONCLUSION: "Emplotted narratives" and structured "behavioral observations" support recognition of familial WED/RLS associated movement patterns and provide a useful tool for the diagnosis of WED/RLS in children with NDCs in a clinical office setting. PMID: 27292821 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Ipsiroglu OS, Beyzaei N, Berger M, Wagner AL, Dhalla S, Garden J, Stockler S Tags: CNS Neurosci Ther Source Type: research

Sleep and Pain in Pediatric Illness: A Conceptual Review.
CONCLUSION: It is essential that research further examine objective sleep, elucidate the pain-sleep relationship, consider physiological and psychosocial mechanisms of this relationship, and investigate nonpharmacological interventions aimed at improving pain and sleep in vulnerable pediatric populations. PMID: 27421251 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Allen JM, Graef DM, Ehrentraut JH, Tynes BL, Crabtree VM Tags: CNS Neurosci Ther Source Type: research

Sleep Complaints as Risk Factor for Suicidal Behavior in Severely Depressed Children and Adolescents.
CONCLUSION: Sleep disturbances are potential warning manifestations of suicidal behaviors in depressed youth. Possibly, the severity of the active affective episode likely underlies in both sleep complaints and suicidal behaviors among depressed underage patients. PMID: 27534369 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Lopes MC, Boronat AC, Wang YP, Fu-I L Tags: CNS Neurosci Ther Source Type: research

The Blind Men and the Elephant: The Risk of Misdiagnosis in Children with Developmental Disabilities.
PMID: 27779373 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 27, 2016 Category: Neuroscience Authors: Spruyt K, Lin JS Tags: CNS Neurosci Ther Source Type: research

Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.
CONCLUSION: We conclude that freshly isolated and neurosphere-grown MGE cells reduced seizures by different mechanisms (inhibitory interneurons vs. astrocytes). Fresh MGE cells appear more appropriate for cell therapies targeting inhibitory interneurons for conferring anticonvulsant outcomes. PMID: 27770487 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 21, 2016 Category: Neuroscience Authors: Romariz SA, Paiva DS, Galindo LT, Barnabé GF, Guedes VA, Borlongan CV, Longo BM Tags: CNS Neurosci Ther Source Type: research

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
CONCLUSIONS: We report, for the first time, that a single METH injection triggers early self-care and hedonic deficits and impairs frontal cortical energetics in mice. PMID: 27762079 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 19, 2016 Category: Neuroscience Authors: Fonseca R, Carvalho RA, Lemos C, Sequeira AC, Pita IR, Carvalho F, Silva CD, Prediger RD, Jarak I, Cunha RA, Fontes Ribeiro CA, Köfalvi A, Pereira FC Tags: CNS Neurosci Ther Source Type: research

Sleep Problems in Young Children with Autism Spectrum Disorders: A Study of Parenting Stress, Mothers' Sleep-Related Cognitions, and Bedtime Behaviors.
CONCLUSION: The results highlight the interplay between sleep-related cognitions, bedtime interactions, and sleep problems and underscore the contribution of disrupted sleep to mothers' experience of parenting stress. As sleep problems in ASD children are common, clinicians are advised to include sleep in consultations with parents. PMID: 27753226 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 17, 2016 Category: Neuroscience Authors: Levin A, Scher A Tags: CNS Neurosci Ther Source Type: research

Sleep Complaints and the 24-h Melatonin Level in Individuals with Smith-Magenis Syndrome: Assessment for Effective Intervention.
CONCLUSION: Treatment of sleep problems in SMS is complex, and our findings may support person-centered sleep and medication management. Future clinical trials including larger groups may shed light on such approaches. PMID: 27743421 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 14, 2016 Category: Neuroscience Authors: Spruyt K, Braam W, Smits M, Curfs LM Tags: CNS Neurosci Ther Source Type: research

