Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons

CONCLUSION: Melatonin alleviated sevoflurane-induced cognitive deficits by suppressing CypD and promoting synaptic development in hippocampal PV neurons. These results provide valuable insights into a promising therapeutic approach for preventing neurotoxic injuries caused by general anesthetics.PMID:37931809 | DOI:10.1016/j.brainresbull.2023.110809

Source: Brain Research Bulletin - November 6, 2023 Category: Neurology Authors: Xuezhu Zou Xiaoyuan Zhang Tingting Qiang Xianwen Hu Li Zhang Source Type: research