MGFKD: A Semi-Supervised Multi-Source Domain Adaptation Algorithm for Cross-Subject EEG Emotion Recognition
Brain Res Bull. 2024 Feb 12:110901. doi: 10.1016/j.brainresbull.2024.110901. Online ahead of print.ABSTRACTCurrently, most models rarely consider the negative transfer problem in the research field of cross-subject EEG emotion recognition. To solve this problem, this paper proposes a semi-supervised domain adaptive algorithm based on few labeled samples of target subject, which called multi-domain geodesic flow kernel dynamic distribution alignment (MGFKD). It consists of three modules: 1) GFK common feature extractor: projects the feature distribution of source and target subjects to the Grassmann manifold space, and obta...
Source: Brain Research Bulletin - February 14, 2024 Category: Neurology Authors: Rui Zhang Huifeng Guo Zongxin Xu Yuxia Hu Mingming Chen Lipeng Zhang Source Type: research
Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral hypoperfusion rats
This study stripped out the different components of EE into physical environmental enrichment (PE) and social environmental enrichment (SE), and compared the neuroprotective effects of PE, SE and typical EE (PSE) in CCH. The results of novel object recognition and Morris water maze tests showed that PE, SE, and PSE improved cognitive function in CCH rats. Additionally, Nissl and TUNEL staining revealed that three EEs reduced neuronal loss in the hippocampus. PSE exhibited superior neuroprotective and functional improvement effects compared to PE and SE, while there was no significant difference between PE and SE. Furthermo...
Source: Brain Research Bulletin - February 10, 2024 Category: Neurology Authors: Bin Fan Ying Zhang Qihang Luo Chizi Hao Weijing Liao Source Type: research
Topological alteration of the brain structural network in Parkinson's disease with apathy
CONCLUSIONS: The findings suggested that apathy in PD presented relatively optimized global topological properties of the brain structural network and disrupted topological organization of the regional network, particularly involving the fronto-striatal-limbic circuits. The altered topological properties of abnormal brain regions might be used to understand the physiopathologic mechanism of the neural network in aPD patients.PMID:38340778 | DOI:10.1016/j.brainresbull.2024.110899 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 10, 2024 Category: Neurology Authors: Shaoyun Ge Jun Liu Yongfeng Jia Zihan Li Jianwei Wang Min Wang Source Type: research
Continuous inhalation of essential oil increases gray matter volume
This study is the first to show that continuous scent inhalation changes brain structure.PMID:38331299 | DOI:10.1016/j.brainresbull.2024.110896 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 8, 2024 Category: Neurology Authors: Keisuke Kokubun Kiyotaka Nemoto Yoshinori Yamakawa Source Type: research
Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke
In this study, we investigated the mechanisms of how canonical transient receptor potential 1 (TRPC1) modulated neutrophil infiltration in male mouse cerebral ischemia and reperfusion injury (CIRI) models. Our findings revealed a notable upregulation of TRPC1 in microglia within both middle cerebral artery occlusion reperfusion (MCAO/R) and in vitro oxygen-glucose deprivation/regeneration (OGD/R) model. Conditional Trpc1 knockdown in microglia markedly reduced infarct volumes and alleviated neurological deficits. Microglia conditional Trpc1 knockdown mice displayed less neutrophil infiltration in peri-infarct area. Trpc1 k...
Source: Brain Research Bulletin - February 7, 2024 Category: Neurology Authors: Hao Qian Hui-Nan Zhang Tian Gao Xin-Shang Wang Xing Wang Man-Yang Yu Ming-Kai Li Jing Huang Source Type: research
Statistical analysis and generative Artificial Intelligence (AI) for assessing pain experience, pain-induced disability, and quality of life in Parkinson's disease patients
This study lays the foundation for future research and the development of interventions aimed at improving the quality of life for individuals affected by this condition.PMID:38316194 | DOI:10.1016/j.brainresbull.2024.110893 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - February 5, 2024 Category: Neurology Authors: Luana Conte Roberto Lupo Pierluigi Lezzi Alessio Pedone Ivan Rubbi Alessia Lezzi Elsa Vitale Antonio Fasano Giorgio De Nunzio Source Type: research
IL-17A deficiency alleviates cerebral ischemia-reperfusion injury via activating ERK/MAPK pathway in hippocampal CA1 region
Brain Res Bull. 2024 Feb 1;208:110890. doi: 10.1016/j.brainresbull.2024.110890. Online ahead of print.ABSTRACTCognitive impairment is a major complication of cerebral ischemia-reperfusion (CIR) injury and has an important impact on the quality of life of patients. However, the precise mechanisms underlying cognitive impairment after CIR injury remain elusive. In the current study, we investigated the role of interleukin 17 A (IL-17A) on CIR injury-induced cognitive impairment in wild-type and IL-17A knockout mice using RNA sequencing analysis, neurological assessments, Golgi-Cox staining, dendritic spine analysis, immunofl...
