Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
CONCLUSION: TP inhibits not only microglia polarization towards the M1 phenotype by suppressing the CTSS/Fractalkine/CX3CR1 pathway activation, but also HT-22 apoptosis by crosstalk with BV-2 cells, thereby ameliorating CIRI. These findings reveal a novel mechanism of TP in improving CIRI, and offer potential implications for addressing the preventive and therapeutic strategies of CIRI.PMID:38574865 | DOI:10.1016/j.brainresbull.2024.110939 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 4, 2024 Category: Neurology Authors: Jiajun Zhou Wei Ye Ling Chen Junheng Li Yijun Zhou Chunfeng Bai Lian Luo Source Type: research
Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol
Brain Res Bull. 2024 Apr 1;211:110935. doi: 10.1016/j.brainresbull.2024.110935. Online ahead of print.ABSTRACTChronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammation. Previous studies from our lab tested β-lactam antibiotics and novel beta-lactam non-antibiotic, MC-100093, and showed these β-lactam upregulated the major astrocytic glutamate transporter, GLT-1, and consequently reduced ethanol intake and normalized glutamate ho...
Source: Brain Research Bulletin - April 3, 2024 Category: Neurology Authors: Shelby Travaglianti Ahmed Alotaibi Woonyen Wong Magid Abou-Gharbia Wayne Childers Youssef Sari Source Type: research
Concurrent brain structural and functional alterations in the thalamus of adult survivors of childhood brain tumors: a multimodal MRI study
This study analyzed voxel-based morphometry (VBM) derived from T1-weighted MRI and the amplitude of low-frequency fluctuation (ALFF) from resting-state functional magnetic resonance imaging (rs-fMRI) to examine the structural and functional alterations in 35 brain tumor survivors using 35 matching healthy individuals as controls. Compared with healthy controls, brain tumor survivors had decreased gray matter volumes (GMV) in the thalamus and increased GMV in the superior frontal gyrus. Functionally, brain tumor survivors had lower ALFF values in the inferior temporal gyrus and medial prefrontal area and higher ALFF values ...
Source: Brain Research Bulletin - April 3, 2024 Category: Neurology Authors: Jinfeng Hou Tricia Z King Hongbo Chen Qian Wang You Xie Hui Mao Liya Wang Luqi Cheng Source Type: research
Single-cell sequencing analysis of chronic subdural hematoma cell subpopulations and their potential therapeutic mechanisms
CONCLUSION: The detailed classification of cells in the peripheral blood and hematoma site of CSDH patients helps us to understand the mechanism of CSDH generation and the reduction in the probability of recurrence by regulating the ratio of cell subpopulations.PMID:38554980 | DOI:10.1016/j.brainresbull.2024.110936 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 30, 2024 Category: Neurology Authors: Qian Zhang Rundong Chen Lufeng Shi Hehe Zhao Fei Yin Cong Yu Yirong Wang Peng Lu Source Type: research
Single-cell sequencing analysis of chronic subdural hematoma cell subpopulations and their potential therapeutic mechanisms
CONCLUSION: The detailed classification of cells in the peripheral blood and hematoma site of CSDH patients helps us to understand the mechanism of CSDH generation and the reduction in the probability of recurrence by regulating the ratio of cell subpopulations.PMID:38554980 | DOI:10.1016/j.brainresbull.2024.110936 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 30, 2024 Category: Neurology Authors: Qian Zhang Rundong Chen Lufeng Shi Hehe Zhao Fei Yin Cong Yu Yirong Wang Peng Lu Source Type: research
Single-cell sequencing analysis of chronic subdural hematoma cell subpopulations and their potential therapeutic mechanisms
CONCLUSION: The detailed classification of cells in the peripheral blood and hematoma site of CSDH patients helps us to understand the mechanism of CSDH generation and the reduction in the probability of recurrence by regulating the ratio of cell subpopulations.PMID:38554980 | DOI:10.1016/j.brainresbull.2024.110936 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 30, 2024 Category: Neurology Authors: Qian Zhang Rundong Chen Lufeng Shi Hehe Zhao Fei Yin Cong Yu Yirong Wang Peng Lu Source Type: research
Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
This study examined somatomotor-putamen resting state connectivity, stress, and their interaction on OCS in adolescents from 9-12 years of age. Participants (n = 6,386) were drawn from the ABCD Study 4.0 release. Multilevel modeling was used to account for nesting in the data and to assess changes in OCS in this age range. Stress moderated the association between somatomotor-putamen connectivity and OCS (β = 0.35, S.E. = 0.13, p = 0.006). Participants who reported more stress than their average and had greater somatomotor-left putamen connectivity reported more OCS, whereas participants who reported less stress than their...
