Cranial venous-outflow obstruction promotes neuroinflammation via ADAM17/solTNF- α/NF-κB pathway following experimental TBI
This study used an acute subdural hematoma (ASDH) model with cranial venous outflow obstruction (CVO) to explore how CVO aggravates the pathological process after TBI, especially for inflammation and tissue damage. The results suggest that intracranial venous return disorder exacerbates neurological deficits and brain edema in rats with ASDH by aggravating the destruction of endothelial cell tight junctions (TJs) proteins and promoting the expression of inflammatory factors, the activation of microglia and expression of recombinant A disintegrin and metalloprotease 17 (ADAM17) as well as the secretion of solTNF-α, a solub...
Source: Brain Research Bulletin - November 2, 2023 Category: Neurology Authors: Cheng Wang Liang Xian Shaorui Zheng Jun Li Xiangrong Chen Shousen Wang Source Type: research
Enhancement of neuronal excitability in the medial prefrontal cortex following prenatal morphine exposure
Brain Res Bull. 2023 Oct 31;204:110803. doi: 10.1016/j.brainresbull.2023.110803. Online ahead of print.ABSTRACTThe clinical use and abuse of opioids during human pregnancy have been widely reported. Several studies have demonstrated that opioids cross the placenta in rats during late gestation, and prenatal morphine exposure has been shown to have negative outcomes in cognitive function. The medial prefrontal cortex (mPFC) is believed to play a crucial role in cognitive processes, motivation, and emotion, integrating neural information from several brain areas and sending converted information to other structures. Dysfunct...
Source: Brain Research Bulletin - November 1, 2023 Category: Neurology Authors: Elham Alaee Narges Pachenari Fatemeh Khani Saeed Semnanian Amir Shojaei Hossein Azizi Source Type: research
Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review
We described the traditional Chinese medicine alleviating neuropathic pain via purinergic receptor P2 signaling pathway including P2X2/3R, P2X3R, P2X4R, P2X7R, P2Y1R. Inhibition of activating glial cells, changing synaptic transmission, increasing painful postsynaptic potential, and activating inflammatory signaling pathways maybe the mechanism. Purine receptor P2 can mediate the occurrence of neuropathic pain. And many of traditional Chinese medicines can target P2 receptors to relieve neuropathic pain, which provides reasonable evidences for the future development of drugs. Also, the safety and efficacy and mechanism nee...
Source: Brain Research Bulletin - November 1, 2023 Category: Neurology Authors: Bo Yang Nengwei Yu Source Type: research
Enhancement of neuronal excitability in the medial prefrontal cortex following prenatal morphine exposure
Brain Res Bull. 2023 Oct 30:110803. doi: 10.1016/j.brainresbull.2023.110803. Online ahead of print.ABSTRACTThe clinical use and abuse of opioids during human pregnancy have been widely reported. Several studies have demonstrated that opioids cross the placenta in rats during late gestation, and prenatal morphine exposure has been shown to have negative outcomes in cognitive function. The medial prefrontal cortex (mPFC) is believed to play a crucial role in cognitive processes, motivation, and emotion, integrating neural information from several brain areas and sending converted information to other structures. Dysfunctions...
Source: Brain Research Bulletin - November 1, 2023 Category: Neurology Authors: Elham Alaee Narges Pachenari Fatemeh Khani Saeed Semnanian Amir Shojaei Hossein Azizi Source Type: research
Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review
We described the traditional Chinese medicine alleviating neuropathic pain via purinergic receptor P2 signaling pathway including P2X2/3R, P2X3R, P2X4R, P2X7R, P2Y1R. Inhibition of activating glial cells, changing synaptic transmission, increasing painful postsynaptic potential, and activating inflammatory signaling pathways maybe the mechanism. Purine receptor P2 can mediate the occurrence of neuropathic pain. And many of traditional Chinese medicines can target P2 receptors to relieve neuropathic pain, which provides reasonable evidences for the future development of drugs. Also, the safety and efficacy and mechanism nee...