Source: Brain Research Bulletin - February 1, 2024 Category: Neurology Authors: Yanan Li Qi Zhang Xupeng Wang Fang Xu Junfang Niu Juan Zhao Qiujun Wang Source Type: research
Baicalein ameliorates cognitive impairment of vascular dementia rats via suppressing neuroinflammation and regulating intestinal microbiota
In conclusion, this study found that baicalein ameliorated cognitive impairment, attenuated hippocampal inflammatory responses, inhibited the TLR4/MyD88/NF-κB signaling pathway, and modulated intestinal microbiota in VD rats.PMID:38295883 | DOI:10.1016/j.brainresbull.2024.110888 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - January 31, 2024 Category: Neurology Authors: Jiaxi Song Meixi Li Ning Kang Wei Jin Yining Xiao Zhe Li Qianqian Qi Jiayu Zhang Yaxin Duan Xiaoxiao Feng Peiyuan Lv Source Type: research
Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation
Brain Res Bull. 2024 Jan 28;208:110889. doi: 10.1016/j.brainresbull.2024.110889. Online ahead of print.ABSTRACTTemporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) may present as comorbid conditions, but treatment options are ineffective. The purpose of this study was to investigate whether valproate (VPA) attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress, which represents a model of pain associated with TMD and FMS comorbidity, and to explore the potential mechanisms. The results showed that VPA inhibited somatic hyperalgesia induced by orofacial inflammation combined with ...
Source: Brain Research Bulletin - January 30, 2024 Category: Neurology Authors: Chen-Xi Xu Xin-Yi Qiu Yi Guo Tian-Ming Xu Richard J Traub Hai-Nan Feng Dong-Yuan Cao Source Type: research
Hippocampal-prefrontal high-gamma flow during performance of a spatial working memory
Brain Res Bull. 2024 Feb;207:110887. doi: 10.1016/j.brainresbull.2024.110887. Epub 2024 Jan 26.ABSTRACTWorking memory refers to a system that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. The prefrontal cortex (PFC) and hippocampus (HPC) are major structures contributing to working memory. Accumulating evidence suggests that the HPC-PFC interactions are critical for the successful execution of working memory tasks. Nevertheless, the directional information transmission within the HPC-PFC pathway remains unclear. Using simultaneous multi-electrode recordings, we record...
Source: Brain Research Bulletin - January 27, 2024 Category: Neurology Authors: Wenwen Bai Yinglong Liu Aili Liu Xinyu Xu Xuyuan Zheng Xin Tian Tiaotiao Liu Source Type: research
Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1
In this study, we investigated the protective mechanism of wogonin against middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation (OGD/R) model-induced cerebral IR injury through adenosine 5'-monophosphate-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome axis. Our results showed that wogonin (20 mg/kg, intraperitoneal injection) effectively reduced infarct size, attenuated brain edema, improved neurological deficits, and alleviated histopathological damage. In addition, wogonin reduced microglial cell activation and infla...
Source: Brain Research Bulletin - January 22, 2024 Category: Neurology Authors: Zhijuan Cheng Jianglong Tu Kai Wang Fang Li Yuan He Wei Wu Source Type: research
Rab3a attenuates spinal cord injury by mediating vesicle release
CONCLUSION: These results suggest that Rab3a promotes the secretion of neuronal cell-derived EVs by interacting with its binding protein STXBP1. Neuronal cells-derived EVs inhibited the polarization of M1 macrophages in the spinal cord microenvironment, thereby promoting SCI repair. Our findings provide a theoretical basis for the clinical treatment of SCI.PMID:38253132 | DOI:10.1016/j.brainresbull.2024.110884 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - January 22, 2024 Category: Neurology Authors: Yuhao Yang Yang Lu Xincheng Yu Rui Zhu Xingda Cai Jinghua Lin Dingsheng Zha Source Type: research
Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis
Brain Res Bull. 2024 Feb;207:110885. doi: 10.1016/j.brainresbull.2024.110885. Epub 2024 Jan 20.ABSTRACTMultiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes to inflammatory disease pathogenesis. In contrast, TNF receptor 2 signaling is neuroprotective. Current anti-TNF MS therapies are shown to be detrimental to patients due to pleiotropic effects on both pro- and anti-inflammatory functions. Using a non-pertussis toxin (nPTX) expe...
Source: Brain Research Bulletin - January 21, 2024 Category: Neurology Authors: Kayla L Nguyen Ishaan J Bhatt Shruti Gupta Nazaf Showkat Kathryn A Swanson Roman Fischer Roland E Kontermann Klaus Pfizenmaier Valerie Bracchi-Ricard John R Bethea Source Type: research
Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review
In conclusion, the interplay of bacterial species and their abundances may have a greater impact on brain diseases than individual drugs or bacterial strains. Future research is needed to better understand drug-induced dysbiosis and the implications for brain disease pathogenesis, with the potential to develop more effective therapeutic options for patients with brain-related diseases.PMID:38244807 | DOI:10.1016/j.brainresbull.2024.110883 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - January 20, 2024 Category: Neurology Authors: Kirti Garg M Hasan Mohajeri Source Type: research
BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis
Brain Res Bull. 2024 Feb;207:110882. doi: 10.1016/j.brainresbull.2024.110882. Epub 2024 Jan 19.ABSTRACTEmerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor and cAMP response element-binding protein known as CREB/BDNF pathway plays have critical functions in the pathogenesis of depression as the same of mechanisms related to antidepressants. However, the putative caus...
Source: Brain Research Bulletin - January 20, 2024 Category: Neurology Authors: Somaieh Matin Masoomeh Dadkhah Source Type: research
