Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling
CONCLUSIONS: Our results suggest that ANO1 plays an important role in the survival of ALS motor neurons. ANO1 can increase cell activity and reduce apoptosis by activating EGFR and CaMKII signals.PMID:37858681 | DOI:10.1016/j.brainresbull.2023.110792 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Ying Wang Weiwei Liang Tianhang Wang Chunting Zhang Yueqing Yang Chaohua Cong Xudong Wang Shuyu Wang Di Wang Di Huo Hongyong Wang Xiaoli Su Xingli Tan Honglin Feng Source Type: research
Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice
CONCLUSIONS: Hsp70 treatment might serve as a potential treatment for mitigating SD-related unfavorable symptoms.PMID:37858682 | DOI:10.1016/j.brainresbull.2023.110791 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 20, 2023 Category: Neurology Authors: Zhenming Kang Yiqin Lin Changsheng Su Shunyuan Li Wenqin Xie Xiaodan Wu Source Type: research
Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction
CONCLUSION: Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia.PMID:37852420 | DOI:10.1016/j.brainresbull.2023.110790 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 18, 2023 Category: Neurology Authors: Binwen Liu Xurui Zhu Qingyun Zhou Yan Su Yue Qian Zhengliang Ma Xiaoping Gu Tianjiao Xia Source Type: research
Central administered xenin induced Fos expression in nesfatin-1 neurons in rats
Brain Res Bull. 2023 Oct 14;204:110788. doi: 10.1016/j.brainresbull.2023.110788. Online ahead of print.ABSTRACTXenin is a 25-amino acid peptide identified in human gastric mucosa, which is widely expressed in peripheral and central tissues. It is known that the central or peripheral administration of xenin decreases food intake in rodents. Nesfatin-1/NUCB2 (nesfatin-1) has been identified as an anorexic neuropeptide, it is often found co-localized with many peptides in the central nervous system. After the intracerebroventricular administration of xenin on nesfain-1-like immunoreactivity (LI) neurons, we examined its effec...
Source: Brain Research Bulletin - October 16, 2023 Category: Neurology Authors: Shota Saito Hirofumi Hashimoto Hidefumi Wakashin Misaki Ishibane Sangjon Pae Shinpei Saito Yoshie Reien Yuri Hirayama Yoshiteru Seo Takashi Mizushima Naohiko Anzai Source Type: research
Central administered xenin induced Fos expression in nesfatin-1 neurons in rats
Brain Res Bull. 2023 Oct 14:110788. doi: 10.1016/j.brainresbull.2023.110788. Online ahead of print.ABSTRACTXenin is a 25-amino acid peptide identified in human gastric mucosa, which is widely expressed in peripheral and central tissues. It is known that the central or peripheral administration of xenin decreases food intake in rodents. Nesfatin-1/NUCB2 (nesfatin-1) has been identified as an anorexic neuropeptide, it is often found co-localized with many peptides in the central nervous system. After the intracerebroventricular administration of xenin on nesfain-1-like immunoreactivity (LI) neurons, we examined its effects o...
Source: Brain Research Bulletin - October 16, 2023 Category: Neurology Authors: Shota Saito Hirofumi Hashimoto Hidefumi Wakashin Misaki Ishibane Sangjon Pae Shinpei Saito Yoshie Reien Yuri Hirayama Yoshiteru Seo Takashi Mizushima Naohiko Anzai Source Type: research
Possible mechanisms involved in the neuroprotective effects of chrysin against mild traumatic brain injury-induced spatial cognitive decline: An in vivo study in a rat model
Brain Res Bull. 2023 Oct 10:110779. doi: 10.1016/j.brainresbull.2023.110779. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is recognized as an important risk factor for cognitive deficits. The present study was designed to determine the potential neuroprotective effects of chrysin, a natural flavonoid compound, against TBI-induced spatial cognitive decline and the possible mechanisms involved. Oral administration of chrysin (25, 50, or 100mg/kg/day) was initiated in rats immediately following the induction of the diffuse TBI model using the weight-dropping Marmarou model. Spatial cognitive ability, hippocampal...
