Downregulation of DEC1 contributes to the neurotoxicity induced by MPP(+) by suppressing PI3K/Akt/GSK3 β pathway.
CONCLUSION: Downregulation of DEC1 contributes to MPP(+) -induced neurotoxicity by suppressing PI3K/Akt/GSK3β pathway. PMID: 28734031 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 21, 2017 Category: Neuroscience Authors: Zhu Z, Wang YW, Ge DH, Lu M, Liu W, Xiong J, Hu G, Li XP, Yang J Tags: CNS Neurosci Ther Source Type: research

Impact of prenatal immune challenge on the demyelination injury during adulthood.
CONCLUSION: These data strongly suggest that prenatal immune challenge dampens the extent of demyelination during adulthood likely by reprogramming the local brain inflammatory response to demyelinating insults. PMID: 28718218 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 17, 2017 Category: Neuroscience Authors: Mouihate A, Al-Hashash H, Rakhshani-Moghadam S, Kalakh S Tags: CNS Neurosci Ther Source Type: research

Clinical features and mutation spectrum in Chinese patients with CADASIL: A multicenter retrospective study.
CONCLUSIONS: These findings broaden the mutational and clinical spectrum of CADASIL and provide additional evidences for the existence of founder effect in CADASIL patients. PMID: 28710804 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 14, 2017 Category: Neuroscience Authors: Chen S, Ni W, Yin X, Liu HQ, Lu C, Zheng QJ, Zhao GX, Xu Y, Wu L, Zhang L, Wang N, Li HF, Wu ZY Tags: CNS Neurosci Ther Source Type: research

Mitochondrial dysfunction and cerebral metabolic abnormalities in patients with mitochondrial encephalomyopathy subtypes: Evidence from proton MR spectroscopy and muscle biopsy.
CONCLUSIONS: Mitochondrial cytopathy (lactic acidosis and RRFs on muscle biopsy) was associated with neuronal viability but not glial proliferation, notably in MELAS. Mitochondrial neuronopathy and neuronal vulnerability are considered significant causes in the pathogenesis of MELAS, particularly with regard to stroke-like episodes. PMID: 28695670 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 11, 2017 Category: Neuroscience Authors: Niu FN, Meng HL, Chang LL, Wu HY, Li WP, Liu RY, Wang HT, Zhang B, Xu Y Tags: CNS Neurosci Ther Source Type: research

The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
CONCLUSION: Our study confirmed the upregulation of NDRG2 in AD animal models and demonstrated its important roles in AD pathology. NDRG2 might be a potential target for studying and treatment of AD. PMID: 28670853 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - July 2, 2017 Category: Neuroscience Authors: Rong XF, Sun YN, Liu DM, Yin HJ, Peng Y, Xu SF, Wang L, Wang XL Tags: CNS Neurosci Ther Source Type: research

Mitochondrial respiratory chain complex enzyme activities of limbic structures and psychiatric diagnosis in temporal lobe epilepsy patients: Preliminary results.
alz R PMID: 28656687 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 27, 2017 Category: Neuroscience Authors: Osório CM, Lin K, Guarnieri R, de Oliveira Thais MER, Dresch Vascouto H, Remor AP, Lopes MW, Linhares MN, Ben J, de Paula Martins R, Hoeller AA, Wolf P, Latini A, Walz R Tags: CNS Neurosci Ther Source Type: research

Long noncoding RNA and its contribution to autism spectrum disorders.
In this study, we review several known functions of lncRNAs and the potential contribution of lncRNAs to ASDs and to other genetic syndromes that have a similar clinical presentation to ASDs, such as fragile X syndrome and Rett syndrome. PMID: 28635106 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 20, 2017 Category: Neuroscience Authors: Tang J, Yu Y, Yang W Tags: CNS Neurosci Ther Source Type: research

Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy.
CONCLUSION: This study suggested that Klt, 25(OH)D and Hcy levels could be a potential predictor for MSA severity evaluation. PMID: 28628270 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 19, 2017 Category: Neuroscience Authors: Guo Y, Zhuang XD, Xian WB, Wu LL, Huang ZN, Hu X, Zhang XS, Chen L, Liao XX Tags: CNS Neurosci Ther Source Type: research

Angiotensin-converting enzyme gene rs4343 polymorphism increases susceptibility to migraine.
PMID: 28626926 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 18, 2017 Category: Neuroscience Authors: Abedin-Do A, Pouriamanesh S, Kamaliyan Z, Mirfakhraie R Tags: CNS Neurosci Ther Source Type: research

