Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice

CONCLUSIONS: Our study shows that inhibition of MMP-2 and MMP-9 alleviates anesthesia/surgery-induced cognitive decline by increasing BBB integrity and inhibiting glial cell activation.PMID:37939860 | DOI:10.1016/j.brainresbull.2023.110810

Source: Brain Research Bulletin - November 8, 2023 Category: Neurology Authors: Yiqin Ji Wanbo Huang Yijun Chen Xincai Zhang Fan Wu Wan Tang Zihui Lu Changshun Huang Source Type: research