Source: Brain Research Bulletin - October 12, 2023 Category: Neurology Authors: Masome Rashno Alireza Sarkaki Yaghoob Farbood Mohammad Rashno Layasadat Khorsandi Mohammad Kazem Gharib Naseri Mahin Dianat Source Type: research
Possible mechanisms involved in the neuroprotective effects of chrysin against mild traumatic brain injury-induced spatial cognitive decline: An in vivo study in a rat model
Brain Res Bull. 2023 Oct 10:110779. doi: 10.1016/j.brainresbull.2023.110779. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is recognized as an important risk factor for cognitive deficits. The present study was designed to determine the potential neuroprotective effects of chrysin, a natural flavonoid compound, against TBI-induced spatial cognitive decline and the possible mechanisms involved. Oral administration of chrysin (25, 50, or 100mg/kg/day) was initiated in rats immediately following the induction of the diffuse TBI model using the weight-dropping Marmarou model. Spatial cognitive ability, hippocampal...
Source: Brain Research Bulletin - October 12, 2023 Category: Neurology Authors: Masome Rashno Alireza Sarkaki Yaghoob Farbood Mohammad Rashno Layasadat Khorsandi Mohammad Kazem Gharib Naseri Mahin Dianat Source Type: research
Possible mechanisms involved in the neuroprotective effects of chrysin against mild traumatic brain injury-induced spatial cognitive decline: An in vivo study in a rat model
Brain Res Bull. 2023 Oct 10:110779. doi: 10.1016/j.brainresbull.2023.110779. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is recognized as an important risk factor for cognitive deficits. The present study was designed to determine the potential neuroprotective effects of chrysin, a natural flavonoid compound, against TBI-induced spatial cognitive decline and the possible mechanisms involved. Oral administration of chrysin (25, 50, or 100mg/kg/day) was initiated in rats immediately following the induction of the diffuse TBI model using the weight-dropping Marmarou model. Spatial cognitive ability, hippocampal...
Source: Brain Research Bulletin - October 12, 2023 Category: Neurology Authors: Masome Rashno Alireza Sarkaki Yaghoob Farbood Mohammad Rashno Layasadat Khorsandi Mohammad Kazem Gharib Naseri Mahin Dianat Source Type: research
Possible mechanisms involved in the neuroprotective effects of chrysin against mild traumatic brain injury-induced spatial cognitive decline: An in vivo study in a rat model
Brain Res Bull. 2023 Oct 10:110779. doi: 10.1016/j.brainresbull.2023.110779. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is recognized as an important risk factor for cognitive deficits. The present study was designed to determine the potential neuroprotective effects of chrysin, a natural flavonoid compound, against TBI-induced spatial cognitive decline and the possible mechanisms involved. Oral administration of chrysin (25, 50, or 100mg/kg/day) was initiated in rats immediately following the induction of the diffuse TBI model using the weight-dropping Marmarou model. Spatial cognitive ability, hippocampal...
Source: Brain Research Bulletin - October 12, 2023 Category: Neurology Authors: Masome Rashno Alireza Sarkaki Yaghoob Farbood Mohammad Rashno Layasadat Khorsandi Mohammad Kazem Gharib Naseri Mahin Dianat Source Type: research
Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage
In conclusion, knockdown of endogenous Arc could aggravate brain damage and neuroinflammation following experimental SAH, and Arc levels in aSAH patients' CSF might be a potential indicator of brain damage and prognosis.PMID:37820952 | DOI:10.1016/j.brainresbull.2023.110780 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - October 11, 2023 Category: Neurology Authors: Tao Chen Ye-Ping Xu Yang Chen Shu Sun Zhi-Zhong Yan Yu-Hai Wang Source Type: research
Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism
This study aims to explore the potential molecular mechanisms by which EE modulates iron metabolism to reduce ferroptosis. The experimental animals were randomly divided into four groups based on the housing environment and the procedure the animals received: the sham-operated + standard environment (SSE) group, the sham-operated + enriched environment (SEE) group, the ischemia/reperfusion + standard environment (ISE) group, and the ischemia/reperfusion + enriched environment (IEE) group. The results showed that EE reduced IL-6 expression during cerebral I/R injury, hence reducing JAK2-STAT3 pathway activation and hepcidin...