Polyethylene glycol-induced motor recovery after total spinal transection in rats.
CONCLUSIONS: We show for the first time in an adequately powered study that the paralysis attendant to a complete transection of the spinal cord can be reversed. This opens the path to a severance-reapposition cure of spinal paralysis, in which the injured segment is excised and the two stumps approximated after vertebrectomy/diskectomies. PMID: 28612398 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 14, 2017 Category: Neuroscience Authors: Ren S, Liu ZH, Wu Q, Fu K, Wu J, Hou LT, Li M, Zhao X, Miao Q, Zhao YL, Wang SY, Xue Y, Xue Z, Guo YS, Canavero S, Ren XP Tags: CNS Neurosci Ther Source Type: research

Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 ( ΔE9) mice.
CONCLUSION: In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an AD mouse model. These results may provide some valid resources for therapy and research of AD. PMID: 28597477 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 8, 2017 Category: Neuroscience Authors: Liu Y, Xu YF, Zhang L, Huang L, Yu P, Zhu H, Deng W, Qin C Tags: CNS Neurosci Ther Source Type: research

Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.
CONCLUSION: TTR stabilization exerts a positive effect on Aβ clearance and LRP1 levels, suggesting that TTR protective role in AD is dependent on its stability. These results provide relevant information for the design of TTR-based therapeutic strategies for AD. PMID: 28570028 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - June 1, 2017 Category: Neuroscience Authors: Alemi M, Silva SC, Santana I, Cardoso I Tags: CNS Neurosci Ther Source Type: research

Pituicytoma-An outlook on possible targeted therapies.
CONCLUSIONS: Pituicytomas were generally positive for VEGFR and showed regular expression of SSTR 3 and 5 indicating a possible treatment option through targeted therapies in cases where resection remains insufficient. Further research is necessary as to whether tumor growth can be inhibited using these pathways. PMID: 28556544 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 28, 2017 Category: Neuroscience Authors: Mende KC, Matschke J, Burkhardt T, Saeger W, Buslei R, Buchfelder M, Fahlbusch R, Westphal M, Flitsch J Tags: CNS Neurosci Ther Source Type: research

Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus.
CONCLUSION: In conclusion, TSG produces antidepressant-like effects in mice via enhancement of the hippocampal BDNF system. PMID: 28547794 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 25, 2017 Category: Neuroscience Authors: Wang H, Zhao Y, Wang YJ, Song L, Wang JL, Huang C, Zhang W, Jiang B Tags: CNS Neurosci Ther Source Type: research

Acute quadriplegia following a minimal injury in the posterior pharyngeal wall by a fishbone.
PMID: 28544487 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 19, 2017 Category: Neuroscience Authors: Zheng SH, Li Y, Zhang SQ Tags: CNS Neurosci Ther Source Type: research

Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1 β-induced thermal hyperalgesia in rats.
This study investigated the role of spinal glutamatergic response in intrathecal IL-1β-induced nociception in rats. METHODS: The pretreatment effects of MK-801 (5 μg), minocycline (20 μg), and SB203580 (5 μg) on intrathecal IL-1β (100 ng) in rats were measured by behavior, Western blotting, CSF analysis, and immunofluorescence studies. RESULTS: IL-1β increased phosphorylation of NR-1 (p-NR1) subunit of N-methyl-D-aspartate receptors in neurons and microglia, reduced glutamate transporters (GTs; glutamate/aspartate transporter by 60.9%, glutamate transporter-1 by 55.0%, ...
Source: CNS Neuroscience and Therapeutics - May 19, 2017 Category: Neuroscience Authors: Sung CS, Wen ZH, Feng CW, Chen CH, Huang SY, Chen NF, Chen WF, Wong CS Tags: CNS Neurosci Ther Source Type: research

Roles of autophagy and endoplasmic reticulum stress in intracerebral hemorrhage-induced secondary brain injury in  rats.
CONCLUSIONS: At 6 hours after ICH, excessive autophagy may participate in ER stress-induced brain injury; at 7 days after ICH, autophagy could enhance the protection of ER stress inhibitor possibly via clearing up the cell rubbish generated due to the early-stage damaged autophagic flux. PMID: 28544790 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 19, 2017 Category: Neuroscience Authors: Duan XC, Wang W, Feng DX, Yin J, Zuo G, Chen DD, Chen ZQ, Li HY, Wang Z, Chen G Tags: CNS Neurosci Ther Source Type: research

