α5GABA < sub > A < /sub > receptor: A potential therapeutic target for perioperative neurocognitive disorders, a review of preclinical studies
Brain Res Bull. 2023 Nov 18;205:110821. doi: 10.1016/j.brainresbull.2023.110821. Online ahead of print.ABSTRACTPerioperative neurocognitive disorders (PND) are a common complication in elderly patients following surgery, which not only prolongs the recovery period but also affects their future quality of life and imposes a significant burden on their family and society. Multiple factors, including aging, vulnerability, anesthetic drugs, cerebral oxygen desaturation, and severe pain, have been associated with PND. Unfortunately, no effective drug is currently available to prevent PND. α5 γ-aminobutyric acid subtype A (α5...
Source: Brain Research Bulletin - November 20, 2023 Category: Neurology Authors: Yueyang Xin Tiantian Chu Siqi Zhou Aijun Xu Source Type: research
The effects of prolyl hydroxylase inhibition during and post, hypoxia, oxygen glucose deprivation and oxidative stress, in isolated rat hippocampal slices
Brain Res Bull. 2023 Nov 18:110822. doi: 10.1016/j.brainresbull.2023.110822. Online ahead of print.ABSTRACTThe contributions of hypoxia and oxidative stress to the pathophysiology of acute ischemic stroke are well established and can lead to disruptions in synaptic signaling. Hypoxia and oxidative stress lead to the neurotoxic overproduction of reactive oxygen species (ROS) and the stabilization of hypoxia inducible factors (HIF). Compounds such as prolyl-4-hydroxylase domain enzyme inhibitors (PHDIs) have been shown to have a preconditioning and neuroprotective effect against ischemic insults such as hypoxia, anoxia, oxyg...
Source: Brain Research Bulletin - November 20, 2023 Category: Neurology Authors: Niamh Moreton Martina Puzio Janet McCormack John J O'connor Source Type: research
The relationship between TGF- β1 and cognitive function in the brain
Brain Res Bull. 2023 Nov 17;205:110820. doi: 10.1016/j.brainresbull.2023.110820. Online ahead of print.ABSTRACTTransforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitiv...
Source: Brain Research Bulletin - November 18, 2023 Category: Neurology Authors: Chen Su Jie Miao Junhong Guo Source Type: research
The relationship between TGF- β1 and cognitive function in the brain
Brain Res Bull. 2023 Nov 16:110820. doi: 10.1016/j.brainresbull.2023.110820. Online ahead of print.ABSTRACTTransforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitive fu...
Source: Brain Research Bulletin - November 18, 2023 Category: Neurology Authors: Chen Su Jie Miao Junhong Guo Source Type: research
Symmetry differences of structural connectivity in multiple sclerosis and healthy state
Brain Res Bull. 2023 Nov 14;205:110816. doi: 10.1016/j.brainresbull.2023.110816. Online ahead of print.ABSTRACTFocal and diffuse cerebral damages occur in Multiple Sclerosis (MS) that promotes profound shifts in local and global structural connectivity parameters, mainly derived from diffusion tensor imaging. Most of the reconstruction analyses have applied conventional tracking algorithms largely based on the controversial streamline count. For a more credible explanation of the diffusion MRI signal, we used convex optimization modeling for the microstructure-informed tractography2 (COMMIT2) framework. All multi-shell dif...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: Fatemeh Shahbodaghy Lida Shafaghi Massoumeh Rostampour Ali Rostampour Pirhossein Kolivand Zeinab Gharaylou Source Type: research
Structural abnormalities in the Fronto-Parietal Network: Linking white matter integrity to sustained attention deficits in Schizophrenia
Brain Res Bull. 2023 Nov 14;205:110818. doi: 10.1016/j.brainresbull.2023.110818. Online ahead of print.ABSTRACTSchizophrenia is associated with a range of cognitive deficits, among which impairments in sustained attention are particularly significant. Previous research has investigated functional changes in the fronto-parietal network (FPN) related to attentional control in schizophrenia. However, the role of structural connectivity within the FPN in sustained attention deficits remains under-explored. Utilizing diffusion tensor imaging (DTI), this study investigated white matter integrity in 75 participants, comprising 37...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: WenMing Liu XinNan Cai Yingjuan Chang Yuanqiang Zhu Min Cai Jian Xu Source Type: research
Symmetry differences of structural connectivity in multiple sclerosis and healthy state