Source: Brain Research Bulletin - November 1, 2023 Category: Neurology Authors: Bo Yang Nengwei Yu Source Type: research
The environmental enrichment ameliorates chronic cerebral hypoperfusion-induced cognitive impairment by activating autophagy signaling pathway and improving synaptic function in hippocampus
CONCLUSION: The study found that EE had a positive impact on CCH-induced synaptic damage. Specifically, EE was found to increase synaptic plasticity-associated proteins and postsynaptic density thickness, while decreasing synaptic space. This multifaceted effect resulted in an amelioration of CCH-induced cognitive impairment. It was shown that this beneficial outcome was mediated via the activation of the autophagy-lysosomal pathway. Overall, the findings suggest that EE may have a therapeutic potential for cognitive impairments associated with CCH through autophagy-mediated synaptic improvement.PMID:37890595 | DOI:10.1016...
Source: Brain Research Bulletin - October 27, 2023 Category: Neurology Authors: Linling Xu Changhua Qu Yan Liu Hua Liu Source Type: research
The environmental enrichment ameliorates chronic cerebral hypoperfusion-induced cognitive impairment by activating autophagy signaling pathway and improving synaptic function in hippocampus
CONCLUSION: The study found that EE had a positive impact on CCH-induced synaptic damage. Specifically, EE was found to increase synaptic plasticity-associated proteins and postsynaptic density thickness, while decreasing synaptic space. This multifaceted effect resulted in an amelioration of CCH-induced cognitive impairment. It was shown that this beneficial outcome was mediated via the activation of the autophagy-lysosomal pathway. Overall, the findings suggest that EE may have a therapeutic potential for cognitive impairments associated with CCH through autophagy-mediated synaptic improvement.PMID:37890595 | DOI:10.1016...
Source: Brain Research Bulletin - October 27, 2023 Category: Neurology Authors: Linling Xu Changhua Qu Yan Liu Hua Liu Source Type: research
The environmental enrichment ameliorates chronic cerebral hypoperfusion-induced cognitive impairment by activating autophagy signaling pathway and improving synaptic function in hippocampus
CONCLUSION: The study found that EE had a positive impact on CCH-induced synaptic damage. Specifically, EE was found to increase synaptic plasticity-associated proteins and postsynaptic density thickness, while decreasing synaptic space. This multifaceted effect resulted in an amelioration of CCH-induced cognitive impairment. It was shown that this beneficial outcome was mediated via the activation of the autophagy-lysosomal pathway. Overall, the findings suggest that EE may have a therapeutic potential for cognitive impairments associated with CCH through autophagy-mediated synaptic improvement.PMID:37890595 | DOI:10.1016...
Source: Brain Research Bulletin - October 27, 2023 Category: Neurology Authors: Linling Xu Changhua Qu Yan Liu Hua Liu Source Type: research
The environmental enrichment ameliorates chronic cerebral hypoperfusion-induced cognitive impairment by activating autophagy signaling pathway and improving synaptic function in hippocampus
CONCLUSION: The study found that EE had a positive impact on CCH-induced synaptic damage. Specifically, EE was found to increase synaptic plasticity-associated proteins and postsynaptic density thickness, while decreasing synaptic space. This multifaceted effect resulted in an amelioration of CCH-induced cognitive impairment. It was shown that this beneficial outcome was mediated via the activation of the autophagy-lysosomal pathway. Overall, the findings suggest that EE may have a therapeutic potential for cognitive impairments associated with CCH through autophagy-mediated synaptic improvement.PMID:37890595 | DOI:10.1016...
Source: Brain Research Bulletin - October 27, 2023 Category: Neurology Authors: Linling Xu Changhua Qu Yan Liu Hua Liu Source Type: research
Next-generation cognitive assessment: Combining functional brain imaging, system perturbations and novel equipment interfaces
Brain Res Bull. 2023 Oct 22;204:110797. doi: 10.1016/j.brainresbull.2023.110797. Online ahead of print.ABSTRACTConventional cognitive assessment is widely used in clinical and research settings, in educational institutions, and in the corporate world for personnel selection. Such approaches involve having a client, a patient, or a research participant complete a series of standardized cognitive tasks in order to challenge specific and global cognitive abilities, and then quantify performance for the desired end purpose. The latter may include a diagnostic confirmation of a disease, description of a state or ability, or mat...