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Daniel J Petrie Kathleen D Meeks Zachary F Fisher Charles F Geier Source Type: research
Consistent abnormal activity in the putamen by dopamine modulation in Parkinson's disease: A resting-state neuroimaging meta-analysis
CONCLUSIONS: The convergence of local brain regions and co-activation neural networks are involved the putamen, suggesting its potential as a specific imaging biomarker to monitor treatment efficacy.SYSTEMATIC REVIEW REGISTRATION: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD CRD42022304150].PMID:38508469 | DOI:10.1016/j.brainresbull.2024.110933 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu Source Type: research
Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
This study examined somatomotor-putamen resting state connectivity, stress, and their interaction on OCS in adolescents from 9-12 years of age. Participants (n = 6,386) were drawn from the ABCD Study 4.0 release. Multilevel modeling was used to account for nesting in the data and to assess changes in OCS in this age range. Stress moderated the association between somatomotor-putamen connectivity and OCS (β = 0.35, S.E. = 0.13, p = 0.006). Participants who reported more stress than their average and had greater somatomotor-left putamen connectivity reported more OCS, whereas participants who reported less stress than their...
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Daniel J Petrie Kathleen D Meeks Zachary F Fisher Charles F Geier Source Type: research
Consistent abnormal activity in the putamen by dopamine modulation in Parkinson's disease: A resting-state neuroimaging meta-analysis
CONCLUSIONS: The convergence of local brain regions and co-activation neural networks are involved the putamen, suggesting its potential as a specific imaging biomarker to monitor treatment efficacy.SYSTEMATIC REVIEW REGISTRATION: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD CRD42022304150].PMID:38508469 | DOI:10.1016/j.brainresbull.2024.110933 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu Source Type: research
Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
This study examined somatomotor-putamen resting state connectivity, stress, and their interaction on OCS in adolescents from 9-12 years of age. Participants (n = 6,386) were drawn from the ABCD Study 4.0 release. Multilevel modeling was used to account for nesting in the data and to assess changes in OCS in this age range. Stress moderated the association between somatomotor-putamen connectivity and OCS (β = 0.35, S.E. = 0.13, p = 0.006). Participants who reported more stress than their average and had greater somatomotor-left putamen connectivity reported more OCS, whereas participants who reported less stress than their...
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Daniel J Petrie Kathleen D Meeks Zachary F Fisher Charles F Geier Source Type: research
Consistent abnormal activity in the putamen by dopamine modulation in Parkinson's disease: A resting-state neuroimaging meta-analysis
CONCLUSIONS: The convergence of local brain regions and co-activation neural networks are involved the putamen, suggesting its potential as a specific imaging biomarker to monitor treatment efficacy.SYSTEMATIC REVIEW REGISTRATION: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD CRD42022304150].PMID:38508469 | DOI:10.1016/j.brainresbull.2024.110933 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu Source Type: research
Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
This study examined somatomotor-putamen resting state connectivity, stress, and their interaction on OCS in adolescents from 9-12 years of age. Participants (n = 6,386) were drawn from the ABCD Study 4.0 release. Multilevel modeling was used to account for nesting in the data and to assess changes in OCS in this age range. Stress moderated the association between somatomotor-putamen connectivity and OCS (β = 0.35, S.E. = 0.13, p = 0.006). Participants who reported more stress than their average and had greater somatomotor-left putamen connectivity reported more OCS, whereas participants who reported less stress than their...
Source: Brain Research Bulletin - March 20, 2024 Category: Neurology Authors: Daniel J Petrie Kathleen D Meeks Zachary F Fisher Charles F Geier Source Type: research
