Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells
In this study, we aimed to evaluate the effects of BMSCs treatment on changes in hippocampal neural function in Sprague-Dawley(SD) rats with RIBI, and to evaluate the therapeutic effect of BMSCs by manganese-enhanced magnetic resonance imaging (MEMRI). First, we assessed cognitive function after RIBI treatment with BMSCs using the Morris water maze. Next, we used MEMRI at two time points to observe the treatment effect and explore the correlation between MEMRI and cognitive function. Finally, we evaluated the expression of specific hippocampal neurofunctional proteins, the ultrastructure of hippocampal nerves, and the hist...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhanhong Liu Kaina Xu Shichao Pan Na Zhang Dapeng Wang Ying Chen Yaru Zhao Siqi Wang Jing Li Xu Tong Source Type: research
Amide proton transfer could be a surrogate imaging marker for predicting vascular cognitive impairment
CONCLUSION: APT imaging can partially identifying and predicting the occurrence of VCI.PMID:37863439 | DOI:10.1016/j.brainresbull.2023.110793 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ronghua Mu Xiaoyan Qin Wei Zheng Peng Yang Bingqin Huang Xin Li Fuzhen Liu Kan Deng Xiqi Zhu Source Type: research
Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
This study aimed to evaluate the antidepressant effects of LJF's active extract and compound chlorogenic acid (CGA) around BDNF-TrkB pathway. The results showed that LJF extracts and CGA had significant antidepressant effects, and the antidepressant effects of different extracts of LJF was highly positively correlated with the content of CGA (FST, r = 0.998; TST, r = 0.934). Moreover, LJF-70% ethanolic extract and CGA improved CUMS induced depressive behavior, upregulated protein expression levels of BDNF and p-TrkB in the hippocampus, restored the damage of hippocampal neurons, and protect liver from damage. In summary, t...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li Source Type: research
Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling
CONCLUSIONS: Our results suggest that ANO1 plays an important role in the survival of ALS motor neurons. ANO1 can increase cell activity and reduce apoptosis by activating EGFR and CaMKII signals.PMID:37858681 | DOI:10.1016/j.brainresbull.2023.110792 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Wang Weiwei Liang Tianhang Wang Chunting Zhang Yueqing Yang Chaohua Cong Xudong Wang Shuyu Wang Di Wang Di Huo Hongyong Wang Xiaoli Su Xingli Tan Honglin Feng Source Type: research
Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice
CONCLUSIONS: Hsp70 treatment might serve as a potential treatment for mitigating SD-related unfavorable symptoms.PMID:37858682 | DOI:10.1016/j.brainresbull.2023.110791 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhenming Kang Yiqin Lin Changsheng Su Shunyuan Li Wenqin Xie Xiaodan Wu Source Type: research
Corrigendum to "Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells" [Brain es. Bull. 153 (2019)]
Brain Res Bull. 2023 Oct 18;204:110787. doi: 10.1016/j.brainresbull.2023.110787. Online ahead of print.NO ABSTRACTPMID:37862943 | DOI:10.1016/j.brainresbull.2023.110787 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Zhang Yong Zuo Bowen Li Jinhong Xie Zhao Ma Anand Thirupathi Peng Yu Guofen Gao Mengtong Shi Changhao Zhou Hongmeng Xu Yanzhong Chang Zhenhua Shi Source Type: research
Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells
In this study, we aimed to evaluate the effects of BMSCs treatment on changes in hippocampal neural function in Sprague-Dawley(SD) rats with RIBI, and to evaluate the therapeutic effect of BMSCs by manganese-enhanced magnetic resonance imaging (MEMRI). First, we assessed cognitive function after RIBI treatment with BMSCs using the Morris water maze. Next, we used MEMRI at two time points to observe the treatment effect and explore the correlation between MEMRI and cognitive function. Finally, we evaluated the expression of specific hippocampal neurofunctional proteins, the ultrastructure of hippocampal nerves, and the hist...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhanhong Liu Kaina Xu Shichao Pan Na Zhang Dapeng Wang Ying Chen Yaru Zhao Siqi Wang Jing Li Xu Tong Source Type: research
Amide proton transfer could be a surrogate imaging marker for predicting vascular cognitive impairment
