Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/ β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats
This study aims to evaluate the therapeutic effects and pharmacological mechanisms of paeonol on the main psychiatric symptoms and hippocampal damage in PMDD. We established a premenstrual irritability rat model by the resident-intruder paradigm and performed elevated plus maze and social interactions. And we employed the HE and Nissl staining techniques to observe the therapeutic effect of paeonol on hippocampal damage in PMDD rats. Subsequently, Elisa, qRT-PCR Array, Western Blotting, and cell models were utilized to elucidate the underlying molecular mechanisms through which paeonol intervenes in treating PMDD. In this ...
Source: Brain Research Bulletin - November 30, 2023 Category: Neurology Authors: Enhua Wei Aiying Gao Xiaofei Mu Songlin Qu Caixing Yang Fengling Li Shujing Li Xuehuan Liu Chunhong Song Yinghui Guo Source Type: research
Effects of Combined Electroacupuncture and Medication Therapy on the RhoA/ROCK-2 Signaling Pathway in the Striatal Region of Rats Afflicted by Cerebral Ischemia
CONCLUSION: The protective mechanism underlying the therapeutic efficacy of EA combined with Gas against cerebral ischemic striatal injury in rats may be associated with the inhibition of the activation of the RhoA/ROCK-2 signaling pathway. Importantly, the therapeutic effects observed with the combination of electroacupuncture and medication were superior to those achieved with EA alone or the sole administration of Gas.PMID:38029846 | DOI:10.1016/j.brainresbull.2023.110828 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 29, 2023 Category: Neurology Authors: Min Liu Wei Wang Yegui Zhang Zhiliang Xu Source Type: research
Effects of Combined Electroacupuncture and Medication Therapy on the RhoA/ROCK-2 Signaling Pathway in the Striatal Region of Rats Afflicted by Cerebral Ischemia
CONCLUSION: The protective mechanism underlying the therapeutic efficacy of EA combined with Gas against cerebral ischemic striatal injury in rats may be associated with the inhibition of the activation of the RhoA/ROCK-2 signaling pathway. Importantly, the therapeutic effects observed with the combination of electroacupuncture and medication were superior to those achieved with EA alone or the sole administration of Gas.PMID:38029846 | DOI:10.1016/j.brainresbull.2023.110828 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 29, 2023 Category: Neurology Authors: Min Liu Wei Wang Yegui Zhang Zhiliang Xu Source Type: research
Meta-analysis of structural integrity of white matter and functional connectivity in developmental stuttering
Brain Res Bull. 2023 Nov 25:110827. doi: 10.1016/j.brainresbull.2023.110827. Online ahead of print.ABSTRACTDevelopmental stuttering is a speech disfluency disorder characterized by repetitions, prolongations, and blocks of speech. While a number of neuroimaging studies have identified alterations in localized brain activation during speaking in persons with stuttering (PWS), it is unclear whether neuroimaging evidence converges on alterations in structural integrity of white matter and functional connectivity (FC) among multiple regions involved in supporting fluent speech. In the present study, we conducted coordinate-bas...
Source: Brain Research Bulletin - November 28, 2023 Category: Neurology Authors: Kengo Matsuhashi Takashi Itahashi Ryuta Aoki Ryu-Ichiro Hashimoto Source Type: research
Meta-analysis of structural integrity of white matter and functional connectivity in developmental stuttering
Brain Res Bull. 2023 Nov 25:110827. doi: 10.1016/j.brainresbull.2023.110827. Online ahead of print.ABSTRACTDevelopmental stuttering is a speech disfluency disorder characterized by repetitions, prolongations, and blocks of speech. While a number of neuroimaging studies have identified alterations in localized brain activation during speaking in persons with stuttering (PWS), it is unclear whether neuroimaging evidence converges on alterations in structural integrity of white matter and functional connectivity (FC) among multiple regions involved in supporting fluent speech. In the present study, we conducted coordinate-bas...