Pseudoginsenoside-F11 attenuates cerebral ischemic injury by  alleviating autophagic/lysosomal defects.
CONCLUSION: These findings indicate that the autophagic flux is impaired in a rat model of pMCAO, and that PF11 exerts an excellent protective effect against ischemic stroke by alleviating autophagic/lysosomal defects. PMID: 28485547 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 9, 2017 Category: Neuroscience Authors: Liu YY, Zhang TY, Xue X, Liu DM, Zhang HT, Yuan LL, Liu YL, Yang HL, Sun SB, Zhang C, Xu HS, Wu CF, Yang JY Tags: CNS Neurosci Ther Source Type: research

Sarsasapogenin-AA13 ameliorates A β-induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation.
CONCLUSION: The present study indicated that the neuroprotective effect of AA13 might relate to its modulatory effects on microglia activation state, phagocytic ability, and expression of Aβ-degrading enzymes, which makes it a promising therapeutic agent in the early stage of Alzheimer's disease (AD). PMID: 28466999 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2017 Category: Neuroscience Authors: Huang C, Dong D, Jiao Q, Pan H, Ma L, Wang R Tags: CNS Neurosci Ther Source Type: research

Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease.
CONCLUSION: The abnormal connectivity of the somatomotor and DMN observed in HD patients may represent an early dysfunction marker, as it preceded volume loss in DMN. Pridopidine reduced connectivity of these networks in all four treated patients, suggesting that connectivity is sensitive to treatment response. PMID: 28464463 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 2, 2017 Category: Neuroscience Authors: Sánchez-Castañeda C, de Pasquale F, Caravasso CF, Marano M, Maffi S, Migliore S, Sabatini U, Squitieri F Tags: CNS Neurosci Ther Source Type: research

Local injection of Lenti-Olig2 at lesion site promotes functional recovery of spinal cord injury in rats.
CONCLUSIONS: Our findings provided the evidence that overexpression Olig2 promotes myelination and locomotor recovery of contusion SCI, which gives us more understanding of Olig2 on spinal cord injury treatment. PMID: 28452182 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2017 Category: Neuroscience Authors: Tan BT, Jiang L, Liu L, Yin Y, Luo ZR, Long ZY, Li S, Yu LH, Wu YM, Liu Y Tags: CNS Neurosci Ther Source Type: research

A cross-circulated bicephalic model of head transplantation.
CONCLUSIONS: Peristaltic pump application can guarantee the blood supply of donor brain tissue per unit time, while the application of temperature change device to the silicone tube can protect the brain tissue hypothermia, postoperative experimental data show that there is no brain tissue ischemia during the whole operation. The application of vascular grafting can also provide the possibility of long-term survival of the model. PMID: 28429535 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2017 Category: Neuroscience Authors: Li PW, Zhao X, Zhao YL, Wang BJ, Song Y, Shen ZL, Jiang HJ, Jin H, Canavero S, Ren XP Tags: CNS Neurosci Ther Source Type: research

α-Mangostin decreases β-amyloid peptides production via modulation of amyloidogenic pathway.
CONCLUSIONS: Our data demonstrate that α-M decreases Aβ production through inhibiting activities of β-secretase and likely γ-secretase in the amyloidogenic pathway. The current data together with previous study indicated that α-M could be a novel neuroprotective agent through intervention of multiple pathological processes of AD. PMID: 28429536 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 21, 2017 Category: Neuroscience Authors: Zhao LX, Wang Y, Liu T, Wang YX, Chen HZ, Xu JR, Qiu Y Tags: CNS Neurosci Ther Source Type: research

Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice.
CONCLUSIONS: Targeting ErbB4 or the modulation of endothelial ErbB4 signaling may represent a rational pharmacological approach to treat neurological disorders. PMID: 28421673 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 18, 2017 Category: Neuroscience Authors: Wu G, Liu XX, Lu NN, Liu QB, Tian Y, Ye WF, Jiang GJ, Tao RR, Han F, Lu YM Tags: CNS Neurosci Ther Source Type: research

Asenapine modulates mood-related behaviors and 5-HT1A/7 receptors-mediated neurotransmission.
CONCLUSION: These results confirm that Asenapine displays robust antimanic property and effective in vivo antagonistic activity at 5-HT1A/7 receptors. PMID: 28417559 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 17, 2017 Category: Neuroscience Authors: Delcourte S, Abrial E, Etiévant A, Rovera R, Arnt J, Didriksen M, Haddjeri N Tags: CNS Neurosci Ther Source Type: research