CONCLUSION: APT imaging can partially identifying and predicting the occurrence of VCI.PMID:37863439 | DOI:10.1016/j.brainresbull.2023.110793 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ronghua Mu Xiaoyan Qin Wei Zheng Peng Yang Bingqin Huang Xin Li Fuzhen Liu Kan Deng Xiqi Zhu Source Type: research
Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
This study aimed to evaluate the antidepressant effects of LJF's active extract and compound chlorogenic acid (CGA) around BDNF-TrkB pathway. The results showed that LJF extracts and CGA had significant antidepressant effects, and the antidepressant effects of different extracts of LJF was highly positively correlated with the content of CGA (FST, r = 0.998; TST, r = 0.934). Moreover, LJF-70% ethanolic extract and CGA improved CUMS induced depressive behavior, upregulated protein expression levels of BDNF and p-TrkB in the hippocampus, restored the damage of hippocampal neurons, and protect liver from damage. In summary, t...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li Source Type: research
Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling
CONCLUSIONS: Our results suggest that ANO1 plays an important role in the survival of ALS motor neurons. ANO1 can increase cell activity and reduce apoptosis by activating EGFR and CaMKII signals.PMID:37858681 | DOI:10.1016/j.brainresbull.2023.110792 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Wang Weiwei Liang Tianhang Wang Chunting Zhang Yueqing Yang Chaohua Cong Xudong Wang Shuyu Wang Di Wang Di Huo Hongyong Wang Xiaoli Su Xingli Tan Honglin Feng Source Type: research
Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice
CONCLUSIONS: Hsp70 treatment might serve as a potential treatment for mitigating SD-related unfavorable symptoms.PMID:37858682 | DOI:10.1016/j.brainresbull.2023.110791 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhenming Kang Yiqin Lin Changsheng Su Shunyuan Li Wenqin Xie Xiaodan Wu Source Type: research
Corrigendum to "Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells" [Brain es. Bull. 153 (2019)]
Brain Res Bull. 2023 Oct 18;204:110787. doi: 10.1016/j.brainresbull.2023.110787. Online ahead of print.NO ABSTRACTPMID:37862943 | DOI:10.1016/j.brainresbull.2023.110787 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Zhang Yong Zuo Bowen Li Jinhong Xie Zhao Ma Anand Thirupathi Peng Yu Guofen Gao Mengtong Shi Changhao Zhou Hongmeng Xu Yanzhong Chang Zhenhua Shi Source Type: research
Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells
In this study, we aimed to evaluate the effects of BMSCs treatment on changes in hippocampal neural function in Sprague-Dawley(SD) rats with RIBI, and to evaluate the therapeutic effect of BMSCs by manganese-enhanced magnetic resonance imaging (MEMRI). First, we assessed cognitive function after RIBI treatment with BMSCs using the Morris water maze. Next, we used MEMRI at two time points to observe the treatment effect and explore the correlation between MEMRI and cognitive function. Finally, we evaluated the expression of specific hippocampal neurofunctional proteins, the ultrastructure of hippocampal nerves, and the hist...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhanhong Liu Kaina Xu Shichao Pan Na Zhang Dapeng Wang Ying Chen Yaru Zhao Siqi Wang Jing Li Xu Tong Source Type: research
Amide proton transfer could be a surrogate imaging marker for predicting vascular cognitive impairment
CONCLUSION: APT imaging can partially identifying and predicting the occurrence of VCI.PMID:37863439 | DOI:10.1016/j.brainresbull.2023.110793 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ronghua Mu Xiaoyan Qin Wei Zheng Peng Yang Bingqin Huang Xin Li Fuzhen Liu Kan Deng Xiqi Zhu Source Type: research
Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
This study aimed to evaluate the antidepressant effects of LJF's active extract and compound chlorogenic acid (CGA) around BDNF-TrkB pathway. The results showed that LJF extracts and CGA had significant antidepressant effects, and the antidepressant effects of different extracts of LJF was highly positively correlated with the content of CGA (FST, r = 0.998; TST, r = 0.934). Moreover, LJF-70% ethanolic extract and CGA improved CUMS induced depressive behavior, upregulated protein expression levels of BDNF and p-TrkB in the hippocampus, restored the damage of hippocampal neurons, and protect liver from damage. In summary, t...
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li Source Type: research