Source: Brain Research Bulletin - October 9, 2023 Category: Neurology Authors: Qihang Luo Jun Zheng Bin Fan Jingying Liu Weijing Liao Xin Zhang Source Type: research
Tau trajectory in Alzheimer's disease: Evidence from the connectome-based computational models
Brain Res Bull. 2023 Oct 7;203:110777. doi: 10.1016/j.brainresbull.2023.110777. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder with an impairment of cognition and memory. Current research on connectomics have now related changes in the network organization in AD to the patterns of accumulation and spread of amyloid and tau, providing insights into the neurobiological mechanisms of the disease. In addition, network analysis and modeling focus on particular use of graphs to provide intuition into key organizational principles of brain structure, that stipulate how neural ac...
Source: Brain Research Bulletin - October 9, 2023 Category: Neurology Authors: Veera Raghavulu Bitra Siva Reddy Challa Paul C Adiukwu Deepthi Rapaka Source Type: research
Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism
This study aims to explore the potential molecular mechanisms by which EE modulates iron metabolism to reduce ferroptosis. The experimental animals were randomly divided into four groups based on the housing environment and the procedure the animals received: the sham-operated + standard environment (SSE) group, the sham-operated + enriched environment (SEE) group, the ischemia/reperfusion + standard environment (ISE) group, and the ischemia/reperfusion + enriched environment (IEE) group. The results showed that EE reduced IL-6 expression during cerebral I/R injury, hence reducing JAK2-STAT3 pathway activation and hepcidin...
Source: Brain Research Bulletin - October 9, 2023 Category: Neurology Authors: Qihang Luo Jun Zheng Bin Fan Jingying Liu Weijing Liao Xin Zhang Source Type: research
Tau trajectory in Alzheimer's disease: Evidence from the connectome-based computational models
Brain Res Bull. 2023 Oct 7:110777. doi: 10.1016/j.brainresbull.2023.110777. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder with an impairment of cognition and memory. Current research on connectomics have now related changes in the network organization in AD to the patterns of accumulation and spread of amyloid and tau, providing insights into the neurobiological mechanisms of the disease. In addition, network analysis and modeling focus on particular use of graphs to provide intuition into key organizational principles of brain structure, that stipulate how neural activi...
Source: Brain Research Bulletin - October 9, 2023 Category: Neurology Authors: Veera Raghavulu Bitra Siva Reddy Challa Paul C Adiukwu Deepthi Rapaka Source Type: research
Plasma A β level alterations after sleep deprivation correspond to brain structural remodeling in medical night shift workers
Brain Res Bull. 2023 Oct 5;203:110776. doi: 10.1016/j.brainresbull.2023.110776. Online ahead of print.ABSTRACTThe relationship between brain structure alteration and metabolic product clearance after night shift work with total sleep deprivation (SD) remains unclear. Twenty-two intensive care unit staff on regularly rotating shift work were implemented with structural and diffusion MRI under both rest wakefulness (RW) and SD conditions. Peripheral blood samples were collected for the measurement of cerebral metabolites. Voxel-based morphometry and diffusion tensor imaging analysis were used to investigate the alterations i...
Source: Brain Research Bulletin - October 7, 2023 Category: Neurology Authors: Hao-Tian Ye Chun-Qiang Lu Cong Wang Di Zhang Yan-Fei Li Xiang-Yun Feng Hua-Peng Wang Yuan-Yuan Mao Mu-Huo Ji Jian-Jun Yang Source Type: research