Source: Brain Research Bulletin - November 28, 2023 Category: Neurology Authors: Kengo Matsuhashi Takashi Itahashi Ryuta Aoki Ryu-Ichiro Hashimoto Source Type: research
Automatic segmentation of white matter hyperintensities in T2-FLAIR with AQUA: A comparative validation study against conventional methods
In this study, we propose AQUA, a deep learning model designed for fully automatic segmentation of WMHs from T2-FLAIR scans, which improves upon our previous study for small lesion detection and incorporating a multicenter approach. AQUA implements a two-dimensional U-Net architecture and uses patch-based training. Additionally, the network was modified to include Bottleneck Attention Module on each convolutional block of both the encoder and decoder to enhance performance for small-sized WMH. We evaluated the performance and robustness of AQUA by comparing it with five well-known supervised and unsupervised methods for au...
Source: Brain Research Bulletin - November 24, 2023 Category: Neurology Authors: Soojin Lee ZunHyan Rieu Regina Ey Kim Minho Lee Kevin Yen Junghyun Yong Donghyeon Kim Source Type: research
Automatic segmentation of white matter hyperintensities in T2-FLAIR with AQUA: a comparative validation study against conventional methods
In this study, we propose AQUA, a deep learning model designed for fully automatic segmentation of WMHs from T2-FLAIR scans, which improves upon our previous study for small lesion detection and incorporating a multicenter approach. AQUA implements a two-dimensional U-Net architecture and uses patch-based training. Additionally, the network was modified to include Bottleneck Attention Module on each convolutional block of both the encoder and decoder to enhance performance for small-sized WMH. We evaluated the performance and robustness of AQUA by comparing it with five well-known supervised and unsupervised methods for au...
Source: Brain Research Bulletin - November 24, 2023 Category: Neurology Authors: Soojin Lee ZunHyan Rieu Regina Ey Kim Minho Lee Kevin Yen Junghyun Yong Donghyeon Kim Source Type: research
Automatic segmentation of white matter hyperintensities in T2-FLAIR with AQUA: a comparative validation study against conventional methods
In this study, we propose AQUA, a deep learning model designed for fully automatic segmentation of WMHs from T2-FLAIR scans, which improves upon our previous study for small lesion detection and incorporating a multicenter approach. AQUA implements a two-dimensional U-Net architecture and uses patch-based training. Additionally, the network was modified to include Bottleneck Attention Module on each convolutional block of both the encoder and decoder to enhance performance for small-sized WMH. We evaluated the performance and robustness of AQUA by comparing it with five well-known supervised and unsupervised methods for au...
Source: Brain Research Bulletin - November 24, 2023 Category: Neurology Authors: Soojin Lee ZunHyan Rieu Regina Ey Kim Minho Lee Kevin Yen Junghyun Yong Donghyeon Kim Source Type: research
Post-Traumatic Hydrocephalus: An Overview of Classification, Diagnosis, Treatment, and Post-Treatment Imaging Evaluation
Brain Res Bull. 2023 Nov 21:110824. doi: 10.1016/j.brainresbull.2023.110824. Online ahead of print.ABSTRACTThe syndrome of post-traumatic hydrocephalus (PTH) has been recognized since Dandy's report in 1914. The pathogenesis of PTH has not been fully clarified. At present, it is believed that the obstacles of cerebrospinal fluid (CSF) secretion, absorption and circulation pathways are the reasons for the development of PTH. However, recent studies have also suggested that the osmotic pressure load of CSF and the pathological changes of CSF dynamics are caused by the development of hydrocephalus. Therefore, a better underst...
Source: Brain Research Bulletin - November 23, 2023 Category: Neurology Authors: Zhao Li Han Zhang Guojie Hu Guohai Zhang Source Type: research
Corrigendum to "Diet containing stearic acid increases food reward-related behaviors in mice compared with oleic acid" [Brain Res. Bull. 164 (2020) 45-54]
Brain Res Bull. 2023 Nov 22:110823. doi: 10.1016/j.brainresbull.2023.110823. Online ahead of print.NO ABSTRACTPMID:37996287 | DOI:10.1016/j.brainresbull.2023.110823 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 23, 2023 Category: Neurology Authors: Yongxiang Li Hanyu Wu Ruixue Zhang Gang Shu Songbo Wang Ping Gao Xiaotong Zhu Qingyan Jiang Lina Wang Source Type: research
Post-Traumatic Hydrocephalus: An Overview of Classification, Diagnosis, Treatment, and Post-Treatment Imaging Evaluation
Brain Res Bull. 2023 Nov 21:110824. doi: 10.1016/j.brainresbull.2023.110824. Online ahead of print.ABSTRACTThe syndrome of post-traumatic hydrocephalus (PTH) has been recognized since Dandy's report in 1914. The pathogenesis of PTH has not been fully clarified. At present, it is believed that the obstacles of cerebrospinal fluid (CSF) secretion, absorption and circulation pathways are the reasons for the development of PTH. However, recent studies have also suggested that the osmotic pressure load of CSF and the pathological changes of CSF dynamics are caused by the development of hydrocephalus. Therefore, a better underst...
