Symmetry differences of structural connectivity in multiple sclerosis and healthy state
Brain Res Bull. 2023 Nov 14;205:110816. doi: 10.1016/j.brainresbull.2023.110816. Online ahead of print.ABSTRACTFocal and diffuse cerebral damages occur in Multiple Sclerosis (MS) that promotes profound shifts in local and global structural connectivity parameters, mainly derived from diffusion tensor imaging. Most of the reconstruction analyses have applied conventional tracking algorithms largely based on the controversial streamline count. For a more credible explanation of the diffusion MRI signal, we used convex optimization modeling for the microstructure-informed tractography2 (COMMIT2) framework. All multi-shell dif...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: Fatemeh Shahbodaghy Lida Shafaghi Massoumeh Rostampour Ali Rostampour Pirhossein Kolivand Zeinab Gharaylou Source Type: research
Structural abnormalities in the Fronto-Parietal Network: Linking white matter integrity to sustained attention deficits in Schizophrenia
Brain Res Bull. 2023 Nov 14;205:110818. doi: 10.1016/j.brainresbull.2023.110818. Online ahead of print.ABSTRACTSchizophrenia is associated with a range of cognitive deficits, among which impairments in sustained attention are particularly significant. Previous research has investigated functional changes in the fronto-parietal network (FPN) related to attentional control in schizophrenia. However, the role of structural connectivity within the FPN in sustained attention deficits remains under-explored. Utilizing diffusion tensor imaging (DTI), this study investigated white matter integrity in 75 participants, comprising 37...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: WenMing Liu XinNan Cai Yingjuan Chang Yuanqiang Zhu Min Cai Jian Xu Source Type: research
Symmetry differences of structural connectivity in multiple sclerosis and healthy state
Brain Res Bull. 2023 Nov 14;205:110816. doi: 10.1016/j.brainresbull.2023.110816. Online ahead of print.ABSTRACTFocal and diffuse cerebral damages occur in Multiple Sclerosis (MS) that promotes profound shifts in local and global structural connectivity parameters, mainly derived from diffusion tensor imaging. Most of the reconstruction analyses have applied conventional tracking algorithms largely based on the controversial streamline count. For a more credible explanation of the diffusion MRI signal, we used convex optimization modeling for the microstructure-informed tractography2 (COMMIT2) framework. All multi-shell dif...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: Fatemeh Shahbodaghy Lida Shafaghi Massoumeh Rostampour Ali Rostampour Pirhossein Kolivand Zeinab Gharaylou Source Type: research
Structural abnormalities in the Fronto-Parietal Network: Linking white matter integrity to sustained attention deficits in Schizophrenia
Brain Res Bull. 2023 Nov 14;205:110818. doi: 10.1016/j.brainresbull.2023.110818. Online ahead of print.ABSTRACTSchizophrenia is associated with a range of cognitive deficits, among which impairments in sustained attention are particularly significant. Previous research has investigated functional changes in the fronto-parietal network (FPN) related to attentional control in schizophrenia. However, the role of structural connectivity within the FPN in sustained attention deficits remains under-explored. Utilizing diffusion tensor imaging (DTI), this study investigated white matter integrity in 75 participants, comprising 37...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: WenMing Liu XinNan Cai Yingjuan Chang Yuanqiang Zhu Min Cai Jian Xu Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10;205:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs could become a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
The Long-Term Effect of Modulated Acoustic Stimulation on Alteration in EEG Brain Network of Chronic Tinnitus Patients: An Exploratory Study
This study provides unique insights into how long-term acoustic intervention affects the network organizations of tinnitus patients and deepens our understanding of the pathophysiological mechanisms underlying tinnitus rehabilitation.PMID:37951276 | DOI:10.1016/j.brainresbull.2023.110812 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 11, 2023 Category: Neurology Authors: Chanlin Yi Chen Liu Jiamin Zhang Xiabing Zhang Lin Jiang Yajing Si Gang He Min Ao Yong Zhao Dezhong Yao Fali Li Xuntai Ma Peng Xu Baoming He Source Type: research
The Long-Term Effect of Modulated Acoustic Stimulation on Alteration in EEG Brain Network of Chronic Tinnitus Patients: An Exploratory Study
This study provides unique insights into how long-term acoustic intervention affects the network organizations of tinnitus patients and deepens our understanding of the pathophysiological mechanisms underlying tinnitus rehabilitation.PMID:37951276 | DOI:10.1016/j.brainresbull.2023.110812 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 11, 2023 Category: Neurology Authors: Chanlin Yi Chen Liu Jiamin Zhang Xiabing Zhang Lin Jiang Yajing Si Gang He Min Ao Yong Zhao Dezhong Yao Fali Li Xuntai Ma Peng Xu Baoming He Source Type: research
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice
CONCLUSIONS: Our study shows that inhibition of MMP-2 and MMP-9 alleviates anesthesia/surgery-induced cognitive decline by increasing BBB integrity and inhibiting glial cell activation.PMID:37939860 | DOI:10.1016/j.brainresbull.2023.110810 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 8, 2023 Category: Neurology Authors: Yiqin Ji Wanbo Huang Yijun Chen Xincai Zhang Fan Wu Wan Tang Zihui Lu Changshun Huang Source Type: research
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice
CONCLUSIONS: Our study shows that inhibition of MMP-2 and MMP-9 alleviates anesthesia/surgery-induced cognitive decline by increasing BBB integrity and inhibiting glial cell activation.PMID:37939860 | DOI:10.1016/j.brainresbull.2023.110810 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 8, 2023 Category: Neurology Authors: Yiqin Ji Wanbo Huang Yijun Chen Xincai Zhang Fan Wu Wan Tang Zihui Lu Changshun Huang Source Type: research
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice
CONCLUSIONS: Our study shows that inhibition of MMP-2 and MMP-9 alleviates anesthesia/surgery-induced cognitive decline by increasing BBB integrity and inhibiting glial cell activation.PMID:37939860 | DOI:10.1016/j.brainresbull.2023.110810 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 8, 2023 Category: Neurology Authors: Yiqin Ji Wanbo Huang Yijun Chen Xincai Zhang Fan Wu Wan Tang Zihui Lu Changshun Huang Source Type: research
Chronic Pain Accelerates Cognitive Impairment by Reducing Hippocampal Neurogenesis may via CCL2/CCR2 Signaling in APP/PS1 Mice
Brain Res Bull. 2023 Nov 4:110801. doi: 10.1016/j.brainresbull.2023.110801. Online ahead of print.ABSTRACTPatients with chronic pain often have cognitive impairment; this is especially true in elderly patients with neurodegenerative diseases such as Alzheimer's disease (AD), but the mechanism underlying this association remains unclear. This was addressed in the present study by investigating the effect of chronic neuropathic pain on hippocampal neurogenesis and cognitive impairment using amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic mice subjected to spared-nerve injury (SNI). The Von Frey test was pe...
Source: Brain Research Bulletin - November 6, 2023 Category: Neurology Authors: Lili Chen Qin Qin Panchuan Huang Fangli Cao Maojia Yin Yachen Xie Wuchao Wang Source Type: research
Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons
CONCLUSION: Melatonin alleviated sevoflurane-induced cognitive deficits by suppressing CypD and promoting synaptic development in hippocampal PV neurons. These results provide valuable insights into a promising therapeutic approach for preventing neurotoxic injuries caused by general anesthetics.PMID:37931809 | DOI:10.1016/j.brainresbull.2023.110809 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 6, 2023 Category: Neurology Authors: Xuezhu Zou Xiaoyuan Zhang Tingting Qiang Xianwen Hu Li Zhang Source Type: research
