BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome
CONCLUSION: BRCC3 shows promise as a novel target to enhance neurological recovery and attenuate the inflammatory responses and pyroptosis caused by NLRP6 activation in cerebral I/R injury.PMID:38544474 | PMC:PMC10973773 | DOI:10.1111/cns.14697 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Xiaohuan Huang Junyi Tan Yanyan Ji Jing Luo Yong Zhao Jing Zhao Source Type: research
Tracing the path of disruption: < sup > 13 < /sup > C isotope applications in traumatic brain injury-induced metabolic dysfunction
CNS Neurosci Ther. 2024 Mar;30(3):e14693. doi: 10.1111/cns.14693.ABSTRACTCerebral metabolic dysfunction is a critical pathological hallmark observed in the aftermath of traumatic brain injury (TBI), as extensively documented in clinical investigations and experimental models. An in-depth understanding of the bioenergetic disturbances that occur following TBI promises to reveal novel therapeutic targets, paving the way for the timely development of interventions to improve patient outcomes. The 13C isotope tracing technique represents a robust methodological advance, harnessing biochemical quantification to delineate the me...
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Charles J Peper Mitchell D Kilgore Yinghua Jiang Yuwen Xiu Winna Xia Yingjie Wang Mengxuan Shi Di Zhou Aaron S Dumont Xiaoying Wang Ning Liu Source Type: research
Serum heme oxygenase-1 level predicts clinical outcome after acute ischemic stroke
CONCLUSIONS: Elevated serum HO-1 levels at baseline were independently associated with improved 3-month functional outcomes post-ischemic stroke. Serum HO-1 measurement may enhance outcome prediction beyond conventional clinical factors.PMID:38544366 | DOI:10.1111/cns.14701 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Huan Wang Ting Cui Yaqi Chen Mingxi Chen Shihong Zhang Xinyi Leng Deren Wang Source Type: research
Identifying of immune-associated genes for assessing the obesity-associated risk to the offspring in maternal obesity: A bioinformatics and machine learning
CONCLUSION: Two candidate hub genes (Sytl4 and Kcnc2) were identified and a nomogram was developed to predict obesity risk in offspring with maternal obesity. These findings offer potential diagnostic candidate genes for identifying obesity-associated risks in the offspring of obese mothers.PMID:38544384 | DOI:10.1111/cns.14700 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Yanxing Shang Xueqin Wang Sixuan Su Feng Ji Donghai Shao Chengwei Duan Tianpeng Chen Caixia Liang Dongmei Zhang Hongjian Lu Source Type: research
BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome
CONCLUSION: BRCC3 shows promise as a novel target to enhance neurological recovery and attenuate the inflammatory responses and pyroptosis caused by NLRP6 activation in cerebral I/R injury.PMID:38544474 | PMC:PMC10973773 | DOI:10.1111/cns.14697 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Xiaohuan Huang Junyi Tan Yanyan Ji Jing Luo Yong Zhao Jing Zhao Source Type: research
Tracing the path of disruption: < sup > 13 < /sup > C isotope applications in traumatic brain injury-induced metabolic dysfunction
CNS Neurosci Ther. 2024 Mar;30(3):e14693. doi: 10.1111/cns.14693.ABSTRACTCerebral metabolic dysfunction is a critical pathological hallmark observed in the aftermath of traumatic brain injury (TBI), as extensively documented in clinical investigations and experimental models. An in-depth understanding of the bioenergetic disturbances that occur following TBI promises to reveal novel therapeutic targets, paving the way for the timely development of interventions to improve patient outcomes. The 13C isotope tracing technique represents a robust methodological advance, harnessing biochemical quantification to delineate the me...
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Charles J Peper Mitchell D Kilgore Yinghua Jiang Yuwen Xiu Winna Xia Yingjie Wang Mengxuan Shi Di Zhou Aaron S Dumont Xiaoying Wang Ning Liu Source Type: research
Serum heme oxygenase-1 level predicts clinical outcome after acute ischemic stroke
CONCLUSIONS: Elevated serum HO-1 levels at baseline were independently associated with improved 3-month functional outcomes post-ischemic stroke. Serum HO-1 measurement may enhance outcome prediction beyond conventional clinical factors.PMID:38544366 | DOI:10.1111/cns.14701 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Huan Wang Ting Cui Yaqi Chen Mingxi Chen Shihong Zhang Xinyi Leng Deren Wang Source Type: research
Identifying of immune-associated genes for assessing the obesity-associated risk to the offspring in maternal obesity: A bioinformatics and machine learning
CONCLUSION: Two candidate hub genes (Sytl4 and Kcnc2) were identified and a nomogram was developed to predict obesity risk in offspring with maternal obesity. These findings offer potential diagnostic candidate genes for identifying obesity-associated risks in the offspring of obese mothers.PMID:38544384 | DOI:10.1111/cns.14700 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Yanxing Shang Xueqin Wang Sixuan Su Feng Ji Donghai Shao Chengwei Duan Tianpeng Chen Caixia Liang Dongmei Zhang Hongjian Lu Source Type: research
BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome
CONCLUSION: BRCC3 shows promise as a novel target to enhance neurological recovery and attenuate the inflammatory responses and pyroptosis caused by NLRP6 activation in cerebral I/R injury.PMID:38544474 | DOI:10.1111/cns.14697 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 28, 2024 Category: Neuroscience Authors: Xiaohuan Huang Junyi Tan Yanyan Ji Jing Luo Yong Zhao Jing Zhao Source Type: research
Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup
CONCLUSION: In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.PMID:38532275 | PMC:PMC10965754 | DOI:10.1111/cns.14619 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Wanqing Xie Szuyao Hsu Yuxuan Lin Lv Xie Xia Jin Ziyu Zhu Yunlu Guo Caiyang Chen Dan Huang Johannes Boltze Peiying Li Source Type: research
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats
CONCLUSION: Our findings indicate that RACK1 protected against TBI-induced neuronal damage partly through autophagy induction by regulating the PERK signaling pathway.PMID:38532543 | PMC:PMC10966134 | DOI:10.1111/cns.14691 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Haibo Ni Xugang Kan Qin Rui Yang Zhang Weiwei Zhai Baole Zhang Zhengquan Yu Source Type: research
Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | PMC:PMC10966135 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup
CONCLUSION: In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.PMID:38532275 | DOI:10.1111/cns.14619 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Wanqing Xie Szuyao Hsu Yuxuan Lin Lv Xie Xia Jin Ziyu Zhu Yunlu Guo Caiyang Chen Dan Huang Johannes Boltze Peiying Li Source Type: research
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats
CONCLUSION: Our findings indicate that RACK1 protected against TBI-induced neuronal damage partly through autophagy induction by regulating the PERK signaling pathway.PMID:38532543 | DOI:10.1111/cns.14691 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Haibo Ni Xugang Kan Qin Rui Yang Zhang Weiwei Zhai Baole Zhang Zhengquan Yu Source Type: research
Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage
CONCLUSIONS: Our results revealed that NBO exerts its neuroprotective effects by reducing C3-mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.PMID:38532579 | DOI:10.1111/cns.14694 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 27, 2024 Category: Neuroscience Authors: Moxin Wu Kai Chen Yasong Zhao Min Jiang Bing Bao Wenmin Yu Zhiying Chen Xiaoping Yin Source Type: research
