The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis
Brain Res Bull. 2024 Feb 21:110907. doi: 10.1016/j.brainresbull.2024.110907. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is considered an immune-mediated inflammatory disorder that causes cognitive impairments by damaging the hippocampal tissue. Conversely, norepinephrine (NEP) has anti-inflammatory and re-myelinating properties, which improve cognitive impairments. The aim of this study was to assess the neuroprotective effects of NEP on learning and memory disorders in an experimental animal model of MS. Two guide cannulas were bilaterally implanted in the rat hippocampal CA1 regions. After recovery, the animal...
Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Narjes Taherian Gholamhassan Vaezi Ali Neamati Vida Hojjati Faezeh Ghorbani-Taherdehi Amirhossein Sahebkar Mahmoud Gorji-Valokola Source Type: research
The role of T-lymphocytes in central nervous system diseases
Brain Res Bull. 2024 Feb 20;209:110904. doi: 10.1016/j.brainresbull.2024.110904. Online ahead of print.ABSTRACTThe central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lymphatic vessels within the dura mater and peripheral immune cells in the meningeal layer indicate that the peripheral immune system can monitor and intervene in the CNS. This review summarizes recent advances in the invo...
Source: Brain Research Bulletin - February 22, 2024 Category: Neurology Authors: Jianing Shen Ning Bian Lu Zhao Jingkuan Wei Source Type: research
The Role of T-lymphocytes in Central Nervous System Diseases
Brain Res Bull. 2024 Feb 20:110904. doi: 10.1016/j.brainresbull.2024.110904. Online ahead of print.ABSTRACTThe central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lymphatic vessels within the dura mater and peripheral immune cells in the meningeal layer indicate that the peripheral immune system can monitor and intervene in the CNS. This review summarizes recent advances in the involvem...
Source: Brain Research Bulletin - February 22, 2024 Category: Neurology Authors: Jianing Shen Ning Bian Lu Zhao Jingkuan Wei Source Type: research
Functional Connectivity Alterations in PTSD Patients with Suicidal Ideation
Brain Res Bull. 2024 Feb 19:110905. doi: 10.1016/j.brainresbull.2024.110905. Online ahead of print.ABSTRACTPost-traumatic stress disorder (PTSD) is a highly prevalent psychological disorder characterized by intense feelings of fear or helplessness after experiencing a traumatic event. PTSD is highly comorbid with mood disorders and patients are at increased risk for suicide. The present study aimed to identify neural connectivity alterations associated with suicidal ideation (SI) in PTSD patients by using resting-state functional magnetic resonance imaging. Voxel-to-voxel intrinsic connectivity was compared between PTSD pa...
Source: Brain Research Bulletin - February 21, 2024 Category: Neurology Authors: Stephen Wood Samuel Booth Ji Hyun Ko Source Type: research
Functional Connectivity Alterations in PTSD Patients with Suicidal Ideation
Brain Res Bull. 2024 Feb 19:110905. doi: 10.1016/j.brainresbull.2024.110905. Online ahead of print.ABSTRACTPost-traumatic stress disorder (PTSD) is a highly prevalent psychological disorder characterized by intense feelings of fear or helplessness after experiencing a traumatic event. PTSD is highly comorbid with mood disorders and patients are at increased risk for suicide. The present study aimed to identify neural connectivity alterations associated with suicidal ideation (SI) in PTSD patients by using resting-state functional magnetic resonance imaging. Voxel-to-voxel intrinsic connectivity was compared between PTSD pa...
Source: Brain Research Bulletin - February 21, 2024 Category: Neurology Authors: Stephen Wood Samuel Booth Ji Hyun Ko Source Type: research
Electroencephalography oscillations can predict the cortical response following theta burst stimulation
CONCLUSION: These findings suggest that EEG features can serve as markers of cortical response to transcranial magnetic stimulation. They offer insights into the association between neural oscillations and variability in individuals' responses to transcranial magnetic stimulation, aiding in the optimization of individualized protocols.PMID:38367675 | DOI:10.1016/j.brainresbull.2024.110902 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Guiyuan Cai Jiayue Xu Qian Ding Tuo Lin Hongying Chen Manfeng Wu Wanqi Li Gengbin Chen Guangqing Xu Yue Lan Source Type: research
Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus
Brain Res Bull. 2024 Feb 15;208:110903. doi: 10.1016/j.brainresbull.2024.110903. Online ahead of print.ABSTRACTChronic stress is a pervasive and complex issue that contributes significantly to various mental and physical health disorders. Using the previously established chronic unpredictable stress (CUS) model, which simulates human stress situations, it has been shown that chronic stress induces major depressive disorder (MDD) and memory deficiency. However, this established model is associated with several drawbacks, such as limited research reproducibility and the inability to sustain stress response. To resolve these ...
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Hyun Seung Shin Seung Hyun Lee Ha Jung Moon Yun Hee So Hyeon Jung Jang Kyung-Ha Lee Changhwan Ahn Eui-Man Jung Source Type: research
Electroencephalography oscillations can predict the cortical response following theta burst stimulation
CONCLUSION: These findings suggest that EEG features can serve as markers of cortical response to transcranial magnetic stimulation. They offer insights into the association between neural oscillations and variability in individuals' responses to transcranial magnetic stimulation, aiding in the optimization of individualized protocols.PMID:38367675 | DOI:10.1016/j.brainresbull.2024.110902 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Guiyuan Cai Jiayue Xu Qian Ding Tuo Lin Hongying Chen Manfeng Wu Wanqi Li Gengbin Chen Guangqing Xu Yue Lan Source Type: research
Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus
Brain Res Bull. 2024 Feb 15;208:110903. doi: 10.1016/j.brainresbull.2024.110903. Online ahead of print.ABSTRACTChronic stress is a pervasive and complex issue that contributes significantly to various mental and physical health disorders. Using the previously established chronic unpredictable stress (CUS) model, which simulates human stress situations, it has been shown that chronic stress induces major depressive disorder (MDD) and memory deficiency. However, this established model is associated with several drawbacks, such as limited research reproducibility and the inability to sustain stress response. To resolve these ...
