SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia

CONCLUSION: BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.PMID:38433018 | DOI:10.1111/cns.14654

Source: CNS Neuroscience and Therapeutics - March 3, 2024 Category: Neuroscience Authors: Mohammad Iqbal H Bhuiyan Khadija Habib Md Tipu Sultan Fenghua Chen Israt Jahan Zhongfang Weng Md Shamim Rahman Rabia Islam Lesley M Foley T Kevin Hitchens Xianming Deng Scott W Canna Dandan Sun Guodong Cao Source Type: research