Calcitonin gene-related peptide (CGRP): A novel target for Alzheimer's disease.
Abstract Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP) is a thirty-seven-amino acid regulatory neuropeptide resulting from different merging of the CGRP gene, which also includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor-stimulating peptide. It is a proof for a CGRP receptor within nucleus accumbens of br...
Source: CNS Neuroscience and Therapeutics - April 17, 2017 Category: Neuroscience Authors: Singh Y, Gupta G, Shrivastava B, Dahiya R, Tiwari J, Ashwathanarayana M, Sharma RK, Agrawal M, Mishra A, Dua K Tags: CNS Neurosci Ther Source Type: research

G-CSF and cognitive dysfunction in elderly diabetic mice with cerebral small vessel disease: Preventive intervention effects and underlying mechanisms.
CONCLUSIONS: In this study, aged diabetic mice were prone to cognitive dysfunction and cerebral small vessel disease. However, administration of G-CSF significantly improved cognitive function in elderly db/db diabetic mice, and this change was likely related to the regulation of autophagy and NF-κB signaling pathways. PMID: 28374506 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 4, 2017 Category: Neuroscience Authors: Guan ZF, Tao YH, Zhang XM, Guo QL, Liu YC, Zhang Y, Wang YM, Ji G, Wu GF, Wang NN, Yang H, Yu ZY, Guo JC, Zhou HG Tags: CNS Neurosci Ther Source Type: research

The neuroprotective effects of caffeine in neurodegenerative diseases.
Abstract Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A2A R antagonism. A study found ...
Source: CNS Neuroscience and Therapeutics - March 22, 2017 Category: Neuroscience Authors: Kolahdouzan M, Hamadeh MJ Tags: CNS Neurosci Ther Source Type: research

Roles of NG2-glia in ischemic stroke.
Abstract Recent studies have shown that a widely distributed class of glial cells, termed NG2-glia, engages in rapid signaling with surrounding neurons through direct synaptic contacts in the developing and mature central nervous system (CNS). This unique glial cell group has a typical function of proliferating and differentiating into oligodendrocytes during early development of the brain, which is crucial to axon myelin formation. Therefore, NG2-glia are also called oligodendrocyte precursor cells (OPCs). In vitro and in vivo studies reveal that NG2-glia expressing receptors and ion channels demonstrate function...
Source: CNS Neuroscience and Therapeutics - March 19, 2017 Category: Neuroscience Authors: Song FE, Huang JL, Lin SH, Wang S, Ma GF, Tong XP Tags: CNS Neurosci Ther Source Type: research

PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
CONCLUSION: PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease. PMID: 28294542 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2017 Category: Neuroscience Authors: Yang W, Yang LF, Song ZQ, Shah SZ, Cui YY, Li CS, Zhao HF, Gao HL, Zhou XM, Zhao DM Tags: CNS Neurosci Ther Source Type: research

Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.
CONCLUSIONS: This study supports an interplay between cGMP-neuroinflammation and GABAergic neurotransmission in impairing motor coordination in PCS rats. PMID: 28296282 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 11, 2017 Category: Neuroscience Authors: Agusti A, Hernández-Rabaza V, Balzano T, Taoro-Gonzalez L, Ibañez-Grau A, Cabrera-Pastor A, Fustero S, Llansola M, Montoliu C, Felipo V Tags: CNS Neurosci Ther Source Type: research

Neurotropin ® alleviates hippocampal neuron damage through a HIF-1α/MAPK pathway.
Neurotropin® alleviates hippocampal neuron damage through a HIF-1α/MAPK pathway. CNS Neurosci Ther. 2017 Mar 07;: Authors: Fang WL, Zhao DQ, Wang F, Li M, Fan SN, Liao W, Zheng YQ, Liao SW, Xiao SH, Luan P, Liu J Abstract AIMS: The main purpose was to verify the potent capacity of Neurotropin® against neuronal damage in hippocampus and to explore its underlying mechanisms. METHODS: HT22 cells were treated with 40 μmol/L Aβ25-35 in the presence of various concentrations of Neurotropin® or in its absence. The cell viability was assessed with a CCK-8 assay, and flow cy...
Source: CNS Neuroscience and Therapeutics - March 7, 2017 Category: Neuroscience Authors: Fang WL, Zhao DQ, Wang F, Li M, Fan SN, Liao W, Zheng YQ, Liao SW, Xiao SH, Luan P, Liu J Tags: CNS Neurosci Ther Source Type: research