Immunotherapy Improves Cognitive Function in Secondary Progressive Multiple Sclerosis.
PMID: 27739247 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - October 13, 2016 Category: Neuroscience Authors: Kinner M, Hoepner R, Klotz P, Prehn C, Faissner S, Salmen A, Linker RA, Gold R, Chan A Tags: CNS Neurosci Ther Source Type: research

Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.
CONCLUSION: Loss of the Rptor gene in mice neural progenitor cells affects normal development in young age and may contribute to alleviate KA seizure-induced behavioral abnormalities, suggesting that raptor protein plays an important role in seizure comorbidities. PMID: 27677248 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 28, 2016 Category: Neuroscience Authors: Chen LL, Wu ML, Zhu F, Kai JJ, Dong JY, Wu XM, Zeng LH Tags: CNS Neurosci Ther Source Type: research

KLF4 Knockdown Attenuates TBI-Induced Neuronal Damage through p53 and JAK-STAT3 Signaling.
CONCLUSION: These findings provide evidence that KLF4 plays an important role in the pathophysiology of TBI. Blocking KLF4 may be a potential therapeutic strategy for the treatment of TBI, either alone or in combination with agents that target complementary mechanisms. PMID: 27671232 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 27, 2016 Category: Neuroscience Authors: Cui DM, Zeng T, Ren J, Wang K, Jin Y, Zhou L, Gao L Tags: CNS Neurosci Ther Source Type: research

Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice.
PMID: 27671373 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 27, 2016 Category: Neuroscience Authors: Wang H, Zhang BF, Zhang TT, Wang L, Zou XY, Xu Y, Chen L, Chen GQ Tags: CNS Neurosci Ther Source Type: research

A Case-Control Study: Infectious Burden Increased the Occurrence of Vascular Cognitive Impairment No Dementia.
PMID: 27663470 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 24, 2016 Category: Neuroscience Authors: Deng YM, Ding ZY, Liu YF, Wu JW, Wang YJ, Zhao XQ Tags: CNS Neurosci Ther Source Type: research

Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease.
CONCLUSION: In PD patients with asymmetrical bradykinesia, levodopa can partially normalize the connectivity of the BGMC with a larger effect on the more severely affected side. Moreover, the beneficial effect of levodopa on bradykinesia is associated with normalization of the striato-thalamo-cortical motor and STN-cortical motor pathways. Our findings inform the neural mechanism of levodopa treatment in PD. PMID: 27663605 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 24, 2016 Category: Neuroscience Authors: Gao LL, Zhang J, Chan P, Wu T Tags: CNS Neurosci Ther Source Type: research

Comparison of 3D Multi-inversion Time Arterial Spin Labeling and Digital Subtraction Angiography in the Evaluation of Cerebral Collateral Circulation.
PMID: 27650696 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 21, 2016 Category: Neuroscience Authors: Wu EZ, Liu X, Dornbos D, Pfeuffer J, Qian TY, Qiao PG, Pan YS, Dou X, Zuo ZW, Liu LP, Xie P Tags: CNS Neurosci Ther Source Type: research

The Relationship Between Sleep-Disordered Breathing Severity and Daytime Adaptive Functioning in Children with Down Syndrome.
PMID: 27637582 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - September 17, 2016 Category: Neuroscience Authors: Nixon GM, Biggs SN, Jitpiriyaroj S, Horne RS Tags: CNS Neurosci Ther Source Type: research

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.
Abstract AIMS: To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples. METHODS: RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed. RESULTS: In the discovery s...
Source: CNS Neuroscience and Therapeutics - September 17, 2016 Category: Neuroscience Authors: Sun LH, Yang FQ, Zhang CB, Wu YP, Liang JS, Jin S, Wang Z, Wang HJ, Bao ZS, Yang ZX, Jiang T Tags: CNS Neurosci Ther Source Type: research

Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
CONCLUSION: Our findings suggest that activation of p-Drp1(Ser616) is related to seizure-induced neuronal damage. Modulation of p-Drp1(Ser616) expression is accompanied by decreases in mitochondrial fission, mitochondrial dysfunction, and oxidation, providing a neuroprotective effect against seizure-induced hippocampal neuronal damage. PMID: 27577016 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 31, 2016 Category: Neuroscience Authors: Chen SD, Zhen YY, Lin JW, Lin TK, Huang CW, Liou CW, Chan SH, Chuang YC Tags: CNS Neurosci Ther Source Type: research

Response to Letter to the Editor by Eisenach and Yaksh on "Successful Pain Management with Epidural Oxytocin".
Response to Letter to the Editor by Eisenach and Yaksh on "Successful Pain Management with Epidural Oxytocin". CNS Neurosci Ther. 2016 Aug 31; Authors: Condés-Lara M, Zayas-González H, Manzano-García A, González-Hernández A PMID: 27577179 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 31, 2016 Category: Neuroscience Authors: Condés-Lara M, Zayas-González H, Manzano-García A, González-Hernández A Tags: CNS Neurosci Ther Source Type: research

Identification of Cholinergic Pallidocortical Neurons.
PMID: 27577268 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 31, 2016 Category: Neuroscience Authors: Guo CN, Machado NL, Zhan SQ, Yang XF, Yang WJ, Lu J Tags: CNS Neurosci Ther Source Type: research

Ethical Concerns Regarding Human Study.
PMID: 27577599 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 31, 2016 Category: Neuroscience Authors: Eisenach JC, Yaksh TL Tags: CNS Neurosci Ther Source Type: research

Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Abstract Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the role of these inflammatory mediators in a broader range of diseases such as in the inflammation associated with the central nervous system (CNS) disorders, vascular inflammation (atherosclerotic), and in cancer. Among the CNS diseases, they, along with their synthesis precursor enzyme 5-lipox...
Source: CNS Neuroscience and Therapeutics - August 19, 2016 Category: Neuroscience Authors: Ghosh A, Chen F, Thakur A, Hong H Tags: CNS Neurosci Ther Source Type: research

Sleep Complaints as Risk Factor for Suicidal Behavior in Severely Depressed Children and Adolescents.
CONCLUSION: Sleep disturbances are potential warning manifestations of suicidal behaviors in depressed youth. Possibly, the severity of the active affective episode likely underlies in both sleep complaints and suicidal behaviors among depressed underage patients. PMID: 27534369 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 18, 2016 Category: Neuroscience Authors: Lopes MC, Boronat AC, Wang YP, Fu-I L Tags: CNS Neurosci Ther Source Type: research

Upregulations of CRH and CRHR1 in the Epileptogenic Tissues of Patients with Intractable Infantile Spasms.
CONCLUSION: These results suggest that the CRH signal transduction pathway might participate in the epileptogenesis of IS, supporting the hypothesis that CRH is related to the pathogenesis of IS. PMID: 27534449 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 18, 2016 Category: Neuroscience Authors: Yang XL, Chen B, Zhang XQ, Chen X, Yang MH, Zhang W, Chen HR, Zang ZL, Li W, Yang H, Liu SY Tags: CNS Neurosci Ther Source Type: research

Establishing Prediction Model of Antiepileptic Drugs Response using Data Mining Approach.
PMID: 27527827 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 15, 2016 Category: Neuroscience Authors: Yin JY, Qu J, Mao CX, Li X, Mao XY, Xiao B, Xiao L, Zheng W, Zhou HH, Liu ZQ Tags: CNS Neurosci Ther Source Type: research

ORM Elevation in Response to Cognitive Impairment Is an Accompanying Phenomenon.
PMID: 27390178 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 9, 2016 Category: Neuroscience Authors: Wan JJ, Qin Z, Liu X Tags: CNS Neurosci Ther Source Type: research

Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat.
Abstract BACKGROUND: Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma. We aimed to investigate the neuroprotective effects of stereotactic administration of edaravone (SI) into the brain parenchyma. METHODS: Intracerebral hemorrhage rat models were established by infusion of collagenase into the caudate nucleus. Neural functional recovery was assessed using modified neurological severity scores (mNSS). A comparative study of therapeutic effects between SI and intraperitoneal injection of...
Source: CNS Neuroscience and Therapeutics - July 8, 2016 Category: Neuroscience Authors: Zhang Y, Yang Y, Zhang GZ, Gao M, Ge GZ, Wang QQ, Ji XC, Sun YL, Zhang HT, Xu RX Tags: CNS Neurosci Ther Source Type: research

Lentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice.
Abstract AIMS: MicroRNAs play an important role in the pathogenesis of ischemic brain injury and in the repair process during postischemic condition. However, the key miRNAs and their function in these processes remain unclear. METHODS: Circulating blood MicroRNAs profiles were examined in the ischemic stroke patients. The predicted network of difference was analyzed by ingenuity pathway analysis. The key MicroRNAs were selected, and the function was further studied in a mouse ischemia model. The predicted downstream target was confirmed. RESULTS: We found that 24 MicroRNAs were differently expressed in ...
Source: CNS Neuroscience and Therapeutics - July 8, 2016 Category: Neuroscience Authors: Zeng LL, He XS, Liu JR, Zheng CB, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Hydrogen Sulfide Promotes Surface Insertion of Hippocampal AMPA Receptor GluR1 Subunit via Phosphorylating at Serine-831/Serine-845 Sites Through a Sulfhydration-Dependent Mechanism.
CONCLUSION: Our data suggest that H2 S promotes surface insertion of AMPARs via phosphorylation of GluR1, which depends on a sulfhydration-mediated mechanism. PMID: 27380893 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2016 Category: Neuroscience Authors: Li YL, Zhou J, Zhang H, Luo Y, Long LH, Hu ZL, Chen JG, Wang F, Wu PF Tags: CNS Neurosci Ther Source Type: research

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy.
PMID: 27380946 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 6, 2016 Category: Neuroscience Authors: Ramos E, Romero A, Marco-Contelles J, Del Pino J Tags: CNS Neurosci Ther Source Type: research

MicroRNA in the Pathophysiology of CNS Injury: Implication in Neuroregenerative Medicine.
PMID: 27297685 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2016 Category: Neuroscience Authors: Abdul-Muneer PM Tags: CNS Neurosci Ther Source Type: research

Pain in Fabry Disease: Practical Recommendations for Diagnosis and Treatment.
CONCLUSION: To improve treatment outcomes, pain should be diagnosed early in unrecognized or newly identified FD patients. Treatment should include: (a) enzyme replacement therapy controlling the progression of underlying pathology; (b) adjunctive, symptomatic pain management with analgesics for chronic neuropathic and acute nociceptive, and inflammatory or mixed pain; and (c) lifestyle modifications. PMID: 27297686 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 15, 2016 Category: Neuroscience Authors: Politei JM, Bouhassira D, Germain DP, Goizet C, Guerrero-Sola A, Hilz MJ, Hutton EJ, Karaa A, Liguori R, Üçeyler N, Zeltzer LK, Burlina A Tags: CNS Neurosci Ther Source Type: research

The Management of LDL Cholesterol and Predictors of Goal Achievement in Stroke Patients in China: A Cross-Sectional Study.
This study was a nation-wide, multicenter, cross-sectional study conducted from July 2013 to August 2013 in mainland China. Patients who had an ischemic stroke within 6-12 months and were more than 18 year old were consecutively included into this study. All data referred to personal information, medical history, medication and results from laboratory tests were collected by face-to-face questionnaires, physical examination and blood tests. The predictors for the achievement of LDL-C target (
Source: CNS Neuroscience and Therapeutics - June 15, 2016 Category: Neuroscience Authors: Wang CJ, Wang YL, Li ZX, Wang YJ Tags: CNS Neurosci Ther Source Type: research