Source: Brain Research Bulletin - November 23, 2023 Category: Neurology Authors: Zhao Li Han Zhang Guojie Hu Guohai Zhang Source Type: research
Corrigendum to "Diet containing stearic acid increases food reward-related behaviors in mice compared with oleic acid" [Brain Res. Bull. 164 (2020) 45-54]
Brain Res Bull. 2023 Nov 22:110823. doi: 10.1016/j.brainresbull.2023.110823. Online ahead of print.NO ABSTRACTPMID:37996287 | DOI:10.1016/j.brainresbull.2023.110823 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - November 23, 2023 Category: Neurology Authors: Yongxiang Li Hanyu Wu Ruixue Zhang Gang Shu Songbo Wang Ping Gao Xiaotong Zhu Qingyan Jiang Lina Wang Source Type: research
Audiovisual integration in children with cochlear implants revealed through EEG and fNIRS
Brain Res Bull. 2023 Nov 19;205:110817. doi: 10.1016/j.brainresbull.2023.110817. Online ahead of print.ABSTRACTSensory deprivation can offset the balance of audio versus visual information in multimodal processing. Such a phenomenon could persist for children born deaf, even after they receive cochlear implants (CIs), and could potentially explain why one modality is given priority over the other. Here, we recorded cortical responses to a single speaker uttering two syllables, presented in audio-only (A), visual-only (V), and audio-visual (AV) modes. Electroencephalography (EEG) and functional near-infrared spectroscopy (f...
Source: Brain Research Bulletin - November 21, 2023 Category: Neurology Authors: Razieh Alemi Jace Wolfe Sara Neumann Jacy Manning Will Towler Nabin Koirala Vincent L Gracco Mickael Deroche Source Type: research
Audiovisual integration in children with cochlear implants revealed through EEG and fNIRS
Brain Res Bull. 2023 Nov 19;205:110817. doi: 10.1016/j.brainresbull.2023.110817. Online ahead of print.ABSTRACTSensory deprivation can offset the balance of audio versus visual information in multimodal processing. Such a phenomenon could persist for children born deaf, even after they receive cochlear implants (CIs), and could potentially explain why one modality is given priority over the other. Here, we recorded cortical responses to a single speaker uttering two syllables, presented in audio-only (A), visual-only (V), and audio-visual (AV) modes. Electroencephalography (EEG) and functional near-infrared spectroscopy (f...
Source: Brain Research Bulletin - November 21, 2023 Category: Neurology Authors: Razieh Alemi Jace Wolfe Sara Neumann Jacy Manning Will Towler Nabin Koirala Vincent L Gracco Mickael Deroche Source Type: research
Audiovisual integration in children with cochlear implants revealed through EEG and fNIRS
Brain Res Bull. 2023 Nov 19:110817. doi: 10.1016/j.brainresbull.2023.110817. Online ahead of print.ABSTRACTSensory deprivation can offset the balance of audio versus visual information in multimodal processing. Such a phenomenon could persist for children born deaf, even after they receive cochlear implants (CIs), and could potentially explain why one modality is given priority over the other. Here, we recorded cortical responses to a single speaker uttering two syllables, presented in audio-only (A), visual-only (V), and audio-visual (AV) modes. Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS...
Source: Brain Research Bulletin - November 21, 2023 Category: Neurology Authors: Razieh Alemi Jace Wolfe Sara Neumann Jacy Manning Will Towler Nabin Koirala Vincent L Gracco Mickael Deroche Source Type: research