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Hyun Seung Shin Seung Hyun Lee Ha Jung Moon Yun Hee So Hyeon Jung Jang Kyung-Ha Lee Changhwan Ahn Eui-Man Jung Source Type: research
Electroencephalography Oscillations Can Predict the Cortical Response Following Theta Burst Stimulation
CONCLUSION: These findings suggest that EEG features can serve as markers of cortical response to transcranial magnetic stimulation. They offer insights into the association between neural oscillations and variability in individuals' responses to transcranial magnetic stimulation, aiding in the optimization of individualized protocols.PMID:38367675 | DOI:10.1016/j.brainresbull.2024.110902 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Guiyuan Cai Jiayue Xu Qian Ding Tuo Lin Hongying Chen Manfeng Wu Wanqi Li Gengbin Chen Guangqing Xu Yue Lan Source Type: research
Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus
Brain Res Bull. 2024 Feb 15;208:110903. doi: 10.1016/j.brainresbull.2024.110903. Online ahead of print.ABSTRACTChronic stress is a pervasive and complex issue that contributes significantly to various mental and physical health disorders. Using the previously established chronic unpredictable stress (CUS) model, which simulates human stress situations, it has been shown that chronic stress induces major depressive disorder (MDD) and memory deficiency. However, this established model is associated with several drawbacks, such as limited research reproducibility and the inability to sustain stress response. To resolve these ...
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Hyun Seung Shin Seung Hyun Lee Ha Jung Moon Yun Hee So Hyeon Jung Jang Kyung-Ha Lee Changhwan Ahn Eui-Man Jung Source Type: research
Electroencephalography Oscillations Can Predict the Cortical Response Following Theta Burst Stimulation
CONCLUSION: These findings suggest that EEG features can serve as markers of cortical response to transcranial magnetic stimulation. They offer insights into the association between neural oscillations and variability in individuals' responses to transcranial magnetic stimulation, aiding in the optimization of individualized protocols.PMID:38367675 | DOI:10.1016/j.brainresbull.2024.110902 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Guiyuan Cai Jiayue Xu Qian Ding Tuo Lin Hongying Chen Manfeng Wu Wanqi Li Gengbin Chen Guangqing Xu Yue Lan Source Type: research
Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus
Brain Res Bull. 2024 Feb 15:110903. doi: 10.1016/j.brainresbull.2024.110903. Online ahead of print.ABSTRACTChronic stress is a pervasive and complex issue that contributes significantly to various mental and physical health disorders. Using the previously established chronic unpredictable stress (CUS) model, which simulates human stress situations, it has been shown that chronic stress induces major depressive disorder (MDD) and memory deficiency. However, this established model is associated with several drawbacks, such as limited research reproducibility and the inability to sustain stress response. To resolve these issu...
Source: Brain Research Bulletin - February 17, 2024 Category: Neurology Authors: Hyun Seung Shin Seung Hyun Lee Ha Jung Moon Yun Hee So Hyeon Jung Jang Kyung-Ha Lee Changhwan Ahn Eui-Man Jung Source Type: research
Exploring resting-state EEG oscillations in patients with Neuromyelitis Optica Spectrum Disorder
CONCLUSION: The results of this study suggest that the rs-EEG power spectra of NMOSD patients show increased slow oscillations and are potential biomarkers of widespread white matter microstructural damage in NMOSD. Moreover, this study revealed the rs-EEG features associated with anxiety, depression, and fatigue in NMOSD patients, which might help in the evaluation of these complications and the development of neuromodulation treatment. Quantitative rs-EEG analysis may play an important role in the management of NMOSD patients, and future studies are warranted to more comprehensively understand its application value.PMID:...
Source: Brain Research Bulletin - February 16, 2024 Category: Neurology Authors: Lili Yang Congyu Xu Yun Qin Kai Chen Yan Xie Xiaobo Zhou Tiejun Liu Song Tan Jie Liu Dezhong Yao Source Type: research
Neonatal inhibition of androgen activity alters the programming of body weight and orexinergic peptides differentially in male and female rats
Brain Res Bull. 2024 Feb 13;208:110898. doi: 10.1016/j.brainresbull.2024.110898. Online ahead of print.ABSTRACTThe involvement of androgens in the regulation of energy metabolism has been demonstrated. The main objective of the present research was to study the involvement of androgens in both the programming of energy metabolism and the regulatory peptides associated with feeding. For this purpose, androgen receptors and the main metabolic pathways of testosterone were inhibited during the first five days of postnatal life in male and female Wistar rats. Pups received a daily s.c. injection from the day of birth, postnata...
Source: Brain Research Bulletin - February 15, 2024 Category: Neurology Authors: Beatriz Carrillo Jose Manuel Fernandez-Garcia Roc ío García-Úbeda Daniela Grassi Ulises Primo Noem í Blanco Antonio Ballesta Maria Angeles Arevalo Paloma Collado Helena Pinos Source Type: research