Source: Brain Research Bulletin - October 24, 2023 Category: Neurology Authors: Peter A Hall Amer M Burhan James C McKillop Dante Duarte Source Type: research
Next-generation cognitive assessment: combining functional brain imaging, system perturbations and novel equipment interfaces
Brain Res Bull. 2023 Oct 22:110797. doi: 10.1016/j.brainresbull.2023.110797. Online ahead of print.ABSTRACTConventional cognitive assessment is widely used in clinical and research settings, educational institutions, and the corporate world for personnel selection. Such approaches involve having an individual a client, a patient, or a research participant complete a series of standardized cognitive tasks in order to challenge specific and global cognitive abilities, and then quantify performance for the desired end purpose. The latter may include a diagnostic confirmation of a disease, description of a state or ability, or...
Source: Brain Research Bulletin - October 24, 2023 Category: Neurology Authors: Peter A Hall Amer M Burhan James C McKillop Dante Duarte Source Type: research
Next-generation cognitive assessment: combining functional brain imaging, system perturbations and novel equipment interfaces
Brain Res Bull. 2023 Oct 22:110797. doi: 10.1016/j.brainresbull.2023.110797. Online ahead of print.ABSTRACTConventional cognitive assessment is widely used in clinical and research settings, educational institutions, and the corporate world for personnel selection. Such approaches involve having an individual a client, a patient, or a research participant complete a series of standardized cognitive tasks in order to challenge specific and global cognitive abilities, and then quantify performance for the desired end purpose. The latter may include a diagnostic confirmation of a disease, description of a state or ability, or...
Source: Brain Research Bulletin - October 24, 2023 Category: Neurology Authors: Peter A Hall Amer M Burhan James C McKillop Dante Duarte Source Type: research
Altered effective connectivity from cerebellum to motor cortex in chronic low back pain: A multivariate pattern analysis and spectral dynamic causal modeling study
Brain Res Bull. 2023 Oct 21:110794. doi: 10.1016/j.brainresbull.2023.110794. Online ahead of print.ABSTRACTTo explore the central processing mechanism of pain perception in chronic low back pain (cLBP) using multi-voxel pattern analysis (MVPA) based on the static and dynamic fractional amplitude of low-frequency fluctuations (fALFF) analysis, and spectral dynamic causal modeling (spDCM). Thirty-two patients with cLBP and 29 matched healthy controls (HCs) for the first cohort and 24 patients with cLBP and 22 HCs for the validation cohort underwent resting-state fMRI scan. The alterations in static and dynamic fALFF were as ...
Source: Brain Research Bulletin - October 23, 2023 Category: Neurology Authors: Yilei Chen Yuchan Yang Zhigang Gong Yingjie Kang Yingying Zhang Hui Chen Ke Zeng Xinbo Men Jianwei Wang Yanwen Huang Hui Wang Songhua Zhan Wenli Tan Wei Wang Source Type: research
Altered effective connectivity from cerebellum to motor cortex in chronic low back pain: A multivariate pattern analysis and spectral dynamic causal modeling study
Brain Res Bull. 2023 Oct 21:110794. doi: 10.1016/j.brainresbull.2023.110794. Online ahead of print.ABSTRACTTo explore the central processing mechanism of pain perception in chronic low back pain (cLBP) using multi-voxel pattern analysis (MVPA) based on the static and dynamic fractional amplitude of low-frequency fluctuations (fALFF) analysis, and spectral dynamic causal modeling (spDCM). Thirty-two patients with cLBP and 29 matched healthy controls (HCs) for the first cohort and 24 patients with cLBP and 22 HCs for the validation cohort underwent resting-state fMRI scan. The alterations in static and dynamic fALFF were as ...
Source: Brain Research Bulletin - October 23, 2023 Category: Neurology Authors: Yilei Chen Yuchan Yang Zhigang Gong Yingjie Kang Yingying Zhang Hui Chen Ke Zeng Xinbo Men Jianwei Wang Yanwen Huang Hui Wang Songhua Zhan Wenli Tan Wei Wang Source Type: research
Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling
CONCLUSIONS: Our results suggest that ANO1 plays an important role in the survival of ALS motor neurons. ANO1 can increase cell activity and reduce apoptosis by activating EGFR and CaMKII signals.PMID:37858681 | DOI:10.1016/j.brainresbull.2023.110792 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Wang Weiwei Liang Tianhang Wang Chunting Zhang Yueqing Yang Chaohua Cong Xudong Wang Shuyu Wang Di Wang Di Huo Hongyong Wang Xiaoli Su Xingli Tan Honglin Feng Source Type: research