Kinect-based gait analyses of patients with Parkinson's disease, patients with stroke with hemiplegia, and healthy adults.
PMID: 28266138 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 6, 2017 Category: Neuroscience Authors: Cao Y, Li BZ, Li QN, Xie JD, Cao BZ, Yu SY Tags: CNS Neurosci Ther Source Type: research

Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by A β25-35 in hippocampus neurons in vitro.
CONCLUSIONS: DNLA prevents Aβ25-35 -induced axonal degeneration via activation of autophagy process and could be a novel therapeutic target. PMID: 28261990 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 5, 2017 Category: Neuroscience Authors: Li LS, Lu YL, Nie J, Xu YY, Zhang W, Yang WJ, Gong QH, Lu YF, Lu Y, Shi JS Tags: CNS Neurosci Ther Source Type: research

GSK-3 β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.
CONCLUSION: TDZD-8 has the therapeutic potential for hypoxic-ischemic brain injury in neonates. The neuroprotective effect of TDZD-8 appears to be mediated through its antiapoptotic activity and by reducing astrogliosis. PMID: 28256059 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 2, 2017 Category: Neuroscience Authors: Huang S, Wang H, Turlova E, Abussaud A, Ji X, Britto LR, Miller SP, Martinez A, Sun HS, Feng ZP Tags: CNS Neurosci Ther Source Type: research

SIRT1-dependent AMPK pathway in the protection of estrogen against ischemic brain injury.
CONCLUSION: Our data support that estrogen protects against ischemic stroke through preventing neuron death via the SIRT1-dependent AMPK pathway. PMID: 28256111 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 2, 2017 Category: Neuroscience Authors: Guo JM, Shu H, Wang L, Xu JJ, Niu XC, Zhang L Tags: CNS Neurosci Ther Source Type: research

Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma.
CONCLUSIONS: Collectively, our study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in GBM. PMID: 28198167 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 17, 2017 Category: Neuroscience Authors: Wei JW, Cai JQ, Fang C, Tan YL, Huang K, Yang C, Chen Q, Jiang CL, Kang CS Tags: CNS Neurosci Ther Source Type: research

Oculomotor deficits in spinocerebellar ataxia type 3: Potential biomarkers of preclinical detection and disease progression.
CONCLUSION: This study showed that a series of neuropathological changes reflected by oculomotor abnormalities appeared preferentially in preclinical stage of SCA3. Accordingly, objective oculomotor preclinical signs may be useful to detect the optimum time-point for therapeutic interventions in future clinical trials of SCA3. Larger and longitudinal data are warranted to confirm our results. PMID: 28195427 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 13, 2017 Category: Neuroscience Authors: Wu C, Chen DB, Feng L, Zhou XX, Zhang JW, You HJ, Liang XL, Pei Z, Li XH Tags: CNS Neurosci Ther Source Type: research

The phosphoinositide-3 kinase signaling is involved in neuroinflammation in hypertensive rats.
CONCLUSION: This study suggests that the PI3K signaling in the RVLM is involved in neuroinflammation in hypertension and plays an important role in the renin-angiotensin system-mediated changes in neuroinflammation in the RVLM. PMID: 28191736 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 12, 2017 Category: Neuroscience Authors: Tan X, Jiao PL, Wang YK, Wu ZT, Zeng XR, Li ML, Wang WZ Tags: CNS Neurosci Ther Source Type: research

The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of Alzheimer's disease.
CONCLUSION: These findings provided evidence that neuroinflammation might be involved in the development and progression of cognitive deficits in APP/PS1 mice, suggesting novel intervention and prevention strategies for AD. PMID: 28191738 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 12, 2017 Category: Neuroscience Authors: Zhu S, Wang J, Zhang Y, He J, Kong J, Wang JF, Li XM Tags: CNS Neurosci Ther Source Type: research

Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure.
CONCLUSION: These results suggest that H3R in the CNS, probably in the hippocampus, may serve as therapeutic target for improvement of anesthesia-associated cognitive deficits. PMID: 28168839 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 6, 2017 Category: Neuroscience Authors: Luo T, Wang Y, Qin J, Liu ZG, Liu M Tags: CNS Neurosci Ther Source Type: research

Cpne5 is Involved in Regulating Rodent Anxiety Level.
PMID: 28168849 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 6, 2017 Category: Neuroscience Authors: Ding XF, Wang HJ, Qian L, Hu ZY, Feng SF, Wu Y, Yang HH, Wu HT, Fan WH, Fan M Tags: CNS Neurosci Ther Source Type: research

Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta-Amyloid Deposition in Mice via BACE1-Antisense Activation.
CONCLUSIONS: This study shows that a CSR accelerates AD pathogenesis in wild-type mice. An upregulation of the BACE1 pathway appears to participate in both cortical Aβ plaque deposition and memory impairment caused by CSR. BACE1-AS is likely activated to initiate a cascade of events that lead to AD pathogenesis. Our study provides, therefore, a molecular mechanism that links CSR to sporadic AD. PMID: 28145081 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 1, 2017 Category: Neuroscience Authors: Zhao HY, Wu HJ, He JL, Zhuang JH, Liu ZY, Huang LQ, Zhao ZX Tags: CNS Neurosci Ther Source Type: research

Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans.
CONCLUSIONS: Our work indicated that AnxA2 played complex roles in traversal of C. neoformans across host BMECs, which might be dependent on downstream cofilin to inhibit fungal adhesion but rely on its partner S100A10 to promote cryptococcal transcytosis. PMID: 28130864 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 28, 2017 Category: Neuroscience Authors: Fang W, Fa ZZ, Xie Q, Wang GZ, Yi J, Zhang C, Meng GX, Gu JL, Liao WQ Tags: CNS Neurosci Ther Source Type: research

Behavioral and Electrophysiological Alterations for Reinforcement Learning in Manic and Euthymic Patients with Bipolar Disorder.
CONCLUSIONS: These findings suggest that patients with bipolar disorder during euthymic or manic states have behavioral and electrophysiological alterations in reward learning compared to healthy subjects. This dysfunctional reward processing may be related to the abnormal decision-making or altered goal-directed activities frequently seen in patients with bipolar disorder. PMID: 28098430 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 18, 2017 Category: Neuroscience Authors: Ryu V, Ha RY, Lee SJ, Ha K, Cho HS Tags: CNS Neurosci Ther Source Type: research

Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor.
CONCLUSION: Cognitive stress reduces the levodopa effect on Parkinson's tremor. This effect may be explained by a stress-related depletion of dopamine in the basal ganglia motor circuit, by stress-related involvement of nondopaminergic mechanisms in tremor (e.g., noradrenaline), or both. Targeting these mechanisms may open new windows for treatment. Clinical tremor assessments under evoked cognitive stress (e.g., counting tasks) may avoid overestimation of treatment effects in real life. PMID: 28071873 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 10, 2017 Category: Neuroscience Authors: Zach H, Dirkx MF, Pasman JW, Bloem BR, Helmich RC Tags: CNS Neurosci Ther Source Type: research

The Change of Nociceptive Neurons in the Rat Trigeminal Ganglia at Different Postnatal Ages.
PMID: 28052528 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2017 Category: Neuroscience Authors: Zeng MQ, Niu JF, Luan P, Ying Y, Pang RP, Su QN, Zhu HZ, Huang JQ, Chi HJ, Zhang LH, Fan XM, Sha O Tags: CNS Neurosci Ther Source Type: research

Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients.
zar JA, Bullón P PMID: 28052569 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 4, 2017 Category: Neuroscience Authors: Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P Tags: CNS Neurosci Ther Source Type: research

Ocular Nerve Growth Factor Administration Modulates Brain-derived Neurotrophic Factor Signaling in Prefrontal Cortex of Healthy and Diabetic Rats.
CONCLUSION: The present data confirm the capacity of ed-NGF treatment to affect brain neurons and lead to brain damage recovery by activating protective and remodeling pathways triggered by BDNF. We suggest that the ed-NGF-induced changes in BDNF signaling might influence the manifestation of depressive phenotype in diabetic rats. PMID: 28044424 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2017 Category: Neuroscience Authors: Rosso P, De Nicolò S, Carito V, Fiore M, Iannitelli A, Moreno S, Tirassa P Tags: CNS Neurosci Ther Source Type: research

Abnormal Resting-State Neural Activity and Connectivity of Fatigue in Parkinson's Disease.
CONCLUSION: Our findings do reveal that abnormal regional brain activity within attention and salience network and altered FC of above abnormal regions are involved in neural mechanism of fatigue in patients with PD. PMID: 28044431 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - January 3, 2017 Category: Neuroscience Authors: Zhang JJ, Ding J, Li JY, Wang M, Yuan YS, Zhang L, Jiang SM, Wang XX, Zhu L, Zhang KZ Tags: CNS Neurosci Ther Source Type: research