Brain Res Bull. 2023 Nov 14;205:110816. doi: 10.1016/j.brainresbull.2023.110816. Online ahead of print.ABSTRACTFocal and diffuse cerebral damages occur in Multiple Sclerosis (MS) that promotes profound shifts in local and global structural connectivity parameters, mainly derived from diffusion tensor imaging. Most of the reconstruction analyses have applied conventional tracking algorithms largely based on the controversial streamline count. For a more credible explanation of the diffusion MRI signal, we used convex optimization modeling for the microstructure-informed tractography2 (COMMIT2) framework. All multi-shell dif...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: Fatemeh Shahbodaghy Lida Shafaghi Massoumeh Rostampour Ali Rostampour Pirhossein Kolivand Zeinab Gharaylou Source Type: research
Structural abnormalities in the Fronto-Parietal Network: Linking white matter integrity to sustained attention deficits in Schizophrenia
Brain Res Bull. 2023 Nov 14;205:110818. doi: 10.1016/j.brainresbull.2023.110818. Online ahead of print.ABSTRACTSchizophrenia is associated with a range of cognitive deficits, among which impairments in sustained attention are particularly significant. Previous research has investigated functional changes in the fronto-parietal network (FPN) related to attentional control in schizophrenia. However, the role of structural connectivity within the FPN in sustained attention deficits remains under-explored. Utilizing diffusion tensor imaging (DTI), this study investigated white matter integrity in 75 participants, comprising 37...
Source: Brain Research Bulletin - November 16, 2023 Category: Neurology Authors: WenMing Liu XinNan Cai Yingjuan Chang Yuanqiang Zhu Min Cai Jian Xu Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10;205:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs could become a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
Feasibility of brain age predictions from clinical T1-weighted MRIs
Brain Res Bull. 2023 Nov 10:110811. doi: 10.1016/j.brainresbull.2023.110811. Online ahead of print.ABSTRACTAn individual's brain predicted age minus chronological age (brain-PAD) obtained from MRIs is a biomarker of disease in research studies. However, brain age reports from clinical MRIs are scant despite the rich clinical information hospitals provide. Since clinical MRI protocols are meant for specific clinical purposes, performance of brain age predictions on clinical data need to be tested. We explored the feasibility of using DeepBrainNet, a deep network previously trained on research-oriented MRIs, to predict the b...
Source: Brain Research Bulletin - November 12, 2023 Category: Neurology Authors: Pedro A Valdes-Hernandez Chavier Laffitte Nodarse James H Cole Yenisel Cruz-Almeida Source Type: research
The Long-Term Effect of Modulated Acoustic Stimulation on Alteration in EEG Brain Network of Chronic Tinnitus Patients: An Exploratory Study
This study provides unique insights into how long-term acoustic intervention affects the network organizations of tinnitus patients and deepens our understanding of the pathophysiological mechanisms underlying tinnitus rehabilitation.PMID:37951276 | DOI:10.1016/j.brainresbull.2023.110812 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 11, 2023 Category: Neurology Authors: Chanlin Yi Chen Liu Jiamin Zhang Xiabing Zhang Lin Jiang Yajing Si Gang He Min Ao Yong Zhao Dezhong Yao Fali Li Xuntai Ma Peng Xu Baoming He Source Type: research
The Long-Term Effect of Modulated Acoustic Stimulation on Alteration in EEG Brain Network of Chronic Tinnitus Patients: An Exploratory Study
This study provides unique insights into how long-term acoustic intervention affects the network organizations of tinnitus patients and deepens our understanding of the pathophysiological mechanisms underlying tinnitus rehabilitation.PMID:37951276 | DOI:10.1016/j.brainresbull.2023.110812 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 11, 2023 Category: Neurology Authors: Chanlin Yi Chen Liu Jiamin Zhang Xiabing Zhang Lin Jiang Yajing Si Gang He Min Ao Yong Zhao Dezhong Yao Fali Li Xuntai Ma Peng Xu Baoming He Source Type: research
Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice
CONCLUSIONS: Our study shows that inhibition of MMP-2 and MMP-9 alleviates anesthesia/surgery-induced cognitive decline by increasing BBB integrity and inhibiting glial cell activation.PMID:37939860 | DOI:10.1016/j.brainresbull.2023.110810 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 8, 2023 Category: Neurology Authors: Yiqin Ji Wanbo Huang Yijun Chen Xincai Zhang Fan Wu Wan Tang Zihui Lu Changshun Huang Source Type: research
